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Probable 3',5'-cyclic phosphodiesterase pde-2 (EC 3.1.4.17)

 PDE2_CAEEL              Reviewed;         831 AA.
P30645; Q65ZC7; Q7JMU8;
01-APR-1993, integrated into UniProtKB/Swiss-Prot.
27-JUL-2011, sequence version 4.
25-OCT-2017, entry version 128.
RecName: Full=Probable 3',5'-cyclic phosphodiesterase pde-2;
EC=3.1.4.17;
Name=pde-2 {ECO:0000312|WormBase:R08D7.6a};
ORFNames=R08D7.6 {ECO:0000312|WormBase:R08D7.6a};
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
NCBI_TaxID=6239;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
PubMed=7906398; DOI=10.1038/368032a0;
Wilson R., Ainscough R., Anderson K., Baynes C., Berks M.,
Bonfield J., Burton J., Connell M., Copsey T., Cooper J., Coulson A.,
Craxton M., Dear S., Du Z., Durbin R., Favello A., Fraser A.,
Fulton L., Gardner A., Green P., Hawkins T., Hillier L., Jier M.,
Johnston L., Jones M., Kershaw J., Kirsten J., Laisster N.,
Latreille P., Lightning J., Lloyd C., Mortimore B., O'Callaghan M.,
Parsons J., Percy C., Rifken L., Roopra A., Saunders D., Shownkeen R.,
Sims M., Smaldon N., Smith A., Smith M., Sonnhammer E., Staden R.,
Sulston J., Thierry-Mieg J., Thomas K., Vaudin M., Vaughan K.,
Waterston R., Watson A., Weinstock L., Wilkinson-Sproat J.,
Wohldman P.;
"2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
elegans.";
Nature 368:32-38(1994).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE
SPLICING.
STRAIN=Bristol N2;
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
[3]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=26434723; DOI=10.1534/genetics.115.177543;
Fujiwara M., Hino T., Miyamoto R., Inada H., Mori I., Koga M.,
Miyahara K., Ohshima Y., Ishihara T.;
"The importance of cGMP signaling in sensory cilia for body size
regulation in Caenorhabditis elegans.";
Genetics 201:1497-1510(2015).
-!- FUNCTION: May negatively regulate the activity of cGMP-dependent
protein kinase egl-4 which in turn controls body size.
{ECO:0000269|PubMed:26434723}.
-!- CATALYTIC ACTIVITY: Nucleoside 3',5'-cyclic phosphate + H(2)O =
nucleoside 5'-phosphate.
-!- COFACTOR:
Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
Evidence={ECO:0000250};
Note=Binds 2 divalent metal cations per subunit. Site 1 may
preferentially bind zinc ions, while site 2 has a preference for
magnesium and/or manganese ions. {ECO:0000250};
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=a {ECO:0000312|WormBase:R08D7.6a};
IsoId=P30645-1; Sequence=Displayed;
Note=No experimental confirmation available.;
Name=b {ECO:0000312|WormBase:R08D7.6b};
IsoId=P30645-3; Sequence=VSP_014355;
Note=No experimental confirmation available.;
-!- DISRUPTION PHENOTYPE: Reduced body size and an egg-laying
constitutive phenotype. {ECO:0000269|PubMed:26434723}.
-!- SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase
family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; Z12017; CAA78052.3; -; Genomic_DNA.
EMBL; Z12017; CAE47469.2; -; Genomic_DNA.
PIR; D88544; D88544.
PIR; S41041; S24462.
RefSeq; NP_001022705.2; NM_001027534.3. [P30645-1]
RefSeq; NP_001022706.2; NM_001027535.4. [P30645-3]
UniGene; Cel.6004; -.
ProteinModelPortal; P30645; -.
SMR; P30645; -.
STRING; 6239.R08D7.6a; -.
iPTMnet; P30645; -.
PaxDb; P30645; -.
PeptideAtlas; P30645; -.
EnsemblMetazoa; R08D7.6a; R08D7.6a; WBGene00011146. [P30645-1]
GeneID; 176270; -.
KEGG; cel:CELE_R08D7.6; -.
UCSC; R08D7.6b; c. elegans. [P30645-1]
CTD; 176270; -.
WormBase; R08D7.6a; CE44867; WBGene00011146; pde-2. [P30645-1]
WormBase; R08D7.6b; CE44922; WBGene00011146; pde-2. [P30645-3]
eggNOG; KOG3689; Eukaryota.
eggNOG; ENOG410XRI7; LUCA.
GeneTree; ENSGT00760000119066; -.
HOGENOM; HOG000018108; -.
InParanoid; P30645; -.
KO; K18283; -.
OMA; RYDIEEP; -.
OrthoDB; EOG091G0L2F; -.
Reactome; R-CEL-418457; cGMP effects.
Reactome; R-CEL-418555; G alpha (s) signalling events.
PRO; PR:P30645; -.
Proteomes; UP000001940; Chromosome III.
Bgee; WBGene00011146; -.
GO; GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:UniProtKB-EC.
GO; GO:0042056; F:chemoattractant activity; IGI:UniProtKB.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0046069; P:cGMP catabolic process; IGI:WormBase.
GO; GO:0007635; P:chemosensory behavior; IGI:UniProtKB.
GO; GO:0006935; P:chemotaxis; IGI:UniProtKB.
GO; GO:0043577; P:chemotropism; IGI:UniProtKB.
GO; GO:0008340; P:determination of adult lifespan; IGI:UniProtKB.
GO; GO:0030827; P:negative regulation of cGMP biosynthetic process; IGI:UniProtKB.
GO; GO:1902160; P:negative regulation of cyclic nucleotide-gated ion channel activity; IGI:WormBase.
GO; GO:0007602; P:phototransduction; IGI:UniProtKB.
GO; GO:1905959; P:positive regulation of cellular response to alcohol; IGI:UniProtKB.
GO; GO:0010753; P:positive regulation of cGMP-mediated signaling; IMP:WormBase.
GO; GO:0050921; P:positive regulation of chemotaxis; IGI:UniProtKB.
GO; GO:0010628; P:positive regulation of gene expression; IGI:UniProtKB.
GO; GO:0040018; P:positive regulation of multicellular organism growth; IMP:UniProtKB.
GO; GO:1901046; P:positive regulation of oviposition; IMP:UniProtKB.
GO; GO:0040014; P:regulation of multicellular organism growth; IGI:UniProtKB.
GO; GO:0046662; P:regulation of oviposition; IGI:UniProtKB.
GO; GO:0010446; P:response to alkaline pH; IGI:UniProtKB.
GO; GO:0042542; P:response to hydrogen peroxide; IGI:UniProtKB.
GO; GO:1990834; P:response to odorant; IGI:UniProtKB.
GO; GO:0070482; P:response to oxygen levels; IMP:WormBase.
CDD; cd00077; HDc; 1.
Gene3D; 1.10.1300.10; -; 1.
Gene3D; 3.30.450.40; -; 1.
InterPro; IPR003018; GAF.
InterPro; IPR029016; GAF_dom-like.
InterPro; IPR003607; HD/PDEase_dom.
InterPro; IPR023088; PDEase.
InterPro; IPR002073; PDEase_catalytic_dom.
InterPro; IPR036971; PDEase_catalytic_dom_sf.
InterPro; IPR023174; PDEase_CS.
Pfam; PF01590; GAF; 1.
Pfam; PF00233; PDEase_I; 1.
PRINTS; PR00387; PDIESTERASE1.
SMART; SM00065; GAF; 1.
SMART; SM00471; HDc; 1.
SUPFAM; SSF55781; SSF55781; 1.
PROSITE; PS00126; PDEASE_I; 1.
3: Inferred from homology;
Alternative splicing; cGMP; Complete proteome; Hydrolase;
Metal-binding; Reference proteome.
CHAIN 1 831 Probable 3',5'-cyclic phosphodiesterase
pde-2.
/FTId=PRO_0000198845.
DOMAIN 177 312 GAF.
ACT_SITE 422 422 Proton donor. {ECO:0000250}.
METAL 426 426 Divalent metal cation 1. {ECO:0000250}.
METAL 462 462 Divalent metal cation 1. {ECO:0000250}.
METAL 463 463 Divalent metal cation 1. {ECO:0000250}.
METAL 463 463 Divalent metal cation 2. {ECO:0000250}.
METAL 576 576 Divalent metal cation 1. {ECO:0000250}.
VAR_SEQ 48 50 Missing (in isoform b). {ECO:0000305}.
/FTId=VSP_014355.
SEQUENCE 831 AA; 94364 MW; 0BCD803345E113B1 CRC64;
MLELRRNSSP SSAHPSPQTN CQNSQRGDGL HHHHHEAASG STCCGGMTVF TGANAAKSSN
EPAGSASPTV WRKTSHPPLH FNNNETRNRN LQMQLKNRGT KDDWGASLRY DIEEPTSSGL
LELLPDVPIV RKLSRPLVKM DDQDDACSVA SNESDRTVLS PLVPMSIFDQ FLCLTNNLSA
LISCIIAEAK KNTEAEDYAV FLHDEDNKQM VLFNNETMLM TGKKFDMGYG IVGKVASTMR
TMNIRDVSRC PFFNEEIDEQ FSIKARNLIA FPLIDSSCSL IGVIVLYNKE NGFSRHDEKY
IKRFSYFVAN SIAHAILAKQ IEEVRTRIHM VEEFKIQGED AVIEEVDIMR LVNDPLRDWR
YFSQNFADFS FPPRSVGENH FHRASMMFFE DLGFSMLYKL NKRKLSYLVL RVSAGYRPVP
YHNWSHAFAV THFCWLTLRT DAIRRALSDM ERLSLLIACL CHDIDHRGTT NSFQMQSLQK
TPLSVLYSTE GSVLERHHFA QTIKLLQQEE CSILENLPAA DFRTIVNTIR EVILATDISA
HLRKQERIKT MISEGYNPMS FDHRYLLMCL VMTASDLSDQ AKNFHNAKRI AENIYLEFFA
QGDLELQLGV KPLEMMDRTN AYVPTVQIDF LFKIGVPVFQ LLASVVPEGR TTSEAIDANH
LCWVALDEEV RNNPSATNTL EYLRDENLER RIYDRVRKQD PRAAEIASKR FEPVYANGSV
PQTQDILDHR FDGYDKKYQI GCSGGQNQSN GKQQQIRSLQ KIRSKTSEDD ALLKPMDNGG
SVAASSTRRG SRTPRRLWRR ARQLISSMSS SCASCSPLPS RRQVSEDSES C


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CNPY2 CNP Gene 2',3'-cyclic nucleotide 3' phosphodiesterase


 

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