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Pro-opiomelanocortin (POMC) (Corticotropin-lipotropin) [Cleaved into: NPP; Melanotropin gamma (Gamma-MSH); Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanocyte-stimulating hormone alpha (Alpha-MSH) (Melanotropin alpha); Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanocyte-stimulating hormone beta (Beta-MSH) (Melanotropin beta); Beta-endorphin; Met-enkephalin]

 COLI_PELRI              Reviewed;         260 AA.
P22923;
01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
01-AUG-1991, sequence version 1.
25-OCT-2017, entry version 69.
RecName: Full=Pro-opiomelanocortin;
Short=POMC;
AltName: Full=Corticotropin-lipotropin;
Contains:
RecName: Full=NPP;
Contains:
RecName: Full=Melanotropin gamma;
AltName: Full=Gamma-MSH;
Contains:
RecName: Full=Corticotropin;
AltName: Full=Adrenocorticotropic hormone;
Short=ACTH;
Contains:
RecName: Full=Melanocyte-stimulating hormone alpha;
Short=Alpha-MSH;
AltName: Full=Melanotropin alpha;
Contains:
RecName: Full=Corticotropin-like intermediary peptide;
Short=CLIP;
Contains:
RecName: Full=Lipotropin beta;
AltName: Full=Beta-LPH;
Contains:
RecName: Full=Lipotropin gamma;
AltName: Full=Gamma-LPH;
Contains:
RecName: Full=Melanocyte-stimulating hormone beta;
Short=Beta-MSH;
AltName: Full=Melanotropin beta;
Contains:
RecName: Full=Beta-endorphin;
Contains:
RecName: Full=Met-enkephalin;
Flags: Precursor;
Name=pomc;
Pelophylax ridibundus (Marsh frog) (Rana ridibunda).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae;
Pelophylax.
NCBI_TaxID=8406;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2260977; DOI=10.1016/S0006-291X(05)80085-3;
Hilario E., Lihrmann I., Vaudry H.;
"Characterization of the cDNA encoding proopiomelanocortin in the frog
Rana ridibunda.";
Biochem. Biophys. Res. Commun. 173:653-659(1990).
-!- FUNCTION: Corticotropin: Stimulates the adrenal glands to release
cortisol.
-!- FUNCTION: Melanocyte-stimulating hormone alpha: Anorexigenic
peptide. Increases the pigmentation of skin by increasing melanin
production in melanocytes.
-!- FUNCTION: Melanocyte-stimulating hormone beta: Increases the
pigmentation of skin by increasing melanin production in
melanocytes.
-!- FUNCTION: Beta-endorphin: Endogenous orexigenic opiate.
-!- FUNCTION: Met-enkephalin: Endogenous opiate.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01193}.
Note=Melanocyte-stimulating hormone alpha and beta-endorphin are
stored in separate granules in hypothalamic POMC neurons,
suggesting that secretion may be under the control of different
regulatory mechanisms. {ECO:0000250|UniProtKB:P01193}.
-!- PTM: Specific enzymatic cleavages at paired basic residues yield
the different active peptides.
-!- SIMILARITY: Belongs to the POMC family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; M62770; AAA49531.1; -; mRNA.
PIR; A36402; A36402.
HOVERGEN; HBG004341; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
InterPro; IPR032246; ACTH_assoc.
InterPro; IPR013531; Mcrtin_ACTH_cent.
InterPro; IPR013593; Melanocortin_N.
InterPro; IPR013532; Opioid_neuropept.
InterPro; IPR001941; PMOC.
Pfam; PF16102; ACTH_assoc; 1.
Pfam; PF00976; ACTH_domain; 3.
Pfam; PF08384; NPP; 1.
Pfam; PF08035; Op_neuropeptide; 1.
PRINTS; PR00383; MELANOCORTIN.
SMART; SM01363; ACTH_domain; 3.
SMART; SM01364; NPP; 1.
SMART; SM01365; Op_neuropeptide; 1.
2: Evidence at transcript level;
Amidation; Cleavage on pair of basic residues; Endorphin;
Glycoprotein; Hormone; Pyrrolidone carboxylic acid; Secreted; Signal.
SIGNAL 1 25 {ECO:0000250}.
PEPTIDE 26 101 NPP. {ECO:0000250}.
/FTId=PRO_0000025133.
PEPTIDE 76 86 Melanotropin gamma. {ECO:0000250}.
/FTId=PRO_0000025134.
PROPEP 104 138
/FTId=PRO_0000025135.
PEPTIDE 141 179 Corticotropin. {ECO:0000250}.
/FTId=PRO_0000025136.
PEPTIDE 141 153 Melanocyte-stimulating hormone alpha.
{ECO:0000250}.
/FTId=PRO_0000025137.
PEPTIDE 159 179 Corticotropin-like intermediary peptide.
{ECO:0000250}.
/FTId=PRO_0000025138.
PEPTIDE 182 260 Lipotropin beta. {ECO:0000250}.
/FTId=PRO_0000025139.
PEPTIDE 182 227 Lipotropin gamma. {ECO:0000250}.
/FTId=PRO_0000025140.
PEPTIDE 211 227 Melanocyte-stimulating hormone beta.
{ECO:0000250}.
/FTId=PRO_0000025141.
PEPTIDE 230 260 Beta-endorphin. {ECO:0000250}.
/FTId=PRO_0000025142.
PEPTIDE 230 234 Met-enkephalin. {ECO:0000250}.
/FTId=PRO_0000025143.
MOD_RES 26 26 Pyrrolidone carboxylic acid.
{ECO:0000250}.
MOD_RES 86 86 Phenylalanine amide. {ECO:0000250}.
MOD_RES 153 153 Valine amide. {ECO:0000250}.
CARBOHYD 90 90 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 260 AA; 30068 MW; 7B0CA8B5D5666833 CRC64;
MLQPVWSCIL ALLGVFIFHV GEVRSQCWES NKCTDLSSED GILECIKACK MDLSAESPVF
PGNGHMQPLS ENIRKYVMSH FRWNKFGRRN STSNDNNNGG YKREDIANYP ILNLLTGSDN
QNTQQGIMED EAVDRQDSKR SYSMEHFRWG KPVGKKRRPI KVFPTDAEEE SSEIFPLELR
RELSLEFDYP DTNSEEDLDD GELLDGPVKK DRKYKMHHFR WEGPPKDKRY GGFMTPERSQ
TPLMTLFKNA IIKNAHKKGQ


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