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Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H (EC 3.4.22.16); Cathepsin H heavy chain; Cathepsin H light chain]

 CATH_BOVIN              Reviewed;         335 AA.
Q3T0I2;
30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
11-OCT-2005, sequence version 1.
25-OCT-2017, entry version 89.
RecName: Full=Pro-cathepsin H;
Contains:
RecName: Full=Cathepsin H mini chain;
Contains:
RecName: Full=Cathepsin H;
EC=3.4.22.16;
Contains:
RecName: Full=Cathepsin H heavy chain;
Contains:
RecName: Full=Cathepsin H light chain;
Flags: Precursor;
Name=CTSH;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Crossbred X Angus; TISSUE=Ileum;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Important for the overall degradation of proteins in
lysosomes. {ECO:0000250}.
-!- CATALYTIC ACTIVITY: Hydrolysis of proteins, acting as an
aminopeptidase (notably, cleaving Arg-|-Xaa bonds) as well as an
endopeptidase.
-!- SUBUNIT: Composed of a mini chain and a large chain. The large
chain may be split into heavy and light chain. All chains are held
together by disulfide bonds (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Lysosome {ECO:0000250}.
-!- SIMILARITY: Belongs to the peptidase C1 family.
{ECO:0000255|PROSITE-ProRule:PRU10088, ECO:0000255|PROSITE-
ProRule:PRU10089, ECO:0000255|PROSITE-ProRule:PRU10090}.
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EMBL; BC102386; AAI02387.1; -; mRNA.
RefSeq; NP_001029557.1; NM_001034385.2.
UniGene; Bt.52393; -.
ProteinModelPortal; Q3T0I2; -.
SMR; Q3T0I2; -.
STRING; 9913.ENSBTAP00000014593; -.
MEROPS; C01.040; -.
PaxDb; Q3T0I2; -.
PRIDE; Q3T0I2; -.
Ensembl; ENSBTAT00000014593; ENSBTAP00000014593; ENSBTAG00000010992.
GeneID; 510524; -.
KEGG; bta:510524; -.
CTD; 1512; -.
eggNOG; KOG1543; Eukaryota.
eggNOG; COG4870; LUCA.
GeneTree; ENSGT00900000140823; -.
HOGENOM; HOG000230774; -.
HOVERGEN; HBG011513; -.
InParanoid; Q3T0I2; -.
KO; K01366; -.
OMA; IMGEDTY; -.
OrthoDB; EOG091G0AKT; -.
TreeFam; TF328985; -.
Reactome; R-BTA-5683826; Surfactant metabolism.
Reactome; R-BTA-6798695; Neutrophil degranulation.
Proteomes; UP000009136; Chromosome 21.
Bgee; ENSBTAG00000010992; -.
GO; GO:0097208; C:alveolar lamellar body; ISS:UniProtKB.
GO; GO:0036464; C:cytoplasmic ribonucleoprotein granule; IEA:Ensembl.
GO; GO:0005829; C:cytosol; ISS:UniProtKB.
GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
GO; GO:0005764; C:lysosome; ISS:UniProtKB.
GO; GO:0004177; F:aminopeptidase activity; ISS:UniProtKB.
GO; GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process; ISS:UniProtKB.
GO; GO:0004197; F:cysteine-type endopeptidase activity; ISS:UniProtKB.
GO; GO:0008234; F:cysteine-type peptidase activity; ISS:UniProtKB.
GO; GO:0004175; F:endopeptidase activity; ISS:UniProtKB.
GO; GO:0030108; F:HLA-A specific activating MHC class I receptor activity; ISS:UniProtKB.
GO; GO:0004252; F:serine-type endopeptidase activity; ISS:UniProtKB.
GO; GO:0070324; F:thyroid hormone binding; ISS:UniProtKB.
GO; GO:0010815; P:bradykinin catabolic process; ISS:UniProtKB.
GO; GO:0097067; P:cellular response to thyroid hormone stimulus; IEA:Ensembl.
GO; GO:0060448; P:dichotomous subdivision of terminal units involved in lung branching; ISS:UniProtKB.
GO; GO:0070371; P:ERK1 and ERK2 cascade; ISS:UniProtKB.
GO; GO:0006955; P:immune response; IBA:GO_Central.
GO; GO:0002764; P:immune response-regulating signaling pathway; ISS:UniProtKB.
GO; GO:0033619; P:membrane protein proteolysis; ISS:UniProtKB.
GO; GO:0001656; P:metanephros development; ISS:UniProtKB.
GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0010813; P:neuropeptide catabolic process; ISS:UniProtKB.
GO; GO:0045766; P:positive regulation of angiogenesis; ISS:UniProtKB.
GO; GO:2001235; P:positive regulation of apoptotic signaling pathway; IBA:GO_Central.
GO; GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
GO; GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.
GO; GO:0010634; P:positive regulation of epithelial cell migration; ISS:UniProtKB.
GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
GO; GO:0010952; P:positive regulation of peptidase activity; ISS:UniProtKB.
GO; GO:0031648; P:protein destabilization; ISS:UniProtKB.
GO; GO:0006508; P:proteolysis; ISS:UniProtKB.
GO; GO:0051603; P:proteolysis involved in cellular protein catabolic process; IBA:GO_Central.
GO; GO:0032526; P:response to retinoic acid; ISS:UniProtKB.
GO; GO:0043129; P:surfactant homeostasis; ISS:UniProtKB.
GO; GO:0001913; P:T cell mediated cytotoxicity; ISS:UniProtKB.
GO; GO:0031638; P:zymogen activation; ISS:UniProtKB.
InterPro; IPR025661; Pept_asp_AS.
InterPro; IPR000169; Pept_cys_AS.
InterPro; IPR025660; Pept_his_AS.
InterPro; IPR013128; Peptidase_C1A.
InterPro; IPR000668; Peptidase_C1A_C.
InterPro; IPR013201; Prot_inhib_I29.
PANTHER; PTHR12411; PTHR12411; 1.
Pfam; PF08246; Inhibitor_I29; 1.
Pfam; PF00112; Peptidase_C1; 1.
PRINTS; PR00705; PAPAIN.
SMART; SM00848; Inhibitor_I29; 1.
SMART; SM00645; Pept_C1; 1.
PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
2: Evidence at transcript level;
Complete proteome; Disulfide bond; Glycoprotein; Hydrolase; Lysosome;
Protease; Reference proteome; Signal; Thiol protease; Zymogen.
SIGNAL 1 22 {ECO:0000250}.
PROPEP 23 97 Activation peptide. {ECO:0000250}.
/FTId=PRO_0000238112.
PEPTIDE 98 105 Cathepsin H mini chain.
/FTId=PRO_0000238113.
PROPEP 106 115 {ECO:0000250}.
/FTId=PRO_0000238114.
CHAIN 116 335 Cathepsin H.
/FTId=PRO_0000238115.
CHAIN 116 292 Cathepsin H heavy chain.
/FTId=PRO_0000238116.
CHAIN 293 335 Cathepsin H light chain.
/FTId=PRO_0000238117.
ACT_SITE 141 141 {ECO:0000250}.
ACT_SITE 281 281 {ECO:0000250}.
ACT_SITE 301 301 {ECO:0000250}.
CARBOHYD 72 72 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 101 101 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 230 230 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 102 327 {ECO:0000250}.
DISULFID 138 181 {ECO:0000250}.
DISULFID 172 214 {ECO:0000250}.
DISULFID 272 322 {ECO:0000250}.
SEQUENCE 335 AA; 37351 MW; 79FDBEBB9984D227 CRC64;
MWAVLPLLCA GAWLLGAPAC GAAELAANSL EKFHFQSWMV QHQKKYSSEE YYHRLQAFAS
NLREINAHNA RNHTFKMGLN QFSDMSFDEL KRKYLWSEPQ NCSATKSNYL RGTGPYPPSM
DWRKKGNFVT PVKNQGSCGS CWTFSTTGAL ESAVAIATGK LPFLAEQQLV DCAQNFNNHG
CQGGLPSQAF EYIRYNKGIM GEDTYPYRGQ DGDCKYQPSK AIAFVKDVAN ITLNDEEAMV
EAVALHNPVS FAFEVTADFM MYRKGIYSST SCHKTPDKVN HAVLAVGYGE EKGIPYWIVK
NSWGPNWGMK GYFLIERGKN MCGLAACASF PIPLV


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