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 NPY_RAT                 Reviewed;          98 AA.
 P07808;
 01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
 01-AUG-1988, sequence version 1.
 12-SEP-2018, entry version 138.
 RecName: Full=Pro-neuropeptide Y;
 Contains:
   RecName: Full=Neuropeptide Y;
   AltName: Full=Neuropeptide tyrosine;
            Short=NPY;
 Contains:
   RecName: Full=C-flanking peptide of NPY;
            Short=CPON;
 Flags: Precursor;
 Name=Npy;
 Rattus norvegicus (Rat).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
 Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
 Muroidea; Muridae; Murinae; Rattus.
 NCBI_TaxID=10116;
 [1]
 NUCLEOTIDE SEQUENCE [MRNA].
 PubMed=3031687; DOI=10.1073/pnas.84.8.2532;
 Allen J., Novotny J., Martin J., Heinrich G.;
 "Molecular structure of mammalian neuropeptide Y: analysis by
 molecular cloning and computer-aided comparison with crystal structure
 of avian homologue.";
 Proc. Natl. Acad. Sci. U.S.A. 84:2532-2536(1987).
 [2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
 PubMed=3031663; DOI=10.1073/pnas.84.7.2068;
 Larhammar D., Ericsson A., Persson H.;
 "Structure and expression of the rat neuropeptide Y gene.";
 Proc. Natl. Acad. Sci. U.S.A. 84:2068-2072(1987).
 [3]
 NUCLEOTIDE SEQUENCE [MRNA].
 PubMed=2834371;
 Higuchi H., Yang H.-Y.T., Sabol S.L.;
 "Rat neuropeptide Y precursor gene expression. mRNA structure, tissue
 distribution, and regulation by glucocorticoids, cyclic AMP, and
 phorbol ester.";
 J. Biol. Chem. 263:6288-6295(1988).
 [4]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
 STRAIN=ACI/SegHsd, BB(DR)/Wor, Brown Norway/SsNHsd, DA/Bkl, F344/NHsd,
 and LEW/NHsd;
 Dracheva T.V., Joe B., Hashiramoto A., Dobbins D.E., Wilder R.L.,
 Remmers E.F.;
 "Polymorphic differences in the neuropeptide Y gene among six
 autoimmune disease susceptible and resistant inbred rat strains.";
 Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
 [5]
 PROTEIN SEQUENCE OF 30-65, AND AMIDATION AT TYR-65.
 PubMed=3413293; DOI=10.1016/0167-0115(88)90008-0;
 Corder R., Gaillard R.C., Boehlen P.;
 "Isolation and sequence of rat peptide YY and neuropeptide Y.";
 Regul. Pept. 21:253-261(1988).
 -!- FUNCTION: NPY is implicated in the control of feeding and in
     secretion of gonadotrophin-release hormone.
 -!- SUBCELLULAR LOCATION: Secreted.
 -!- TISSUE SPECIFICITY: One of the most abundant peptides in the
     nervous system. Also found in some chromaffin cells of the adrenal
     medulla.
 -!- PTM: The neuropeptide Y form is cleaved at Pro-31 by the prolyl
     endopeptidase FAP (seprase) activity (in vitro).
     {ECO:0000250|UniProtKB:P01303}.
 -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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 EMBL; M15880; AAA41722.1; -; mRNA.
 EMBL; M15793; AAA41723.1; -; Genomic_DNA.
 EMBL; M15792; AAA41723.1; JOINED; Genomic_DNA.
 EMBL; M20373; AAA41724.1; -; mRNA.
 EMBL; AF392056; AAL28016.1; -; Genomic_DNA.
 EMBL; AF392057; AAL28017.1; -; Genomic_DNA.
 EMBL; AF392058; AAL28018.1; -; Genomic_DNA.
 EMBL; AF392059; AAL28019.1; -; Genomic_DNA.
 EMBL; AF392060; AAL28020.1; -; Genomic_DNA.
 EMBL; AF392061; AAL28021.1; -; Genomic_DNA.
 PIR; A27651; A25916.
 RefSeq; NP_036746.1; NM_012614.2.
 RefSeq; XP_003749793.1; XM_003749745.4.
 UniGene; Rn.9714; -.
 ProteinModelPortal; P07808; -.
 SMR; P07808; -.
 STRING; 10116.ENSRNOP00000013146; -.
 BindingDB; P07808; -.
 iPTMnet; P07808; -.
 PhosphoSitePlus; P07808; -.
 PaxDb; P07808; -.
 Ensembl; ENSRNOT00000013145; ENSRNOP00000013146; ENSRNOG00000009768.
 Ensembl; ENSRNOT00000074351; ENSRNOP00000066713; ENSRNOG00000046449.
 GeneID; 100912228; -.
 GeneID; 24604; -.
 KEGG; rno:100912228; -.
 KEGG; rno:24604; -.
 UCSC; RGD:3197; rat.
 CTD; 4852; -.
 RGD; 3197; Npy.
 eggNOG; ENOG410J0KC; Eukaryota.
 eggNOG; ENOG41128I2; LUCA.
 GeneTree; ENSGT00390000010775; -.
 HOGENOM; HOG000252942; -.
 HOVERGEN; HBG006485; -.
 InParanoid; P07808; -.
 KO; K05232; -.
 OMA; FEDPSMW; -.
 OrthoDB; EOG091G0ZRE; -.
 PhylomeDB; P07808; -.
 TreeFam; TF332778; -.
 Reactome; R-RNO-375276; Peptide ligand-binding receptors.
 Reactome; R-RNO-418594; G alpha (i) signalling events.
 PMAP-CutDB; P07808; -.
 PRO; PR:P07808; -.
 Proteomes; UP000002494; Chromosome 4.
 Bgee; ENSRNOG00000009768; Expressed in 8 organ(s), highest expression level in spleen.
 ExpressionAtlas; P07808; differential.
 Genevisible; P07808; RN.
 GO; GO:0005615; C:extracellular space; IDA:HGNC.
 GO; GO:0043005; C:neuron projection; IDA:RGD.
 GO; GO:0043204; C:perikaryon; IDA:RGD.
 GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
 GO; GO:0043195; C:terminal bouton; IDA:RGD.
 GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
 GO; GO:0031841; F:neuropeptide Y receptor binding; IMP:RGD.
 GO; GO:0008343; P:adult feeding behavior; IDA:HGNC.
 GO; GO:0007568; P:aging; IEP:RGD.
 GO; GO:0007268; P:chemical synaptic transmission; IDA:RGD.
 GO; GO:0042117; P:monocyte activation; IDA:RGD.
 GO; GO:0002865; P:negative regulation of acute inflammatory response to antigenic stimulus; IDA:RGD.
 GO; GO:0045776; P:negative regulation of blood pressure; IMP:RGD.
 GO; GO:1901215; P:negative regulation of neuron death; IDA:RGD.
 GO; GO:0007218; P:neuropeptide signaling pathway; IMP:RGD.
 GO; GO:0032100; P:positive regulation of appetite; IDA:HGNC.
 GO; GO:0008284; P:positive regulation of cell proliferation; IDA:RGD.
 GO; GO:0010811; P:positive regulation of cell-substrate adhesion; IDA:RGD.
 GO; GO:0045964; P:positive regulation of dopamine metabolic process; IDA:RGD.
 GO; GO:1904000; P:positive regulation of eating behavior; IDA:RGD.
 GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:RGD.
 GO; GO:1904407; P:positive regulation of nitric oxide metabolic process; IDA:RGD.
 GO; GO:0032903; P:regulation of nerve growth factor production; IDA:RGD.
 GO; GO:0050909; P:sensory perception of taste; IEP:RGD.
 GO; GO:0048572; P:short-day photoperiodism; IEP:RGD.
 CDD; cd00126; PAH; 1.
 InterPro; IPR001955; Pancreatic_hormone-like.
 InterPro; IPR020392; Pancreatic_hormone-like_CS.
 PANTHER; PTHR10533; PTHR10533; 1.
 Pfam; PF00159; Hormone_3; 1.
 PRINTS; PR00278; PANCHORMONE.
 ProDom; PD001267; Pancreatic_hormone-like; 1.
 SMART; SM00309; PAH; 1.
 PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
 PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
 1: Evidence at protein level;
 Amidation; Cleavage on pair of basic residues; Complete proteome;
 Direct protein sequencing; Neuropeptide; Phosphoprotein;
 Reference proteome; Secreted; Signal.
 SIGNAL        1     29       {ECO:0000269|PubMed:3413293}.
 PEPTIDE      30     65       Neuropeptide Y.
                              {ECO:0000269|PubMed:3413293}.
                              /FTId=PRO_0000025329.
 PEPTIDE      69     98       C-flanking peptide of NPY.
                              /FTId=PRO_0000025330.
 SITE         31     32       Cleavage; by FAP.
                              {ECO:0000250|UniProtKB:P01303}.
 MOD_RES      65     65       Tyrosine amide.
                              {ECO:0000269|PubMed:2834371,
                              ECO:0000269|PubMed:3413293}.
 MOD_RES      84     84       Phosphothreonine.
                              {ECO:0000250|UniProtKB:P01303}.
 SEQUENCE   98 AA;  11033 MW;  E77EACEF3A3914B7 CRC64;
 MMLGNKRMGL CGLTLALSLL VCLGILAEGY PSKPDNPGED APAEDMARYY SALRHYINLI
 TRQRYGKRSS PETLISDLLM RESTENAPRT RLEDPSMW

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