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Pro-opiomelanocortin (POMC) (Corticotropin-lipotropin) [Cleaved into: NPP; Melanotropin gamma (Gamma-MSH); Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanocyte-stimulating hormone alpha (Alpha-MSH) (Melanotropin alpha); Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanocyte-stimulating hormone beta (Beta-MSH) (Melanotropin beta); Beta-endorphin; Met-enkephalin]

 COLI_LITCT              Reviewed;         263 AA.
P11885;
01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
01-OCT-1989, sequence version 1.
25-OCT-2017, entry version 75.
RecName: Full=Pro-opiomelanocortin;
Short=POMC;
AltName: Full=Corticotropin-lipotropin;
Contains:
RecName: Full=NPP;
Contains:
RecName: Full=Melanotropin gamma;
AltName: Full=Gamma-MSH;
Contains:
RecName: Full=Corticotropin;
AltName: Full=Adrenocorticotropic hormone;
Short=ACTH;
Contains:
RecName: Full=Melanocyte-stimulating hormone alpha;
Short=Alpha-MSH;
AltName: Full=Melanotropin alpha;
Contains:
RecName: Full=Corticotropin-like intermediary peptide;
Short=CLIP;
Contains:
RecName: Full=Lipotropin beta;
AltName: Full=Beta-LPH;
Contains:
RecName: Full=Lipotropin gamma;
AltName: Full=Gamma-LPH;
Contains:
RecName: Full=Melanocyte-stimulating hormone beta;
Short=Beta-MSH;
AltName: Full=Melanotropin beta;
Contains:
RecName: Full=Beta-endorphin;
Contains:
RecName: Full=Met-enkephalin;
Flags: Precursor;
Name=pomc;
Lithobates catesbeiana (American bullfrog) (Rana catesbeiana).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Rana;
Aquarana.
NCBI_TaxID=8400;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2788269; DOI=10.1093/nar/17.14.5843;
Pan F.-M., Chang W.-C.;
"Nucleotide sequence of bullfrog pro-opiomelanocortin cDNA.";
Nucleic Acids Res. 17:5843-5843(1989).
[2]
PROTEIN SEQUENCE OF 30-74 AND 107-141.
TISSUE=Pituitary;
PubMed=1331997; DOI=10.1016/0196-9781(92)90179-7;
Iwamuro S., Hayashi H., Delbende C., Vaudry H., Kikuyama S.;
"Purification and characterization of joining peptide and N-terminal
peptide of proopiomelanocortin from the pars distalis of the bullfrog
pituitary.";
Peptides 13:729-735(1992).
-!- FUNCTION: Corticotropin: Stimulates the adrenal glands to release
cortisol.
-!- FUNCTION: Melanocyte-stimulating hormone alpha: Anorexigenic
peptide. Increases the pigmentation of skin by increasing melanin
production in melanocytes.
-!- FUNCTION: Melanocyte-stimulating hormone beta: Increases the
pigmentation of skin by increasing melanin production in
melanocytes.
-!- FUNCTION: Beta-endorphin: Endogenous orexigenic opiate.
-!- FUNCTION: Met-enkephalin: Endogenous opiate.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01193}.
Note=Melanocyte-stimulating hormone alpha and beta-endorphin are
stored in separate granules in hypothalamic POMC neurons,
suggesting that secretion may be under the control of different
regulatory mechanisms. {ECO:0000250|UniProtKB:P01193}.
-!- PTM: Specific enzymatic cleavages at paired basic residues yield
the different active peptides.
-!- SIMILARITY: Belongs to the POMC family. {ECO:0000305}.
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EMBL; X15510; CAA33530.1; -; mRNA.
PIR; S05433; S05433.
HOVERGEN; HBG004341; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
InterPro; IPR013531; Mcrtin_ACTH_cent.
InterPro; IPR013593; Melanocortin_N.
InterPro; IPR013532; Opioid_neuropept.
InterPro; IPR001941; PMOC.
Pfam; PF00976; ACTH_domain; 3.
Pfam; PF08384; NPP; 1.
Pfam; PF08035; Op_neuropeptide; 1.
PRINTS; PR00383; MELANOCORTIN.
SMART; SM01363; ACTH_domain; 3.
SMART; SM01364; NPP; 1.
SMART; SM01365; Op_neuropeptide; 1.
1: Evidence at protein level;
Amidation; Cleavage on pair of basic residues;
Direct protein sequencing; Endorphin; Glycoprotein; Hormone;
Pyrrolidone carboxylic acid; Secreted; Signal.
SIGNAL 1 26 {ECO:0000255}.
PEPTIDE 27 104 NPP. {ECO:0000250}.
/FTId=PRO_0000025122.
PEPTIDE 77 87 Melanotropin gamma. {ECO:0000250}.
/FTId=PRO_0000025123.
PROPEP 107 141
/FTId=PRO_0000025124.
PEPTIDE 144 182 Corticotropin. {ECO:0000250}.
/FTId=PRO_0000025125.
PEPTIDE 144 156 Melanocyte-stimulating hormone alpha.
{ECO:0000250}.
/FTId=PRO_0000025126.
PEPTIDE 162 182 Corticotropin-like intermediary peptide.
{ECO:0000250}.
/FTId=PRO_0000025127.
PEPTIDE 185 263 Lipotropin beta. {ECO:0000250}.
/FTId=PRO_0000025128.
PEPTIDE 185 230 Lipotropin gamma. {ECO:0000250}.
/FTId=PRO_0000025129.
PEPTIDE 214 230 Melanocyte-stimulating hormone beta.
{ECO:0000250}.
/FTId=PRO_0000025130.
PEPTIDE 233 263 Beta-endorphin. {ECO:0000250}.
/FTId=PRO_0000025131.
PEPTIDE 233 237 Met-enkephalin. {ECO:0000250}.
/FTId=PRO_0000025132.
MOD_RES 27 27 Pyrrolidone carboxylic acid.
{ECO:0000250}.
MOD_RES 87 87 Phenylalanine amide. {ECO:0000250}.
MOD_RES 156 156 Valine amide. {ECO:0000250}.
CARBOHYD 91 91 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CONFLICT 67 67 I -> M (in Ref. 2; AA sequence).
{ECO:0000305}.
CONFLICT 119 119 L -> P (in Ref. 2; AA sequence).
{ECO:0000305}.
CONFLICT 134 134 D -> E (in Ref. 2; AA sequence).
{ECO:0000305}.
SEQUENCE 263 AA; 30389 MW; CC09C6608AD0B67A CRC64;
MLQPVWHACI LAILGVFIFH VGEVRSQCWE SNKCTDLSSE DGILECIKAC KMDLSAESPV
FPGNGHIQPL SENIRKYVMS HFRWNKFGRR NSTSNDNNNN NGGYKREDIA NYPILNLFLG
SDNQNTQEGI MEDDALDRQD SKRSYSMEHF RWGKPVGKKR RPIKVFPTDA EEESSESFPI
ELRRELSLEF DYPDTNSEEE LDNGELLEGP VKKGRKYKMH HFRWEGPPKD KRYGGFMTPE
RSQTPLMTLF KNAIIKNAHK KGQ


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