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Proenkephalin-A [Cleaved into: Synenkephalin; Met-enkephalin (Opioid growth factor) (OGF); PENK(114-133); PENK(143-184); Met-enkephalin-Arg-Gly-Leu; Leu-enkephalin; PENK(238-259); Met-enkephalin-Arg-Phe]

 PENK_MESAU              Reviewed;         268 AA.
P50175; Q64030;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 1.
25-OCT-2017, entry version 61.
RecName: Full=Proenkephalin-A;
Contains:
RecName: Full=Synenkephalin;
Contains:
RecName: Full=Met-enkephalin;
AltName: Full=Opioid growth factor;
Short=OGF;
Contains:
RecName: Full=PENK(114-133);
Contains:
RecName: Full=PENK(143-184);
Contains:
RecName: Full=Met-enkephalin-Arg-Gly-Leu;
Contains:
RecName: Full=Leu-enkephalin;
Contains:
RecName: Full=PENK(238-259);
Contains:
RecName: Full=Met-enkephalin-Arg-Phe;
Flags: Precursor;
Name=PENK; Synonyms=ENK;
Mesocricetus auratus (Golden hamster).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Cricetidae; Cricetinae; Mesocricetus.
NCBI_TaxID=10036;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Syrian; TISSUE=Liver;
PubMed=8286036; DOI=10.1089/dna.1994.13.25;
Zhu Y.S., Branch A.D., Robertson H.D., Inturrisi C.E.;
"Cloning and characterization of hamster proenkephalin gene.";
DNA Cell Biol. 13:25-35(1994).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Syrian; TISSUE=Adrenal gland;
PubMed=7917015; DOI=10.1089/dna.1994.13.933;
Beaulieu M., Ouellette M., Desgroseillers L., Brakier-Gingras L.;
"Molecular cloning and characterization of the hamster
preproenkephalin A cDNA.";
DNA Cell Biol. 13:933-940(1994).
-!- FUNCTION: Met- and Leu-enkephalins compete with and mimic the
effects of opiate drugs. They play a role in a number of
physiologic functions, including pain perception and responses to
stress. PENK(114-133) and PENK(238-259) increase glutamate release
in the striatum. PENK(114-133) decreases GABA concentration in the
striatum.
-!- SUBCELLULAR LOCATION: Secreted.
-!- PTM: The N-terminal domain contains 6 conserved cysteines thought
to be involved in disulfide bonding and/or processing.
-!- SIMILARITY: Belongs to the opioid neuropeptide precursor family.
{ECO:0000305}.
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EMBL; U09941; AAA63650.1; -; Genomic_DNA.
EMBL; S74095; AAB32115.1; -; mRNA.
PIR; I53029; I53029.
HOVERGEN; HBG000063; -.
Proteomes; UP000189706; Genome assembly.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0001515; F:opioid peptide activity; IEA:UniProtKB-KW.
GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
InterPro; IPR006024; Opioid_neupept.
InterPro; IPR000703; Proenkphlin_A.
PANTHER; PTHR11438; PTHR11438; 1.
PANTHER; PTHR11438:SF3; PTHR11438:SF3; 1.
Pfam; PF01160; Opiods_neuropep; 1.
PRINTS; PR01028; OPIOIDPRCRSR.
PRINTS; PR01029; PENKAPRCRSR.
PROSITE; PS01252; OPIOIDS_PRECURSOR; 1.
2: Evidence at transcript level;
Cleavage on pair of basic residues; Complete proteome; Disulfide bond;
Endorphin; Neuropeptide; Opioid peptide; Phosphoprotein;
Reference proteome; Secreted; Signal.
SIGNAL 1 24 {ECO:0000255}.
PEPTIDE 25 97 Synenkephalin.
/FTId=PRO_0000008255.
PEPTIDE 100 104 Met-enkephalin.
/FTId=PRO_0000008256.
PEPTIDE 107 111 Met-enkephalin.
/FTId=PRO_0000008257.
PEPTIDE 114 133 PENK(114-133). {ECO:0000250}.
/FTId=PRO_0000377688.
PEPTIDE 136 140 Met-enkephalin.
/FTId=PRO_0000008259.
PEPTIDE 143 184 PENK(143-184). {ECO:0000250}.
/FTId=PRO_0000377689.
PEPTIDE 187 194 Met-enkephalin-Arg-Gly-Leu.
/FTId=PRO_0000008261.
PROPEP 197 208
/FTId=PRO_0000008262.
PEPTIDE 211 215 Met-enkephalin.
/FTId=PRO_0000008263.
PROPEP 218 228
/FTId=PRO_0000008264.
PEPTIDE 231 235 Leu-enkephalin.
/FTId=PRO_0000008265.
PEPTIDE 238 259 PENK(238-259). {ECO:0000250}.
/FTId=PRO_0000377690.
PEPTIDE 262 268 Met-enkephalin-Arg-Phe.
/FTId=PRO_0000008267.
MOD_RES 252 252 Phosphoserine.
{ECO:0000250|UniProtKB:P04094}.
DISULFID 26 48 {ECO:0000250|UniProtKB:P01210}.
DISULFID 30 52 {ECO:0000250|UniProtKB:P01210}.
DISULFID 33 65 {ECO:0000250|UniProtKB:P01210}.
CONFLICT 78 78 C -> W (in Ref. 2; AAB32115).
{ECO:0000305}.
SEQUENCE 268 AA; 30733 MW; 9670D1DEEA936725 CRC64;
MARFLRLCTW LLVLGSCLLA TVQAECSQDC AKCSYHLVSP GDINFLACTL ECEGQMPSHK
IWETCKDLLQ VSKPEFPCDS INMFKDSNKQ DESHLLAKKY GGFMKRYGGF MKKMDELYPV
EPEEEANGGE ILAKKYGGFM KKDADEGDTL ANSSDLLKEL LGTGDNRARE GRHQESTDND
DNMSKRYGGF MRGLKRSPQV EDEAKELQKR YGGFMRRVGR PEWWMDYQKR YGGFLKRFAE
SLPSDEEAES YSKEVPEIEK RYGGFMRF


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