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Pro-opiomelanocortin (POMC) (Corticotropin-lipotropin) [Cleaved into: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide; Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanocyte-stimulating hormone alpha (Alpha-MSH) (Melanotropin alpha); Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanocyte-stimulating hormone beta (Beta-MSH) (Melanotropin beta); Beta-endorphin; Met-enkephalin]

 COLI_MACNE              Reviewed;         264 AA.
P01201; P19403;
01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
01-MAY-1991, sequence version 2.
28-MAR-2018, entry version 79.
RecName: Full=Pro-opiomelanocortin;
Short=POMC;
AltName: Full=Corticotropin-lipotropin;
Contains:
RecName: Full=NPP;
Contains:
RecName: Full=Melanotropin gamma;
AltName: Full=Gamma-MSH;
Contains:
RecName: Full=Potential peptide;
Contains:
RecName: Full=Corticotropin;
AltName: Full=Adrenocorticotropic hormone;
Short=ACTH;
Contains:
RecName: Full=Melanocyte-stimulating hormone alpha;
Short=Alpha-MSH;
AltName: Full=Melanotropin alpha;
Contains:
RecName: Full=Corticotropin-like intermediary peptide;
Short=CLIP;
Contains:
RecName: Full=Lipotropin beta;
AltName: Full=Beta-LPH;
Contains:
RecName: Full=Lipotropin gamma;
AltName: Full=Gamma-LPH;
Contains:
RecName: Full=Melanocyte-stimulating hormone beta;
Short=Beta-MSH;
AltName: Full=Melanotropin beta;
Contains:
RecName: Full=Beta-endorphin;
Contains:
RecName: Full=Met-enkephalin;
Flags: Precursor;
Name=POMC;
Macaca nemestrina (Pig-tailed macaque).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9545;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND AMIDATION AT PHE-87; GLU-131 AND
VAL-147.
PubMed=3229286; DOI=10.1089/dna.1988.7.627;
Patel P.D., Sherman T.G., Watson S.J.;
"Characterization of pro-opiomelanocortin cDNA from the Old World
monkey, Macaca nemestrina.";
DNA 7:627-635(1988).
[2]
PROTEIN SEQUENCE OF 135-147 AND 214-231, AND AMIDATION AT VAL-147.
PubMed=13760276;
Lee T.H., Lerner A.B., Buettner-Janusch V.;
"The isolation and structure of alpha- and beta-melanocyte-stimulating
hormones from monkey pituitary glands.";
J. Biol. Chem. 236:1390-1394(1961).
-!- FUNCTION: Corticotropin: Stimulates the adrenal glands to release
cortisol.
-!- FUNCTION: Melanocyte-stimulating hormone alpha: Anorexigenic
peptide. Increases the pigmentation of skin by increasing melanin
production in melanocytes.
-!- FUNCTION: Melanocyte-stimulating hormone beta: Increases the
pigmentation of skin by increasing melanin production in
melanocytes.
-!- FUNCTION: Beta-endorphin: Endogenous orexigenic opiate.
-!- FUNCTION: Met-enkephalin: Endogenous opiate.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01193}.
Note=Melanocyte-stimulating hormone alpha and beta-endorphin are
stored in separate granules in hypothalamic POMC neurons,
suggesting that secretion may be under the control of different
regulatory mechanisms. {ECO:0000250|UniProtKB:P01193}.
-!- TISSUE SPECIFICITY: ACTH and MSH are produced by the pituitary
gland.
-!- PTM: Specific enzymatic cleavages at paired basic residues yield
the different active peptides.
-!- SIMILARITY: Belongs to the POMC family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; M19658; AAA66022.1; -; mRNA.
PIR; A31855; CTMKP.
HOVERGEN; HBG004341; -.
Proteomes; UP000233120; Whole Genome Shotgun Assembly.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
InterPro; IPR013531; Mcrtin_ACTH_cent.
InterPro; IPR013593; Melanocortin_N.
InterPro; IPR013532; Opioid_neuropept.
InterPro; IPR001941; PMOC.
Pfam; PF00976; ACTH_domain; 3.
Pfam; PF08384; NPP; 1.
Pfam; PF08035; Op_neuropeptide; 1.
PRINTS; PR00383; MELANOCORTIN.
SMART; SM01363; ACTH_domain; 3.
SMART; SM01364; NPP; 1.
SMART; SM01365; Op_neuropeptide; 1.
1: Evidence at protein level;
Acetylation; Amidation; Cleavage on pair of basic residues;
Complete proteome; Direct protein sequencing; Endorphin; Glycoprotein;
Hormone; Phosphoprotein; Secreted; Signal.
SIGNAL 1 26 {ECO:0000250}.
PEPTIDE 27 99 NPP.
/FTId=PRO_0000024985.
PEPTIDE 77 87 Melanotropin gamma.
/FTId=PRO_0000024986.
PEPTIDE 91 131 Potential peptide.
/FTId=PRO_0000024987.
PEPTIDE 135 173 Corticotropin.
/FTId=PRO_0000024988.
PEPTIDE 135 147 Melanocyte-stimulating hormone alpha.
/FTId=PRO_0000024989.
PEPTIDE 153 173 Corticotropin-like intermediary peptide.
/FTId=PRO_0000024990.
PEPTIDE 176 264 Lipotropin beta.
/FTId=PRO_0000024991.
PEPTIDE 176 231 Lipotropin gamma.
/FTId=PRO_0000024992.
PEPTIDE 214 231 Melanocyte-stimulating hormone beta.
/FTId=PRO_0000024993.
PEPTIDE 234 264 Beta-endorphin.
/FTId=PRO_0000024994.
PEPTIDE 234 238 Met-enkephalin.
/FTId=PRO_0000024995.
MOD_RES 87 87 Phenylalanine amide.
{ECO:0000269|PubMed:3229286}.
MOD_RES 131 131 Glutamic acid 1-amide.
{ECO:0000269|PubMed:3229286}.
MOD_RES 135 135 N-acetylserine; in Corticotropin.
{ECO:0000250|UniProtKB:P01191}.
MOD_RES 147 147 Valine amide.
{ECO:0000269|PubMed:13760276,
ECO:0000269|PubMed:3229286}.
MOD_RES 165 165 Phosphoserine.
{ECO:0000250|UniProtKB:P01189}.
CARBOHYD 91 91 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 264 AA; 29172 MW; BC73B100D9BAD052 CRC64;
MPRSCCSRSG ALLLALLLQA SMEVRGWCLE SSQCQDLTTE SNLLECIRAC KPDLSAETPV
FPGNGDEQPL TENPRKYVMG HFRWDRFGRR NSSSGSAHQK REDVAAGEDR GLLPEGGPEP
RGDGAGPGPR EGKRSYSMEH FRWGKPVGKK RRPVKVYPNG AEDESAEAFP LEFKRELTGQ
RPRAGDGPDG PADDGAGPRA DLEHSLLVAA EKKDEGPYRM EHFRWGSPPK DKRYGGFMTS
EKSQTPLVTL FKNAIIKNAY KKGQ


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