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Pro-opiomelanocortin (POMC) (Corticotropin-lipotropin) [Cleaved into: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide; Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanocyte-stimulating hormone alpha (Alpha-MSH) (Melanotropin alpha); Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanocyte-stimulating hormone beta (Beta-MSH) (Melanotropin beta); Beta-endorphin; Met-enkephalin]

 COLI_RAT                Reviewed;         235 AA.
P01194;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
01-JAN-1988, sequence version 1.
23-MAY-2018, entry version 114.
RecName: Full=Pro-opiomelanocortin;
Short=POMC;
AltName: Full=Corticotropin-lipotropin;
Contains:
RecName: Full=NPP;
Contains:
RecName: Full=Melanotropin gamma;
AltName: Full=Gamma-MSH;
Contains:
RecName: Full=Potential peptide;
Contains:
RecName: Full=Corticotropin;
AltName: Full=Adrenocorticotropic hormone;
Short=ACTH;
Contains:
RecName: Full=Melanocyte-stimulating hormone alpha;
Short=Alpha-MSH;
AltName: Full=Melanotropin alpha;
Contains:
RecName: Full=Corticotropin-like intermediary peptide;
Short=CLIP;
Contains:
RecName: Full=Lipotropin beta;
AltName: Full=Beta-LPH;
Contains:
RecName: Full=Lipotropin gamma;
AltName: Full=Gamma-LPH;
Contains:
RecName: Full=Melanocyte-stimulating hormone beta;
Short=Beta-MSH;
AltName: Full=Melanotropin beta;
Contains:
RecName: Full=Beta-endorphin;
Contains:
RecName: Full=Met-enkephalin;
Flags: Precursor;
Name=Pomc; Synonyms=Pomc2;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2998878; DOI=10.1016/0014-5793(85)80078-8;
Drouin J., Chamberland M., Charron J., Jeannotte L., Nemer M.;
"Structure of the rat pro-opiomelanocortin (POMC) gene.";
FEBS Lett. 193:54-58(1985).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-56.
PubMed=6547437;
Oates E., Herbert E.;
"5' sequence of porcine and rat pro-opiomelanocortin mRNA. One porcine
and two rat forms.";
J. Biol. Chem. 259:7421-7425(1984).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 45-235.
PubMed=6255341; DOI=10.1038/288610a0;
Drouin J., Goodman H.M.;
"Most of the coding region of rat ACTH beta-LPH precursor gene lacks
intervening sequences.";
Nature 288:610-613(1980).
[4]
PROTEIN SEQUENCE OF 76-100.
TISSUE=Pituitary;
PubMed=7259753; DOI=10.1016/S0006-291X(81)80101-5;
Browne C.A., Bennett H.P., Solomon S.;
"The isolation of characterization of gamma 3-melanotropin from the
neurointermediary lobe of the rat pituitary.";
Biochem. Biophys. Res. Commun. 100:336-343(1981).
-!- FUNCTION: Corticotropin: Stimulates the adrenal glands to release
cortisol.
-!- FUNCTION: Melanocyte-stimulating hormone alpha: Anorexigenic
peptide. Increases the pigmentation of skin by increasing melanin
production in melanocytes.
-!- FUNCTION: Melanocyte-stimulating hormone beta: Increases the
pigmentation of skin by increasing melanin production in
melanocytes.
-!- FUNCTION: Beta-endorphin: Endogenous orexigenic opiate.
-!- FUNCTION: Met-enkephalin: Endogenous opiate.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01193}.
Note=Melanocyte-stimulating hormone alpha and beta-endorphin are
stored in separate granules in hypothalamic POMC neurons,
suggesting that secretion may be under the control of different
regulatory mechanisms. {ECO:0000250|UniProtKB:P01193}.
-!- TISSUE SPECIFICITY: ACTH and MSH are produced by the pituitary
gland.
-!- PTM: Specific enzymatic cleavages at paired basic residues yield
the different active peptides.
-!- SIMILARITY: Belongs to the POMC family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; X03176; CAA26937.1; -; Genomic_DNA.
EMBL; K01877; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; J00759; AAA41903.1; -; Genomic_DNA.
EMBL; K01878; AAA41903.1; JOINED; Genomic_DNA.
PIR; A91353; CTRTP.
UniGene; Rn.108195; -.
STRING; 10116.ENSRNOP00000016976; -.
PaxDb; P01194; -.
PRIDE; P01194; -.
RGD; 3366; Pomc.
eggNOG; ENOG410IKR5; Eukaryota.
eggNOG; ENOG410Z5R4; LUCA.
HOGENOM; HOG000111887; -.
HOVERGEN; HBG004341; -.
InParanoid; P01194; -.
PhylomeDB; P01194; -.
PRO; PR:P01194; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0005576; C:extracellular region; IDA:RGD.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0030141; C:secretory granule; IBA:GO_Central.
GO; GO:0001664; F:G-protein coupled receptor binding; IBA:GO_Central.
GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
GO; GO:0007631; P:feeding behavior; NAS:RGD.
GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
GO; GO:2000852; P:regulation of corticosterone secretion; IBA:GO_Central.
InterPro; IPR013531; Mcrtin_ACTH_cent.
InterPro; IPR013593; Melanocortin_N.
InterPro; IPR013532; Opioid_neuropept.
InterPro; IPR001941; PMOC.
Pfam; PF00976; ACTH_domain; 3.
Pfam; PF08384; NPP; 1.
Pfam; PF08035; Op_neuropeptide; 1.
PRINTS; PR00383; MELANOCORTIN.
SMART; SM01363; ACTH_domain; 2.
SMART; SM01364; NPP; 1.
SMART; SM01365; Op_neuropeptide; 1.
1: Evidence at protein level;
Acetylation; Amidation; Cleavage on pair of basic residues;
Complete proteome; Direct protein sequencing; Endorphin; Glycoprotein;
Hormone; Phosphoprotein; Reference proteome; Secreted; Signal.
SIGNAL 1 26 {ECO:0000250}.
PEPTIDE 27 100 NPP.
/FTId=PRO_0000025029.
PEPTIDE 77 87 Melanotropin gamma.
/FTId=PRO_0000025030.
PEPTIDE 101 123 Potential peptide.
/FTId=PRO_0000437245.
PEPTIDE 124 162 Corticotropin.
/FTId=PRO_0000025031.
PEPTIDE 124 136 Melanocyte-stimulating hormone alpha.
/FTId=PRO_0000025032.
PEPTIDE 142 162 Corticotropin-like intermediary peptide.
/FTId=PRO_0000025033.
PEPTIDE 165 235 Lipotropin beta.
/FTId=PRO_0000025034.
PEPTIDE 165 202 Lipotropin gamma.
/FTId=PRO_0000025035.
PEPTIDE 185 202 Melanocyte-stimulating hormone beta.
/FTId=PRO_0000025036.
PEPTIDE 205 235 Beta-endorphin.
/FTId=PRO_0000025037.
PEPTIDE 205 209 Met-enkephalin.
/FTId=PRO_0000025038.
MOD_RES 87 87 Phenylalanine amide. {ECO:0000250}.
MOD_RES 124 124 N-acetylserine; in Corticotropin.
{ECO:0000250|UniProtKB:P01191}.
MOD_RES 136 136 Valine amide. {ECO:0000250}.
MOD_RES 154 154 Phosphoserine.
{ECO:0000250|UniProtKB:P01189}.
CARBOHYD 152 152 N-linked (GlcNAc...) asparagine.
{ECO:0000305}.
CONFLICT 6 6 N -> Y (in Ref. 1; CAA26937/AAA41903).
{ECO:0000305}.
CONFLICT 40 40 E -> Y (in Ref. 2). {ECO:0000305}.
SEQUENCE 235 AA; 26540 MW; A1AEC6AC9DBF1C13 CRC64;
MPRFCNSRSG ALLLALLLQT SIDVWSWCLE SSQCQDLTTE SNLLACIRAC RLDLSAETPV
FPGNGDEQPL TENPRKYVMG HFRWDRFGPR NSSSAGGSAQ RRAEEETAGG DGRPEPSPRE
GKRSYSMEHF RWGKPVGKKR RPVKVYPNVA ENESAEAFPL EFKRELEGEQ PDGLEQVLEP
DTEKADGPYR VEHFRWGNPP KDKRYGGFMT SEKSQTPLVT LFKNAIIKNV HKKGQ


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