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Pro-opiomelanocortin B (POMC-B) (Corticotropin-lipotropin B) [Cleaved into: NPP 2; Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanocyte-stimulating hormone alpha 2 (Alpha-MSH 2) (Melanotropin alpha 2); Corticotropin-like intermediary peptide 2 (CLIP-2); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanocyte-stimulating hormone beta 2 (Beta-MSH 2) (Melanotropin beta 2); Beta-endorphin 2; Met-enkephalin]

 COLI2_ONCMY             Reviewed;         240 AA.
Q04618;
01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
01-OCT-1993, sequence version 1.
25-OCT-2017, entry version 74.
RecName: Full=Pro-opiomelanocortin B;
Short=POMC-B;
AltName: Full=Corticotropin-lipotropin B;
Contains:
RecName: Full=NPP 2;
Contains:
RecName: Full=Corticotropin;
AltName: Full=Adrenocorticotropic hormone;
Short=ACTH;
Contains:
RecName: Full=Melanocyte-stimulating hormone alpha 2;
Short=Alpha-MSH 2;
AltName: Full=Melanotropin alpha 2;
Contains:
RecName: Full=Corticotropin-like intermediary peptide 2;
Short=CLIP-2;
Contains:
RecName: Full=Lipotropin beta;
AltName: Full=Beta-LPH;
Contains:
RecName: Full=Lipotropin gamma;
AltName: Full=Gamma-LPH;
Contains:
RecName: Full=Melanocyte-stimulating hormone beta 2;
Short=Beta-MSH 2;
AltName: Full=Melanotropin beta 2;
Contains:
RecName: Full=Beta-endorphin 2;
Contains:
RecName: Full=Met-enkephalin;
Flags: Precursor;
Name=pomcb;
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii;
Salmoniformes; Salmonidae; Salmoninae; Oncorhynchus.
NCBI_TaxID=8022;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Pituitary;
PubMed=1448114; DOI=10.1210/mend.6.10.1448114;
Salbert G., Chauveau I., Bonnec G., Valotaire Y., Jego P.;
"One of the two trout proopiomelanocortin messenger RNAs potentially
encodes new peptides.";
Mol. Endocrinol. 6:1605-1613(1992).
-!- FUNCTION: Corticotropin: Stimulates the adrenal glands to release
cortisol.
-!- FUNCTION: Melanocyte-stimulating hormone alpha: Anorexigenic
peptide. Increases the pigmentation of skin by increasing melanin
production in melanocytes.
-!- FUNCTION: Melanocyte-stimulating hormone beta: Increases the
pigmentation of skin by increasing melanin production in
melanocytes.
-!- FUNCTION: Beta-endorphin: Endogenous orexigenic opiate.
-!- FUNCTION: Met-enkephalin: Endogenous opiate.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01193}.
Note=Melanocyte-stimulating hormone alpha and beta-endorphin are
stored in separate granules in hypothalamic POMC neurons,
suggesting that secretion may be under the control of different
regulatory mechanisms. {ECO:0000250|UniProtKB:P01193}.
-!- TISSUE SPECIFICITY: Pituitary and hypothalamus of adult diploid
animals.
-!- DEVELOPMENTAL STAGE: Expressed only in sexually active fish.
-!- PTM: Specific enzymatic cleavages at paired basic residues yield
the different active peptides.
-!- PTM: Acetylation of beta-endorphin occurs in a tissue-specific
manner.
-!- SIMILARITY: Belongs to the POMC family. {ECO:0000305}.
-!- CAUTION: It is uncertain whether Met-1 or Met-15 is the initiator.
{ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; X69809; CAA49467.1; -; mRNA.
PIR; B45359; B45359.
RefSeq; NP_001118191.1; NM_001124719.1.
UniGene; Omy.8198; -.
GeneID; 100136772; -.
HOVERGEN; HBG004341; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
InterPro; IPR013531; Mcrtin_ACTH_cent.
InterPro; IPR013593; Melanocortin_N.
InterPro; IPR013532; Opioid_neuropept.
InterPro; IPR001941; PMOC.
Pfam; PF00976; ACTH_domain; 2.
Pfam; PF08384; NPP; 1.
Pfam; PF08035; Op_neuropeptide; 1.
PRINTS; PR00383; MELANOCORTIN.
SMART; SM01363; ACTH_domain; 2.
SMART; SM01364; NPP; 1.
SMART; SM01365; Op_neuropeptide; 1.
2: Evidence at transcript level;
Acetylation; Amidation; Cleavage on pair of basic residues; Endorphin;
Hormone; Pyrrolidone carboxylic acid; Secreted; Signal.
SIGNAL 1 36 {ECO:0000255}.
PEPTIDE 37 108 NPP 2. {ECO:0000250}.
/FTId=PRO_0000025103.
PROPEP 111 111 {ECO:0000255}.
/FTId=PRO_0000025104.
PEPTIDE 112 152 Corticotropin. {ECO:0000250}.
/FTId=PRO_0000025105.
PEPTIDE 112 124 Melanocyte-stimulating hormone alpha 2.
{ECO:0000250}.
/FTId=PRO_0000025106.
PEPTIDE 130 152 Corticotropin-like intermediary peptide
2. {ECO:0000250}.
/FTId=PRO_0000025107.
PEPTIDE 155 240 Lipotropin beta. {ECO:0000250}.
/FTId=PRO_0000025108.
PEPTIDE 155 209 Lipotropin gamma. {ECO:0000250}.
/FTId=PRO_0000025109.
PEPTIDE 193 209 Melanocyte-stimulating hormone beta 2.
{ECO:0000250}.
/FTId=PRO_0000025110.
PEPTIDE 212 240 Beta-endorphin 2. {ECO:0000250}.
/FTId=PRO_0000025111.
PEPTIDE 212 216 Met-enkephalin.
/FTId=PRO_0000025112.
MOD_RES 37 37 Pyrrolidone carboxylic acid.
{ECO:0000250}.
MOD_RES 112 112 N-acetylserine; in Corticotropin.
{ECO:0000250}.
MOD_RES 124 124 Isoleucine amide. {ECO:0000250}.
SEQUENCE 240 AA; 26719 MW; 4F715CE8E6424F6C CRC64;
MFGTFLQNQS VRLNMVCAPW LLAVVVVCVC NPGVEGQCWD SSHCKDLPSE DKILECIHLF
RSGLQDESPE PRSAAQQSTE ESLSLGILLA ALTSGERALD ADPEPHSDKR HSYSMEHFRW
GKPIGHKRRP IKVYASSLEG GDSSEGTFPL QARRQLSSWE DEMVGALGNQ GAKAQTKVVP
RTLTVTGLQD KKDGSYRMGH FRWGSPTAIK RYGGFMKPYT QQSHKPLITL LKHVTLKNEQ


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