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Pro-opiomelanocortin (POMC) (Corticotropin-lipotropin) [Cleaved into: Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanocyte-stimulating hormone alpha (Alpha-MSH) (Melanotropin alpha); Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanocyte-stimulating hormone beta (Beta-MSH) (Melanotropin beta); Beta-endorphin; Met-enkephalin]

 COLI_ONCKE              Reviewed;         226 AA.
P10000; P01199; P01204; P87470; P87471; P87472; P87473; P87474;
P87475; P87476; P87477; P87478; Q90521; Q92024;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
01-FEB-1991, sequence version 2.
25-OCT-2017, entry version 84.
RecName: Full=Pro-opiomelanocortin;
Short=POMC;
AltName: Full=Corticotropin-lipotropin;
Contains:
RecName: Full=Corticotropin;
AltName: Full=Adrenocorticotropic hormone;
Short=ACTH;
Contains:
RecName: Full=Melanocyte-stimulating hormone alpha;
Short=Alpha-MSH;
AltName: Full=Melanotropin alpha;
Contains:
RecName: Full=Corticotropin-like intermediary peptide;
Short=CLIP;
Contains:
RecName: Full=Lipotropin beta;
AltName: Full=Beta-LPH;
Contains:
RecName: Full=Lipotropin gamma;
AltName: Full=Gamma-LPH;
Contains:
RecName: Full=Melanocyte-stimulating hormone beta;
Short=Beta-MSH;
AltName: Full=Melanotropin beta;
Contains:
RecName: Full=Beta-endorphin;
Contains:
RecName: Full=Met-enkephalin;
Flags: Precursor;
Name=pomc;
Oncorhynchus keta (Chum salmon) (Salmo keta).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii;
Salmoniformes; Salmonidae; Salmoninae; Oncorhynchus.
NCBI_TaxID=8018;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3197404;
Kitahara N., Nishizawa T., Iida K., Okazaki H., Andoh T., Soma G.;
"Absence of a gamma-melanocyte-stimulating hormone sequence in
proopiomelanocortin mRNA of chum salmon Oncorhynchus keta.";
Comp. Biochem. Physiol. 91B:365-370(1988).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 92-226.
PubMed=6095185; DOI=10.1093/nar/12.21.8029;
Soma G., Kitahara N., Nishizawa T., Nanami H., Kotake C., Okazaki H.,
Andoh T.;
"Nucleotide sequence of a cloned cDNA for proopiomelanocortin
precursor of chum salmon, Onchorynchus keta.";
Nucleic Acids Res. 12:8029-8041(1984).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 92-226.
PubMed=6087806; DOI=10.1016/S0006-291X(84)80069-8;
Nishizawa T., Kitahara N., Nanami H., Hara N., Kotake C., Okazaki H.,
Andoh T., Soma G.;
"Heterogeneity of 3' nontranslated regions in proopiomelanocortin
(POMC) precursor mRNA of chum salmon Onchorynchus keta: polymorphism
of the gene.";
Biochem. Biophys. Res. Commun. 122:556-562(1984).
[4]
PROTEIN SEQUENCE OF 98-112, AND ACETYLATION AT SER-98.
PubMed=7447938; DOI=10.1016/0006-291X(80)91345-5;
Kawauchi H., Adachi Y., Tsubokawa M.;
"Occurrence of a new melanocyte stimulating hormone in the salmon
pituitary gland.";
Biochem. Biophys. Res. Commun. 96:1508-1517(1980).
[5]
PROTEIN SEQUENCE OF 198-226, AND ACETYLATION AT TYR-198.
PubMed=475783; DOI=10.1016/0006-291X(79)91114-8;
Kawauchi H., Tsubokawa M., Muramoto K.;
"Isolation and primary structure of endorphin from salmon pituitary
glands.";
Biochem. Biophys. Res. Commun. 88:1249-1254(1979).
-!- FUNCTION: Corticotropin: Stimulates the adrenal glands to release
cortisol.
-!- FUNCTION: Melanocyte-stimulating hormone alpha: Anorexigenic
peptide. Increases the pigmentation of skin by increasing melanin
production in melanocytes.
-!- FUNCTION: Melanocyte-stimulating hormone beta: Increases the
pigmentation of skin by increasing melanin production in
melanocytes.
-!- FUNCTION: Beta-endorphin: Endogenous orexigenic opiate.
-!- FUNCTION: Met-enkephalin: Endogenous opiate.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01193}.
Note=Melanocyte-stimulating hormone alpha and beta-endorphin are
stored in separate granules in hypothalamic POMC neurons,
suggesting that secretion may be under the control of different
regulatory mechanisms. {ECO:0000250|UniProtKB:P01193}.
-!- PTM: Specific enzymatic cleavages at paired basic residues yield
the different active peptides.
-!- SIMILARITY: Belongs to the POMC family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAA49426.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; M27692; AAA49426.1; ALT_INIT; mRNA.
EMBL; K02613; AAA49424.1; -; mRNA.
EMBL; K02614; AAA49425.1; -; mRNA.
EMBL; X01122; CAA25591.1; -; mRNA.
PIR; I51080; CTONPK.
iPTMnet; P10000; -.
HOVERGEN; HBG004341; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
InterPro; IPR013531; Mcrtin_ACTH_cent.
InterPro; IPR013593; Melanocortin_N.
InterPro; IPR013532; Opioid_neuropept.
InterPro; IPR001941; PMOC.
Pfam; PF00976; ACTH_domain; 2.
Pfam; PF08384; NPP; 1.
Pfam; PF08035; Op_neuropeptide; 1.
PRINTS; PR00383; MELANOCORTIN.
SMART; SM01363; ACTH_domain; 2.
SMART; SM01364; NPP; 1.
SMART; SM01365; Op_neuropeptide; 1.
1: Evidence at protein level;
Acetylation; Cleavage on pair of basic residues;
Direct protein sequencing; Endorphin; Hormone; Secreted; Signal.
SIGNAL 1 22 {ECO:0000255}.
PROPEP 23 97 {ECO:0000255}.
/FTId=PRO_0000025083.
PEPTIDE 98 138 Corticotropin.
/FTId=PRO_0000025084.
PEPTIDE 98 112 Melanocyte-stimulating hormone alpha.
{ECO:0000269|PubMed:7447938}.
/FTId=PRO_0000025085.
PEPTIDE 116 138 Corticotropin-like intermediary peptide.
/FTId=PRO_0000025086.
PEPTIDE 141 226 Lipotropin beta.
/FTId=PRO_0000025087.
PEPTIDE 141 195 Lipotropin gamma.
/FTId=PRO_0000025088.
PEPTIDE 179 195 Melanocyte-stimulating hormone beta.
/FTId=PRO_0000025089.
PEPTIDE 198 226 Beta-endorphin.
{ECO:0000269|PubMed:475783}.
/FTId=PRO_0000025090.
PEPTIDE 198 202 Met-enkephalin.
{ECO:0000269|PubMed:475783}.
/FTId=PRO_0000025091.
MOD_RES 98 98 N-acetylserine; in Corticotropin.
{ECO:0000269|PubMed:7447938}.
MOD_RES 198 198 N-acetyltyrosine; in Beta-endorphin and
Met-enkephalin.
{ECO:0000269|PubMed:475783}.
SEQUENCE 226 AA; 24982 MW; 327CA785F69B1B24 CRC64;
MVCAPWLLAV VVVCVCNPGV GGQCWDSSHC KDLPSEDKIL ECTHLFRSGL QDESPEPRSA
AQQSTEESLS LGILLAALTS GERALDADPE PHSDKRHSYS MEHFRWGKPI GHKRRPIKVY
ASSLEGGDSS EGTFPLQARR QLGSWEDEMV GALGNQGAKA QTKVVPRTLT VTGLQDKKDG
SYRMGHFRWG SPTAIKRYGG FMKPYTKQSH KPLITLLKHI TLKNEQ


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