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ProSAAS (Proprotein convertase subtilisin/kexin type 1 inhibitor) (Proprotein convertase 1 inhibitor) (pro-SAAS) [Cleaved into: KEP; Big SAAS (b-SAAS); Little SAAS (l-SAAS); Big PEN-LEN (b-PEN-LEN) (SAAS CT(1-49)); PEN; PEN-20; Little LEN (l-LEN); Big LEN (b-LEN) (SAAS CT(25-40))]

 PCSK1_RAT               Reviewed;         260 AA.
Q9QXU9;
31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
22-NOV-2017, entry version 80.
RecName: Full=ProSAAS;
AltName: Full=Proprotein convertase subtilisin/kexin type 1 inhibitor;
Short=Proprotein convertase 1 inhibitor;
AltName: Full=pro-SAAS;
Contains:
RecName: Full=KEP;
Contains:
RecName: Full=Big SAAS;
Short=b-SAAS;
Contains:
RecName: Full=Little SAAS;
Short=l-SAAS;
Contains:
RecName: Full=Big PEN-LEN;
Short=b-PEN-LEN;
AltName: Full=SAAS CT(1-49);
Contains:
RecName: Full=PEN;
Contains:
RecName: Full=PEN-20;
Contains:
RecName: Full=Little LEN;
Short=l-LEN;
Contains:
RecName: Full=Big LEN;
Short=b-LEN;
AltName: Full=SAAS CT(25-40);
Flags: Precursor;
Name=Pcsk1n;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
PubMed=10632593;
Fricker L., McKinzie A.A., Sun J., Curran E., Qian Y., Yan L.,
Patterson S.D., Courchesne P.L., Richards B., Levin N., Mzhavia N.,
Devi L.A., Douglass J.;
"Identification and characterization of proSAAS, a granin-like
neuroendocrine peptide precursor that inhibits prohormone
processing.";
J. Neurosci. 20:639-648(2000).
[2]
TISSUE SPECIFICITY.
PubMed=9630436; DOI=10.1159/000054314;
Donadel G., Marinos N., DeSilva M.G., Lu J., Notkins A.L., Lan M.S.;
"Molecular cloning and characterization of a highly basic protein, IA-
4, expressed in pancreatic islets and brain.";
Neuroendocrinology 67:190-196(1998).
[3]
FUNCTION, AND INTERACTION WITH PCSK1.
PubMed=10816562; DOI=10.1074/jbc.M001583200;
Qian Y., Devi L.A., Mzhavia N., Munzer S., Seidah N.G., Fricker L.D.;
"The C-terminal region of proSAAS is a potent inhibitor of prohormone
convertase 1.";
J. Biol. Chem. 275:23596-23601(2000).
[4]
PROTEOLYTIC PROCESSING (BIG SAAS; LITTLE SAAS; BIG PEN-LEN; PEN;
PEN-20 AND BIG LEN).
PubMed=11742530; DOI=10.1042/0264-6021:3610067;
Mzhavia N., Qian Y., Feng Y., Che F.-Y., Devi L.A., Fricker L.D.;
"Processing of proSAAS in neuroendocrine cell lines.";
Biochem. J. 361:67-76(2002).
[5]
DEVELOPMENTAL STAGE.
PubMed=15935061; DOI=10.1111/j.1471-4159.2005.03138.x;
Morgan D.J., Mzhavia N., Peng B., Pan H., Devi L.A., Pintar J.E.;
"Embryonic gene expression and pro-protein processing of proSAAS
during rodent development.";
J. Neurochem. 93:1454-1462(2005).
-!- FUNCTION: May function in the control of the neuroendocrine
secretory pathway. Proposed be a specific endogenous inhibitor of
PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal
inhibitory domain, but not the processed peptides reduce PCSK1
activity in the endoplasmic reticulum and Golgi. It reduces the
activity of the 87 kDa form but not the autocatalytically derived
65 kDa form of PCSK1. Subsequent processing of proSAAS may
eliminate the inhibition. Slows down convertase-mediated
processing of proopiomelanocortin and proenkephalin. May control
the intracellular timing of PCSK1 rather than its total level of
activity. The function of the processed secreted peptides is not
known (By similarity). {ECO:0000250, ECO:0000269|PubMed:10632593,
ECO:0000269|PubMed:10816562}.
-!- SUBUNIT: Interacts via the C-terminal inhibitory domain with PCSK1
65 kDa form. {ECO:0000269|PubMed:10816562}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9QXV0}.
Golgi apparatus, trans-Golgi network
{ECO:0000250|UniProtKB:Q9QXV0}.
-!- TISSUE SPECIFICITY: Expressed in adult brain (all major structural
regions), adrenal gland (medulla) and spinal chord (dorsal and
ventral horn). Expressed in pancreatic islands.
{ECO:0000269|PubMed:10632593, ECO:0000269|PubMed:9630436}.
-!- DEVELOPMENTAL STAGE: Expressed by E12.5 in essentially all
differentiating neurons in the mantle layer of the myelencephalon,
metencephalon, diencephalon, spinal cord and several sympathetic
ganglia. During later stages of prenatal development, widespread
expression continues in post-mitotic neurons of both the CNS and
PNS and begins in endocrine cells of the anterior and intermediate
pituitary. {ECO:0000269|PubMed:15935061}.
-!- DOMAIN: ProSAAS(1-180) increases secretion of enzymatically
inactive PCSK1. {ECO:0000250}.
-!- DOMAIN: The C-terminal inhibitory domain is involved in inhibition
of PCSK1. It corresponds to the probable processing intermediate
Big PEN-LEN, binds to PCSK1 in vitro and contains the hexapeptide
L-L-R-V-K-R, which, as a synthetic peptide, is sufficient for
PCSK1 inhibition.
-!- PTM: Proteolytically cleaved in the Golgi. Big SAAS, Little SAAS,
PEN and Big LEN are the major processed peptides in proSAAS-
overexpressing PC-12 phaeochromocytoma cells (lacking PCSK1 and
PCSK2 endopeptidases). Peptides corresponding to PEN and a proSAAS
aa 40-59 have been detected in wild-type PC-12 cells.
{ECO:0000269|PubMed:11742530}.
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EMBL; AF181561; AAF22642.1; -; mRNA.
RefSeq; NP_062152.1; NM_019279.1.
UniGene; Rn.25745; -.
SMR; Q9QXU9; -.
BioGrid; 251598; 1.
IntAct; Q9QXU9; 1.
STRING; 10116.ENSRNOP00000066891; -.
MEROPS; I49.001; -.
iPTMnet; Q9QXU9; -.
PhosphoSitePlus; Q9QXU9; -.
PaxDb; Q9QXU9; -.
PRIDE; Q9QXU9; -.
GeneID; 246333; -.
KEGG; rno:246333; -.
UCSC; RGD:3617; rat.
CTD; 27344; -.
RGD; 3617; Pcsk1n.
eggNOG; ENOG410IWT4; Eukaryota.
eggNOG; ENOG4111DVB; LUCA.
HOGENOM; HOG000261638; -.
HOVERGEN; HBG080210; -.
InParanoid; Q9QXU9; -.
PhylomeDB; Q9QXU9; -.
PRO; PR:Q9QXU9; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0070062; C:extracellular exosome; ISO:RGD.
GO; GO:0005615; C:extracellular space; IDA:RGD.
GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
GO; GO:0004866; F:endopeptidase inhibitor activity; IDA:RGD.
GO; GO:0007420; P:brain development; IEP:RGD.
GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
InterPro; IPR010832; ProSAAS.
PANTHER; PTHR15531; PTHR15531; 1.
Pfam; PF07259; ProSAAS; 1.
1: Evidence at protein level;
Cleavage on pair of basic residues; Complete proteome;
Golgi apparatus; Neuropeptide; Reference proteome; Secreted; Signal.
SIGNAL 1 33 {ECO:0000255}.
CHAIN 34 260 ProSAAS.
/FTId=PRO_0000259691.
PEPTIDE 34 59 Big SAAS.
/FTId=PRO_0000259693.
PEPTIDE 34 40 KEP. {ECO:0000250}.
/FTId=PRO_0000259692.
PEPTIDE 42 59 Little SAAS.
/FTId=PRO_0000259694.
PEPTIDE 221 260 Big PEN-LEN. {ECO:0000250}.
/FTId=PRO_0000259695.
PEPTIDE 221 242 PEN.
/FTId=PRO_0000259696.
PEPTIDE 221 240 PEN-20.
/FTId=PRO_0000259697.
PEPTIDE 245 260 Big LEN.
/FTId=PRO_0000259698.
PEPTIDE 245 254 Little LEN. {ECO:0000250}.
/FTId=PRO_0000259699.
REGION 34 215 ProSAAS(1-180).
REGION 221 260 C-terminal inhibitory domain; interacts
with PCSK1.
MOTIF 239 244 Sufficient for inhibition of PCSK1.
{ECO:0000250}.
SEQUENCE 260 AA; 27414 MW; C84F688BDEB5313E CRC64;
MAGSPLLCGP RAGGVGLLVL LLLGLLRLPP TLSARPVKEP RSLSAASAPL AETSTPLRLR
RAVPRGEAAG AVQELARALA HLLEAERQER ARAEAQEAED QQARVLAQLL RAWGSPRASD
PPLAPDDDPD APAAQLARAL LRARLDPAAL AAQLVPAPAP AAALRPRPPV YDDGPTGPDV
EDAADETPDV DPELLRYLLG RILTGSSEPE AAPAPRRLRR AVDQDLGPEV PPENVLGALL
RVKRLENSSP QAPARRLLPP


Related products :

Catalog number Product name Quantity
EIAAB30199 Homo sapiens,Human,PCSK1N,Proprotein convertase 1 inhibitor,Proprotein convertase subtilisin_kexin type 1 inhibitor,ProSAAS,pro-SAAS
EIAAB30200 Pcsk1n,Proprotein convertase 1 inhibitor,Proprotein convertase subtilisin_kexin type 1 inhibitor,ProSAAS,pro-SAAS,Rat,Rattus norvegicus
EIAAB30198 IA-4,Mouse,Mus musculus,Pcsk1n,Proprotein convertase 1 inhibitor,Proprotein convertase subtilisin_kexin type 1 inhibitor,ProSAAS,pro-SAAS
004-63 SAAS (68_89)_Pro _ 100ug 100 µg
004-54 SAAS (42_59) _Pro (little PEN)(Rat) _ 200ug 200 µg
004-55 SAAS (221_242) _Pro (PEN)(Rat) _ 200ug 200 µg
004-62 SAAS (221_254) _Pro (Rat) _ 100ug 100 µg
004-64 SAAS (62_89)_Pro _ 100ug 100 µg
004-56 SAAS (245_260) _Pro (big PEN)(Rat) _ 200ug 200 µg
004-57 SAAS (42_59) _Pro (little PEN)(Mouse) _ 200ug 200 µg
004-58 SAAS (219_240) _Pro (PEN)(Mouse) _ 200ug 200 µg
004-53 SAAS (245_260) _Pro (big PEN)(Human) _ 200ug 200 µg
004-61 SAAS (235_244) _Pro (Human, Rat) _ 200ug 200 µg
004-59 SAAS (243_258) _Pro (big PEN)(Mouse) _ 200ug 200 µg
004-51 SAAS (42_59) _Pro (Human) _ 200ug 200 µg
004-60 SAAS (235_246) _Pro (Human, Rat) _ 200ug 200 µg
004-52 SAAS (221_242) _Pro (PEN)(Human) _ 200ug 200 µg
DBK-004-52 SAAS (221_242) _Pro (PEN)(Human) _ Dot Blot Kit Kit
FG-004-52A SAAS (221_242) _Pro (PEN)(Human) _ FAM Labeled _ 1 nmol 1 nmol
B-004-54 SAAS (42_59) _Pro (little PEN)(Rat) _ Biotin Labeled _ 20ug 20 µg
B-004-56 SAAS (245_260) _Pro (big PEN)(Rat) _ Biotin Labeled _ 20ug 20 µg
WBK-004-52 SAAS (221_242) _Pro (PEN)(Human) _ Western Blot Kit Kit
G-004-52 SAAS (221_242) _Pro (PEN)(Human) _ Purified IgG Antibody _ 200ug 200 µg
FG-G-004-52A SAAS (221_242) _Pro (PEN)(Human) _ FAM Labeled Purified IgG _ 100ul 100 µl
FR-004-52 SAAS (221_242) _Pro (PEN)(Human) _ Rhodamine Labeled _ 1 nmol 1 nmol


 

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