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Probable zinc transporter cis4

 CIS4_SCHPO              Reviewed;         732 AA.
Q9HGQ3; P78888;
16-MAY-2003, integrated into UniProtKB/Swiss-Prot.
01-MAR-2001, sequence version 1.
05-JUL-2017, entry version 97.
RecName: Full=Probable zinc transporter cis4;
Name=cis4; ORFNames=SPAC17D4.03c;
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
Schizosaccharomycetes; Schizosaccharomycetales;
Schizosaccharomycetaceae; Schizosaccharomyces.
NCBI_TaxID=284812;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=972 / ATCC 24843;
PubMed=11859360; DOI=10.1038/nature724;
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 377-732.
STRAIN=PR745;
PubMed=9501991; DOI=10.1093/dnares/4.6.363;
Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.;
"Identification of open reading frames in Schizosaccharomyces pombe
cDNAs.";
DNA Res. 4:363-369(1997).
[3]
SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
PubMed=16823372; DOI=10.1038/nbt1222;
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
Yoshida M.;
"ORFeome cloning and global analysis of protein localization in the
fission yeast Schizosaccharomyces pombe.";
Nat. Biotechnol. 24:841-847(2006).
[4]
FUNCTION, MUTAGENESIS OF GLY-375 AND GLY-393, SUBCELLULAR LOCATION,
AND INTERACTION WITH ZRG17.
PubMed=18199682; DOI=10.1091/mbc.E07-08-0805;
Fang Y., Sugiura R., Ma Y., Yada-Matsushima T., Umeno H., Kuno T.;
"Cation diffusion facilitator Cis4 is implicated in Golgi membrane
trafficking via regulating zinc homeostasis in fission yeast.";
Mol. Biol. Cell 19:1295-1303(2008).
-!- FUNCTION: Probable zinc transporter involved in Golgi membrane
trafficking through the regulation of zinc homeostasis.
{ECO:0000269|PubMed:18199682}.
-!- SUBUNIT: Interacts with zrg17. {ECO:0000269|PubMed:18199682}.
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
membrane protein. Golgi apparatus, cis-Golgi network membrane;
Multi-pass membrane protein.
-!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; CU329670; CAC05733.1; -; Genomic_DNA.
EMBL; D89239; BAA13900.1; -; mRNA.
PIR; T43145; T43145.
RefSeq; NP_594694.1; NM_001020122.2.
ProteinModelPortal; Q9HGQ3; -.
BioGrid; 278720; 45.
MINT; MINT-4703455; -.
STRING; 4896.SPAC17D4.03c.1; -.
MaxQB; Q9HGQ3; -.
PRIDE; Q9HGQ3; -.
EnsemblFungi; SPAC17D4.03c.1; SPAC17D4.03c.1:pep; SPAC17D4.03c.
GeneID; 2542250; -.
KEGG; spo:SPAC17D4.03c; -.
EuPathDB; FungiDB:SPAC17D4.03c; -.
PomBase; SPAC17D4.03c; cis4.
InParanoid; Q9HGQ3; -.
KO; K14692; -.
OrthoDB; EOG092C2X9S; -.
PhylomeDB; Q9HGQ3; -.
Reactome; R-SPO-264876; Insulin processing.
Reactome; R-SPO-435368; Zinc efflux and compartmentalization by the SLC30 family.
PRO; PR:Q9HGQ3; -.
Proteomes; UP000002485; Chromosome I.
GO; GO:0005783; C:endoplasmic reticulum; IDA:PomBase.
GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0000139; C:Golgi membrane; IDA:PomBase.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005385; F:zinc ion transmembrane transporter activity; IMP:PomBase.
GO; GO:0006882; P:cellular zinc ion homeostasis; IMP:PomBase.
GO; GO:0061088; P:regulation of sequestering of zinc ion; IBA:GO_Central.
GO; GO:0010043; P:response to zinc ion; IBA:GO_Central.
GO; GO:0071577; P:zinc II ion transmembrane transport; IMP:PomBase.
InterPro; IPR002524; Cation_efflux.
Pfam; PF01545; Cation_efflux; 1.
TIGRFAMs; TIGR01297; CDF; 1.
1: Evidence at protein level;
Complete proteome; Endoplasmic reticulum; Golgi apparatus;
Ion transport; Membrane; Reference proteome; Transmembrane;
Transmembrane helix; Transport; Zinc; Zinc transport.
CHAIN 1 732 Probable zinc transporter cis4.
/FTId=PRO_0000206116.
TRANSMEM 52 72 Helical. {ECO:0000255}.
TRANSMEM 79 99 Helical. {ECO:0000255}.
TRANSMEM 111 131 Helical. {ECO:0000255}.
TRANSMEM 163 183 Helical. {ECO:0000255}.
TRANSMEM 189 209 Helical. {ECO:0000255}.
TRANSMEM 219 239 Helical. {ECO:0000255}.
TRANSMEM 240 260 Helical. {ECO:0000255}.
TRANSMEM 268 288 Helical. {ECO:0000255}.
TRANSMEM 350 370 Helical. {ECO:0000255}.
TRANSMEM 380 400 Helical. {ECO:0000255}.
TRANSMEM 415 435 Helical. {ECO:0000255}.
TRANSMEM 453 473 Helical. {ECO:0000255}.
TRANSMEM 586 606 Helical. {ECO:0000255}.
TRANSMEM 615 635 Helical. {ECO:0000255}.
COMPBIAS 482 487 Poly-His.
COMPBIAS 572 578 Poly-His.
MUTAGEN 375 375 G->E: In cis4-1; confers sensitivities to
the calcineurin inhibitor FK506 and to a
high concentration of MgCl2.
{ECO:0000269|PubMed:18199682}.
MUTAGEN 393 393 G->D: In cis4-2; confers sensitivities to
the calcineurin inhibitor FK506 and to a
high concentration of MgCl2.
{ECO:0000269|PubMed:18199682}.
CONFLICT 618 618 L -> S (in Ref. 2; BAA13900).
{ECO:0000305}.
CONFLICT 665 665 N -> H (in Ref. 2; BAA13900).
{ECO:0000305}.
CONFLICT 668 668 I -> V (in Ref. 2; BAA13900).
{ECO:0000305}.
SEQUENCE 732 AA; 82740 MW; DBA5452D4329CB0B CRC64;
MNVNSSAFER TNRFPSFPVL KDDQKTSSDS IAAAKKKDLL SLISSKSLLS SETLGWFSVI
CAFSITGSGL EVNTMSIPFY LIFGIFAFVS FTTQYLGIYS FSFQPFQLLN VIIASLSMVF
ITLGAFVLGT LDTTCLLLLA FKLFFIRNDP TPFNARSANL KNYIAFPICL FVINHILILL
GYFQCSYSVF YASVFYILLG VFIRVFYLVN KEKFEKKELA FLFSSIVVAC LIQFNVLPLG
TINLSVTRFT ILCFMQIFCI NWDGIARIQF YLGKFDISLI MALISAIINK TASQNSIKII
SCLYQVGFCF FKIGSSITAN LKLPDNSRIY RLYNDFIVNG VLADKESRSI FYFFLLNVSY
MFVQVIYGLW TNSLGLISDA IHMAFDCIAI LVGLVATTLA KMPLNYAYPF GFAKIEALSG
FTNGIFLVLI SFSIVGEALY RLFHPPQMNT DQLLLVSFLG LVVNLVGILA FNHGHNHDHG
SHHHHSHSNH SMCLPNTTND INIFEEFEEE KDNVEAQKMG YTNDDHVSQH EHTHENSQEH
HHEHNHNHDH IHKYNEKCDH ESISLQNLDN DHHCHHHHEN HNMHGIFLHI IADTMGSVGV
IVSTILIQWF SWTGFDPLAS LIIAALIFVS VLPLIKDSAK NLLSVTDPES EYLLKQCLSN
ISLSNSVISL SNPKFWTNER GEVYGILHIQ VSIDGDLNVV RNEVFRKLSI AVPNLKHICI
QSERPNNCWC GK


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