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Probable ATP-dependent RNA helicase DDX46 (EC 3.6.4.13) (DEAD box protein 46)

 DDX46_MOUSE             Reviewed;        1032 AA.
Q569Z5; Q6ZQ42; Q8R0R6;
10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
10-JAN-2006, sequence version 2.
12-SEP-2018, entry version 127.
RecName: Full=Probable ATP-dependent RNA helicase DDX46;
EC=3.6.4.13;
AltName: Full=DEAD box protein 46;
Name=Ddx46; Synonyms=Kiaa0801;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Embryonic tail;
PubMed=14621295; DOI=10.1093/dnares/10.4.167;
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
Saga Y., Nagase T., Ohara O., Koga H.;
"Prediction of the coding sequences of mouse homologues of KIAA gene:
III. The complete nucleotide sequences of 500 mouse KIAA-homologous
cDNAs identified by screening of terminal sequences of cDNA clones
randomly sampled from size-fractionated libraries.";
DNA Res. 10:167-180(2003).
[2]
SEQUENCE REVISION.
Okazaki N., Kikuno R., Nagase T., Ohara O., Koga H.;
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
STRAIN=C57BL/6J; TISSUE=Eye, and Head;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-804, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
Thibault P.;
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Immunity 30:143-154(2009).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-294; SER-295; SER-296
AND SER-804, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
ANALYSIS].
TISSUE=Kidney, Pancreas, Spleen, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[6]
ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-904, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Embryonic fibroblast;
PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z.,
Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
"SIRT5-mediated lysine desuccinylation impacts diverse metabolic
pathways.";
Mol. Cell 50:919-930(2013).
-!- FUNCTION: Plays an essential role in splicing, either prior to, or
during A complex formation. {ECO:0000250}.
-!- CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
-!- SUBUNIT: Integral component of the 17S U2 snRNP. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250}. Nucleus,
Cajal body {ECO:0000250}. Membrane {ECO:0000250|UniProtKB:Q7L014};
Lipid-anchor {ECO:0000250|UniProtKB:Q7L014}. Note=Present in Cajal
bodies (CBs) and nuclear speckles. {ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q569Z5-1; Sequence=Displayed;
Name=2;
IsoId=Q569Z5-2; Sequence=VSP_016859;
Note=No experimental confirmation available.;
-!- SIMILARITY: Belongs to the DEAD box helicase family. DDX46/PRP5
subfamily. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAH26492.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=AAH92240.1; Type=Erroneous termination; Positions=1028; Note=Translated as Arg.; Evidence={ECO:0000305};
Sequence=BAC98030.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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EMBL; AK129220; BAC98030.2; ALT_INIT; Transcribed_RNA.
EMBL; BC026492; AAH26492.1; ALT_INIT; mRNA.
EMBL; BC092240; AAH92240.1; ALT_SEQ; mRNA.
CCDS; CCDS70464.1; -. [Q569Z5-1]
RefSeq; NP_001268984.1; NM_001282055.1. [Q569Z5-1]
UniGene; Mm.202725; -.
ProteinModelPortal; Q569Z5; -.
SMR; Q569Z5; -.
BioGrid; 229365; 1.
IntAct; Q569Z5; 1.
MINT; Q569Z5; -.
STRING; 10090.ENSMUSP00000133245; -.
iPTMnet; Q569Z5; -.
PhosphoSitePlus; Q569Z5; -.
EPD; Q569Z5; -.
PaxDb; Q569Z5; -.
PeptideAtlas; Q569Z5; -.
PRIDE; Q569Z5; -.
Ensembl; ENSMUST00000172272; ENSMUSP00000133245; ENSMUSG00000021500. [Q569Z5-1]
Ensembl; ENSMUST00000223736; ENSMUSP00000153328; ENSMUSG00000021500. [Q569Z5-1]
GeneID; 212880; -.
KEGG; mmu:212880; -.
UCSC; uc033gma.1; mouse. [Q569Z5-1]
CTD; 9879; -.
MGI; MGI:1920895; Ddx46.
eggNOG; KOG0334; Eukaryota.
eggNOG; ENOG410XSQV; LUCA.
GeneTree; ENSGT00920000149152; -.
HOGENOM; HOG000007229; -.
HOVERGEN; HBG081426; -.
InParanoid; Q569Z5; -.
KO; K12811; -.
OMA; SKFHSIR; -.
OrthoDB; EOG091G02BY; -.
PhylomeDB; Q569Z5; -.
TreeFam; TF354236; -.
Reactome; R-MMU-72163; mRNA Splicing - Major Pathway.
ChiTaRS; Ddx46; mouse.
PRO; PR:Q569Z5; -.
Proteomes; UP000000589; Chromosome 13.
Bgee; ENSMUSG00000021500; Expressed in 278 organ(s), highest expression level in paneth cell.
CleanEx; MM_DDX46; -.
ExpressionAtlas; Q569Z5; baseline and differential.
Genevisible; Q569Z5; MM.
GO; GO:0015030; C:Cajal body; IEA:UniProtKB-SubCell.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0001650; C:fibrillar center; ISO:MGI.
GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO; GO:0016607; C:nuclear speck; ISO:MGI.
GO; GO:0005730; C:nucleolus; IBA:GO_Central.
GO; GO:0005634; C:nucleus; ISO:MGI.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004004; F:ATP-dependent RNA helicase activity; IBA:GO_Central.
GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
GO; GO:0010501; P:RNA secondary structure unwinding; IBA:GO_Central.
CDD; cd00079; HELICc; 1.
InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
InterPro; IPR014001; Helicase_ATP-bd.
InterPro; IPR001650; Helicase_C.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
Pfam; PF00270; DEAD; 1.
Pfam; PF00271; Helicase_C; 1.
SMART; SM00487; DEXDc; 1.
SMART; SM00490; HELICc; 1.
SUPFAM; SSF52540; SSF52540; 3.
PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PROSITE; PS51194; HELICASE_CTER; 1.
PROSITE; PS51195; Q_MOTIF; 1.
1: Evidence at protein level;
Acetylation; Alternative splicing; ATP-binding; Coiled coil;
Complete proteome; Helicase; Hydrolase; Isopeptide bond; Lipoprotein;
Membrane; mRNA processing; mRNA splicing; Myristate;
Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome;
RNA-binding; Ubl conjugation.
INIT_MET 1 1 Removed. {ECO:0000250|UniProtKB:Q7L014}.
CHAIN 2 1032 Probable ATP-dependent RNA helicase
DDX46.
/FTId=PRO_0000055122.
DOMAIN 403 581 Helicase ATP-binding.
{ECO:0000255|PROSITE-ProRule:PRU00541}.
DOMAIN 592 753 Helicase C-terminal.
{ECO:0000255|PROSITE-ProRule:PRU00542}.
NP_BIND 416 423 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00541}.
COILED 152 197 {ECO:0000255}.
MOTIF 372 400 Q motif.
MOTIF 529 532 DEAD box.
COMPBIAS 3 103 Arg-rich.
COMPBIAS 202 209 Poly-Asp.
COMPBIAS 297 300 Poly-Glu.
MOD_RES 199 199 Phosphoserine.
{ECO:0000250|UniProtKB:Q62780}.
MOD_RES 263 263 N6-acetyllysine.
{ECO:0000250|UniProtKB:Q7L014}.
MOD_RES 294 294 Phosphotyrosine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 295 295 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 296 296 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 346 346 Phosphoserine.
{ECO:0000250|UniProtKB:Q7L014}.
MOD_RES 776 776 N6-acetyllysine.
{ECO:0000250|UniProtKB:Q7L014}.
MOD_RES 804 804 Phosphoserine.
{ECO:0000244|PubMed:19144319,
ECO:0000244|PubMed:21183079}.
MOD_RES 904 904 N6-acetyllysine.
{ECO:0000244|PubMed:23806337}.
MOD_RES 929 929 Phosphoserine.
{ECO:0000250|UniProtKB:Q7L014}.
LIPID 2 2 N-myristoyl glycine.
{ECO:0000250|UniProtKB:Q7L014}.
CROSSLNK 186 186 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q7L014}.
CROSSLNK 325 325 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q7L014}.
CROSSLNK 779 779 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q7L014}.
CROSSLNK 908 908 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q7L014}.
CROSSLNK 916 916 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q7L014}.
VAR_SEQ 516 544 RVTNLRRVTYVVLDEADRMFDMGFEPQVM -> KSRVFYYL
FSLLFVLDMIFVEADL (in isoform 2).
{ECO:0000303|PubMed:14621295}.
/FTId=VSP_016859.
SEQUENCE 1032 AA; 117448 MW; F690CE9973A079AA CRC64;
MGRESRHYRK RSASRGRSGS RSRSRSPSDK RSKRGDDRRS RSRDRDRRRE RSRSRDKRRS
RSRDRKRLRR SRSRERDRSR ERRRSRSRDR RRSRSRSRGR RSRSSSPGSK TKKTENRSRS
KEKAEGGDSS KEKKKDKDDK EDEKEKDAGN FDQNKLEEEM RKRKERVEKW REEQRKKAME
NIGELKKEIE EMKQGKKWSL EDDDDDEDDP AEAEKEGTEM EDEELDPLDA YMEEVKEEVK
KFNMRSVKGG AGNEKKSGPT VTKVVTVVTT KKAVVDADKK KGELMENDQD AMEYSSEEEE
VDLQTALTGY QTKQRKLLEP VDHGKIEYEP FRKNFYVEVP ELAKMSQEEV NVFRLEMEGI
TVKGKGCPKP IKSWVQCGIS MKILNSLKKH GYEKPTPIQT QAIPAIMSGR DLIGIAKTGS
GKTIAFLLPM FRHIMDQRSL EEGEGPIAVI MTPTRELALQ ITKECKKFSK TLGLRVVCVY
GGTGISEQIA ELKRGAEIIV CTPGRMIDML AANSGRVTNL RRVTYVVLDE ADRMFDMGFE
PQVMRIVDNV RPDRQTVMFS ATFPRAMEAL ARRILSKPIE VQVGGRSVVC SDVEQQVIVI
EEEKKFLKLL ELLGHYQESG SVIIFVDKQE HADGLLKDLM RASYPCMSLH GGIDQYDRDS
IINDFKNGTC KLLVATSVAA RGLDVKHLIL VVNYSCPNHY EDYVHRAGRT GRAGNKGYAY
TFITEDQARY AGDIIKALEL SGTAVPPDLE KLWSDFKDQQ KAEGKIIKKS SGFSGKGFKF
DETEQALANE RKKLQKAALG LQDSDDEDAA VDIDEQIESM FNSKKRVKDM AAPGTSSVPA
PTAGNAEKLE IAKRLALRIN AQKNLGIESQ VDVMQQATNA ILRGGTILAP TVSAKTIAEQ
LAEKINAKLN YVPLEKQEEE RQEGGQSESF KRYEEELEIN DFPQTARWKV TSKEALQRIS
EYSEAAITIR GTYFPPGKEP KEGERKIYLA IESANELAVQ KAKAEITRLI KEELIRLQNS
YQPTNKGRYK VL


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