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Pro-opiomelanocortin-1 (POMC-1) (Corticotropin-lipotropin 1) (Corticotropin-lipotropin I) (Pro-opiomelanocortin I) (POMC I) [Cleaved into: Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanocyte-stimulating hormone alpha (Alpha-MSH) (Melanotropin alpha); Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanocyte-stimulating hormone beta (Beta-MSH) (Melanotropin beta); Beta-endorphin; Met-enkephalin]

 COLI1_CYPCA             Reviewed;         222 AA.
Q9YGK4;
01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
01-MAY-1999, sequence version 1.
25-OCT-2017, entry version 58.
RecName: Full=Pro-opiomelanocortin-1;
Short=POMC-1;
AltName: Full=Corticotropin-lipotropin 1;
AltName: Full=Corticotropin-lipotropin I;
AltName: Full=Pro-opiomelanocortin I;
Short=POMC I;
Contains:
RecName: Full=Corticotropin;
AltName: Full=Adrenocorticotropic hormone;
Short=ACTH;
Contains:
RecName: Full=Melanocyte-stimulating hormone alpha;
Short=Alpha-MSH;
AltName: Full=Melanotropin alpha;
Contains:
RecName: Full=Corticotropin-like intermediary peptide;
Short=CLIP;
Contains:
RecName: Full=Lipotropin beta;
AltName: Full=Beta-LPH;
Contains:
RecName: Full=Lipotropin gamma;
AltName: Full=Gamma-LPH;
Contains:
RecName: Full=Melanocyte-stimulating hormone beta;
Short=Beta-MSH;
AltName: Full=Melanotropin beta;
Contains:
RecName: Full=Beta-endorphin;
Contains:
RecName: Full=Met-enkephalin;
Flags: Precursor;
Name=pomca;
Cyprinus carpio (Common carp).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Cyprinus.
NCBI_TaxID=7962;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Pituitary;
PubMed=9806347; DOI=10.1016/S0303-7207(98)00139-7;
Arends R.J., Vermeer H., Martens G.J.M., Leunissen J.A.M.,
Wendelaar Bonga S.E., Flik G.;
"Cloning and expression of two proopiomelanocortin mRNAs in the common
carp (Cyprinus carpio L.).";
Mol. Cell. Endocrinol. 143:23-31(1998).
-!- FUNCTION: Corticotropin: Stimulates the adrenal glands to release
cortisol.
-!- FUNCTION: Melanocyte-stimulating hormone alpha: Anorexigenic
peptide. Increases the pigmentation of skin by increasing melanin
production in melanocytes.
-!- FUNCTION: Melanocyte-stimulating hormone beta: Increases the
pigmentation of skin by increasing melanin production in
melanocytes.
-!- FUNCTION: Beta-endorphin: Endogenous orexigenic opiate.
-!- FUNCTION: Met-enkephalin: Endogenous opiate.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01193}.
Note=Melanocyte-stimulating hormone alpha and beta-endorphin are
stored in separate granules in hypothalamic POMC neurons,
suggesting that secretion may be under the control of different
regulatory mechanisms. {ECO:0000250|UniProtKB:P01193}.
-!- PTM: Specific enzymatic cleavages at paired basic residues yield
the different active peptides.
-!- SIMILARITY: Belongs to the POMC family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; Y14618; CAA74968.1; -; mRNA.
PRIDE; Q9YGK4; -.
HOVERGEN; HBG004341; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
InterPro; IPR013531; Mcrtin_ACTH_cent.
InterPro; IPR013593; Melanocortin_N.
InterPro; IPR013532; Opioid_neuropept.
InterPro; IPR001941; PMOC.
Pfam; PF00976; ACTH_domain; 2.
Pfam; PF08384; NPP; 1.
Pfam; PF08035; Op_neuropeptide; 1.
PRINTS; PR00383; MELANOCORTIN.
SMART; SM01363; ACTH_domain; 2.
SMART; SM01364; NPP; 1.
SMART; SM01365; Op_neuropeptide; 1.
2: Evidence at transcript level;
Cleavage on pair of basic residues; Endorphin; Hormone; Secreted;
Signal.
SIGNAL 1 28 {ECO:0000255}.
PROPEP 29 105
/FTId=PRO_0000025057.
PEPTIDE 108 146 Corticotropin.
/FTId=PRO_0000025058.
PEPTIDE 108 122 Melanocyte-stimulating hormone alpha.
/FTId=PRO_0000025059.
PEPTIDE 126 146 Corticotropin-like intermediary peptide.
/FTId=PRO_0000025060.
PEPTIDE 149 222 Lipotropin beta.
/FTId=PRO_0000025061.
PEPTIDE 149 187 Lipotropin gamma.
/FTId=PRO_0000025062.
PEPTIDE 171 187 Melanocyte-stimulating hormone beta.
/FTId=PRO_0000025063.
PEPTIDE 190 222 Beta-endorphin.
/FTId=PRO_0000025064.
PEPTIDE 190 194 Met-enkephalin.
/FTId=PRO_0000025065.
SEQUENCE 222 AA; 25417 MW; 7EBE315BFE6EC1E5 CRC64;
MVRGERMLCP AWLLALAVLC AAGSEVRAQC MEDARCRDLT TDENILDCIQ LCRSDLTDET
PVYPGESHLQ PPSELEQTEV LVPLSPAALA PAEQMDPESS PQHEHKRSYS MEHFRWGKPV
GRKRRPIKVY TNGVEEESTE TLPAEMRREL ATNEIDYPQE EGALNQQDKK DGSYKMSHFR
WSSPPASKRY GGFMKSWDER SQKPLLTLFK NVINKEHQKK DQ


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