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Probable translation initiation factor IF-2

 IF2P_HALSA              Reviewed;         600 AA.
Q9HNQ2; O93625;
05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
01-MAR-2001, sequence version 1.
23-MAY-2018, entry version 111.
RecName: Full=Probable translation initiation factor IF-2 {ECO:0000255|HAMAP-Rule:MF_00100};
Name=infB {ECO:0000255|HAMAP-Rule:MF_00100}; Synonyms=hif2;
OrderedLocusNames=VNG_1997G;
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
(Halobacterium halobium).
Archaea; Euryarchaeota; Halobacteria; Halobacteriales;
Halobacteriaceae; Halobacterium.
NCBI_TaxID=64091;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=A9;
PubMed=9818089;
Hasegawa Y., Sawaoka N., Kado N., Ochi M., Itoh T.;
"Cloning and sequencing of the homologues of both the bacterial and
eukaryotic initiation factor genes (hIF-2 and heIF-2gamma) from
archaeal Halobacterium halobium.";
Biochem. Mol. Biol. Int. 46:495-507(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
PubMed=11016950; DOI=10.1073/pnas.190337797;
Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M.,
Shukla H.D., Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J.,
Swartzell S., Weir D., Hall J., Dahl T.A., Welti R., Goo Y.A.,
Leithauser B., Keller K., Cruz R., Danson M.J., Hough D.W.,
Maddocks D.G., Jablonski P.E., Krebs M.P., Angevine C.M., Dale H.,
Isenbarger T.A., Peck R.F., Pohlschroder M., Spudich J.L., Jung K.-H.,
Alam M., Freitas T., Hou S., Daniels C.J., Dennis P.P., Omer A.D.,
Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L., DasSarma S.;
"Genome sequence of Halobacterium species NRC-1.";
Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
-!- FUNCTION: Function in general translation initiation by promoting
the binding of the formylmethionine-tRNA to ribosomes. Seems to
function along with eIF-2. {ECO:0000255|HAMAP-Rule:MF_00100}.
-!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
superfamily. Classic translation factor GTPase family. IF-2
subfamily. {ECO:0000255|HAMAP-Rule:MF_00100}.
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EMBL; AB015763; BAA35081.1; -; Genomic_DNA.
EMBL; AE004437; AAG20168.1; -; Genomic_DNA.
PIR; D84350; D84350.
PIR; T43849; T43849.
RefSeq; WP_010903469.1; NC_002607.1.
ProteinModelPortal; Q9HNQ2; -.
SMR; Q9HNQ2; -.
STRING; 64091.VNG1997G; -.
PaxDb; Q9HNQ2; -.
EnsemblBacteria; AAG20168; AAG20168; VNG_1997G.
GeneID; 5953198; -.
KEGG; hal:VNG_1997G; -.
PATRIC; fig|64091.14.peg.1525; -.
eggNOG; arCOG01560; Archaea.
eggNOG; COG0532; LUCA.
InParanoid; Q9HNQ2; -.
KO; K03243; -.
OMA; FRQSKPA; -.
OrthoDB; POG093Z012A; -.
PhylomeDB; Q9HNQ2; -.
Proteomes; UP000000554; Chromosome.
GO; GO:0005622; C:intracellular; IEA:InterPro.
GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO; GO:0003924; F:GTPase activity; IEA:InterPro.
GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
Gene3D; 3.40.50.10050; -; 1.
HAMAP; MF_00100_A; IF_2_A; 1.
InterPro; IPR004161; EFTu-like_2.
InterPro; IPR029459; EFTU-type.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR005225; Small_GTP-bd_dom.
InterPro; IPR000795; TF_GTP-bd_dom.
InterPro; IPR004544; TIF_aIF-2_arc.
InterPro; IPR015760; TIF_IF2.
InterPro; IPR023115; TIF_IF2_dom3.
InterPro; IPR036925; TIF_IF2_dom3_sf.
InterPro; IPR009000; Transl_B-barrel_sf.
PANTHER; PTHR43381; PTHR43381; 1.
Pfam; PF00009; GTP_EFTU; 1.
Pfam; PF03144; GTP_EFTU_D2; 1.
Pfam; PF14578; GTP_EFTU_D4; 1.
Pfam; PF11987; IF-2; 1.
PRINTS; PR00315; ELONGATNFCT.
SUPFAM; SSF50447; SSF50447; 1.
SUPFAM; SSF52156; SSF52156; 1.
SUPFAM; SSF52540; SSF52540; 1.
TIGRFAMs; TIGR00491; aIF-2; 1.
TIGRFAMs; TIGR00231; small_GTP; 1.
PROSITE; PS51722; G_TR_2; 1.
3: Inferred from homology;
Complete proteome; GTP-binding; Initiation factor; Nucleotide-binding;
Protein biosynthesis; Reference proteome.
CHAIN 1 600 Probable translation initiation factor
IF-2.
/FTId=PRO_0000137300.
DOMAIN 13 228 tr-type G.
NP_BIND 22 29 GTP. {ECO:0000255|HAMAP-Rule:MF_00100}.
NP_BIND 84 88 GTP. {ECO:0000255|HAMAP-Rule:MF_00100}.
NP_BIND 138 141 GTP. {ECO:0000255|HAMAP-Rule:MF_00100}.
REGION 22 29 G1. {ECO:0000250}.
REGION 47 51 G2. {ECO:0000250}.
REGION 84 87 G3. {ECO:0000250}.
REGION 138 141 G4. {ECO:0000250}.
REGION 206 208 G5. {ECO:0000250}.
CONFLICT 59 68 LDTVSEVAGS -> AGHRLGGRRQ (in Ref. 1;
BAA35081). {ECO:0000305}.
CONFLICT 92 97 STLRSR -> FEHALG (in Ref. 1; BAA35081).
{ECO:0000305}.
CONFLICT 113 114 DG -> ER (in Ref. 1; BAA35081).
{ECO:0000305}.
CONFLICT 163 164 DR -> EP (in Ref. 1; BAA35081).
{ECO:0000305}.
CONFLICT 330 334 PIRVV -> RSAWS (in Ref. 1; BAA35081).
{ECO:0000305}.
CONFLICT 580 600 EREALKSYLDIMRKRDPFWGK -> GARR (in Ref.
1). {ECO:0000305}.
SEQUENCE 600 AA; 64430 MW; 3D356AF39F01F5C9 CRC64;
MPDADTTDDP GDLRTPIVAV LGHVDHGKTS LLDKIRGSAV IEGEAGAITQ HIGATAVPLD
TVSEVAGSLV DPTEFDLPGL LFIDTPGHHS FSTLRSRGGA LADIAILVVD VNDGFQPQTE
EAIRILKDTG TPFVVAANKI DTTPGWNPNP DAPVQGTYDD QSDRVRSDLD DALYELIGEM
SDAGFSSDLY WRVQNFQKNV GVIPVSAETG EGVPDLLTVL MGLAQRYMKS EMEVTIDGPG
AGTVLEVKDE QGFGTTVDVI LYDGTIRSGD TVVVGAQPEP IVTDVRALLK PGDLAEMRTE
KRFGNVDRMQ AAAGLKVAAP DLDDAMAGAP IRVVGDRDVA DVVTEVEAEL AEVAVETGEE
GIVVKADTLG SLEALVSALE EAEIPVMSAE VGDVAPRDVA MATTVDSEKH RVLLGFNVDV
LPAAAENAER ESVRVFNSDV IYQLVEDYEA FVDAQEREQK EAVFDNIVRP ARFRILKDHV
FRQNDPAVVG VEVVSGTLKR NTPVGGIEGN DLDRAGIVKG IQDQGEDVDE ARAGNRVSVS
IDGPTVGRDI KEGDELWVDL PEKHAKVLDQ ELTSDLPADE REALKSYLDI MRKRDPFWGK


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