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Probable clathrin heavy chain 1

 CLH_CAEEL               Reviewed;        1681 AA.
P34574;
01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
01-FEB-1994, sequence version 1.
25-APR-2018, entry version 137.
RecName: Full=Probable clathrin heavy chain 1;
Name=chc-1; ORFNames=T20G5.1;
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
NCBI_TaxID=6239;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
[2]
INTERACTION WITH ARR-1.
PubMed=15878875; DOI=10.1074/jbc.M502637200;
Palmitessa A., Hess H.A., Bany I.A., Kim Y.M., Koelle M.R.,
Benovic J.L.;
"Caenorhabditus elegans arrestin regulates neural G protein signaling
and olfactory adaptation and recovery.";
J. Biol. Chem. 280:24649-24662(2005).
[3]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=19798448; DOI=10.1371/journal.pgen.1000675;
Giuliani C., Troglio F., Bai Z., Patel F.B., Zucconi A.,
Malabarba M.G., Disanza A., Stradal T.B., Cassata G., Confalonieri S.,
Hardin J.D., Soto M.C., Grant B.D., Scita G.;
"Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics
and membrane trafficking during Caenorhabditis elegans oocyte growth
and embryonic epidermal morphogenesis.";
PLoS Genet. 5:E1000675-E1000675(2009).
-!- FUNCTION: Clathrin is the major protein of the polyhedral coat of
coated pits and vesicles (By similarity). May play a role in yolk
protein clatherin-mediated endocytosis by oocytes during oogenesis
(PubMed:19798448). {ECO:0000250, ECO:0000269|PubMed:19798448}.
-!- SUBUNIT: Clathrin triskelions, composed of 3 heavy chains and 3
light chains, are the basic subunits of the clathrin coat (By
similarity). May interact with beta arrestin arr-1
(PubMed:15878875). {ECO:0000250|UniProtKB:Q00610,
ECO:0000269|PubMed:15878875}.
-!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250};
Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
{ECO:0000250}. Membrane, coated pit {ECO:0000250}; Peripheral
membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Note=Cytoplasmic face of coated pits and vesicles. {ECO:0000250}.
-!- DOMAIN: The C-terminal third of the heavy chains forms the hub of
the triskelion. This region contains the trimerization domain and
the light-chain binding domain involved in the assembly of the
clathrin lattice.
-!- DOMAIN: The N-terminal seven-bladed beta-propeller is formed by
WD40-like repeats, and projects inward from the polyhedral outer
clathrin coat. It constitutes a major protein-protein interaction
node (By similarity). {ECO:0000250}.
-!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in defective
endocytosis by oocytes characterized by an accumulation of
aggregated yolk protein in the pseudocoelomatic space.
{ECO:0000269|PubMed:19798448}.
-!- SIMILARITY: Belongs to the clathrin heavy chain family.
{ECO:0000305}.
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EMBL; Z30423; CAA83003.1; -; Genomic_DNA.
PIR; S42369; S42369.
RefSeq; NP_499260.1; NM_066859.4.
UniGene; Cel.5115; -.
ProteinModelPortal; P34574; -.
SMR; P34574; -.
BioGrid; 41628; 16.
DIP; DIP-25251N; -.
IntAct; P34574; 20.
MINT; P34574; -.
STRING; 6239.T20G5.1.1; -.
EPD; P34574; -.
PaxDb; P34574; -.
PeptideAtlas; P34574; -.
PRIDE; P34574; -.
EnsemblMetazoa; T20G5.1; T20G5.1; WBGene00011867.
GeneID; 176434; -.
KEGG; cel:CELE_T20G5.1; -.
UCSC; T20G5.1; c. elegans.
CTD; 176434; -.
WormBase; T20G5.1; CE00480; WBGene00011867; chc-1.
eggNOG; KOG0985; Eukaryota.
eggNOG; ENOG410XPH1; LUCA.
GeneTree; ENSGT00400000022107; -.
HOGENOM; HOG000188877; -.
InParanoid; P34574; -.
KO; K04646; -.
OMA; VQQCTAF; -.
OrthoDB; EOG091G009O; -.
PhylomeDB; P34574; -.
Reactome; R-CEL-437239; Recycling pathway of L1.
Reactome; R-CEL-5099900; WNT5A-dependent internalization of FZD4.
Reactome; R-CEL-5140745; WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
Reactome; R-CEL-8856825; Cargo recognition for clathrin-mediated endocytosis.
Reactome; R-CEL-8856828; Clathrin-mediated endocytosis.
Reactome; R-CEL-8866427; VLDLR internalisation and degradation.
Reactome; R-CEL-8964038; LDL clearance.
PRO; PR:P34574; -.
Proteomes; UP000001940; Chromosome III.
Bgee; WBGene00011867; -.
GO; GO:0016324; C:apical plasma membrane; IDA:WormBase.
GO; GO:0005938; C:cell cortex; IDA:WormBase.
GO; GO:0030132; C:clathrin coat of coated pit; IEA:InterPro.
GO; GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
GO; GO:0071439; C:clathrin complex; IEA:InterPro.
GO; GO:0045334; C:clathrin-coated endocytic vesicle; IDA:WormBase.
GO; GO:0005737; C:cytoplasm; IDA:WormBase.
GO; GO:0009898; C:cytoplasmic side of plasma membrane; IDA:WormBase.
GO; GO:0031410; C:cytoplasmic vesicle; IDA:WormBase.
GO; GO:0030139; C:endocytic vesicle; IDA:WormBase.
GO; GO:0072686; C:mitotic spindle; IDA:WormBase.
GO; GO:0005886; C:plasma membrane; IDA:WormBase.
GO; GO:0032051; F:clathrin light chain binding; IEA:InterPro.
GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
GO; GO:0045176; P:apical protein localization; IMP:WormBase.
GO; GO:0048268; P:clathrin coat assembly; IEA:InterPro.
GO; GO:0030866; P:cortical actin cytoskeleton organization; IMP:WormBase.
GO; GO:0008340; P:determination of adult lifespan; IGI:UniProtKB.
GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
GO; GO:2000370; P:positive regulation of clathrin-dependent endocytosis; IMP:UniProtKB.
GO; GO:0008104; P:protein localization; IMP:WormBase.
GO; GO:0006898; P:receptor-mediated endocytosis; IMP:WormBase.
Gene3D; 1.25.40.10; -; 4.
Gene3D; 2.130.10.110; -; 1.
InterPro; IPR016024; ARM-type_fold.
InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
InterPro; IPR015348; Clathrin_H-chain_linker_core.
InterPro; IPR016025; Clathrin_H-chain_N.
InterPro; IPR022365; Clathrin_H-chain_propeller_rpt.
InterPro; IPR016341; Clathrin_heavy_chain.
InterPro; IPR011990; TPR-like_helical_dom_sf.
Pfam; PF00637; Clathrin; 7.
Pfam; PF09268; Clathrin-link; 1.
Pfam; PF01394; Clathrin_propel; 4.
PIRSF; PIRSF002290; Clathrin_H_chain; 1.
SMART; SM00299; CLH; 7.
SUPFAM; SSF48371; SSF48371; 6.
SUPFAM; SSF50989; SSF50989; 1.
PROSITE; PS50236; CHCR; 7.
1: Evidence at protein level;
Coated pit; Complete proteome; Cytoplasmic vesicle; Membrane;
Reference proteome; Repeat.
CHAIN 1 1681 Probable clathrin heavy chain 1.
/FTId=PRO_0000205781.
REPEAT 539 685 CHCR 1.
REPEAT 688 830 CHCR 2.
REPEAT 835 974 CHCR 3.
REPEAT 981 1126 CHCR 4.
REPEAT 1130 1271 CHCR 5.
REPEAT 1276 1422 CHCR 6.
REPEAT 1425 1568 CHCR 7.
REGION 22 65 WD40-like repeat 1.
REGION 66 105 WD40-like repeat 2.
REGION 106 147 WD40-like repeat 3.
REGION 148 193 WD40-like repeat 4.
REGION 194 255 WD40-like repeat 5.
REGION 256 299 WD40-like repeat 6.
REGION 300 328 WD40-like repeat 7.
SEQUENCE 1681 AA; 191542 MW; 44D15C61339009D9 CRC64;
MALPIKFHEH LQLPNAGIRV PNITFSNVTM ESDKNIVVRE MIGDQQQVVI IDLADTANPT
RRPISADSVI MHPTAKILAL KSGKTLQIFN IELKAKVKAH QNVEDVVYWK WISEKTIALV
SDTAVYHWSI EGDAAPVKMF DRHQSLAGTQ IINYRADAEN KWLVLIGISA KDSRVVGSMQ
LYSTERKVSQ PIEGHAACFV RFKVDGNQNP SNLFCFSVKT DNGGKLHVIE VGTPAAGNTP
FQKKNVDVPY TADTAGDFPV SMQVSAKQGI IYLVTKQGYV HLYDVESGTR IYSNRISTDT
VFVTCEYTAT GGIMGINRKG QVLSVSIDEA NLVPFVTNQL QNPDLALKLA VRCDLPGAEE
LFVRKFNLLF SNGQFGESAK VAASAPQGIL RTPATIQKFQ QCPSTGPGPS PLLQYFGILL
DQGKLNKYET LELCRPVLAQ GRKELITKWL NDQKLECCEE LGDLIKPHDV NTALSVYLRG
NVPHKVVQSF AETGQFDKIV MYAKRVGFQP DYLFQLRQIL RNSNPDHGAK FAQLLVSESE
NGEPLADLSQ IIDCFMEVQA VQPCTSFLLE VLKGDKPEEG HLQTRLLEMN LLAAPAVADA
ILANKMFSHY DRAAIGQLCE KAGLLQRALE HFTDLYDIKR TVVHTHLLKP DWLVGYFGSL
SVEDSVECLK AMLTQNIRQN LQVVVQIASK YHEQLGADKL IEMFENHKSY EGLFYFLGSI
VNFSQDPEVH FKYIQAATRT GQIKEVERIC RESQCYDAER VKNFLKEAKL NDQLPLIIVC
DRHNMVHDLV LYLYRNQLQK YIEVFVQKVN AARLPIVVGA LLDVDCSEDA IKQLIINTRG
KFDIDELVEE VEKRNRLKLL NHWLESKIQE GATDAATHNA MAKIYIDSNN NPERFLKENP
YYDSKVVGKY CEKRDPHYAF LSYERGQCDA ELINVCNENS LFKNLARYLV KRRDFTLWEQ
VLNEENVHRR QLIDQVVQTA LSETQDPEDI SVTVKAFMAA DLPNELIELL EKIVLDNSAF
SEHRNLQNLL ILTAMRADRT RVMEYIQKLD NYDAPDIANI AITSELYEEA FAIFKKFDVN
SSAINVLIEN VNNLDRAYEF AEKCNQSDVW ASLAKAQLQQ NLVKEAVDSF IKADDPGAYM
EVVNKCSQTE HWEDLVRYLQ MARKKSRESY IETELVFALA KTGRLTELEE FIAGPNHAQI
GQIGDRCFDN GMFDSAKILF NNVSNFAKLS VTLVRLGEYQ GAVDAARKAN STKTWKQVCF
SCVENGEFRL AQMCGLHIVV HADELEELIN FYQDRGHFEE LIALLEAALG LERAHMGMFT
ELAILYSKYK PEKMREHLEL FWSRVNIPKV LRAAEQAHLW SELVFLYDKY EEYDNAALTM
MQHPTESWRE QHFKEVIAKV ANVELYYKAM QFYLDYKPLL LNDLLTVLSP RLDHSRTVLF
FNKLKQIPLV KPYLRQVQNL NNKAINEALN QLLIDEEDHA GLRSSIEAQD NFDNITLAQQ
LEKHPLVEFR RISAYLFKGN NRWKQSIELC KKDKLYKDAM EYAAESRNGE LAEELLSFFL
DEKLYDCFAA SLYHCYDLLH PDVIMELAWK HKIMDYAMPY MIQVMRDYQT RLEKLERSEH
ERKEEKAEQQ QNNGMTMEPQ LMLTYGAPAP QMTYPGTTGG YGGQPAYGQP GQPGYNAPGF
M


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