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Proctolin-like G protein-coupled receptor

 N1NVE5_TRICA            Unreviewed;       525 AA.
N1NVE5;
11-MAY-2016, integrated into UniProtKB/TrEMBL.
11-MAY-2016, sequence version 1.
07-JUN-2017, entry version 9.
SubName: Full=Proctolin-like G protein-coupled receptor {ECO:0000313|EMBL:DAA64477.1};
Tribolium castaneum (Red flour beetle).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Coleoptera; Polyphaga;
Cucujiformia; Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
NCBI_TaxID=7070 {ECO:0000313|EMBL:DAA64477.1};
[1] {ECO:0000313|EMBL:DAA64477.1}
NUCLEOTIDE SEQUENCE.
PubMed=18054377; DOI=10.1016/j.yfrne.2007.10.003;
Hauser F., Cazzamali G., Williamson M., Park Y., Li B., Tanaka Y.,
Predel R., Neupert S., Schachtner J., Verleyen P.,
Grimmelikhuijzen C.J.;
"A genome-wide inventory of neurohormone GPCRs in the red flour beetle
Tribolium castaneum.";
Front. Neuroendocrinol. 29:142-165(2008).
[2] {ECO:0000313|EMBL:DAA64477.1}
NUCLEOTIDE SEQUENCE.
PubMed=18025266; DOI=10.1101/gr.6714008;
Li B., Predel R., Neupert S., Hauser F., Tanaka Y., Cazzamali G.,
Williamson M., Arakane Y., Verleyen P., Schoofs L., Schachtner J.,
Grimmelikhuijzen C.J., Park Y.;
"Genomics, transcriptomics, and peptidomics of neuropeptides and
protein hormones in the red flour beetle Tribolium castaneum.";
Genome Res. 18:113-122(2008).
[3] {ECO:0000313|EMBL:DAA64477.1}
NUCLEOTIDE SEQUENCE.
PubMed=18316733; DOI=10.1073/pnas.0710897105;
Stafflinger E., Hansen K.K., Hauser F., Schneider M., Cazzamali G.,
Williamson M., Grimmelikhuijzen C.J.;
"Cloning and identification of an oxytocin/vasopressin-like receptor
and its ligand from insects.";
Proc. Natl. Acad. Sci. U.S.A. 105:3262-3267(2008).
[4] {ECO:0000313|EMBL:DAA64477.1}
NUCLEOTIDE SEQUENCE.
PubMed=20068045; DOI=10.1074/jbc.M109.045369;
Hansen K.K., Stafflinger E., Schneider M., Hauser F., Cazzamali G.,
Williamson M., Kollmann M., Schachtner J., Grimmelikhuijzen C.J.;
"Discovery of a novel insect neuropeptide signaling system closely
related to the insect adipokinetic hormone and corazonin hormonal
systems.";
J. Biol. Chem. 285:10736-10747(2010).
[5] {ECO:0000313|EMBL:DAA64477.1}
NUCLEOTIDE SEQUENCE.
PubMed=21843505; DOI=10.1016/j.bbrc.2011.07.131;
Collin C., Hauser F., Krogh-Meyer P., Hansen K.K.,
Gonzalez de Valdivia E., Williamson M., Grimmelikhuijzen C.J.;
"Identification of the Drosophila and Tribolium receptors for the
recently discovered insect RYamide neuropeptides.";
Biochem. Biophys. Res. Commun. 412:578-583(2011).
[6] {ECO:0000313|EMBL:DAA64477.1}
NUCLEOTIDE SEQUENCE.
PubMed=23604020;
Collin C., Hauser F., Gonzalez de Valdivia E., Li S., Reisenberger J.,
Carlsen E.M., Khan Z., Hansen N.O., Puhm F., Sondergaard L.,
Niemiec J., Heninger M., Ren G.R., Grimmelikhuijzen C.J.;
"Two types of muscarinic acetylcholine receptors in Drosophila and
other arthropods.";
Cell. Mol. Life Sci. 70:3231-3242(2013).
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EMBL; BK006096; DAA64477.1; -; mRNA.
RefSeq; NP_001280541.1; NM_001293612.1.
ProteinModelPortal; N1NVE5; -.
GeneID; 103312335; -.
KEGG; tca:103312335; -.
eggNOG; KOG3656; Eukaryota.
eggNOG; ENOG410XRW9; LUCA.
OMA; STAFEHT; -.
PhylomeDB; N1NVE5; -.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0008528; F:G-protein coupled peptide receptor activity; IEA:InterPro.
InterPro; IPR019427; 7TM_GPCR_serpentine_rcpt_Srw.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
Pfam; PF10324; 7TM_GPCR_Srw; 2.
PRINTS; PR00237; GPCRRHODOPSN.
SMART; SM01381; 7TM_GPCR_Srsx; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
2: Evidence at transcript level;
Membrane {ECO:0000256|SAM:Phobius};
Receptor {ECO:0000313|EMBL:DAA64477.1};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
TRANSMEM 22 42 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 54 74 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 94 115 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 136 156 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 326 352 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 391 412 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 432 451 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 34 448 G_PROTEIN_RECEP_F1_2.
{ECO:0000259|PROSITE:PS50262}.
SEQUENCE 525 AA; 60551 MW; 427D4E84E34ADCF7 CRC64;
MDESEDPSVL FLKSTRFWIQ RVFVPIVVCI GVGGNTVTVM VLTRKRMRCS TNIYLTALAV
ADIIYLLFVF VLSFSVYDNI NDRKYELFWR FFGLTHWLCD AASNASVWLT VSFTLERYIA
VCHPIKGKVL CTENRAKIII TGIAIFCILS TLSTTFEYEL AMKEKCVRNC TQEELKNRQH
VPGKCFQNVT FHHLPNHNIV VSNLQSHESD DSNEKLIREI YTSLEPAINK LLPVNCTSHP
HIIYVPVQMF NKTTPKKINT NLIDGSVRNN SEVSKDRTDH AHLVPTGKLI TNDTSDNDTC
CLKKFTVSTV LTNLGKNKNY KIFISWFPAL CFALIPLILI ATFNCFLVHA VYKSQSRRRK
MTNSQVRKKN STSQFIRTET VSMSNENRIT VMLIGVVFLF LICQTPTASF LIYSNFYEAE
DLATENIHRG NIFNFLVNIN AATNFIMYCI LSKKYRTTFR TLFCGRRKNR QDTLILTDTR
TRYSSFNNGL RRNVSEYHTP RNLEVTIYFF NKGKYVNTYN LCIKI


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