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Proctolin (Proctolin, isoform A) (Proctolin, isoform B) (RH15319p)

 Q9VLV9_DROME            Unreviewed;       140 AA.
Q9VLV9;
01-MAY-2000, integrated into UniProtKB/TrEMBL.
01-OCT-2002, sequence version 2.
22-NOV-2017, entry version 123.
SubName: Full=Proctolin {ECO:0000313|EMBL:CAD30643.1};
SubName: Full=Proctolin, isoform A {ECO:0000313|EMBL:AAF52572.2};
SubName: Full=Proctolin, isoform B {ECO:0000313|EMBL:AHN54243.1};
SubName: Full=RH15319p {ECO:0000313|EMBL:AAM51021.1};
Name=Proc {ECO:0000313|EMBL:AAF52572.2,
ECO:0000313|FlyBase:FBgn0045038};
Synonyms=Dmel\CG7105 {ECO:0000313|EMBL:AAF52572.2},
Prct {ECO:0000313|EMBL:AAF52572.2},
PROC {ECO:0000313|EMBL:AAF52572.2},
PROCT {ECO:0000313|EMBL:AAF52572.2},
Proct {ECO:0000313|EMBL:AAF52572.2, ECO:0000313|FlyBase:FBgn0045038},
proct {ECO:0000313|EMBL:AAF52572.2};
ORFNames=CG7105 {ECO:0000313|EMBL:AAF52572.2,
ECO:0000313|FlyBase:FBgn0045038},
Dmel_CG7105 {ECO:0000313|EMBL:AAF52572.2};
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF52572.2, ECO:0000313|Proteomes:UP000000803};
[1] {ECO:0000313|EMBL:AAF52572.2, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=10731132; DOI=10.1126/science.287.5461.2185;
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D.,
Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L.,
Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D.,
Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J.,
Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C.,
Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X.,
Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J.,
Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[2] {ECO:0000313|EMBL:AAF52572.2, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=12537568;
Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
"Finishing a whole-genome shotgun: release 3 of the Drosophila
melanogaster euchromatic genome sequence.";
Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
[3] {ECO:0000313|EMBL:AAF52572.2, ECO:0000313|Proteomes:UP000000803}
GENOME REANNOTATION.
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P.,
Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A.,
Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[4] {ECO:0000313|EMBL:AAF52572.2, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=12537573;
Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M.,
Ashburner M., Celniker S.E.;
"The transposable elements of the Drosophila melanogaster euchromatin:
a genomics perspective.";
Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
[5] {ECO:0000313|EMBL:AAF52572.2, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=12537574;
Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
Karpen G.H.;
"Heterochromatic sequences in a Drosophila whole-genome shotgun
assembly.";
Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
[6] {ECO:0000313|EMBL:CAD30643.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Head {ECO:0000313|EMBL:CAD30643.1};
Naessel D.R., Winther A.M.E., Siviter R.J., Dushay D., Shirras A.D.,
Isaac R.E.;
"A proctolin precursor (Proct) gene of Drosophila
melanogaster:Identification,neuronal expression and predicted
preproprotein processing.";
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
[7] {ECO:0000313|EMBL:AAM51021.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Berkeley {ECO:0000313|EMBL:AAM51021.1};
Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.,
Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E.,
George R., Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G.,
Miranda A., Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S.,
Patel S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M.,
Celniker S.;
Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
[8] {ECO:0000313|EMBL:AAF52572.2, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
Ashburner M., Anxolabehere D.;
"Combined evidence annotation of transposable elements in genome
sequences.";
PLoS Comput. Biol. 1:166-175(2005).
[9] {ECO:0000313|EMBL:AAF52572.2}
NUCLEOTIDE SEQUENCE.
Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S.,
Svirskas R., Rubin G.;
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
[10] {ECO:0000313|EMBL:AAF52572.2}
NUCLEOTIDE SEQUENCE.
Berkeley Drosophila Genome Project;
Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R.,
Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E.,
Yu C., Rubin G.;
"Drosophila melanogaster release 4 sequence.";
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
[11] {ECO:0000313|EMBL:AAF52572.2, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=17569856; DOI=10.1126/science.1139815;
Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
"The Release 5.1 annotation of Drosophila melanogaster
heterochromatin.";
Science 316:1586-1591(2007).
[12] {ECO:0000313|EMBL:AAF52572.2, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=17569867; DOI=10.1126/science.1139816;
Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
Dimitri P., Karpen G.H., Celniker S.E.;
"Sequence finishing and mapping of Drosophila melanogaster
heterochromatin.";
Science 316:1625-1628(2007).
[13] {ECO:0000313|EMBL:AAF52572.2}
NUCLEOTIDE SEQUENCE.
FlyBase;
Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AE014134; AAF52572.2; -; Genomic_DNA.
EMBL; AY119161; AAM51021.1; -; mRNA.
EMBL; AE014134; AHN54243.1; -; Genomic_DNA.
EMBL; AJ458447; CAD30643.1; -; mRNA.
RefSeq; NP_001285728.1; NM_001298799.1.
RefSeq; NP_609158.2; NM_135314.3.
UniGene; Dm.12192; -.
STRING; 7227.FBpp0079184; -.
EnsemblMetazoa; FBtr0079562; FBpp0079184; FBgn0045038.
EnsemblMetazoa; FBtr0343420; FBpp0310066; FBgn0045038.
GeneID; 250710; -.
KEGG; dme:Dmel_CG7105; -.
UCSC; CG7105-RA; d. melanogaster.
CTD; 5624; -.
FlyBase; FBgn0045038; Proc.
eggNOG; ENOG410KBZC; Eukaryota.
eggNOG; ENOG4110MS4; LUCA.
OMA; LHNEATG; -.
OrthoDB; EOG091G15U6; -.
GenomeRNAi; 250710; -.
Proteomes; UP000000803; Chromosome 2L.
Bgee; FBgn0045038; -.
GO; GO:0005615; C:extracellular space; ISM:FlyBase.
GO; GO:0005184; F:neuropeptide hormone activity; IDA:FlyBase.
GO; GO:0071860; F:proctolin receptor binding; IPI:FlyBase.
GO; GO:0003723; F:RNA binding; IEA:InterPro.
GO; GO:0007218; P:neuropeptide signaling pathway; IDA:FlyBase.
GO; GO:0010460; P:positive regulation of heart rate; IMP:FlyBase.
Gene3D; 3.30.1370.10; -; 1.
InterPro; IPR036612; KH_dom_type_1_sf.
2: Evidence at transcript level;
Complete proteome {ECO:0000313|Proteomes:UP000000803};
Reference proteome {ECO:0000313|Proteomes:UP000000803};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 38 {ECO:0000256|SAM:SignalP}.
CHAIN 39 140 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5011213040.
SEQUENCE 140 AA; 15404 MW; BC35E04861A7514B CRC64;
MGVPRSHGTG IGCGSGHRWL LVWMTVLLLV VPPHLVDGRY LPTRSHGDDL DKLRELMLQI
LELSNEDPQQ QQQQQQQQQH PQLRLHNEAT GGSSSSSNIN NPRVSNGNSN AAWLQKLSAM
GALDELGGDG ARFGPNYGRY


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