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Probable ubiquitination network signaling protein acrB (Acriflavine resistance protein B)

 ACRB_ASPCL              Reviewed;        1018 AA.
A1CIK0;
13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 1.
28-MAR-2018, entry version 37.
RecName: Full=Probable ubiquitination network signaling protein acrB;
AltName: Full=Acriflavine resistance protein B;
Name=acrB; Synonyms=acr2; ORFNames=ACLA_051770;
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC
3887 / NRRL 1).
Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
NCBI_TaxID=344612;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P.,
Anderson M.J., Crabtree J., Silva J.C., Badger J.H., Albarraq A.,
Angiuoli S., Bussey H., Bowyer P., Cotty P.J., Dyer P.S., Egan A.,
Galens K., Fraser-Liggett C.M., Haas B.J., Inman J.M., Kent R.,
Lemieux S., Malavazi I., Orvis J., Roemer T., Ronning C.M.,
Sundaram J.P., Sutton G., Turner G., Venter J.C., White O.R.,
Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H., Wortman J.R.,
Jiang B., Denning D.W., Nierman W.C.;
"Genomic islands in the pathogenic filamentous fungus Aspergillus
fumigatus.";
PLoS Genet. 4:E1000046-E1000046(2008).
-!- FUNCTION: Component of the regulatory network controlling carbon
source utilization through ubiquitination and deubiquitination
involving creA, creB, creC, creD and acrB. Involved in resistance
to acriflavine, and required for normal growth on a range of sole
carbon sources, including fructose, cellobiose, raffinose, and
starch, and reduced utilization of amino acids, including GABA and
beta-alanine, as sole carbon and nitrogen sources (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
protein {ECO:0000305}.
-!- SIMILARITY: Belongs to the acrB family. {ECO:0000305}.
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EMBL; DS027054; EAW10705.1; -; Genomic_DNA.
RefSeq; XP_001272131.1; XM_001272130.1.
SMR; A1CIK0; -.
EnsemblFungi; CADACLAT00004795; CADACLAP00004694; CADACLAG00004795.
GeneID; 4703619; -.
KEGG; act:ACLA_051770; -.
EuPathDB; FungiDB:ACLA_051770; -.
HOGENOM; HOG000192370; -.
OMA; EWYLRRE; -.
OrthoDB; EOG092C2TBP; -.
Proteomes; UP000006701; Unassembled WGS sequence.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PROSITE; PS00589; PTS_HPR_SER; 1.
3: Inferred from homology;
Coiled coil; Complete proteome; Membrane; Reference proteome;
Transmembrane; Transmembrane helix; Ubl conjugation pathway.
CHAIN 1 1018 Probable ubiquitination network signaling
protein acrB.
/FTId=PRO_0000395726.
TRANSMEM 162 182 Helical. {ECO:0000255}.
TRANSMEM 217 237 Helical. {ECO:0000255}.
TRANSMEM 258 278 Helical. {ECO:0000255}.
COILED 601 788 {ECO:0000255}.
COMPBIAS 65 72 Poly-Ala.
COMPBIAS 775 826 Gln-rich.
COMPBIAS 865 1012 Ser-rich.
SEQUENCE 1018 AA; 109618 MW; 213017EEBF382787 CRC64;
MPRSSATARK NQSNRNENGA SSGKKVAKQK SNGHLNGSLN GGSTPGSVSS SQVDLPSSRS
TSDSAIAPAA AASSNLNGIS DSSKEDCNGR EKLNGYTKGN ADMSYVQTNG AGSQNGGDHA
GQASHRTDKS ATGAKRSTSN ASINPLQLAS TILKSCPMYD TIAILIFLLQ LPPMVLTLVQ
FLFASLTFMP PSGASAGSLS SNFDIFQGPA GTPSLSTMIA MDGFCLLIWA LLMWTWAQNF
ALDLAHVQVA ITLGGGGSGK NGGVNTLCVG IVLILHLIRS KGIQDFVIGH LLSSNIISPD
LLAQYSHLLP TEFRRTESQT SPSWIRSLLA VHILAQAGTA MARRSMAKNR SPNPPRPGKR
VDTEASAGSQ TQIDSAFESG ASVSSYLGPD GQLITPTAHK DGRDRLLSAK KRRRQANQVR
SRQPFWAALA STKVTVMREY EHSRALSKTA RGLPMTENDL QGVSFDDGLV WITDVDASTI
KFAAGDFASA DDSGLSGACE DGRLGNEEIE PFYVCVNGAL WATATISRVP DAQKGSGMVH
WRGEVSGLAP NCAYTCSFMR SDTDEEICAI SVKTPVTNDT EQFSLVSPPP QPSYRPSSPT
TTLKNSIVNA EAKLNEKRSR LRKAKNDHKL IISKIRKELD NYNHRLHSGT DENRQKQRSL
QLERNIRQTE EATALLEGQL DSLENIPEEE LREWSDQKAK YDQELQLLNS AKEELVSARS
AVAREVSSLE SDLGSTVQRR ERLQSRRTRV NEQYERIVSA NAQGLNERER RAAEQFAREQ
DQAKLEANFN EQFGSIGQSV QEYQLRAQQI WQQCDAIEQA IQQQQQRMLL DSAPLTPEGN
LPGTNPFSET SALPLGALTS TAPNSRSLLG LSFPAIKSSP LQTISSALDA SSSHPTSPVQ
PPSFLNFPAS PLVNATSHLD SDFTYRDRSF SNRSARSSLY GSEFLDSSRR QPFQIDLPEL
LGEKRNSGSD STALKSGLRP VSSPFQRAGS RGSGSGSNGS GGSGSGSGSP SSAYGKPN


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