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Probable clathrin heavy chain

 CLH_SCHPO               Reviewed;        1666 AA.
Q10161;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 1.
20-JUN-2018, entry version 133.
RecName: Full=Probable clathrin heavy chain;
Name=chc1; ORFNames=SPAC26A3.05;
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
Schizosaccharomycetes; Schizosaccharomycetales;
Schizosaccharomycetaceae; Schizosaccharomyces.
NCBI_TaxID=284812;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=972 / ATCC 24843;
PubMed=11859360; DOI=10.1038/nature724;
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
[2]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-392 AND SER-393, AND
IDENTIFICATION BY MASS SPECTROMETRY.
PubMed=18257517; DOI=10.1021/pr7006335;
Wilson-Grady J.T., Villen J., Gygi S.P.;
"Phosphoproteome analysis of fission yeast.";
J. Proteome Res. 7:1088-1097(2008).
-!- FUNCTION: Clathrin is the major protein of the polyhedral coat of
coated pits and vesicles. {ECO:0000250}.
-!- SUBUNIT: Clathrin triskelions, composed of 3 heavy chains and 3
light chains, are the basic subunits of the clathrin coat.
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250};
Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
{ECO:0000250}. Membrane, coated pit {ECO:0000250}; Peripheral
membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Note=Cytoplasmic face of coated pits and vesicles. {ECO:0000250}.
-!- DOMAIN: The C-terminal third of the heavy chains forms the hub of
the triskelion. This region contains the trimerization domain and
the light-chain binding domain involved in the assembly of the
clathrin lattice.
-!- DOMAIN: The N-terminal seven-bladed beta-propeller is formed by
WD40-like repeats, and projects inward from the polyhedral outer
clathrin coat. It constitutes a major protein-protein interaction
node (By similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the clathrin heavy chain family.
{ECO:0000305}.
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EMBL; CU329670; CAA93228.1; -; Genomic_DNA.
PIR; T38393; T38393.
RefSeq; NP_594148.1; NM_001019572.2.
ProteinModelPortal; Q10161; -.
SMR; Q10161; -.
BioGrid; 278555; 3.
STRING; 4896.SPAC26A3.05.1; -.
iPTMnet; Q10161; -.
MaxQB; Q10161; -.
PaxDb; Q10161; -.
PRIDE; Q10161; -.
EnsemblFungi; SPAC26A3.05.1; SPAC26A3.05.1:pep; SPAC26A3.05.
GeneID; 2542078; -.
KEGG; spo:SPAC26A3.05; -.
EuPathDB; FungiDB:SPAC26A3.05; -.
PomBase; SPAC26A3.05; chc1.
HOGENOM; HOG000188877; -.
InParanoid; Q10161; -.
KO; K04646; -.
OMA; VQQCTAF; -.
OrthoDB; EOG092C02CU; -.
PhylomeDB; Q10161; -.
Reactome; R-SPO-8866427; VLDLR internalisation and degradation.
Reactome; R-SPO-8964038; LDL clearance.
PRO; PR:Q10161; -.
Proteomes; UP000002485; Chromosome I.
GO; GO:0030479; C:actin cortical patch; IDA:PomBase.
GO; GO:0030132; C:clathrin coat of coated pit; IEA:InterPro.
GO; GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
GO; GO:0071439; C:clathrin complex; IEA:InterPro.
GO; GO:0005737; C:cytoplasm; HDA:PomBase.
GO; GO:0032051; F:clathrin light chain binding; IEA:InterPro.
GO; GO:0005198; F:structural molecule activity; ISO:PomBase.
GO; GO:0048268; P:clathrin coat assembly; IEA:InterPro.
GO; GO:0006897; P:endocytosis; ISO:PomBase.
GO; GO:0006886; P:intracellular protein transport; IC:PomBase.
Gene3D; 1.25.40.10; -; 5.
Gene3D; 2.130.10.110; -; 1.
InterPro; IPR016024; ARM-type_fold.
InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
InterPro; IPR015348; Clathrin_H-chain_linker_core.
InterPro; IPR016025; Clathrin_H-chain_N.
InterPro; IPR022365; Clathrin_H-chain_propeller_rpt.
InterPro; IPR016341; Clathrin_heavy_chain.
InterPro; IPR011990; TPR-like_helical_dom_sf.
Pfam; PF00637; Clathrin; 7.
Pfam; PF09268; Clathrin-link; 1.
Pfam; PF01394; Clathrin_propel; 1.
PIRSF; PIRSF002290; Clathrin_H_chain; 1.
SMART; SM00299; CLH; 7.
SUPFAM; SSF48371; SSF48371; 6.
SUPFAM; SSF50989; SSF50989; 1.
PROSITE; PS50236; CHCR; 7.
1: Evidence at protein level;
Coated pit; Complete proteome; Cytoplasmic vesicle; Membrane;
Phosphoprotein; Reference proteome; Repeat.
CHAIN 1 1666 Probable clathrin heavy chain.
/FTId=PRO_0000205784.
REPEAT 534 680 CHCR 1.
REPEAT 683 825 CHCR 2.
REPEAT 830 969 CHCR 3.
REPEAT 975 1120 CHCR 4.
REPEAT 1124 1265 CHCR 5.
REPEAT 1270 1415 CHCR 6.
REPEAT 1418 1561 CHCR 7.
REGION 24 67 WD40-like repeat 1.
REGION 68 107 WD40-like repeat 2.
REGION 108 148 WD40-like repeat 3.
REGION 149 194 WD40-like repeat 4.
REGION 195 255 WD40-like repeat 5.
REGION 256 299 WD40-like repeat 6.
REGION 300 328 WD40-like repeat 7.
MOD_RES 392 392 Phosphothreonine.
{ECO:0000269|PubMed:18257517}.
MOD_RES 393 393 Phosphoserine.
{ECO:0000269|PubMed:18257517}.
SEQUENCE 1666 AA; 190018 MW; 16A6E84FEA2A7EA9 CRC64;
MAQQLPIRFS EVLQLASVGI QPSSFGFANV TLESDKYVCV RDNPNGVNQV VIVDLEDPSN
VLRRPISADS VILHPKKKII ALKAQRQLQV FDLEAKAKIN SYVMNQDVVY WTWISDSVIG
MVTDTSVFHW TVSGSDPVKM FDRHSSLNGT QIISYKSNYN EEWFTLIGIS SRDNRIAGNL
QLYSKKRKVS QPLESHASAF AVIQPEGVDH EVQVLALASR LPTGSKLSIV EVDRNPNNPA
FATKTVDLFF PPEAVNDFPI AIEIGSTYNV AYVVTKYGFI HVYDLETAKC IYMNRVSGES
IFVTTAHKSV NGLMAINRKG QVLSVSINPE TIIPYILSNL NDPGLAVRMA SHANLPGADN
LYMQQFQQLM AQGNYSEAAK VAASSPRGIL RTSQVIDQFK LIQAAPGQIA PILQYFGTLL
DKGPLNEHET IELARPVLAQ NRIQLLEKWY GENKLACTEA LGDLVKPYNT PFALKIYETA
NVPNKVVMCL SELGDFGKLA TYTSQQNITP DYVSLLQNLV RVNPDQAAEF ATQMFNSNPS
INLEKIVDIF MSQNLVQQAT AFLLDALKDD NPEHSHLQTR LLEINLINAP QVADAILGNQ
MFTHFDRAVI ASLCERAGLV QRALELYDKP ADIKRVIVHS NLLNPEWLMN YFSRFSPDEV
YDYLREMLRS NLRQNLQIVV QIATRYSDLV GAQRIIEMFE KFKTFEGLYY YLGSIVNITE
DPEVVYKYIQ AACLMNQFTE VERICRDNNV YNPEKVKNLL KEAKLADQLP LILVCDRYDF
VNDLVFYLFR NNMFQFIEIY VQRINPSKTP QVVGALLDID CDEELVQNLL MSVVGQVPVD
ELVEEVERRN RLKLLLPYLE SLLQSGSQDR AIYDALAKIY IDSNNNPEVF LKENNFYDTL
TVGKYCEKRD PYLAFIAYEK GGNDTEIINL CNENSMFKQL ARYLLKRSDS NLWSEVLQDS
AYRRPLLDQV IATAVPESSD PEAVSIVVKA LMEVDLPSQL IELLEKIVLQ PSSFSENANL
QNLLFLTAIK ADKSRVMEYI DKLDKYDVDE IAEIAIENGL YEEAFRIYKI HNKHEQAMKV
LVEDIVSLDR AQDYAETVEQ PEVWSRLAKA QLDGIRIPDA IESYLKADDP SNYSEVIELA
SRAGKYEELI KYLLMARSKM HEPDVDSALL IAYAKTNQLT EMETFLIGSN VADVKAVGDE
CFESKNYEAA KLMYSSISNW SMLATTLVYL GEYQGAVDCA RKANSIKVWK QVGTACIDKR
EFRLAQICGL NLIVHAEELP GLIRLYEERG YFEEVISLME AGLGLERAHM AFYTELAILY
AKYKPERMME HLKLFWGRLN MAKVIRACDQ MHLWNEAVFL YVHDQSYDNA AAVMMEQPEA
FDHQSFKDII VHVANLELYY RALNFYLEQH PMLLTDLLAA LTPRIDHPRV IRIFEKSENT
PLILNFMVAI QHLNIQAVNH AYNDLLIEME DYQSLQDSIE NYDHFDAIAL ARRLEKHSLL
EFRRIAAYIY RKNKRWTQSI ELSKQDRFYK DAIITARDSD QTTIAEDLMK YFVEIGNYEC
FAAILYTCYH LLRNDLVMEI SWRKGLQDYA YPYFINFQCE MFSKVLNLEK DLKDRQAVKS
EEESASTIGA GILGNTLMLT QGPMANNNDQ FDSFQQASPM PRLGNF


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