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Probable cyclic nucleotide-gated ion channel 6 (AtCNGC6) (Cyclic nucleotide- and calmodulin-regulated ion channel 6)

 CNGC6_ARATH             Reviewed;         747 AA.
O82226; Q9XFS4;
21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
01-JUN-2002, sequence version 2.
18-JUL-2018, entry version 141.
RecName: Full=Probable cyclic nucleotide-gated ion channel 6;
Short=AtCNGC6;
AltName: Full=Cyclic nucleotide- and calmodulin-regulated ion channel 6;
Name=CNGC6; OrderedLocusNames=At2g23980; ORFNames=T29E15.18;
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=cv. Columbia;
PubMed=10341447; DOI=10.1046/j.1365-313X.1999.00422.x;
Koehler C., Merkle T., Neuhaus G.;
"Characterisation of a novel gene family of putative cyclic
nucleotide- and calmodulin-regulated ion channels in Arabidopsis
thaliana.";
Plant J. 18:97-104(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=10617197; DOI=10.1038/45471;
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L.,
Moffat K.S., Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L.,
Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H.,
Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D.,
Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M.,
Venter J.C.;
"Sequence and analysis of chromosome 2 of the plant Arabidopsis
thaliana.";
Nature 402:761-768(1999).
[3]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
PubMed=27862469; DOI=10.1111/tpj.13415;
Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
Town C.D.;
"Araport11: a complete reannotation of the Arabidopsis thaliana
reference genome.";
Plant J. 89:789-804(2017).
[4]
GENE FAMILY, AND NOMENCLATURE.
PubMed=11500563; DOI=10.1104/pp.126.4.1646;
Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A.,
Guerinot M.L.;
"Phylogenetic relationships within cation transporter families of
Arabidopsis.";
Plant Physiol. 126:1646-1667(2001).
[5]
STRUCTURE BY NMR OF 509-632.
RIKEN structural genomics initiative (RSGI);
"Solution structure of the cnmp-binding domain from Arabidopsis
thaliana cyclic nucleotide-regulated ion channel.";
Submitted (NOV-2004) to the PDB data bank.
-!- FUNCTION: Probable cyclic nucleotide-gated ion channel.
-!- SUBUNIT: Homotetramer or heterotetramer. {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass
membrane protein {ECO:0000305}.
-!- DOMAIN: The binding of calmodulin to the C-terminus might
interfere with cyclic nucleotide binding and thus channel
activation. {ECO:0000250}.
-!- SIMILARITY: Belongs to the cyclic nucleotide-gated cation channel
(TC 1.A.1.5) family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; Y17914; CAB40131.1; -; mRNA.
EMBL; AC005170; AAC63666.2; -; Genomic_DNA.
EMBL; CP002685; AEC07510.1; -; Genomic_DNA.
EMBL; CP002685; ANM61675.1; -; Genomic_DNA.
EMBL; CP002685; ANM61676.1; -; Genomic_DNA.
EMBL; CP002685; ANM61680.1; -; Genomic_DNA.
EMBL; CP002685; ANM61682.1; -; Genomic_DNA.
PIR; B84631; B84631.
PIR; T52572; T52572.
RefSeq; NP_001318278.1; NM_001335878.1.
RefSeq; NP_001323879.1; NM_001335882.1.
RefSeq; NP_001323883.1; NM_001335886.1.
RefSeq; NP_001323885.1; NM_001335881.1.
RefSeq; NP_565560.1; NM_127960.3.
UniGene; At.402; -.
PDB; 1WGP; NMR; -; A=509-632.
PDBsum; 1WGP; -.
ProteinModelPortal; O82226; -.
SMR; O82226; -.
BioGrid; 2283; 17.
IntAct; O82226; 16.
STRING; 3702.AT2G23980.1; -.
TCDB; 1.A.1.5.14; the voltage-gated ion channel (vic) superfamily.
iPTMnet; O82226; -.
PaxDb; O82226; -.
PRIDE; O82226; -.
EnsemblPlants; AT2G23980.1; AT2G23980.1; AT2G23980.
EnsemblPlants; AT2G23980.10; AT2G23980.10; AT2G23980.
EnsemblPlants; AT2G23980.4; AT2G23980.4; AT2G23980.
EnsemblPlants; AT2G23980.5; AT2G23980.5; AT2G23980.
EnsemblPlants; AT2G23980.9; AT2G23980.9; AT2G23980.
GeneID; 816931; -.
Gramene; AT2G23980.1; AT2G23980.1; AT2G23980.
Gramene; AT2G23980.10; AT2G23980.10; AT2G23980.
Gramene; AT2G23980.4; AT2G23980.4; AT2G23980.
Gramene; AT2G23980.5; AT2G23980.5; AT2G23980.
Gramene; AT2G23980.9; AT2G23980.9; AT2G23980.
KEGG; ath:AT2G23980; -.
Araport; AT2G23980; -.
TAIR; locus:2061401; AT2G23980.
eggNOG; KOG0498; Eukaryota.
eggNOG; ENOG410XPSE; LUCA.
HOGENOM; HOG000238338; -.
InParanoid; O82226; -.
KO; K05391; -.
OMA; NQNCTRN; -.
OrthoDB; EOG093603N1; -.
PhylomeDB; O82226; -.
EvolutionaryTrace; O82226; -.
PRO; PR:O82226; -.
Proteomes; UP000006548; Chromosome 2.
ExpressionAtlas; O82226; baseline and differential.
Genevisible; O82226; AT.
GO; GO:0071944; C:cell periphery; IDA:TAIR.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; IDA:TAIR.
GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
GO; GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
GO; GO:0030553; F:cGMP binding; IEA:UniProtKB-KW.
GO; GO:0005223; F:intracellular cGMP activated cation channel activity; IDA:TAIR.
GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
GO; GO:0046686; P:response to cadmium ion; IEP:TAIR.
CDD; cd00038; CAP_ED; 1.
Gene3D; 2.60.120.10; -; 1.
InterPro; IPR018490; cNMP-bd-like.
InterPro; IPR000595; cNMP-bd_dom.
InterPro; IPR005821; Ion_trans_dom.
InterPro; IPR000048; IQ_motif_EF-hand-BS.
InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
InterPro; IPR014710; RmlC-like_jellyroll.
Pfam; PF00520; Ion_trans; 1.
PRINTS; PR01463; EAGCHANLFMLY.
SMART; SM00100; cNMP; 1.
SUPFAM; SSF51206; SSF51206; 1.
PROSITE; PS50042; CNMP_BINDING_3; 1.
PROSITE; PS50096; IQ; 1.
1: Evidence at protein level;
3D-structure; Calmodulin-binding; cAMP; cAMP-binding; Cell membrane;
cGMP; cGMP-binding; Complete proteome; Ion channel; Ion transport;
Ligand-gated ion channel; Membrane; Nucleotide-binding;
Reference proteome; Transmembrane; Transmembrane helix; Transport.
CHAIN 1 747 Probable cyclic nucleotide-gated ion
channel 6.
/FTId=PRO_0000219334.
TOPO_DOM 1 117 Cytoplasmic. {ECO:0000255}.
TRANSMEM 118 138 Helical; Name=H1. {ECO:0000255}.
TOPO_DOM 139 150 Extracellular. {ECO:0000255}.
TRANSMEM 151 171 Helical; Name=H2. {ECO:0000255}.
TOPO_DOM 172 205 Cytoplasmic. {ECO:0000255}.
TRANSMEM 206 226 Helical; Name=H3. {ECO:0000255}.
TOPO_DOM 227 239 Extracellular. {ECO:0000255}.
TRANSMEM 240 260 Helical; Name=H4. {ECO:0000255}.
TOPO_DOM 261 280 Cytoplasmic. {ECO:0000255}.
TRANSMEM 281 301 Helical; Name=H5. {ECO:0000255}.
TOPO_DOM 302 407 Extracellular. {ECO:0000255}.
TRANSMEM 408 428 Helical; Name=H6. {ECO:0000255}.
TOPO_DOM 429 747 Cytoplasmic. {ECO:0000255}.
DOMAIN 650 679 IQ. {ECO:0000255|PROSITE-
ProRule:PRU00116}.
NP_BIND 514 638 cNMP.
REGION 630 645 Calmodulin-binding. {ECO:0000250}.
BINDING 585 585 cNMP. {ECO:0000250}.
HELIX 514 516 {ECO:0000244|PDB:1WGP}.
HELIX 520 529 {ECO:0000244|PDB:1WGP}.
STRAND 539 542 {ECO:0000244|PDB:1WGP}.
STRAND 549 556 {ECO:0000244|PDB:1WGP}.
STRAND 560 562 {ECO:0000244|PDB:1WGP}.
STRAND 568 572 {ECO:0000244|PDB:1WGP}.
STRAND 574 576 {ECO:0000244|PDB:1WGP}.
STRAND 582 584 {ECO:0000244|PDB:1WGP}.
HELIX 586 592 {ECO:0000244|PDB:1WGP}.
STRAND 598 600 {ECO:0000244|PDB:1WGP}.
STRAND 604 611 {ECO:0000244|PDB:1WGP}.
STRAND 613 619 {ECO:0000244|PDB:1WGP}.
HELIX 620 630 {ECO:0000244|PDB:1WGP}.
SEQUENCE 747 AA; 85441 MW; 601234797E44700F CRC64;
MFDTCGPKGV KSQVISGQRE NFVRLDSMDS RYSQSSETGL NKCTLNIQGG PKRFAQGSKA
SSGSFKKGFR KGSEGLWSIG RSIGLGVSRA VFPEDLEVSE KKIFDPQDKF LLLCNKLFVA
SCILAVSVDP LFLYLPFIND KAKCVGIDRK LAIIVTTIRT VIDSFYLFHM ALRFRTAYVA
PSSRVFGRGE LVIDPAQIAK RYLQQYFIID LLSVLPVPQI IVWRFLYTSR GANVLATKQA
LRYIVLVQYI PRFLRMYPLS SELKRTAGVF AETAWAGAAY YLLLYMLASH IVGALWYLLA
LERNNDCWSK ACHNNQNCTR NFLFCGNQNM KGYAAWDNIK VSYLQLKCPV NVPEDEEPPF
DFGIYLRALS SGIVSSKNFV SKYFFCLWWG LQNLSTLGQG LETSTYPGEV IFSITLAIAG
LLLFALLIGN MQTYLQSLTI RLEEMRVKRR DSEQWMHHRM LPPELRERVR RYDQYKWLET
RGVDEENLVQ NLPKDLRRDI KRHLCLALVR RVPLFENMDE RLLDAICERL KPCLFTEKSY
LVREGDPVNE MLFIIRGRLE SVTTDGGRSG FYNRSLLKEG DFCGDELLTW ALDPKSGSNL
PSSTRTVKAL TEVEAFALIA DELKFVASQF RRLHSRQVQH TFRFYSQQWR TWAACFMQAA
WRRYIKRKKL EQLRKEEEEE EAAAASVIAG GSPYSIRATF LASKFAANAL RSVHKNRTAK
STLLLSSTKE LVKFQKPPEP DFSAEDH


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