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Pro-opiomelanocortin (POMC) (Corticotropin-lipotropin) [Cleaved into: NPP; Gamma-melanotropin-like segment; Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanocyte-stimulating hormone alpha (Alpha-MSH) (Melanotropin alpha); Corticotropin-like intermediary peptide (CLIP); Melanocyte-stimulating hormone beta (Beta-MSH) (Melanotropin beta); Beta-endorphin; Met-enkephalin]

 COLI_LEPOS              Reviewed;         259 AA.
Q91082;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
25-OCT-2017, entry version 66.
RecName: Full=Pro-opiomelanocortin;
Short=POMC;
AltName: Full=Corticotropin-lipotropin;
Contains:
RecName: Full=NPP;
Contains:
RecName: Full=Gamma-melanotropin-like segment;
Contains:
RecName: Full=Corticotropin;
AltName: Full=Adrenocorticotropic hormone;
Short=ACTH;
Contains:
RecName: Full=Melanocyte-stimulating hormone alpha;
Short=Alpha-MSH;
AltName: Full=Melanotropin alpha;
Contains:
RecName: Full=Corticotropin-like intermediary peptide;
Short=CLIP;
Contains:
RecName: Full=Melanocyte-stimulating hormone beta;
Short=Beta-MSH;
AltName: Full=Melanotropin beta;
Contains:
RecName: Full=Beta-endorphin;
Contains:
RecName: Full=Met-enkephalin;
Flags: Precursor;
Name=pomc;
Lepisosteus osseus (Long-nosed gar) (Esox osseus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
Lepisosteus.
NCBI_TaxID=34771;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Pituitary;
PubMed=9268621; DOI=10.1006/gcen.1997.6947;
Dores R.M., Smith T.R., Rubin D.A., Danielson P., Marra L.E.,
Youson J.H.;
"Deciphering posttranslational processing events in the pituitary of a
neopterygian fish: cloning of a gar proopiomelanocortin cDNA.";
Gen. Comp. Endocrinol. 107:401-413(1997).
-!- FUNCTION: Corticotropin: Stimulates the adrenal glands to release
cortisol.
-!- FUNCTION: Melanocyte-stimulating hormone alpha: Anorexigenic
peptide. Increases the pigmentation of skin by increasing melanin
production in melanocytes.
-!- FUNCTION: Melanocyte-stimulating hormone beta: Increases the
pigmentation of skin by increasing melanin production in
melanocytes.
-!- FUNCTION: Beta-endorphin: Endogenous orexigenic opiate.
-!- FUNCTION: Met-enkephalin: Endogenous opiate.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01193}.
Note=Melanocyte-stimulating hormone alpha and beta-endorphin are
stored in separate granules in hypothalamic POMC neurons,
suggesting that secretion may be under the control of different
regulatory mechanisms. {ECO:0000250|UniProtKB:P01193}.
-!- PTM: Specific enzymatic cleavages at paired basic residues yield
the different active peptides.
-!- SIMILARITY: Belongs to the POMC family. {ECO:0000305}.
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EMBL; U59910; AAB03227.1; -; mRNA.
SMR; Q91082; -.
HOVERGEN; HBG004341; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
InterPro; IPR013531; Mcrtin_ACTH_cent.
InterPro; IPR013593; Melanocortin_N.
InterPro; IPR013532; Opioid_neuropept.
InterPro; IPR001941; PMOC.
Pfam; PF00976; ACTH_domain; 2.
Pfam; PF08384; NPP; 1.
Pfam; PF08035; Op_neuropeptide; 1.
PRINTS; PR00383; MELANOCORTIN.
SMART; SM01363; ACTH_domain; 2.
SMART; SM01364; NPP; 1.
SMART; SM01365; Op_neuropeptide; 1.
2: Evidence at transcript level;
Amidation; Cleavage on pair of basic residues; Disulfide bond;
Endorphin; Hormone; Pyrrolidone carboxylic acid; Secreted; Signal.
SIGNAL 1 22 {ECO:0000255}.
PEPTIDE 23 132 NPP. {ECO:0000250}.
/FTId=PRO_0000025075.
PEPTIDE 72 94 Gamma-melanotropin-like segment.
/FTId=PRO_0000025076.
PEPTIDE 135 173 Corticotropin. {ECO:0000250}.
/FTId=PRO_0000025077.
PEPTIDE 135 147 Melanocyte-stimulating hormone alpha.
{ECO:0000250}.
/FTId=PRO_0000025078.
PEPTIDE 153 204 Corticotropin-like intermediary peptide.
{ECO:0000250}.
/FTId=PRO_0000025079.
PEPTIDE 207 223 Melanocyte-stimulating hormone beta.
{ECO:0000250}.
/FTId=PRO_0000025080.
PEPTIDE 226 259 Beta-endorphin.
/FTId=PRO_0000025081.
PEPTIDE 226 230 Met-enkephalin. {ECO:0000250}.
/FTId=PRO_0000025082.
MOD_RES 23 23 Pyrrolidone carboxylic acid.
{ECO:0000250}.
MOD_RES 147 147 Valine amide. {ECO:0000250}.
DISULFID 24 46 {ECO:0000250}.
DISULFID 30 42 {ECO:0000250}.
SEQUENCE 259 AA; 29675 MW; 6C0533AB20020EED CRC64;
MLRSVWVYSL GLAVLLQQSG REQCWEHSQC RDLSSEENIL ECIQACNSDL TAESPIFPGN
GHLQPPSEAD RNYAKSHFRS TALGRRTNGS VGSSKQAGEN AALSILFAAL APPQAEEEME
ESESSQQQRR EDKRSYSMEH FRWGKPVGRK RRPVKVYPNG VEEESAEAYP TEMRRDLMSD
LDYPLLEEVE EELGGENEVL NLQEKKDGSY KMHHFRWSRP PKDKRYGGFM KSWDERSQKP
LLTLFKNVII KDGHQKKGQ


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