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Probable ubiquitin carboxyl-terminal hydrolase creB (EC 3.4.19.12) (Carbon catabolite repression protein B) (Deubiquitinating enzyme creB) (Ubiquitin thioesterase creB) (Ubiquitin-hydrolyzing enzyme creB) (Ubiquitin-specific-processing protease creB)

 CREB_ASPNC              Reviewed;         758 AA.
A2Q9N1;
13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
13-JUL-2010, sequence version 2.
20-JUN-2018, entry version 52.
RecName: Full=Probable ubiquitin carboxyl-terminal hydrolase creB;
EC=3.4.19.12;
AltName: Full=Carbon catabolite repression protein B;
AltName: Full=Deubiquitinating enzyme creB;
AltName: Full=Ubiquitin thioesterase creB;
AltName: Full=Ubiquitin-hydrolyzing enzyme creB;
AltName: Full=Ubiquitin-specific-processing protease creB;
Name=creB; ORFNames=An01g08470;
Aspergillus niger (strain CBS 513.88 / FGSC A1513).
Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
NCBI_TaxID=425011;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CBS 513.88 / FGSC A1513;
PubMed=17259976; DOI=10.1038/nbt1282;
Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G.,
Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K.,
Andersen M.R., Bendtsen J.D., Benen J.A.E., van den Berg M.,
Breestraat S., Caddick M.X., Contreras R., Cornell M., Coutinho P.M.,
Danchin E.G.J., Debets A.J.M., Dekker P., van Dijck P.W.M.,
van Dijk A., Dijkhuizen L., Driessen A.J.M., d'Enfert C., Geysens S.,
Goosen C., Groot G.S.P., de Groot P.W.J., Guillemette T.,
Henrissat B., Herweijer M., van den Hombergh J.P.T.W.,
van den Hondel C.A.M.J.J., van der Heijden R.T.J.M.,
van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P.,
van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J.E.C.,
Meulenberg R., Menke H., Mortimer M.A., Nielsen J., Oliver S.G.,
Olsthoorn M., Pal K., van Peij N.N.M.E., Ram A.F.J., Rinas U.,
Roubos J.A., Sagt C.M.J., Schmoll M., Sun J., Ussery D., Varga J.,
Vervecken W., van de Vondervoort P.J.J., Wedler H., Woesten H.A.B.,
Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.;
"Genome sequencing and analysis of the versatile cell factory
Aspergillus niger CBS 513.88.";
Nat. Biotechnol. 25:221-231(2007).
-!- FUNCTION: Ubiquitin thioesterase component of the regulatory
network controlling carbon source utilization through
ubiquitination and deubiquitination involving creA, creB, creC,
creD and acrB. Deubiquitinates the creA catabolic repressor and
the quinate permease qutD. Plays also a role in response to carbon
starvation and the control of extracellular proteases activity (By
similarity). {ECO:0000250}.
-!- CATALYTIC ACTIVITY: Thiol-dependent hydrolysis of ester,
thioester, amide, peptide and isopeptide bonds formed by the C-
terminal Gly of ubiquitin (a 76-residue protein attached to
proteins as an intracellular targeting signal).
-!- SUBUNIT: Interacts with creA, creC and qutD. {ECO:0000250}.
-!- SIMILARITY: Belongs to the peptidase C19 family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=CAK43937.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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EMBL; AM269976; CAK43937.1; ALT_SEQ; Genomic_DNA.
RefSeq; XP_001389270.2; XM_001389233.2.
SMR; A2Q9N1; -.
STRING; 5061.CADANGAP00000821; -.
PaxDb; A2Q9N1; -.
EnsemblFungi; CAK43937; CAK43937; An01g08470.
GeneID; 4978128; -.
KEGG; ang:ANI_1_1130014; -.
HOGENOM; HOG000192482; -.
KO; K11872; -.
OrthoDB; EOG092C0UAA; -.
Proteomes; UP000006706; Chromosome 2R.
GO; GO:0036459; F:thiol-dependent ubiquitinyl hydrolase activity; ISS:UniProtKB.
GO; GO:0045013; P:carbon catabolite repression of transcription; ISS:UniProtKB.
GO; GO:0016579; P:protein deubiquitination; IEA:InterPro.
GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
InterPro; IPR038765; Papain_like_cys_pep_sf.
InterPro; IPR001394; Peptidase_C19_UCH.
InterPro; IPR018200; USP_CS.
InterPro; IPR028889; USP_dom.
Pfam; PF00443; UCH; 1.
SUPFAM; SSF54001; SSF54001; 3.
PROSITE; PS00972; USP_1; 1.
PROSITE; PS00973; USP_2; 1.
PROSITE; PS50235; USP_3; 1.
3: Inferred from homology;
Coiled coil; Complete proteome; Hydrolase; Protease;
Reference proteome; Thiol protease; Ubl conjugation pathway.
CHAIN 1 758 Probable ubiquitin carboxyl-terminal
hydrolase creB.
/FTId=PRO_0000395681.
DOMAIN 57 468 USP.
COILED 573 631 {ECO:0000255}.
COMPBIAS 530 572 Pro-rich.
ACT_SITE 66 66 Nucleophile. {ECO:0000255|PROSITE-
ProRule:PRU10092, ECO:0000255|PROSITE-
ProRule:PRU10093}.
ACT_SITE 419 419 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU10092, ECO:0000255|PROSITE-
ProRule:PRU10093}.
SEQUENCE 758 AA; 84902 MW; 66D526B4DA07ED6D CRC64;
MGSFLRSFRR DVGSSTPSVG ATPAKKEPLA LPITPLEKML QEMGSDSVRQ DGSDKFFGME
NYGNTCYCNS ILQCLYYSVP FREAVLNYPT RTPIESLEAA LAKNLRYQNF AANQEAEAQA
EKQRLANAQR PGAPPAQPPK PEDKDSSEYK KKIALQSLPL LETKNNAGSY GMSESLFTSL
KDIFESVVAS QSRIGIVRPQ HFLDVLRREN EMFRSAMHQD AHEFLNLVLN EVVANVEAEA
MKQPIPSLPP ADTTDSSRQS ISSGSKTPNT TRWVHELFEG TLTSETQCLT CENVSQRDEI
FLDLSVDLEQ HSSVTSCLRK FSAEEMLCER NKFHCDNCGG LQEAEKRMKI KRLPRILALH
LKRFKYTEDL QRLQKLFHRV VYPYHLRLFN TTDDAEDPDR LYELYAVVVH IGGGPYHGHY
VSIIKTQDRG WLLFDDEMVE PVDKNYVRNF FGDKPGLACA YVLFYQETTL EAVLKEQEME
NMNASAADAN EAAVKPNGFP QPAGLAHVHS ASQIPVQDEP QRHTGLRRAP TAPQLPTHTE
YPGPDIEPSS PAVATPPPVP PIPETANRPL SPKKSDIQSK KERAKEEKER KAAEKEMEKQ
RRKEQEARVK ENQRREEAEL KAALEASKAS KADEDRRNPT ENGKDGDPKR SSNGLSRLKR
GSKSFSQRLG KDKESRASSS GLPSVPSAEP LTPNPVPLEP VQQLSPRKAS PPKESHVVHK
PLGQDDEPDA LKSPKGDRAG HGKWRSFSIR KKSFSILS


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