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Probable Delta(7)-sterol 5(6)-desaturase (EC 1.14.19.20) (C-5 sterol desaturase) (Ergosterol Delta(5,6) desaturase) (Sterol-C5-desaturase)

 ERG3_NEUCR              Reviewed;         344 AA.
Q7SBB6;
31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
15-DEC-2003, sequence version 1.
25-OCT-2017, entry version 90.
RecName: Full=Probable Delta(7)-sterol 5(6)-desaturase;
EC=1.14.19.20;
AltName: Full=C-5 sterol desaturase;
AltName: Full=Ergosterol Delta(5,6) desaturase;
AltName: Full=Sterol-C5-desaturase;
ORFNames=NCU06207;
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM
1257 / FGSC 987).
Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae;
Neurospora.
NCBI_TaxID=367110;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
PubMed=12712197; DOI=10.1038/nature01554;
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A.,
Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L.,
Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C.,
Marcotte E., Greenberg D., Roy A., Foley K., Naylor J.,
Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M.,
Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S.,
Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C.,
Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M.,
Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
"The genome sequence of the filamentous fungus Neurospora crassa.";
Nature 422:859-868(2003).
-!- FUNCTION: Catalyzes the introduction of a C-5 double bond in the B
ring of ergosterol. May contribute to the regulation of ergosterol
biosynthesis. {ECO:0000250|UniProtKB:P32353}.
-!- CATALYTIC ACTIVITY: A Delta(7)-sterol + 2 ferrocytochrome b5 +
O(2) + 2 H(+) = a Delta(5,7)-sterol + 2 ferricytochrome b5 + 2
H(2)O. {ECO:0000250|UniProtKB:P32353}.
-!- COFACTOR:
Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000250};
-!- PATHWAY: Steroid metabolism; ergosterol biosynthesis; ergosterol
from zymosterol: step 3/5.
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
{ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
-!- DOMAIN: The histidine box domains may contain the active site
and/or be involved in metal ion binding.
-!- SIMILARITY: Belongs to the sterol desaturase family.
{ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
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EMBL; CM002238; EAA33687.1; -; Genomic_DNA.
RefSeq; XP_962923.1; XM_957830.2.
EnsemblFungi; EAA33687; EAA33687; NCU06207.
GeneID; 3879071; -.
KEGG; ncr:NCU06207; -.
EuPathDB; FungiDB:NCU06207; -.
HOGENOM; HOG000200579; -.
InParanoid; Q7SBB6; -.
KO; K00227; -.
OMA; FDYNYGQ; -.
OrthoDB; EOG092C3V4R; -.
UniPathway; UPA00768; UER00762.
Proteomes; UP000001805; Chromosome 3, Linkage Group III.
GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:EnsemblFungi.
GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0000248; F:C-5 sterol desaturase activity; IBA:GO_Central.
GO; GO:0005506; F:iron ion binding; IEA:InterPro.
GO; GO:0006696; P:ergosterol biosynthetic process; IEA:EnsemblFungi.
GO; GO:0016126; P:sterol biosynthetic process; IBA:GO_Central.
InterPro; IPR006694; Fatty_acid_hydroxylase.
Pfam; PF04116; FA_hydroxylase; 1.
3: Inferred from homology;
Complete proteome; Endoplasmic reticulum; Iron; Lipid biosynthesis;
Lipid metabolism; Membrane; Oxidoreductase; Reference proteome;
Steroid biosynthesis; Steroid metabolism; Sterol biosynthesis;
Sterol metabolism; Transmembrane; Transmembrane helix.
CHAIN 1 344 Probable Delta(7)-sterol 5(6)-desaturase.
/FTId=PRO_0000117024.
TRANSMEM 76 96 Helical. {ECO:0000255}.
TRANSMEM 123 143 Helical. {ECO:0000255}.
TRANSMEM 160 180 Helical. {ECO:0000255}.
TRANSMEM 224 244 Helical. {ECO:0000255}.
MOTIF 181 185 Histidine box-1.
MOTIF 194 198 Histidine box-2.
MOTIF 269 273 Histidine box-3.
SEQUENCE 344 AA; 40663 MW; 392432B46C40E448 CRC64;
MDVVLEVTDQ FMFDYMYAWL LPARPALYDF PDKTNGTAQA FSSWVYEPAT KFFSLEPSQA
AYQSIWTRDN IYRQALSLFL ILWLFGLVTY YVFASLSYIF VFDKKTMEHP KFLKNQVWLE
IKQTNAALPV MAFFTFPFLV AEVRGYSLLY DTTAEGPGRW YDFFQFPLFI MFTDFGIYWI
HRGLHHPLVY KHLHKPHHKW IMPTPYASHA FHPIDGFAQS IPYHIFPFIF PLQKMAYVGL
FVFINFWTIM IHDGEYYANN PVINGAACHS VHHFAFNYNY GQFTTLWDRL GGSYREPDGD
MFAKEKKMST TTWKKQVNEM EKIVKEVEGE DDRLYEPTET KKSK


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