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Proenkephalin-A [Cleaved into: Synenkephalin; Met-enkephalin (Opioid growth factor) (OGF); PENK(114-133); PENK(143-184); Met-enkephalin-Arg-Gly-Leu; Leu-enkephalin; PENK(238-259); Met-enkephalin-Arg-Phe]

 PENK_CAVPO              Reviewed;         268 AA.
P47969;
01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
01-FEB-1996, sequence version 1.
25-OCT-2017, entry version 81.
RecName: Full=Proenkephalin-A;
Contains:
RecName: Full=Synenkephalin;
Contains:
RecName: Full=Met-enkephalin;
AltName: Full=Opioid growth factor;
Short=OGF;
Contains:
RecName: Full=PENK(114-133);
Contains:
RecName: Full=PENK(143-184);
Contains:
RecName: Full=Met-enkephalin-Arg-Gly-Leu;
Contains:
RecName: Full=Leu-enkephalin;
Contains:
RecName: Full=PENK(238-259);
Contains:
RecName: Full=Met-enkephalin-Arg-Phe;
Flags: Precursor;
Name=PENK;
Cavia porcellus (Guinea pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
Hystricomorpha; Caviidae; Cavia.
NCBI_TaxID=10141;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Hartley;
PubMed=7891703; DOI=10.1128/MCB.15.4.2080;
Laforge K.S., Unterwald E.M., Kreek M.J.;
"Structure and expression of the guinea pig preproenkephalin gene:
site-specific cleavage in the 3' untranslated region yields truncated
mRNA transcripts in specific brain regions.";
Mol. Cell. Biol. 15:2080-2089(1995).
[2]
PROTEIN SEQUENCE OF 211-235, AND POSSIBLE BIOLOGICAL FUNCTION.
PubMed=6265943; DOI=10.1073/pnas.78.5.3265;
Kilpatrick D.L., Taniguchi T., Jones B.N., Stern A.S., Shively J.E.,
Hullihan J., Kimura S., Stein S., Udenfriend S.;
"A highly potent 3200-dalton adrenal opioid peptide that contains both
a [Met]- and [Leu]enkephalin sequence.";
Proc. Natl. Acad. Sci. U.S.A. 78:3265-3268(1981).
-!- FUNCTION: Met- and Leu-enkephalins compete with and mimic the
effects of opiate drugs. They play a role in a number of
physiologic functions, including pain perception and responses to
stress. PENK(114-133) and PENK(238-259) increase glutamate release
in the striatum. PENK(114-133) decreases GABA concentration in the
striatum.
-!- SUBCELLULAR LOCATION: Secreted.
-!- PTM: The N-terminal domain contains 6 conserved cysteines thought
to be involved in disulfide bonding and/or processing.
-!- SIMILARITY: Belongs to the opioid neuropeptide precursor family.
{ECO:0000305}.
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EMBL; U16138; AAA87900.1; -; Genomic_DNA.
PIR; A18864; A18864.
RefSeq; NP_001166888.1; NM_001173417.1.
STRING; 10141.ENSCPOP00000011497; -.
GeneID; 100379621; -.
CTD; 5179; -.
eggNOG; ENOG410IJUY; Eukaryota.
eggNOG; ENOG4110ZYD; LUCA.
HOGENOM; HOG000013003; -.
HOVERGEN; HBG000063; -.
InParanoid; P47969; -.
Proteomes; UP000005447; Unassembled WGS sequence.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0001515; F:opioid peptide activity; IEA:UniProtKB-KW.
GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
InterPro; IPR006024; Opioid_neupept.
InterPro; IPR000703; Proenkphlin_A.
PANTHER; PTHR11438; PTHR11438; 1.
PANTHER; PTHR11438:SF3; PTHR11438:SF3; 1.
Pfam; PF01160; Opiods_neuropep; 1.
PRINTS; PR01028; OPIOIDPRCRSR.
PRINTS; PR01029; PENKAPRCRSR.
PROSITE; PS01252; OPIOIDS_PRECURSOR; 1.
1: Evidence at protein level;
Cleavage on pair of basic residues; Complete proteome;
Direct protein sequencing; Disulfide bond; Endorphin; Neuropeptide;
Opioid peptide; Phosphoprotein; Reference proteome; Secreted; Signal.
SIGNAL 1 24 {ECO:0000255}.
PEPTIDE 25 97 Synenkephalin.
/FTId=PRO_0000008219.
PEPTIDE 100 104 Met-enkephalin.
/FTId=PRO_0000008220.
PEPTIDE 107 111 Met-enkephalin.
/FTId=PRO_0000008221.
PEPTIDE 114 133 PENK(114-133). {ECO:0000250}.
/FTId=PRO_0000377685.
PEPTIDE 136 140 Met-enkephalin.
/FTId=PRO_0000008223.
PEPTIDE 143 184 PENK(143-184). {ECO:0000250}.
/FTId=PRO_0000377686.
PEPTIDE 187 194 Met-enkephalin-Arg-Gly-Leu.
/FTId=PRO_0000008225.
PROPEP 197 208
/FTId=PRO_0000008226.
PEPTIDE 211 215 Met-enkephalin.
/FTId=PRO_0000008227.
PROPEP 218 228
/FTId=PRO_0000008228.
PEPTIDE 231 235 Leu-enkephalin.
/FTId=PRO_0000008229.
PEPTIDE 238 259 PENK(238-259). {ECO:0000250}.
/FTId=PRO_0000377687.
PEPTIDE 262 268 Met-enkephalin-Arg-Phe.
/FTId=PRO_0000008231.
MOD_RES 252 252 Phosphoserine.
{ECO:0000250|UniProtKB:P04094}.
DISULFID 26 48 {ECO:0000250|UniProtKB:P01210}.
DISULFID 30 52 {ECO:0000250|UniProtKB:P01210}.
DISULFID 33 65 {ECO:0000250|UniProtKB:P01210}.
SEQUENCE 268 AA; 30436 MW; 64C85EE9F480F238 CRC64;
MARLLRLCTW LVALGPGLLA TVQAECSQDC AACSYRLVRP GDLNFLACTL ECEGQLPSLK
IWETCKDLLQ VSKQELPQEG ASSLRESGKQ DESHLLSKKY GGFMKRYGGF MKKVDELYPV
EPEEEANGGE ILTKRYGGFM KKDAEDGDAL ANSSDLLKEL LGTGDDRDRE NHHQEGGDSD
EGVSKRYGGF MRGLKRSPQV EDEAKELQKR YGGFMRRVGR PEWWMDYQKR YGGFLKRFAE
FLPSDEEGES YSKEVPEMEK RYGGFMRF


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