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Proenkephalin-A [Cleaved into: Synenkephalin; Met-enkephalin (Opioid growth factor) (OGF); PENK(111-130); PENK(140-179); Met-enkephalin-Arg-Gly-Leu; Leu-enkephalin; Enkelytin; PENK(233-254); Met-enkephalin-Arg-Phe]

 PENK_BOVIN              Reviewed;         263 AA.
P01211; Q2T9T4;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
21-JUL-1986, sequence version 1.
07-NOV-2018, entry version 116.
RecName: Full=Proenkephalin-A;
Contains:
RecName: Full=Synenkephalin;
Contains:
RecName: Full=Met-enkephalin;
AltName: Full=Opioid growth factor;
Short=OGF;
Contains:
RecName: Full=PENK(111-130);
Contains:
RecName: Full=PENK(140-179);
Contains:
RecName: Full=Met-enkephalin-Arg-Gly-Leu;
Contains:
RecName: Full=Leu-enkephalin;
Contains:
RecName: Full=Enkelytin;
Contains:
RecName: Full=PENK(233-254);
Contains:
RecName: Full=Met-enkephalin-Arg-Phe;
Flags: Precursor;
Name=PENK;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=6276759; DOI=10.1038/295202a0;
Noda M., Furutani Y., Takahashi H., Toyosato M., Hirose T.,
Inayama S., Nakanishi S., Numa S.;
"Cloning and sequence analysis of cDNA for bovine adrenal
preproenkephalin.";
Nature 295:202-206(1982).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Crossbred X Angus; TISSUE=Liver;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 47-263.
PubMed=6173760; DOI=10.1038/295206a0;
Gubler U., Seeburg P., Hoffman B.J., Gage L.P., Udenfriend S.;
"Molecular cloning establishes proenkephalin as precursor of
enkephalin-containing peptides.";
Nature 295:206-208(1982).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 211-229.
PubMed=6952189; DOI=10.1073/pnas.79.2.360;
Comb M., Herbert E., Crea R.;
"Partial characterization of the mRNA that codes for enkephalins in
bovine adrenal medulla and human pheochromocytoma.";
Proc. Natl. Acad. Sci. U.S.A. 79:360-364(1982).
[5]
PROTEIN SEQUENCE OF 233-261.
TISSUE=Chromaffin cell;
PubMed=8654396; DOI=10.1111/j.1432-1033.1996.t01-1-00516.x;
Goumon Y., Strub J.-M., Moniatte M., Nulans G., Poteur L., Hubert P.,
van Dorsselaer A., Aunis D., Metz-Boutigue M.-H.;
"The C-terminal bisphosphorylated proenkephalin-A-(209-237)-peptide
from adrenal medullary chromaffin granules possesses antibacterial
activity.";
Eur. J. Biochem. 235:516-525(1996).
-!- FUNCTION: Met- and Leu-enkephalins compete with and mimic the
effects of opiate drugs. They play a role in a number of
physiologic functions, including pain perception and responses to
stress. PENK(111-130) and PENK(233-254) increase glutamate release
in the striatum. PENK(111-130) decreases GABA concentration in the
striatum.
-!- FUNCTION: Enkelytin possesses antibacterial activity against Gram-
positive bacteria such as Micrococcus luteus and Bacillus
megaterium.
-!- SUBCELLULAR LOCATION: Secreted.
-!- PTM: The N-terminal domain contains 6 conserved cysteines thought
to be involved in disulfide bonding and/or processing.
-!- SIMILARITY: Belongs to the opioid neuropeptide precursor family.
{ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; V00109; CAA23443.1; -; mRNA.
EMBL; BC111279; AAI11280.1; -; mRNA.
EMBL; V00108; CAA23442.1; -; mRNA.
EMBL; J00012; AAA30673.1; -; mRNA.
PIR; A93272; EQBOA.
RefSeq; NP_776566.1; NM_174141.2.
UniGene; Bt.166; -.
STRING; 9913.ENSBTAP00000006478; -.
iPTMnet; P01211; -.
PaxDb; P01211; -.
PRIDE; P01211; -.
Ensembl; ENSBTAT00000006478; ENSBTAP00000006478; ENSBTAG00000004924.
GeneID; 281387; -.
KEGG; bta:281387; -.
CTD; 5179; -.
VGNC; VGNC:32746; PENK.
eggNOG; ENOG410IJUY; Eukaryota.
eggNOG; ENOG4110ZYD; LUCA.
GeneTree; ENSGT00530000063761; -.
HOGENOM; HOG000013003; -.
HOVERGEN; HBG000063; -.
InParanoid; P01211; -.
KO; K18832; -.
OMA; FMKKDAE; -.
OrthoDB; EOG091G0HV8; -.
TreeFam; TF332620; -.
Reactome; R-BTA-375276; Peptide ligand-binding receptors.
Reactome; R-BTA-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
Reactome; R-BTA-418594; G alpha (i) signalling events.
Reactome; R-BTA-8957275; Post-translational protein phosphorylation.
Proteomes; UP000009136; Chromosome 14.
Bgee; ENSBTAG00000004924; Expressed in 9 organ(s), highest expression level in brain.
GO; GO:0043679; C:axon terminus; IBA:GO_Central.
GO; GO:0030425; C:dendrite; IBA:GO_Central.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0043025; C:neuronal cell body; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0001515; F:opioid peptide activity; IEA:UniProtKB-KW.
GO; GO:0002118; P:aggressive behavior; IEA:Ensembl.
GO; GO:0001662; P:behavioral fear response; IEA:Ensembl.
GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
GO; GO:0019233; P:sensory perception of pain; IEA:Ensembl.
GO; GO:0001964; P:startle response; IEA:Ensembl.
InterPro; IPR006024; Opioid_neupept.
InterPro; IPR000703; Proenkphlin_A.
PANTHER; PTHR11438; PTHR11438; 1.
PANTHER; PTHR11438:SF3; PTHR11438:SF3; 1.
Pfam; PF01160; Opiods_neuropep; 1.
PRINTS; PR01028; OPIOIDPRCRSR.
PRINTS; PR01029; PENKAPRCRSR.
PROSITE; PS01252; OPIOIDS_PRECURSOR; 1.
1: Evidence at protein level;
Antibiotic; Antimicrobial; Cleavage on pair of basic residues;
Complete proteome; Direct protein sequencing; Disulfide bond;
Endorphin; Neuropeptide; Opioid peptide; Phosphoprotein;
Reference proteome; Secreted; Signal.
SIGNAL 1 24 {ECO:0000255}.
PEPTIDE 25 94 Synenkephalin.
/FTId=PRO_0000008206.
PEPTIDE 97 101 Met-enkephalin.
/FTId=PRO_0000008207.
PEPTIDE 104 108 Met-enkephalin.
/FTId=PRO_0000008208.
PEPTIDE 111 130 PENK(111-130). {ECO:0000250}.
/FTId=PRO_0000377682.
PEPTIDE 133 137 Met-enkephalin.
/FTId=PRO_0000008210.
PEPTIDE 140 179 PENK(140-179). {ECO:0000250}.
/FTId=PRO_0000377683.
PEPTIDE 182 189 Met-enkephalin-Arg-Gly-Leu.
/FTId=PRO_0000008212.
PROPEP 192 203
/FTId=PRO_0000008213.
PEPTIDE 206 210 Met-enkephalin.
/FTId=PRO_0000008214.
PROPEP 213 223
/FTId=PRO_0000008215.
PEPTIDE 226 230 Leu-enkephalin.
/FTId=PRO_0000008216.
PEPTIDE 233 261 Enkelytin.
/FTId=PRO_0000008217.
PEPTIDE 233 254 PENK(233-254). {ECO:0000250}.
/FTId=PRO_0000377684.
PEPTIDE 257 263 Met-enkephalin-Arg-Phe.
/FTId=PRO_0000008218.
MOD_RES 247 247 Phosphoserine.
{ECO:0000250|UniProtKB:P04094}.
DISULFID 26 48 {ECO:0000250|UniProtKB:P01210}.
DISULFID 30 52 {ECO:0000250|UniProtKB:P01210}.
DISULFID 33 65 {ECO:0000250|UniProtKB:P01210}.
SEQUENCE 263 AA; 29788 MW; 0E400338A228B0D8 CRC64;
MARFLGLCTW LLALGPGLLA TVRAECSQDC ATCSYRLARP TDLNPLACTL ECEGKLPSLK
TWETCKELLQ LTKLELPPDA TSALSKQEES HLLAKKYGGF MKRYGGFMKK MDELYPLEVE
EEANGGEVLG KRYGGFMKKD AEEDDGLGNS SNLLKELLGA GDQREGSLHQ EGSDAEDVSK
RYGGFMRGLK RSPHLEDETK ELQKRYGGFM RRVGRPEWWM DYQKRYGGFL KRFAEPLPSE
EEGESYSKEV PEMEKRYGGF MRF


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