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Probable small nuclear ribonucleoprotein Sm D1 (Sm-D1) (snRNP core protein D1)

 SMD1_DROME              Reviewed;         124 AA.
Q9VU02; B3DML3; Q8SYR6;
19-JUL-2003, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
22-NOV-2017, entry version 120.
RecName: Full=Probable small nuclear ribonucleoprotein Sm D1;
Short=Sm-D1;
AltName: Full=snRNP core protein D1;
Name=SmD1; Synonyms=snRNP69D; ORFNames=CG10753;
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227 {ECO:0000312|EMBL:AAL48981.1};
[1] {ECO:0000305}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
PubMed=10731132; DOI=10.1126/science.287.5461.2185;
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[2]
GENOME REANNOTATION.
STRAIN=Berkeley;
PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Berkeley; TISSUE=Embryo;
PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M.,
George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H.,
Rubin G.M., Celniker S.E.;
"A Drosophila full-length cDNA resource.";
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
[4] {ECO:0000305}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Berkeley;
Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C.,
Celniker S.E.;
Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
[5]
INTERACTION WITH THE SMN COMPLEX.
PubMed=18621711; DOI=10.1073/pnas.0802287105;
Kroiss M., Schultz J., Wiesner J., Chari A., Sickmann A., Fischer U.;
"Evolution of an RNP assembly system: a minimal SMN complex
facilitates formation of UsnRNPs in Drosophila melanogaster.";
Proc. Natl. Acad. Sci. U.S.A. 105:10045-10050(2008).
[6]
METHYLATION.
PubMed=18369183; DOI=10.1261/rna.940708;
Gonsalvez G.B., Praveen K., Hicks A.J., Tian L., Matera A.G.;
"Sm protein methylation is dispensable for snRNP assembly in
Drosophila melanogaster.";
RNA 14:878-887(2008).
-!- FUNCTION: Essential for pre-mRNA splicing. Implicated in the
formation of stable, biologically active snRNP structures (By
similarity). {ECO:0000250|UniProtKB:Q02260}.
-!- SUBUNIT: Interacts with the SMN complex.
{ECO:0000269|PubMed:18621711}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
-!- PTM: Methylated on arginine residues by Art5 and Art7; methylation
is not required for assembly and biogenesis of snRNPs.
{ECO:0000269|PubMed:18369183}.
-!- SIMILARITY: Belongs to the snRNP core protein family.
{ECO:0000305}.
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EMBL; AE014296; AAF49893.1; -; Genomic_DNA.
EMBL; AY071359; AAL48981.1; -; mRNA.
EMBL; BT032651; ACD81665.1; -; mRNA.
RefSeq; NP_524774.1; NM_080035.3.
UniGene; Dm.1823; -.
ProteinModelPortal; Q9VU02; -.
SMR; Q9VU02; -.
BioGrid; 69191; 31.
DIP; DIP-18826N; -.
IntAct; Q9VU02; 6.
MINT; MINT-897207; -.
STRING; 7227.FBpp0075684; -.
PaxDb; Q9VU02; -.
PRIDE; Q9VU02; -.
EnsemblMetazoa; FBtr0075952; FBpp0075684; FBgn0261933.
GeneID; 44668; -.
KEGG; dme:Dmel_CG10753; -.
CTD; 44668; -.
FlyBase; FBgn0261933; SmD1.
eggNOG; KOG3428; Eukaryota.
eggNOG; COG1958; LUCA.
GeneTree; ENSGT00510000047245; -.
InParanoid; Q9VU02; -.
KO; K11087; -.
OMA; PQMNTAL; -.
OrthoDB; EOG091G11O6; -.
PhylomeDB; Q9VU02; -.
Reactome; R-DME-72163; mRNA Splicing - Major Pathway.
Reactome; R-DME-72165; mRNA Splicing - Minor Pathway.
GenomeRNAi; 44668; -.
PRO; PR:Q9VU02; -.
Proteomes; UP000000803; Chromosome 3L.
Bgee; FBgn0261933; -.
Genevisible; Q9VU02; DM.
GO; GO:0071013; C:catalytic step 2 spliceosome; IDA:FlyBase.
GO; GO:0000243; C:commitment complex; IBA:GO_Central.
GO; GO:0005829; C:cytosol; IDA:FlyBase.
GO; GO:0005634; C:nucleus; IDA:FlyBase.
GO; GO:0034715; C:pICln-Sm protein complex; IBA:GO_Central.
GO; GO:0071011; C:precatalytic spliceosome; IDA:FlyBase.
GO; GO:0071010; C:prespliceosome; IBA:GO_Central.
GO; GO:0030532; C:small nuclear ribonucleoprotein complex; ISS:UniProtKB.
GO; GO:0034719; C:SMN-Sm protein complex; IBA:GO_Central.
GO; GO:0005681; C:spliceosomal complex; ISS:FlyBase.
GO; GO:0097526; C:spliceosomal tri-snRNP complex; IBA:GO_Central.
GO; GO:0005685; C:U1 snRNP; IBA:GO_Central.
GO; GO:0005689; C:U12-type spliceosomal complex; IBA:GO_Central.
GO; GO:0005686; C:U2 snRNP; IBA:GO_Central.
GO; GO:0005687; C:U4 snRNP; IBA:GO_Central.
GO; GO:0005682; C:U5 snRNP; IBA:GO_Central.
GO; GO:0003723; F:RNA binding; ISS:FlyBase.
GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
GO; GO:0000245; P:spliceosomal complex assembly; IBA:GO_Central.
GO; GO:0000387; P:spliceosomal snRNP assembly; IBA:GO_Central.
CDD; cd01724; Sm_D1; 1.
InterPro; IPR027141; LSm4/Sm_D1/D3.
InterPro; IPR001163; LSM_dom_euk/arc.
InterPro; IPR010920; LSM_dom_sf.
InterPro; IPR034102; Sm_D1.
PANTHER; PTHR23338; PTHR23338; 1.
Pfam; PF01423; LSM; 1.
SMART; SM00651; Sm; 1.
SUPFAM; SSF50182; SSF50182; 1.
1: Evidence at protein level;
Complete proteome; Methylation; mRNA processing; mRNA splicing;
Nucleus; Reference proteome; Repeat; Ribonucleoprotein.
CHAIN 1 124 Probable small nuclear ribonucleoprotein
Sm D1.
/FTId=PRO_0000122204.
REPEAT 100 101 1.
REPEAT 102 103 2.
REPEAT 104 105 3.
REPEAT 107 108 4.
REPEAT 109 110 5.
REPEAT 111 112 6; approximate.
REPEAT 113 114 7.
REPEAT 115 116 8.
REPEAT 117 118 9.
REGION 100 118 9 X 2 AA approximate tandem repeats of R-
G.
COMPBIAS 86 124 Arg/Lys-rich (basic).
CONFLICT 52 52 P -> H (in Ref. 3; AAL48981).
{ECO:0000305}.
SEQUENCE 124 AA; 13796 MW; 36FA511D3FBE6B65 CRC64;
MKLVRFLMKL SHETVTIELK NGTQIHGTIT GVDVAMNTHL KSVRMTIKNR DPVHLETLSI
RGNNIRYFIL PDSLPLETLL IDDTPKSKTK KKDSGRVGNR GRGRGARGRG GPRGRGRGRA
SGRR


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