Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pro-opiomelanocortin (POMC) (Corticotropin-lipotropin) [Cleaved into: NPP; Melanotropin gamma (Gamma-MSH); Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanocyte-stimulating hormone alpha (Alpha-MSH) (Melanotropin alpha); Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanocyte-stimulating hormone beta (Beta-MSH) (Melanotropin beta); Beta-endorphin; Met-enkephalin]

 COLI_CAVPO              Reviewed;         256 AA.
P19402;
01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 2.
23-MAY-2018, entry version 95.
RecName: Full=Pro-opiomelanocortin;
Short=POMC;
AltName: Full=Corticotropin-lipotropin;
Contains:
RecName: Full=NPP;
Contains:
RecName: Full=Melanotropin gamma;
AltName: Full=Gamma-MSH;
Contains:
RecName: Full=Corticotropin;
AltName: Full=Adrenocorticotropic hormone;
Short=ACTH;
Contains:
RecName: Full=Melanocyte-stimulating hormone alpha;
Short=Alpha-MSH;
AltName: Full=Melanotropin alpha;
Contains:
RecName: Full=Corticotropin-like intermediary peptide;
Short=CLIP;
Contains:
RecName: Full=Lipotropin beta;
AltName: Full=Beta-LPH;
Contains:
RecName: Full=Lipotropin gamma;
AltName: Full=Gamma-LPH;
Contains:
RecName: Full=Melanocyte-stimulating hormone beta;
Short=Beta-MSH;
AltName: Full=Melanotropin beta;
Contains:
RecName: Full=Beta-endorphin;
Contains:
RecName: Full=Met-enkephalin;
Flags: Precursor;
Name=POMC;
Cavia porcellus (Guinea pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
Hystricomorpha; Caviidae; Cavia.
NCBI_TaxID=10141;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Pituitary;
PubMed=1662166; DOI=10.1016/0303-7207(91)90012-H;
Keightley M.C., Funder J.W., Fuller P.J.;
"Molecular cloning and sequencing of a guinea-pig pro-opiomelanocortin
cDNA.";
Mol. Cell. Endocrinol. 82:89-98(1991).
[2]
PROTEIN SEQUENCE OF 125-163.
PubMed=2830360; DOI=10.1677/joe.0.115R005;
Smith A.I., Wallace C.A., Moritz R.L., Simpson R.J.,
Schmauk-White L.B., Woodcock E.A., Funder J.W.;
"Isolation, amino acid sequence and action of guinea-pig ACTH on
aldosterone production by glomerulosa cells.";
J. Endocrinol. 115:R5-R8(1987).
-!- FUNCTION: ACTH stimulates the adrenal glands to release cortisol.
-!- FUNCTION: MSH (melanocyte-stimulating hormone) increases the
pigmentation of skin by increasing melanin production in
melanocytes.
-!- FUNCTION: Beta-endorphin and Met-enkephalin are endogenous
opiates.
-!- FUNCTION: Corticotropin: Stimulates the adrenal glands to release
cortisol.
-!- FUNCTION: Melanocyte-stimulating hormone alpha: Anorexigenic
peptide. Increases the pigmentation of skin by increasing melanin
production in melanocytes.
-!- FUNCTION: Melanocyte-stimulating hormone beta: Increases the
pigmentation of skin by increasing melanin production in
melanocytes.
-!- FUNCTION: Beta-endorphin: Endogenous orexigenic opiate.
-!- FUNCTION: Met-enkephalin: Endogenous opiate.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01193}.
Note=Melanocyte-stimulating hormone alpha and beta-endorphin are
stored in separate granules in hypothalamic POMC neurons,
suggesting that secretion may be under the control of different
regulatory mechanisms. {ECO:0000250|UniProtKB:P01193}.
-!- TISSUE SPECIFICITY: ACTH and MSH are produced by the pituitary
gland.
-!- PTM: Specific enzymatic cleavages at paired basic residues yield
the different active peptides.
-!- SIMILARITY: Belongs to the POMC family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; S78260; AAB20814.2; -; mRNA.
PIR; A54322; A54322.
STRING; 10141.ENSCPOP00000020054; -.
PRIDE; P19402; -.
eggNOG; ENOG410IKR5; Eukaryota.
eggNOG; ENOG410Z5R4; LUCA.
HOGENOM; HOG000111887; -.
HOVERGEN; HBG004341; -.
InParanoid; P19402; -.
Proteomes; UP000005447; Unassembled WGS sequence.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
InterPro; IPR013531; Mcrtin_ACTH_cent.
InterPro; IPR013593; Melanocortin_N.
InterPro; IPR013532; Opioid_neuropept.
InterPro; IPR001941; PMOC.
Pfam; PF00976; ACTH_domain; 3.
Pfam; PF08384; NPP; 1.
Pfam; PF08035; Op_neuropeptide; 1.
PRINTS; PR00383; MELANOCORTIN.
SMART; SM01363; ACTH_domain; 2.
SMART; SM01364; NPP; 1.
SMART; SM01365; Op_neuropeptide; 1.
1: Evidence at protein level;
Acetylation; Amidation; Cleavage on pair of basic residues;
Complete proteome; Direct protein sequencing; Disulfide bond;
Endorphin; Glycoprotein; Hormone; Phosphoprotein; Reference proteome;
Secreted; Signal.
SIGNAL 1 26 {ECO:0000255}.
PEPTIDE 27 97 NPP.
/FTId=PRO_0000024955.
PEPTIDE 77 87 Melanotropin gamma.
/FTId=PRO_0000024956.
PROPEP 100 122
/FTId=PRO_0000024957.
PEPTIDE 125 163 Corticotropin.
/FTId=PRO_0000024958.
PEPTIDE 125 137 Melanocyte-stimulating hormone alpha.
/FTId=PRO_0000024959.
PEPTIDE 143 163 Corticotropin-like intermediary peptide.
/FTId=PRO_0000024960.
PEPTIDE 166 256 Lipotropin beta.
/FTId=PRO_0000024961.
PEPTIDE 166 223 Lipotropin gamma.
/FTId=PRO_0000024962.
PEPTIDE 206 223 Melanocyte-stimulating hormone beta.
/FTId=PRO_0000024963.
PEPTIDE 226 256 Beta-endorphin.
/FTId=PRO_0000024964.
PEPTIDE 226 230 Met-enkephalin.
/FTId=PRO_0000024965.
MOD_RES 87 87 Phenylalanine amide.
{ECO:0000250|UniProtKB:P01190}.
MOD_RES 125 125 N-acetylserine; in Corticotropin.
{ECO:0000250|UniProtKB:P01191}.
MOD_RES 137 137 Valine amide.
{ECO:0000250|UniProtKB:P01190}.
MOD_RES 155 155 Phosphoserine.
{ECO:0000250|UniProtKB:P01189}.
CARBOHYD 71 71 O-linked (GalNAc...) threonine.
{ECO:0000250}.
CARBOHYD 91 91 N-linked (GlcNAc...) asparagine.
{ECO:0000250}.
DISULFID 28 50 {ECO:0000250}.
SEQUENCE 256 AA; 28264 MW; 02619BE7C0A0DA54 CRC64;
MPRSCYSRSG TLLLALLLQI SMEVRGWCLE SSQCQDLTTE RHLLECLRAC KPDLSAETPV
FPGGADEQTP TESPRKYVTG HFRWGRFGRG NSSGASQKRE EEAAAADPGF HGDGVEPGLR
EDKRSYSMEH FRWGKPVGKK RRPVKVYANG AEEESAEAFP LEFKRELTGE RPAAAPGPDG
LGFGLVAEAE AEAAAAEKKD AAEKKDDGSY RMEHFRWGTP RKGKRYGGFM TSEKSQTPLV
TLFKNAIVKN AHKKGQ


Related products :

Catalog number Product name Quantity
18-783-77917 RABBIT ANTI HUMAN BETA MELANOCYTE STIMULATING HORMONE - beta-MSH Polyclonal 1 ml
15-288-21445 Corticotropin-lipotropin - Pro-opiomelanocortin; POMC Polyclonal 0.05 mg
15-288-21445 Corticotropin-lipotropin - Pro-opiomelanocortin; POMC Polyclonal 0.1 mg
10-271-82074 Follicle Stimulating Hormone Human (Native) - Follicle-stimulating hormone beta subunit; FSH-beta; FSH-B; Follitropin beta chain 0.01 mg
10-271-82074 Follicle Stimulating Hormone Human (Native) - Follicle-stimulating hormone beta subunit; FSH-beta; FSH-B; Follitropin beta chain 0.05 mg
SCH-6045-0504 SYNTHETIC ALPHA MELANOCYTE STIMULATING HORMONE, Product Type Purified Protein, Specificity ALPHA MELANOCYTE STIMULATING HORMONE, Target Species , Host N_A, Format Purified, Isotypes , Applicatio 0.5 mg
6045-0504 SYNTHETIC ALPHA MELANOCYTE STIMULATING HORMONE, Product Type Purified Protein, Specificity ALPHA MELANOCYTE STIMULATING HORMONE, Target Species , Host N_A, Format Purified, Isotypes , Applicatio 0.5 mg
20-272-190363 FSH beta - Mouse monoclonal [INN - hFSH - 60] to FSH beta; Follicle-stimulating hormone beta subunit; FSH-beta; FSH-B; Follitropin beta chain Monoclonal 0.25 mg
E1311b ELISA Bos taurus,Bovine,Corticotropin-lipotropin,POMC,POMC,Pro-opiomelanocortin 96T
E1311b ELISA kit Bos taurus,Bovine,Corticotropin-lipotropin,POMC,POMC,Pro-opiomelanocortin 96T
U1311b CLIA Bos taurus,Bovine,Corticotropin-lipotropin,POMC,POMC,Pro-opiomelanocortin 96T
U1311r CLIA Corticotropin-lipotropin,POMC,Pomc,Pomc2,Pro-opiomelanocortin,Rat,Rattus norvegicus 96T
E1311r ELISA kit Corticotropin-lipotropin,POMC,Pomc,Pomc2,Pro-opiomelanocortin,Rat,Rattus norvegicus 96T
U1311Rb CLIA Corticotropin-lipotropin,Oryctolagus cuniculus,POMC,POMC,Pro-opiomelanocortin,Rabbit 96T
E1311h ELISA kit Corticotropin-lipotropin,Homo sapiens,Human,POMC,POMC,Pro-opiomelanocortin 96T
E1311m ELISA kit Corticotropin-lipotropin,Mouse,Mus musculus,POMC,Pomc,Pomc1,Pro-opiomelanocortin 96T
E1311r ELISA Corticotropin-lipotropin,POMC,Pomc,Pomc2,Pro-opiomelanocortin,Rat,Rattus norvegicus 96T
E1311Rb ELISA kit Corticotropin-lipotropin,Oryctolagus cuniculus,POMC,POMC,Pro-opiomelanocortin,Rabbit 96T
E1311h ELISA Corticotropin-lipotropin,Homo sapiens,Human,POMC,POMC,Pro-opiomelanocortin 96T
E1311m ELISA Corticotropin-lipotropin,Mouse,Mus musculus,POMC,Pomc,Pomc1,Pro-opiomelanocortin 96T
E1311Rb ELISA Corticotropin-lipotropin,Oryctolagus cuniculus,POMC,POMC,Pro-opiomelanocortin,Rabbit 96T
U1311h CLIA Corticotropin-lipotropin,Homo sapiens,Human,POMC,POMC,Pro-opiomelanocortin 96T
U1311m CLIA Corticotropin-lipotropin,Mouse,Mus musculus,POMC,Pomc,Pomc1,Pro-opiomelanocortin 96T
EIAAB32354 Homo sapiens,Human,PERC,Peroxisome proliferator-activated receptor gamma coactivator 1-beta,PGC1,PGC1B,PGC-1-beta,PGC-1-related estrogen receptor alpha coactivator,PPAR-gamma coactivator 1-beta,PPARGC
E1311p ELISA Corticotropin-lipotropin,POMC,POMC,POMC,Pro-opiomelanocortin,Sus scrofa 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: +49 0241 40 08 90 86, +49 0241 95 78 94 78, +49 0241 40 08 90 86
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur