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Probetacellulin [Cleaved into: Betacellulin (BTC)]

 BTC_BOVIN               Reviewed;         178 AA.
Q9TTC5;
27-APR-2001, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
10-MAY-2017, entry version 97.
RecName: Full=Probetacellulin;
Contains:
RecName: Full=Betacellulin;
Short=BTC;
Flags: Precursor;
Name=BTC;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Kidney, and Milk;
PubMed=10585857; DOI=10.1042/bj3440713;
Dunbar A.J., Goddard C., Priebe I.K.P., Belford D.A.;
"Identification of betacellulin as a major peptide growth factor in
milk: purification, characterization, and molecular cloning of bovine
betacellulin.";
Biochem. J. 344:713-721(1999).
-!- FUNCTION: Growth factor that binds to EGFR, ERBB4 and other EGF
receptor family members. Potent mitogen for retinal pigment
epithelial cells and vascular smooth muscle cells (By similarity).
{ECO:0000250}.
-!- SUBUNIT: Monomer. Interacts with EGFR and ERBB4 (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Betacellulin: Secreted, extracellular space
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Probetacellulin: Cell membrane
{ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
-!- TISSUE SPECIFICITY: Expressed in a wide range of tissues,
including the mammary gland.
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EMBL; AF140597; AAF15401.1; -; mRNA.
UniGene; Bt.236; -.
ProteinModelPortal; Q9TTC5; -.
SMR; Q9TTC5; -.
STRING; 9913.ENSBTAP00000005549; -.
PaxDb; Q9TTC5; -.
PRIDE; Q9TTC5; -.
eggNOG; ENOG410IWUI; Eukaryota.
eggNOG; ENOG41126JP; LUCA.
HOGENOM; HOG000237352; -.
HOVERGEN; HBG004905; -.
InParanoid; Q9TTC5; -.
Proteomes; UP000009136; Unplaced.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0005154; F:epidermal growth factor receptor binding; IBA:GO_Central.
GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IBA:GO_Central.
GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
GO; GO:0008284; P:positive regulation of cell proliferation; IBA:GO_Central.
InterPro; IPR013032; EGF-like_CS.
InterPro; IPR000742; EGF-like_dom.
InterPro; IPR015497; EGF_rcpt_ligand.
PANTHER; PTHR10740; PTHR10740; 1.
Pfam; PF00008; EGF; 1.
PROSITE; PS00022; EGF_1; 1.
PROSITE; PS01186; EGF_2; 1.
PROSITE; PS50026; EGF_3; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Disulfide bond; EGF-like domain;
Glycoprotein; Growth factor; Membrane; Mitogen; Reference proteome;
Secreted; Signal; Transmembrane; Transmembrane helix.
SIGNAL 1 31 {ECO:0000250}.
CHAIN 32 178 Probetacellulin.
/FTId=PRO_0000300684.
CHAIN 32 111 Betacellulin.
/FTId=PRO_0000007488.
PROPEP 112 178 Removed in mature form. {ECO:0000250}.
/FTId=PRO_0000007489.
TOPO_DOM 32 118 Extracellular. {ECO:0000255}.
TRANSMEM 119 139 Helical. {ECO:0000255}.
TOPO_DOM 140 178 Cytoplasmic. {ECO:0000255}.
DOMAIN 65 105 EGF-like. {ECO:0000255|PROSITE-
ProRule:PRU00076}.
COMPBIAS 146 154 Arg/Lys-rich (basic).
CARBOHYD 34 34 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 69 82 {ECO:0000255|PROSITE-ProRule:PRU00076}.
DISULFID 77 93 {ECO:0000255|PROSITE-ProRule:PRU00076}.
DISULFID 95 104 {ECO:0000255|PROSITE-ProRule:PRU00076}.
SEQUENCE 178 AA; 19640 MW; 158B67B24A64E0CB CRC64;
MARAAPGSGA SPLPLLPALA LGLVILHCVV ADGNSTRSPE DDGLLCGDHA ENCPATTTQP
KRRGHFSRCP KQYKHYCIKG RCRFVVAEQT PSCVCDEGYA GARCERVDLF YLRGDRGQIL
VICLIAVMVI FIILVVSICT CCHPLRKRRK RRKKEEEMET LGKDITPIND DIQETSIA


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