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Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H (EC 3.4.22.16); Cathepsin H heavy chain; Cathepsin H light chain]

 CATH_RAT                Reviewed;         333 AA.
P00786;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
01-AUG-1988, sequence version 1.
22-NOV-2017, entry version 152.
RecName: Full=Pro-cathepsin H;
Contains:
RecName: Full=Cathepsin H mini chain;
Contains:
RecName: Full=Cathepsin H;
EC=3.4.22.16;
Contains:
RecName: Full=Cathepsin H heavy chain;
Contains:
RecName: Full=Cathepsin H light chain;
Flags: Precursor;
Name=Ctsh;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Wistar; TISSUE=Kidney;
PubMed=3691815; DOI=10.1016/0014-5793(87)80545-8;
Ishidoh K., Imajoh S., Emori Y., Ohno S., Kawasaki H., Minami Y.,
Kominami E., Katunuma N., Suzuki K.;
"Molecular cloning and sequencing of cDNA for rat cathepsin H.
Homology in pro-peptide regions of cysteine proteinases.";
FEBS Lett. 226:33-37(1987).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
PubMed=2759235; DOI=10.1016/0014-5793(89)80939-1;
Ishidoh K., Kominami E., Katunuma N., Suzuki K.;
"Gene structure of rat cathepsin H.";
FEBS Lett. 253:103-107(1989).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Testis;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 4-333.
TISSUE=Liver;
PubMed=2276418; DOI=10.1016/0020-711X(90)90237-W;
Qian F., Frankfater A., Miller R.V., Chan S.J., Steiner D.F.;
"Molecular cloning of rat precursor cathepsin H and the expression of
five lysosomal cathepsins in normal tissues and in a rat
carcinosarcoma.";
Int. J. Biochem. 22:1457-1464(1990).
[5]
PROTEIN SEQUENCE OF 114-333.
TISSUE=Liver;
PubMed=6574504; DOI=10.1073/pnas.80.12.3666;
Takio K., Towatari T., Katunuma N., Teller D.C., Titani K.;
"Homology of amino acid sequences of rat liver cathepsins B and H with
that of papain.";
Proc. Natl. Acad. Sci. U.S.A. 80:3666-3670(1983).
-!- FUNCTION: Important for the overall degradation of proteins in
lysosomes.
-!- CATALYTIC ACTIVITY: Hydrolysis of proteins, acting as an
aminopeptidase (notably, cleaving Arg-|-Xaa bonds) as well as an
endopeptidase.
-!- SUBUNIT: Composed of a mini chain and a large chain. The large
chain may be split into heavy and light chain. All chains are held
together by disulfide bonds.
-!- SUBCELLULAR LOCATION: Lysosome.
-!- SIMILARITY: Belongs to the peptidase C1 family.
{ECO:0000255|PROSITE-ProRule:PRU10088, ECO:0000255|PROSITE-
ProRule:PRU10089, ECO:0000255|PROSITE-ProRule:PRU10090}.
-!- SEQUENCE CAUTION:
Sequence=AAA63484.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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EMBL; Y00708; CAA68699.1; -; mRNA.
EMBL; BC085352; AAH85352.1; -; mRNA.
EMBL; M38135; AAA63484.1; ALT_INIT; mRNA.
PIR; S00211; KHRTH.
RefSeq; NP_037071.1; NM_012939.1.
RefSeq; XP_008764662.1; XM_008766440.2.
UniGene; Rn.1997; -.
ProteinModelPortal; P00786; -.
SMR; P00786; -.
STRING; 10116.ENSRNOP00000019285; -.
BindingDB; P00786; -.
MEROPS; I29.003; -.
iPTMnet; P00786; -.
PhosphoSitePlus; P00786; -.
PaxDb; P00786; -.
PRIDE; P00786; -.
GeneID; 25425; -.
KEGG; rno:25425; -.
UCSC; RGD:2447; rat.
CTD; 1512; -.
RGD; 2447; Ctsh.
eggNOG; KOG1543; Eukaryota.
eggNOG; COG4870; LUCA.
HOGENOM; HOG000230774; -.
HOVERGEN; HBG011513; -.
InParanoid; P00786; -.
KO; K01366; -.
PhylomeDB; P00786; -.
TreeFam; TF328985; -.
PRO; PR:P00786; -.
Proteomes; UP000002494; Unplaced.
Genevisible; P00786; RN.
GO; GO:0001669; C:acrosomal vesicle; IDA:RGD.
GO; GO:0097208; C:alveolar lamellar body; IDA:RGD.
GO; GO:0005930; C:axoneme; IDA:RGD.
GO; GO:0005829; C:cytosol; ISS:UniProtKB.
GO; GO:0070062; C:extracellular exosome; ISO:RGD.
GO; GO:0005615; C:extracellular space; IDA:RGD.
GO; GO:0005764; C:lysosome; IDA:RGD.
GO; GO:0001520; C:outer dense fiber; IDA:RGD.
GO; GO:0004177; F:aminopeptidase activity; IDA:RGD.
GO; GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process; ISS:UniProtKB.
GO; GO:0004197; F:cysteine-type endopeptidase activity; ISS:UniProtKB.
GO; GO:0008234; F:cysteine-type peptidase activity; ISO:RGD.
GO; GO:0004175; F:endopeptidase activity; ISO:RGD.
GO; GO:0030108; F:HLA-A specific activating MHC class I receptor activity; ISS:UniProtKB.
GO; GO:0030984; F:kininogen binding; IPI:RGD.
GO; GO:0016505; F:peptidase activator activity involved in apoptotic process; ISO:RGD.
GO; GO:0008233; F:peptidase activity; ISO:RGD.
GO; GO:0032403; F:protein complex binding; IPI:RGD.
GO; GO:0043621; F:protein self-association; IDA:RGD.
GO; GO:0004252; F:serine-type endopeptidase activity; ISS:UniProtKB.
GO; GO:0070324; F:thyroid hormone binding; ISS:UniProtKB.
GO; GO:0002250; P:adaptive immune response; ISO:RGD.
GO; GO:0010815; P:bradykinin catabolic process; ISS:UniProtKB.
GO; GO:0097067; P:cellular response to thyroid hormone stimulus; IEP:UniProtKB.
GO; GO:0060448; P:dichotomous subdivision of terminal units involved in lung branching; ISS:UniProtKB.
GO; GO:0070371; P:ERK1 and ERK2 cascade; ISS:UniProtKB.
GO; GO:0006955; P:immune response; IBA:GO_Central.
GO; GO:0002764; P:immune response-regulating signaling pathway; ISS:UniProtKB.
GO; GO:0033619; P:membrane protein proteolysis; ISS:UniProtKB.
GO; GO:0001656; P:metanephros development; IEP:UniProtKB.
GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0010813; P:neuropeptide catabolic process; ISS:UniProtKB.
GO; GO:0045766; P:positive regulation of angiogenesis; ISS:UniProtKB.
GO; GO:2001235; P:positive regulation of apoptotic signaling pathway; ISO:RGD.
GO; GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
GO; GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.
GO; GO:0010634; P:positive regulation of epithelial cell migration; ISS:UniProtKB.
GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
GO; GO:0010952; P:positive regulation of peptidase activity; ISS:UniProtKB.
GO; GO:0031648; P:protein destabilization; ISS:UniProtKB.
GO; GO:0006508; P:proteolysis; IEP:RGD.
GO; GO:0051603; P:proteolysis involved in cellular protein catabolic process; IBA:GO_Central.
GO; GO:1990834; P:response to odorant; IEP:RGD.
GO; GO:0032526; P:response to retinoic acid; ISS:UniProtKB.
GO; GO:0007283; P:spermatogenesis; IEP:RGD.
GO; GO:0043129; P:surfactant homeostasis; ISS:UniProtKB.
GO; GO:0001913; P:T cell mediated cytotoxicity; ISS:UniProtKB.
GO; GO:0031638; P:zymogen activation; ISS:UniProtKB.
InterPro; IPR025661; Pept_asp_AS.
InterPro; IPR000169; Pept_cys_AS.
InterPro; IPR025660; Pept_his_AS.
InterPro; IPR013128; Peptidase_C1A.
InterPro; IPR000668; Peptidase_C1A_C.
InterPro; IPR013201; Prot_inhib_I29.
PANTHER; PTHR12411; PTHR12411; 1.
Pfam; PF08246; Inhibitor_I29; 1.
Pfam; PF00112; Peptidase_C1; 1.
PRINTS; PR00705; PAPAIN.
SMART; SM00848; Inhibitor_I29; 1.
SMART; SM00645; Pept_C1; 1.
PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
1: Evidence at protein level;
Complete proteome; Direct protein sequencing; Disulfide bond;
Glycoprotein; Hydrolase; Lysosome; Protease; Reference proteome;
Signal; Thiol protease; Zymogen.
SIGNAL 1 20 {ECO:0000255}.
PROPEP 21 95 Activation peptide.
/FTId=PRO_0000026224.
CHAIN 96 103 Cathepsin H mini chain.
/FTId=PRO_0000026225.
PROPEP 104 113 {ECO:0000255}.
/FTId=PRO_0000026226.
CHAIN 114 333 Cathepsin H.
/FTId=PRO_0000026227.
CHAIN 114 290 Cathepsin H heavy chain.
/FTId=PRO_0000026228.
CHAIN 291 333 Cathepsin H light chain.
/FTId=PRO_0000026229.
ACT_SITE 139 139 {ECO:0000250}.
ACT_SITE 279 279 {ECO:0000250}.
ACT_SITE 299 299 {ECO:0000250}.
CARBOHYD 228 228 N-linked (GlcNAc...) asparagine.
{ECO:0000269|PubMed:6574504}.
DISULFID 100 325 {ECO:0000250}.
DISULFID 136 179 {ECO:0000250}.
DISULFID 170 212 {ECO:0000250}.
DISULFID 270 320 {ECO:0000250}.
VARIANT 287 287 G -> A.
SEQUENCE 333 AA; 37104 MW; A90AC66338F0B744 CRC64;
MWTALPLLCA GAWLLSAGAT AELTVNAIEK FHFTSWMKQH QKTYSSREYS HRLQVFANNW
RKIQAHNQRN HTFKMGLNQF SDMSFAEIKH KYLWSEPQNC SATKSNYLRG TGPYPSSMDW
RKKGNVVSPV KNQGACGSCW TFSTTGALES AVAIASGKMM TLAEQQLVDC AQNFNNHGCQ
GGLPSQAFEY ILYNKGIMGE DSYPYIGKNG QCKFNPEKAV AFVKNVVNIT LNDEAAMVEA
VALYNPVSFA FEVTEDFMMY KSGVYSSNSC HKTPDKVNHA VLAVGYGEQN GLLYWIVKNS
WGSNWGNNGY FLIERGKNMC GLAACASYPI PQV


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