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Probable ergosterol biosynthetic protein 28

 ERG28_HUMAN             Reviewed;         140 AA.
Q9UKR5; Q9P093; Q9UPI2;
27-APR-2001, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
22-NOV-2017, entry version 143.
RecName: Full=Probable ergosterol biosynthetic protein 28;
Name=ERG28 {ECO:0000312|HGNC:HGNC:1187};
Synonyms=C14orf1 {ECO:0000312|HGNC:HGNC:1187};
ORFNames=AD-011, HSPC288, x0006;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=10449901;
Veitia R.A., Ottolenghi C., Bissery M.-C., Fellous A.;
"A novel human gene, encoding a potential membrane protein conserved
from yeast to man, is strongly expressed in testis and cancer cell
lines.";
Cytogenet. Cell Genet. 85:217-220(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Umbilical cord blood;
PubMed=11042152; DOI=10.1101/gr.140200;
Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
"Cloning and functional analysis of cDNAs with open reading frames for
300 previously undefined genes expressed in CD34+ hematopoietic
stem/progenitor cells.";
Genome Res. 10:1546-1560(2000).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
PubMed=11230166; DOI=10.1101/gr.GR1547R;
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H.,
Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N.,
Mewes H.-W., Ottenwaelder B., Obermaier B., Tampe J., Heubner D.,
Wambutt R., Korn B., Klein M., Poustka A.;
"Towards a catalog of human genes and proteins: sequencing and
analysis of 500 novel complete protein coding human cDNAs.";
Genome Res. 11:422-435(2001).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Adrenal gland;
PubMed=10931946; DOI=10.1073/pnas.160270997;
Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X.,
Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H.,
Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M., Zhou J.,
Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M.,
Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.;
"Gene expression profiling in the human hypothalamus-pituitary-adrenal
axis and full-length cDNA cloning.";
Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=12508121; DOI=10.1038/nature01348;
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S.,
Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C.,
Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P.,
Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N.,
Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C.,
Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S.,
Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B.,
Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M.,
Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S.,
Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D.,
Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A.,
Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L.,
Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J.,
Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W.,
Quetier F., Waterston R., Hood L., Weissenbach J.;
"The DNA sequence and analysis of human chromosome 14.";
Nature 421:601-607(2003).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21269460; DOI=10.1186/1752-0509-5-17;
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
"Initial characterization of the human central proteome.";
BMC Syst. Biol. 5:17-17(2011).
[8]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=25944712; DOI=10.1002/pmic.201400617;
Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
"N-terminome analysis of the human mitochondrial proteome.";
Proteomics 15:2519-2524(2015).
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
{ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
-!- TISSUE SPECIFICITY: Ubiquitous; strongly expressed in testis and
some cancer cell lines.
-!- SIMILARITY: Belongs to the ERG28 family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAD51373.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Sequence=AAF28966.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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EMBL; AF134159; AAD54079.1; -; mRNA.
EMBL; AF161406; AAF28966.1; ALT_INIT; mRNA.
EMBL; AL136658; CAB66593.1; -; mRNA.
EMBL; AF136971; AAG49432.1; -; mRNA.
EMBL; AC007182; AAD51373.1; ALT_SEQ; Genomic_DNA.
EMBL; BC002444; AAH02444.1; -; mRNA.
CCDS; CCDS9845.1; -.
RefSeq; NP_009107.1; NM_007176.3.
UniGene; Hs.15106; -.
ProteinModelPortal; Q9UKR5; -.
BioGrid; 116332; 65.
IntAct; Q9UKR5; 72.
MINT; MINT-1376742; -.
STRING; 9606.ENSP00000256319; -.
iPTMnet; Q9UKR5; -.
PhosphoSitePlus; Q9UKR5; -.
BioMuta; C14orf1; -.
DMDM; 13431328; -.
EPD; Q9UKR5; -.
MaxQB; Q9UKR5; -.
PaxDb; Q9UKR5; -.
PeptideAtlas; Q9UKR5; -.
PRIDE; Q9UKR5; -.
TopDownProteomics; Q9UKR5; -.
DNASU; 11161; -.
Ensembl; ENST00000256319; ENSP00000256319; ENSG00000133935.
GeneID; 11161; -.
KEGG; hsa:11161; -.
UCSC; uc001xrt.4; human.
CTD; 11161; -.
DisGeNET; 11161; -.
EuPathDB; HostDB:ENSG00000133935.6; -.
GeneCards; C14orf1; -.
HGNC; HGNC:1187; ERG28.
HPA; HPA043172; -.
HPA; HPA063568; -.
MIM; 604576; gene.
neXtProt; NX_Q9UKR5; -.
OpenTargets; ENSG00000133935; -.
PharmGKB; PA25513; -.
eggNOG; KOG3455; Eukaryota.
eggNOG; ENOG4111J9X; LUCA.
GeneTree; ENSGT00390000010925; -.
HOGENOM; HOG000164093; -.
HOVERGEN; HBG051505; -.
InParanoid; Q9UKR5; -.
OMA; VQSFRDH; -.
OrthoDB; EOG091G16N5; -.
PhylomeDB; Q9UKR5; -.
TreeFam; TF300191; -.
ChiTaRS; C14orf1; human.
GeneWiki; C14orf1; -.
GenomeRNAi; 11161; -.
PRO; PR:Q9UKR5; -.
Proteomes; UP000005640; Chromosome 14.
Bgee; ENSG00000133935; -.
CleanEx; HS_C14orf1; -.
ExpressionAtlas; Q9UKR5; baseline and differential.
Genevisible; Q9UKR5; HS.
GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
GO; GO:0030133; C:transport vesicle; IDA:LIFEdb.
GO; GO:0030674; F:protein binding, bridging; IBA:GO_Central.
GO; GO:0006696; P:ergosterol biosynthetic process; IBA:GO_Central.
InterPro; IPR005352; Erg28.
PANTHER; PTHR15451; PTHR15451; 1.
Pfam; PF03694; Erg28; 1.
1: Evidence at protein level;
Complete proteome; Endoplasmic reticulum; Lipid biosynthesis;
Lipid metabolism; Membrane; Reference proteome; Steroid biosynthesis;
Steroid metabolism; Sterol biosynthesis; Sterol metabolism;
Transmembrane; Transmembrane helix.
CHAIN 1 140 Probable ergosterol biosynthetic protein
28.
/FTId=PRO_0000193903.
TRANSMEM 4 24 Helical. {ECO:0000255}.
TRANSMEM 52 72 Helical. {ECO:0000255}.
TRANSMEM 79 99 Helical. {ECO:0000255}.
TRANSMEM 105 125 Helical. {ECO:0000255}.
SEQUENCE 140 AA; 15864 MW; BDD089148BC60E50 CRC64;
MSRFLNVLRS WLVMVSIIAM GNTLQSFRDH TFLYEKLYTG KPNLVNGLQA RTFGIWTLLS
SVIRCLCAID IHNKTLYHIT LWTFLLALGH FLSELFVYGT AAPTIGVLAP LMVASFSILG
MLVGLRYLEV EPVSRQKKRN


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