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Proenkephalin-B (Beta-neoendorphin-dynorphin) (Preprodynorphin) [Cleaved into: Alpha-neoendorphin; Beta-neoendorphin; Big dynorphin (Big Dyn); Dynorphin A(1-17) (Dyn-A17) (Dynorphin A); Dynorphin A(1-13); Dynorphin A(1-8); Leu-enkephalin; Rimorphin (Dynorphin B) (Dyn-B) (Dynorphin B(1-13)); Leumorphin (Dynorphin B-29)]

 PDYN_PIG                Reviewed;         256 AA.
P01214;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
21-JUL-1986, sequence version 1.
25-OCT-2017, entry version 89.
RecName: Full=Proenkephalin-B;
AltName: Full=Beta-neoendorphin-dynorphin;
AltName: Full=Preprodynorphin;
Contains:
RecName: Full=Alpha-neoendorphin;
Contains:
RecName: Full=Beta-neoendorphin;
Contains:
RecName: Full=Big dynorphin;
Short=Big Dyn;
Contains:
RecName: Full=Dynorphin A(1-17);
Short=Dyn-A17;
Short=Dynorphin A;
Contains:
RecName: Full=Dynorphin A(1-13);
Contains:
RecName: Full=Dynorphin A(1-8);
Contains:
RecName: Full=Leu-enkephalin;
Contains:
RecName: Full=Rimorphin;
AltName: Full=Dynorphin B;
Short=Dyn-B;
AltName: Full=Dynorphin B(1-13);
Contains:
RecName: Full=Leumorphin;
AltName: Full=Dynorphin B-29;
Flags: Precursor;
Name=PDYN;
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
Sus.
NCBI_TaxID=9823;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Hypothalamus;
PubMed=6123953; DOI=10.1038/298245a0;
Kakidani H., Furutani Y., Takahashi H., Noda M., Morimoto Y.,
Hirose T., Asai M., Inayama S., Nakanishi S., Numa S.;
"Cloning and sequence analysis of cDNA for porcine beta-neo-
endorphin/dynorphin precursor.";
Nature 298:245-249(1982).
[2]
PROTEIN SEQUENCE OF 209-221, IDENTIFICATION, AND CHARACTERIZATION OF
DYNORPHIN A(1-13).
PubMed=230519; DOI=10.1073/pnas.76.12.6666;
Goldstein A., Tachibana S., Lowney L.I., Hunkapiller M., Hood L.;
"Dynorphin-(1-13), an extraordinarily potent opioid peptide.";
Proc. Natl. Acad. Sci. U.S.A. 76:6666-6670(1979).
[3]
PROTEIN SEQUENCE OF 209-216, AND IDENTIFICATION OF DYNORPHIN A(1-8).
TISSUE=Hypothalamus;
PubMed=7191256; DOI=10.1016/S0006-291X(80)80063-5;
Minamino N., Kangawa K., Fukuda A., Matsuo H., Iagarashi M.;
"A new opioid octapeptide related to dynorphin from porcine
hypothalamus.";
Biochem. Biophys. Res. Commun. 95:1475-1481(1980).
[4]
IDENTIFICATION OF LEUMORPHIN AND RIMORPHIN.
PubMed=6689399; DOI=10.1016/0006-291X(83)91653-4;
Nakao K., Suda M., Sakamoto M., Yoshimasa T., Morii N., Ikeda Y.,
Yanaihara C., Yanaihara N., Numa S., Imura H.;
"Leumorphin is a novel endogenous opioid peptide derived from
preproenkephalin B.";
Biochem. Biophys. Res. Commun. 117:695-701(1983).
-!- FUNCTION: Leu-enkephalins compete with and mimic the effects of
opiate drugs. They play a role in a number of physiologic
functions, including pain perception and responses to stress (By
similarity). {ECO:0000250}.
-!- FUNCTION: Dynorphin peptides differentially regulate the kappa
opioid receptor. Dynorphin A(1-13) has a typical opiod activity,
it is 700 times more potent than Leu-enkephalin.
-!- FUNCTION: Leumorphin has a typical opiod activity and may have
anti-apoptotic effect. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- PTM: The N-terminal domain contains 6 conserved cysteines thought
to be involved in disulfide bonding and/or processing.
-!- SIMILARITY: Belongs to the opioid neuropeptide precursor family.
{ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; V01362; CAA24650.1; -; mRNA.
PIR; A93280; DFPG.
RefSeq; NP_001004040.1; NM_001004040.1.
UniGene; Ssc.121; -.
UniGene; Ssc.87911; -.
STRING; 9823.ENSSSCP00000007643; -.
PaxDb; P01214; -.
PRIDE; P01214; -.
GeneID; 445529; -.
KEGG; ssc:445529; -.
CTD; 5173; -.
eggNOG; ENOG410IIMD; Eukaryota.
eggNOG; ENOG4111RTT; LUCA.
HOGENOM; HOG000013003; -.
HOVERGEN; HBG000063; -.
InParanoid; P01214; -.
KO; K15840; -.
Proteomes; UP000008227; Unplaced.
GO; GO:0043679; C:axon terminus; IBA:GO_Central.
GO; GO:0030425; C:dendrite; IBA:GO_Central.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0043025; C:neuronal cell body; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
GO; GO:0001515; F:opioid peptide activity; IEA:UniProtKB-KW.
GO; GO:0031628; F:opioid receptor binding; IBA:GO_Central.
GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
GO; GO:0007600; P:sensory perception; IBA:GO_Central.
InterPro; IPR006024; Opioid_neupept.
InterPro; IPR000750; Proenkphlin_B.
PANTHER; PTHR11438; PTHR11438; 1.
PANTHER; PTHR11438:SF4; PTHR11438:SF4; 1.
Pfam; PF01160; Opiods_neuropep; 1.
PRINTS; PR01028; OPIOIDPRCRSR.
PRINTS; PR01030; PENKBPRCRSR.
PROSITE; PS01252; OPIOIDS_PRECURSOR; 1.
1: Evidence at protein level;
Cleavage on pair of basic residues; Complete proteome;
Direct protein sequencing; Disulfide bond; Endorphin; Neuropeptide;
Neurotransmitter; Opioid peptide; Reference proteome; Secreted;
Signal.
SIGNAL 1 20 {ECO:0000255}.
PROPEP 21 172
/FTId=PRO_0000008191.
PEPTIDE 175 184 Alpha-neoendorphin. {ECO:0000250}.
/FTId=PRO_0000306358.
PEPTIDE 175 183 Beta-neoendorphin.
/FTId=PRO_0000008192.
PEPTIDE 175 179 Leu-enkephalin. {ECO:0000250}.
/FTId=PRO_0000306359.
PROPEP 186 206
/FTId=PRO_0000008193.
PEPTIDE 209 240 Big dynorphin. {ECO:0000250}.
/FTId=PRO_0000306360.
PEPTIDE 209 225 Dynorphin A(1-17).
/FTId=PRO_0000306361.
PEPTIDE 209 221 Dynorphin A(1-13).
/FTId=PRO_0000306362.
PEPTIDE 209 216 Dynorphin A(1-8).
/FTId=PRO_0000306363.
PEPTIDE 209 213 Leu-enkephalin. {ECO:0000250}.
/FTId=PRO_0000306364.
PEPTIDE 228 256 Leumorphin.
/FTId=PRO_0000008195.
PEPTIDE 228 240 Rimorphin.
/FTId=PRO_0000008196.
PEPTIDE 228 232 Leu-enkephalin.
/FTId=PRO_0000008197.
VARIANT 147 147 G -> E.
VARIANT 197 197 R -> G.
SEQUENCE 256 AA; 28617 MW; 6814412E3A8DB3AE CRC64;
MAWQGLLLAA CLLVLPSTMA DCLSGCSLCA VKTQDGPKPI NPLICSLECQ AALQPAEEWE
RCQGLLSFLA PLSLGLEGKE DLESKAALEE PSSELVKYMG PFLKELEKNR FLLSTPAEET
SLSRSLVEKL RSLPGRLGEE TESELMGDAQ QNDGAMEAAA LDSSVEDPKE QVKRYGGFLR
KYPKRSSEVA GEGDGDRDKV GHEDLYKRYG GFLRRIRPKL KWDNQKRYGG FLRRQFKVVT
RSQEDPNAYY EELFDV


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