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Pro-neuropeptide Y [Cleaved into: Neuropeptide Y (Neuropeptide tyrosine) (NPY); C-flanking peptide of NPY (CPON)]
NPY_RAT Reviewed; 98 AA.
P07808;
01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
01-AUG-1988, sequence version 1.
22-NOV-2017, entry version 136.
RecName: Full=Pro-neuropeptide Y;
Contains:
RecName: Full=Neuropeptide Y;
AltName: Full=Neuropeptide tyrosine;
Short=NPY;
Contains:
RecName: Full=C-flanking peptide of NPY;
Short=CPON;
Flags: Precursor;
Name=Npy;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3031687; DOI=10.1073/pnas.84.8.2532;
Allen J., Novotny J., Martin J., Heinrich G.;
"Molecular structure of mammalian neuropeptide Y: analysis by
molecular cloning and computer-aided comparison with crystal structure
of avian homologue.";
Proc. Natl. Acad. Sci. U.S.A. 84:2532-2536(1987).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3031663; DOI=10.1073/pnas.84.7.2068;
Larhammar D., Ericsson A., Persson H.;
"Structure and expression of the rat neuropeptide Y gene.";
Proc. Natl. Acad. Sci. U.S.A. 84:2068-2072(1987).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2834371;
Higuchi H., Yang H.-Y.T., Sabol S.L.;
"Rat neuropeptide Y precursor gene expression. mRNA structure, tissue
distribution, and regulation by glucocorticoids, cyclic AMP, and
phorbol ester.";
J. Biol. Chem. 263:6288-6295(1988).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ACI/SegHsd, BB(DR)/Wor, Brown Norway/SsNHsd, DA/Bkl, F344/NHsd,
and LEW/NHsd;
Dracheva T.V., Joe B., Hashiramoto A., Dobbins D.E., Wilder R.L.,
Remmers E.F.;
"Polymorphic differences in the neuropeptide Y gene among six
autoimmune disease susceptible and resistant inbred rat strains.";
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
[5]
PROTEIN SEQUENCE OF 30-65, AND AMIDATION AT TYR-65.
PubMed=3413293; DOI=10.1016/0167-0115(88)90008-0;
Corder R., Gaillard R.C., Boehlen P.;
"Isolation and sequence of rat peptide YY and neuropeptide Y.";
Regul. Pept. 21:253-261(1988).
-!- FUNCTION: NPY is implicated in the control of feeding and in
secretion of gonadotrophin-release hormone.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: One of the most abundant peptides in the
nervous system. Also found in some chromaffin cells of the adrenal
medulla.
-!- PTM: The neuropeptide Y form is cleaved at Pro-31 by the prolyl
endopeptidase FAP (seprase) activity (in vitro).
{ECO:0000250|UniProtKB:P01303}.
-!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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EMBL; M15880; AAA41722.1; -; mRNA.
EMBL; M15793; AAA41723.1; -; Genomic_DNA.
EMBL; M15792; AAA41723.1; JOINED; Genomic_DNA.
EMBL; M20373; AAA41724.1; -; mRNA.
EMBL; AF392056; AAL28016.1; -; Genomic_DNA.
EMBL; AF392057; AAL28017.1; -; Genomic_DNA.
EMBL; AF392058; AAL28018.1; -; Genomic_DNA.
EMBL; AF392059; AAL28019.1; -; Genomic_DNA.
EMBL; AF392060; AAL28020.1; -; Genomic_DNA.
EMBL; AF392061; AAL28021.1; -; Genomic_DNA.
PIR; A27651; A25916.
RefSeq; NP_036746.1; NM_012614.2.
RefSeq; XP_003749793.1; XM_003749745.4.
UniGene; Rn.9714; -.
ProteinModelPortal; P07808; -.
SMR; P07808; -.
STRING; 10116.ENSRNOP00000013146; -.
BindingDB; P07808; -.
iPTMnet; P07808; -.
PhosphoSitePlus; P07808; -.
PaxDb; P07808; -.
PRIDE; P07808; -.
Ensembl; ENSRNOT00000013145; ENSRNOP00000013146; ENSRNOG00000009768.
Ensembl; ENSRNOT00000074351; ENSRNOP00000066713; ENSRNOG00000046449.
GeneID; 100912228; -.
GeneID; 24604; -.
KEGG; rno:100912228; -.
KEGG; rno:24604; -.
UCSC; RGD:3197; rat.
CTD; 4852; -.
RGD; 3197; Npy.
eggNOG; ENOG410J0KC; Eukaryota.
eggNOG; ENOG41128I2; LUCA.
GeneTree; ENSGT00390000010775; -.
HOGENOM; HOG000252942; -.
HOVERGEN; HBG006485; -.
InParanoid; P07808; -.
KO; K05232; -.
OMA; FEDPSMW; -.
OrthoDB; EOG091G0ZRE; -.
PhylomeDB; P07808; -.
TreeFam; TF332778; -.
Reactome; R-RNO-375276; Peptide ligand-binding receptors.
Reactome; R-RNO-418594; G alpha (i) signalling events.
PMAP-CutDB; P07808; -.
PRO; PR:P07808; -.
Proteomes; UP000002494; Chromosome 4.
Bgee; ENSRNOG00000009768; -.
ExpressionAtlas; P07808; differential.
Genevisible; P07808; RN.
GO; GO:0005737; C:cytoplasm; ISO:RGD.
GO; GO:0005615; C:extracellular space; IDA:HGNC.
GO; GO:0043005; C:neuron projection; IDA:RGD.
GO; GO:0043204; C:perikaryon; IDA:RGD.
GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
GO; GO:0043195; C:terminal bouton; IDA:RGD.
GO; GO:0001664; F:G-protein coupled receptor binding; ISO:RGD.
GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
GO; GO:0031841; F:neuropeptide Y receptor binding; IMP:RGD.
GO; GO:0008343; P:adult feeding behavior; IDA:HGNC.
GO; GO:0007568; P:aging; IEP:RGD.
GO; GO:0021954; P:central nervous system neuron development; ISO:RGD.
GO; GO:0021987; P:cerebral cortex development; ISO:RGD.
GO; GO:0007268; P:chemical synaptic transmission; IDA:RGD.
GO; GO:0042117; P:monocyte activation; IDA:RGD.
GO; GO:0002865; P:negative regulation of acute inflammatory response to antigenic stimulus; IDA:RGD.
GO; GO:0045776; P:negative regulation of blood pressure; IMP:RGD.
GO; GO:1901215; P:negative regulation of neuron death; IDA:RGD.
GO; GO:0031175; P:neuron projection development; ISO:RGD.
GO; GO:0007218; P:neuropeptide signaling pathway; IMP:RGD.
GO; GO:0032100; P:positive regulation of appetite; IDA:HGNC.
GO; GO:0008284; P:positive regulation of cell proliferation; IDA:RGD.
GO; GO:0010811; P:positive regulation of cell-substrate adhesion; IDA:RGD.
GO; GO:0045964; P:positive regulation of dopamine metabolic process; IDA:RGD.
GO; GO:1904000; P:positive regulation of eating behavior; IDA:RGD.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:RGD.
GO; GO:1904407; P:positive regulation of nitric oxide metabolic process; IDA:RGD.
GO; GO:0008217; P:regulation of blood pressure; ISO:RGD.
GO; GO:0032903; P:regulation of nerve growth factor production; IDA:RGD.
GO; GO:0050909; P:sensory perception of taste; IEP:RGD.
GO; GO:0048572; P:short-day photoperiodism; IEP:RGD.
CDD; cd00126; PAH; 1.
InterPro; IPR001955; Pancreatic_hormone-like.
InterPro; IPR020392; Pancreatic_hormone-like_CS.
PANTHER; PTHR10533; PTHR10533; 1.
Pfam; PF00159; Hormone_3; 1.
PRINTS; PR00278; PANCHORMONE.
ProDom; PD001267; Pancreatic_hormone-like; 1.
SMART; SM00309; PAH; 1.
PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
1: Evidence at protein level;
Amidation; Cleavage on pair of basic residues; Complete proteome;
Direct protein sequencing; Neuropeptide; Phosphoprotein;
Reference proteome; Secreted; Signal.
SIGNAL 1 29 {ECO:0000269|PubMed:3413293}.
PEPTIDE 30 65 Neuropeptide Y.
{ECO:0000269|PubMed:3413293}.
/FTId=PRO_0000025329.
PEPTIDE 69 98 C-flanking peptide of NPY.
/FTId=PRO_0000025330.
SITE 31 32 Cleavage; by FAP.
{ECO:0000250|UniProtKB:P01303}.
MOD_RES 65 65 Tyrosine amide.
{ECO:0000269|PubMed:2834371,
ECO:0000269|PubMed:3413293}.
MOD_RES 84 84 Phosphothreonine.
{ECO:0000250|UniProtKB:P01303}.
SEQUENCE 98 AA; 11033 MW; E77EACEF3A3914B7 CRC64;
MMLGNKRMGL CGLTLALSLL VCLGILAEGY PSKPDNPGED APAEDMARYY SALRHYINLI
TRQRYGKRSS PETLISDLLM RESTENAPRT RLEDPSMW
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Pathways :
WP1001: Peptide GPCRs
WP1117: Peptide GPCRs
WP120: Phenylalanine and Tyrosine Biosynthesis
WP131: Peptide GPCRs
WP1338: Peptide GPCRs
WP1687: Phenylalanine, tyrosine and tryptophan biosynthesi
WP1714: Tyrosine metabolism
WP234: Peptide GPCRs
WP24: Peptide GPCRs
WP27: Phenylalanine, Tyrosine, Tryptophan biosynthesis
WP538: Tyrosine Biosynthesis
WP582: Cre-lox for W846X
WP771: Peptide GPCRs
WP883: Peptide GPCRs
Related Genes :
[Pmch Mch] Pro-MCH [Cleaved into: Neuropeptide-glycine-glutamic acid (NGE) (Neuropeptide G-E); Neuropeptide-glutamic acid-isoleucine (NEI) (Neuropeptide E-I); Melanin-concentrating hormone (MCH)]
[Npff] Pro-FMRFamide-related neuropeptide FF (FMRFamide-related peptides) [Cleaved into: Neuropeptide SF (NPSF); Neuropeptide FF (NPFF); Neuropeptide AF-like (NPAF)]
[NPFF] Pro-FMRFamide-related neuropeptide FF (FMRFamide-related peptides) [Cleaved into: Neuropeptide SF (NPSF); Neuropeptide FF (NPFF); Neuropeptide AF (NPAF)]
[NPY] Pro-neuropeptide Y [Cleaved into: Neuropeptide Y (Neuropeptide tyrosine) (NPY); C-flanking peptide of NPY (CPON)]
[Npy] Pro-neuropeptide Y [Cleaved into: Neuropeptide Y (Neuropeptide tyrosine) (NPY); C-flanking peptide of NPY (CPON)]
[NPVF C7orf9 RFRP] Pro-FMRFamide-related neuropeptide VF [Cleaved into: Neuropeptide NPSF; Neuropeptide RFRP-1; Neuropeptide RFRP-2; Neuropeptide NPVF (Neuropeptide RFRP-3)]
[Npff] Pro-FMRFamide-related neuropeptide FF (FMRFamide-related peptides) [Cleaved into: Neuropeptide SF (NPSF); Neuropeptide FF (NPFF); Neuropeptide AF-like (NPAF)]
[Npvf Rfrp] Pro-FMRFamide-related neuropeptide VF (FMRFamide-related peptides) [Cleaved into: Neuropeptide NPSF; Neuropeptide RFRP-1; Neuropeptide NPVF (Neuropeptide RFRP-2)]
[] PBAN-type neuropeptides (Neo-PBAN) (Pheromone/pyrokinin biosynthesis-activating neuropeptide) [Cleaved into: Diapause hormone (DH) (DH-PBAN); Alpha-SG neuropeptide (Alpha-SGNP); Beta-SG neuropeptide (Beta-SGNP); Pheromone biosynthesis-activating neuropeptide I (Bom-PBAN-I) (PBAN-I) (Melanization and reddish coloration hormone I) (MRCH-I); Pheromone biosynthesis-activating neuropeptide II (PBAN-II); Gamma-SG neuropeptide (Gamma-SGNP)]
[NPY] Pro-neuropeptide Y [Cleaved into: Neuropeptide Y (Neuropeptide tyrosine) (NPY); C-flanking peptide of NPY (CPON)] (Fragment)
[PMCH MCH] Pro-MCH [Cleaved into: Neuropeptide-glycine-glutamic acid (NGE) (Neuropeptide G-E); Neuropeptide-glutamic acid-isoleucine (NEI) (Neuropeptide E-I); Melanin-concentrating hormone (MCH)]
[Npy] Pro-neuropeptide Y [Cleaved into: Neuropeptide Y (Neuropeptide tyrosine) (NPY); C-flanking peptide of NPY (CPON)]
[Pmch Mch] Pro-MCH [Cleaved into: Neuropeptide-glycine-glutamic acid (NGE) (Neuropeptide G-E); Neuropeptide-glutamic acid-isoleucine (NEI) (Neuropeptide E-I); Melanin-concentrating hormone (MCH)]
[TAC1 NKA NKNA TAC2] Protachykinin-1 (PPT) [Cleaved into: Substance P; Neurokinin A (NKA) (Neuromedin L) (Substance K); Neuropeptide K (NPK); Neuropeptide gamma; C-terminal-flanking peptide]
[Tac1 Nka Nkna Tac2] Protachykinin-1 (PPT) [Cleaved into: Substance P; Neurokinin A (NKA) (Neuromedin L) (Substance K); Neuropeptide K (NPK); Neuropeptide gamma; C-terminal-flanking peptide]
[Tac1 Nka Nkna Tac2] Protachykinin-1 (PPT) [Cleaved into: Substance P; Neurokinin A (NKA) (Neuromedin L) (Substance K); Neuropeptide K (NPK); Neuropeptide gamma; C-terminal-flanking peptide]
[TAC1 NKA NKNA TAC2] Protachykinin-1 (PPT) [Cleaved into: Substance P; Neurokinin A (NKA) (Neuromedin L) (Substance K); Neuropeptide K (NPK); Neuropeptide gamma; C-terminal-flanking peptide]
[NPFFR2 GPR74 NPFF2 NPGPR] Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (G-protein coupled receptor HLWAR77) (Neuropeptide G-protein coupled receptor)
[NPY] Pro-neuropeptide Y [Cleaved into: Neuropeptide Y (Neuropeptide tyrosine) (NPY); C-flanking peptide of NPY (CPON)]
[NPVF RFRP] Pro-FMRFamide-related neuropeptide VF (FMRFamide-related peptides) [Cleaved into: Neuropeptide NPSF; Neuropeptide RFRP-1; Neuropeptide RFRP-2; Neuropeptide NPVF (Neuropeptide RFRP-3)]
[NPY2R] Neuropeptide Y receptor type 2 (NPY2-R) (NPY-Y2 receptor) (Y2 receptor)
[NPF CG10342] Neuropeptide F (NPF) (dNPF)
[Pdf CG6496] Protein PDF [Cleaved into: PDF precursor-related peptide (PAP); Neuropeptide PDF (Pigment-dispersing factor homolog)]
[NPY1R NPYR NPYY1] Neuropeptide Y receptor type 1 (NPY1-R)
[NPY] Pro-neuropeptide Y [Cleaved into: Neuropeptide Y (Neuropeptide tyrosine) (NPY); C-flanking peptide of NPY (CPON)]
[sNPF CG13968] Short neuropeptide F [Cleaved into: sNPF-associated peptide (sNPF-AP); sNPF peptide 2 (sNPF-2); sNPF peptide 3 (sNPF-3); sNPF peptide 4 (sNPF-4); RLRF peptide 1; RLRF peptide 2]
[NPFR NPFR1 CG1147] Neuropeptide F receptor (DmNPFR1)
[NPSR1 GPR154 GPRA PGR14] Neuropeptide S receptor (G-protein coupled receptor 154) (G-protein coupled receptor PGR14) (G-protein coupled receptor for asthma susceptibility)
[Npy5r Npyr5] Neuropeptide Y receptor type 5 (NPY5-R) (NPY-Y5 receptor) (NPYY5-R) (Y5 receptor)
[NPY5R NPYR5] Neuropeptide Y receptor type 5 (NPY5-R) (NPY-Y5 receptor) (NPYY5-R) (Y5 receptor)
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