Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Proenkephalin-A [Cleaved into: Synenkephalin; Met-enkephalin (Opioid growth factor) (OGF); PENK(114-133); PENK(143-185); Met-enkephalin-Arg-Gly-Leu; Leu-enkephalin; PENK(239-260); Met-enkephalin-Arg-Phe]

 PENK_RAT                Reviewed;         269 AA.
P04094; Q53X05;
01-NOV-1986, integrated into UniProtKB/Swiss-Prot.
01-NOV-1986, sequence version 1.
05-JUL-2017, entry version 121.
RecName: Full=Proenkephalin-A;
Contains:
RecName: Full=Synenkephalin;
Contains:
RecName: Full=Met-enkephalin;
AltName: Full=Opioid growth factor;
Short=OGF;
Contains:
RecName: Full=PENK(114-133);
Contains:
RecName: Full=PENK(143-185);
Contains:
RecName: Full=Met-enkephalin-Arg-Gly-Leu;
Contains:
RecName: Full=Leu-enkephalin;
Contains:
RecName: Full=PENK(239-260);
Contains:
RecName: Full=Met-enkephalin-Arg-Phe;
Flags: Precursor;
Name=Penk; Synonyms=Penk-rs, Penk1;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Fischer 344; TISSUE=Brain;
PubMed=6548748;
Yoshikawa K., Williams C., Sabol S.L.;
"Rat brain preproenkephalin mRNA. cDNA cloning, primary structure, and
distribution in the central nervous system.";
J. Biol. Chem. 259:14301-14308(1984).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Fischer 344;
PubMed=6094550;
Rosen H., Douglass J., Herbert E.;
"Isolation and characterization of the rat proenkephalin gene.";
J. Biol. Chem. 259:14309-14313(1984).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Fischer 344; TISSUE=Brain;
PubMed=6594709; DOI=10.1073/pnas.81.23.7651;
Howells R.D., Kilpatrick D.L., Bhatt R., Monahan J.J., Poonian M.,
Udenfriend S.;
"Molecular cloning and sequence determination of rat preproenkephalin
cDNA: sensitive probe for studying transcriptional changes in rat
tissues.";
Proc. Natl. Acad. Sci. U.S.A. 81:7651-7655(1984).
[4]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
PubMed=3093884;
Howells R.D.;
"Proenkephalin biosynthesis in the rat.";
NIDA Res. Monogr. 70:43-65(1986).
[5]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Wistar; TISSUE=Testis;
PubMed=2707437; DOI=10.1016/0014-5793(89)80281-9;
Yoshikawa K., Maruyama K., Aizawa T., Yamamoto A.;
"A new species of enkephalin precursor mRNA with a distinct 5'-
untranslated region in haploid germ cells.";
FEBS Lett. 246:193-196(1989).
[6]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Heart;
PubMed=1438982; DOI=10.1016/0167-0115(92)90526-Z;
Rao S.M., Howells R.D.;
"Molecular cloning, sequence analysis and translation of proenkephalin
mRNA from rat heart.";
Regul. Pept. 40:397-408(1992).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Testis;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[8]
PROTEIN SEQUENCE OF 114-133; 143-185 AND 239-260, FUNCTION, AND MASS
SPECTROMETRY.
STRAIN=Wistar; TISSUE=Corpus striatum;
PubMed=19164277; DOI=10.1074/mcp.M800501-MCP200;
Bernay B., Gaillard M.-C., Guryca V., Emadali A., Kuhn L.,
Bertrand A., Detraz I., Carcenac C., Savasta M., Brouillet E.,
Garin J., Elalouf J.-M.;
"Discovering new bioactive neuropeptides in the striatum secretome
using in vivo microdialysis and versatile proteomics.";
Mol. Cell. Proteomics 8:946-958(2009).
[9]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-253, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: Met- and Leu-enkephalins compete with and mimic the
effects of opiate drugs. They play a role in a number of
physiologic functions, including pain perception and responses to
stress. PENK(114-133) and PENK(239-260) increase glutamate release
in the striatum. PENK(114-133) decreases GABA concentration in the
striatum. {ECO:0000269|PubMed:19164277}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Expressed in brain, heart and testis.
-!- PTM: The N-terminal domain contains 6 conserved cysteines thought
to be involved in disulfide bonding and/or processing.
-!- MASS SPECTROMETRY: Mass=2203.971; Method=Electrospray; Range=114-
133; Evidence={ECO:0000269|PubMed:19164277};
-!- MASS SPECTROMETRY: Mass=4592.8; Method=Electrospray; Range=143-
185; Evidence={ECO:0000269|PubMed:19164277};
-!- MASS SPECTROMETRY: Mass=2504.027; Method=Electrospray; Range=239-
260; Evidence={ECO:0000269|PubMed:19164277};
-!- SIMILARITY: Belongs to the opioid neuropeptide precursor family.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; K02807; AAA60734.1; -; Genomic_DNA.
EMBL; M28263; AAA41115.1; -; mRNA.
EMBL; Y07503; CAA68804.1; -; mRNA.
EMBL; S49491; AAB24022.1; -; mRNA.
EMBL; BC083563; AAH83563.1; -; mRNA.
PIR; A92464; EQRTA.
RefSeq; NP_058835.1; NM_017139.1.
RefSeq; XP_006237897.1; XM_006237835.1.
UniGene; Rn.10015; -.
STRING; 10116.ENSRNOP00000011892; -.
iPTMnet; P04094; -.
PhosphoSitePlus; P04094; -.
PaxDb; P04094; -.
Ensembl; ENSRNOT00000011892; ENSRNOP00000011892; ENSRNOG00000008943.
Ensembl; ENSRNOT00000089318; ENSRNOP00000074581; ENSRNOG00000008943.
GeneID; 29237; -.
KEGG; rno:29237; -.
UCSC; RGD:68946; rat.
CTD; 5179; -.
RGD; 68946; Penk.
eggNOG; ENOG410IJUY; Eukaryota.
eggNOG; ENOG4110ZYD; LUCA.
GeneTree; ENSGT00530000063761; -.
HOGENOM; HOG000013003; -.
HOVERGEN; HBG000063; -.
InParanoid; P04094; -.
KO; K18832; -.
OMA; GFMKKMD; -.
OrthoDB; EOG091G0HV8; -.
PhylomeDB; P04094; -.
TreeFam; TF332620; -.
Reactome; R-RNO-375276; Peptide ligand-binding receptors.
Reactome; R-RNO-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
Reactome; R-RNO-418594; G alpha (i) signalling events.
Reactome; R-RNO-8957275; Post-translational protein phosphorylation.
PMAP-CutDB; P04094; -.
PRO; PR:P04094; -.
Proteomes; UP000002494; Chromosome 5.
Bgee; ENSRNOG00000008943; -.
Genevisible; P04094; RN.
GO; GO:0030424; C:axon; IDA:RGD.
GO; GO:0043679; C:axon terminus; IDA:RGD.
GO; GO:0070852; C:cell body fiber; IDA:RGD.
GO; GO:0030425; C:dendrite; IDA:RGD.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0043025; C:neuronal cell body; IDA:RGD.
GO; GO:0043204; C:perikaryon; IDA:RGD.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0032280; C:symmetric synapse; IDA:RGD.
GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
GO; GO:0001515; F:opioid peptide activity; IEA:UniProtKB-KW.
GO; GO:0031628; F:opioid receptor binding; IBA:GO_Central.
GO; GO:0002118; P:aggressive behavior; IEA:Ensembl.
GO; GO:0007568; P:aging; IEP:RGD.
GO; GO:0001662; P:behavioral fear response; IEA:Ensembl.
GO; GO:0071320; P:cellular response to cAMP; IEP:RGD.
GO; GO:0034599; P:cellular response to oxidative stress; IEP:RGD.
GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEP:RGD.
GO; GO:0098586; P:cellular response to virus; IEP:RGD.
GO; GO:0071305; P:cellular response to vitamin D; IEP:RGD.
GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
GO; GO:0051867; P:general adaptation syndrome, behavioral process; IEP:RGD.
GO; GO:0014009; P:glial cell proliferation; IEP:RGD.
GO; GO:0035641; P:locomotory exploration behavior; IMP:RGD.
GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
GO; GO:0001649; P:osteoblast differentiation; IEP:RGD.
GO; GO:2000987; P:positive regulation of behavioral fear response; IMP:RGD.
GO; GO:0051592; P:response to calcium ion; IEP:RGD.
GO; GO:0071871; P:response to epinephrine; IEP:RGD.
GO; GO:0032355; P:response to estradiol; IEP:RGD.
GO; GO:0045471; P:response to ethanol; IEP:RGD.
GO; GO:0001666; P:response to hypoxia; IEP:RGD.
GO; GO:0032496; P:response to lipopolysaccharide; IEP:RGD.
GO; GO:0043278; P:response to morphine; IEP:RGD.
GO; GO:0035094; P:response to nicotine; IEP:RGD.
GO; GO:0009314; P:response to radiation; IEP:RGD.
GO; GO:0009636; P:response to toxic substance; IEP:RGD.
GO; GO:0007600; P:sensory perception; IBA:GO_Central.
GO; GO:0019233; P:sensory perception of pain; IEA:Ensembl.
GO; GO:0001964; P:startle response; IEA:Ensembl.
InterPro; IPR006024; Opioid_neupept.
InterPro; IPR000703; Proenkphlin_A.
PANTHER; PTHR11438; PTHR11438; 1.
PANTHER; PTHR11438:SF7; PTHR11438:SF7; 1.
Pfam; PF01160; Opiods_neuropep; 1.
PRINTS; PR01028; OPIOIDPRCRSR.
PRINTS; PR01029; PENKAPRCRSR.
PROSITE; PS01252; OPIOIDS_PRECURSOR; 1.
1: Evidence at protein level;
Cleavage on pair of basic residues; Complete proteome;
Direct protein sequencing; Disulfide bond; Endorphin; Neuropeptide;
Opioid peptide; Phosphoprotein; Reference proteome; Secreted; Signal.
SIGNAL 1 24 {ECO:0000255}.
PEPTIDE 25 97 Synenkephalin.
/FTId=PRO_0000008281.
PEPTIDE 100 104 Met-enkephalin.
/FTId=PRO_0000008282.
PEPTIDE 107 111 Met-enkephalin.
/FTId=PRO_0000008283.
PEPTIDE 114 133 PENK(114-133).
/FTId=PRO_0000008284.
PEPTIDE 136 140 Met-enkephalin.
/FTId=PRO_0000008285.
PEPTIDE 143 185 PENK(143-185).
/FTId=PRO_0000008286.
PEPTIDE 188 195 Met-enkephalin-Arg-Gly-Leu.
/FTId=PRO_0000008287.
PROPEP 198 209
/FTId=PRO_0000008288.
PEPTIDE 212 216 Met-enkephalin.
/FTId=PRO_0000008289.
PROPEP 219 229
/FTId=PRO_0000008290.
PEPTIDE 232 236 Leu-enkephalin.
/FTId=PRO_0000008291.
PEPTIDE 239 260 PENK(239-260).
/FTId=PRO_0000008292.
PEPTIDE 263 269 Met-enkephalin-Arg-Phe.
/FTId=PRO_0000008293.
MOD_RES 253 253 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
DISULFID 26 48 {ECO:0000250|UniProtKB:P01210}.
DISULFID 30 52 {ECO:0000250|UniProtKB:P01210}.
DISULFID 33 65 {ECO:0000250|UniProtKB:P01210}.
CONFLICT 12 12 L -> V (in Ref. 2; AAA60734 and 5;
CAA68804). {ECO:0000305}.
SEQUENCE 269 AA; 30932 MW; 2BF0EA81A1D59692 CRC64;
MAQFLRLCIW LLALGSCLLA TVQADCSQDC AKCSYRLVRP GDINFLACTL ECEGQLPSFK
IWETCKDLLQ VSKPEFPWDN IDMYKDSSKQ DESHLLAKKY GGFMKRYGGF MKKMDELYPV
EPEEEANGGE ILAKRYGGFM KKDADEGDTL ANSSDLLKEL LGTGDNRAKD SHQQESTNND
EDSTSKRYGG FMRGLKRSPQ LEDEAKELQK RYGGFMRRVG RPEWWMDYQK RYGGFLKRFA
ESLPSDEEGE SYSKEVPEME KRYGGFMRF


Related products :

Catalog number Product name Quantity
'BP5044 Proenkephalin-A (PENK) (Met-enkephalin) antibody Ab host: Rabbit 50 Вµl
'BP5044 Proenkephalin-A (PENK) (Met-enkephalin) antibody Host rabbit 50
EIAAB30551 Penk,Penk1,Penk-rs,Proenkephalin-A,Rat,Rattus norvegicus
DL-PENK-Mu Mouse Proenkephalin (PENK) ELISA Kit 96T
DL-PENK-Hu Human Proenkephalin (PENK) ELISA Kit 96T
18-783-76520 RABBIT ANTI HUMAN CARBOXYPEPTIDASE H (MATURE N-TERMINAL) - ENKEPHALIN CONVERTASE; EC 3.4.17.10; CPE; Carboxypeptidase H; CPH; Enkephalin convertase; Prohormone-processing carboxypeptidase Polyclonal 0.1 ml
18-783-76521 RABBIT ANTI HUMAN CARBOXYPEPTIDASE H (C-TERMINAL) - ENKEPHALIN CONVERTASE; EC 3.4.17.10; CPE; Carboxypeptidase H; CPH; Enkephalin convertase; Prohormone-processing carboxypeptidase Polyclonal 0.1 ml
orb70808 Leu-Enkephalin peptide This is Leu-Enkephalin peptide. For research use only. 1 mg
orb70860 [Met]-Enkephalin peptide This is [Met]-Enkephalin peptide. For research use only. 1 mg
orb70861 [Met]-Enkephalin peptide This is [Met]-Enkephalin peptide. For research use only. 1 mg
orb70807 Leu-Enkephalin peptide This is Leu-Enkephalin peptide. For research use only. 1 mg
E-0701-20 Met-Enkephalin-Arg-Gly-Leu Proenkephalin, MERGL 98 percent C41H61N11O10S CAS: 80501-44-6 5mg
UB-E10524 Rat Proenkephalin(PENK)ELISA kit 96T
PEPC PENK Gene proenkephalin
201-11-1121 Rat Proenkephalin (PENK)ELISA kit 96T
G1562 Proenkephalin(PENK), Cat, ELISA Kit 96T
E93396Mu ELISA Kit for Proenkephalin (PENK) 96T/Kit
CSB-EL017781RA Rat proenkephalin (PENK) ELISA kit 96T
201-20-4149 PENK{proenkephalin}rabbit.pAb 0.2ml
CSB-EL017781CA Cat proenkephalin (PENK) ELISA kit 96T
G1565 Proenkephalin(PENK), Rat, ELISA Kit 96T
201-11-1121 Rat Proenkephalin(PENK)ELISA kit 96T
QY-E10524 Rat Proenkephalin(PENK)ELISA kit 96T
E13812176 Proenkephalin (PENK) ELISA Kit 1
orb70097 [D-Ala2]-Leu-Enkephalin peptide This is [D-Ala2]-Leu-Enkephalin peptide. For research use only. 1 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur