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Proenkephalin-B (Beta-neoendorphin-dynorphin) (Preprodynorphin) [Cleaved into: Alpha-neoendorphin; Beta-neoendorphin; Big dynorphin (Big Dyn); Dynorphin A(1-17) (Dyn-A17) (Dynorphin A); Dynorphin A(1-13); Dynorphin A(1-8); Leu-enkephalin; Rimorphin (Dynorphin B) (Dyn-B) (Dynorphin B(1-13)); Leumorphin (Dynorphin B-29)]

 PDYN_BOVIN              Reviewed;         258 AA.
Q95104;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-FEB-1997, sequence version 1.
25-OCT-2017, entry version 88.
RecName: Full=Proenkephalin-B;
AltName: Full=Beta-neoendorphin-dynorphin;
AltName: Full=Preprodynorphin;
Contains:
RecName: Full=Alpha-neoendorphin;
Contains:
RecName: Full=Beta-neoendorphin;
Contains:
RecName: Full=Big dynorphin;
Short=Big Dyn;
Contains:
RecName: Full=Dynorphin A(1-17);
Short=Dyn-A17;
Short=Dynorphin A;
Contains:
RecName: Full=Dynorphin A(1-13);
Contains:
RecName: Full=Dynorphin A(1-8);
Contains:
RecName: Full=Leu-enkephalin;
Contains:
RecName: Full=Rimorphin;
AltName: Full=Dynorphin B;
Short=Dyn-B;
AltName: Full=Dynorphin B(1-13);
Contains:
RecName: Full=Leumorphin;
AltName: Full=Dynorphin B-29;
Flags: Precursor;
Name=PDYN;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
PubMed=9074507; DOI=10.1016/S0378-1119(96)00721-4;
Jiang H., Weesner G.D., Malven P.V.;
"cDNA sequence and expression of bovine prodynorphin.";
Gene 186:279-283(1997).
-!- FUNCTION: Leu-enkephalins compete with and mimic the effects of
opiate drugs. They play a role in a number of physiologic
functions, including pain perception and responses to stress (By
similarity). {ECO:0000250}.
-!- FUNCTION: Dynorphin peptides differentially regulate the kappa
opioid receptor. Dynorphin A(1-13) has a typical opiod activity,
it is 700 times more potent than Leu-enkephalin (By similarity).
{ECO:0000250}.
-!- FUNCTION: Leumorphin has a typical opiod activity and may have
anti-apoptotic effect. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- PTM: The N-terminal domain contains 6 conserved cysteines thought
to be involved in disulfide bonding and/or processing.
-!- SIMILARITY: Belongs to the opioid neuropeptide precursor family.
{ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; U58500; AAC48706.1; -; mRNA.
PIR; JC6318; JC6318.
RefSeq; NP_776564.1; NM_174139.2.
UniGene; Bt.124; -.
ProteinModelPortal; Q95104; -.
STRING; 9913.ENSBTAP00000055430; -.
PaxDb; Q95104; -.
GeneID; 281385; -.
KEGG; bta:281385; -.
CTD; 5173; -.
eggNOG; ENOG410IIMD; Eukaryota.
eggNOG; ENOG4111RTT; LUCA.
HOGENOM; HOG000013003; -.
HOVERGEN; HBG000063; -.
InParanoid; Q95104; -.
KO; K15840; -.
Proteomes; UP000009136; Unplaced.
GO; GO:0043679; C:axon terminus; IBA:GO_Central.
GO; GO:0030425; C:dendrite; IBA:GO_Central.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0043025; C:neuronal cell body; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
GO; GO:0001515; F:opioid peptide activity; IEA:UniProtKB-KW.
GO; GO:0031628; F:opioid receptor binding; IBA:GO_Central.
GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
GO; GO:0007600; P:sensory perception; IBA:GO_Central.
InterPro; IPR006024; Opioid_neupept.
InterPro; IPR000750; Proenkphlin_B.
PANTHER; PTHR11438; PTHR11438; 1.
PANTHER; PTHR11438:SF4; PTHR11438:SF4; 1.
Pfam; PF01160; Opiods_neuropep; 1.
PRINTS; PR01028; OPIOIDPRCRSR.
PRINTS; PR01030; PENKBPRCRSR.
PROSITE; PS01252; OPIOIDS_PRECURSOR; 1.
2: Evidence at transcript level;
Cleavage on pair of basic residues; Complete proteome; Disulfide bond;
Endorphin; Neuropeptide; Neurotransmitter; Opioid peptide;
Reference proteome; Secreted; Signal.
SIGNAL 1 20 {ECO:0000255}.
PROPEP 21 172
/FTId=PRO_0000008162.
PEPTIDE 175 184 Alpha-neoendorphin. {ECO:0000250}.
/FTId=PRO_0000306335.
PEPTIDE 175 183 Beta-neoendorphin.
/FTId=PRO_0000008163.
PEPTIDE 175 179 Leu-enkephalin. {ECO:0000250}.
/FTId=PRO_0000306336.
PROPEP 186 208
/FTId=PRO_0000008164.
PEPTIDE 211 242 Big dynorphin. {ECO:0000250}.
/FTId=PRO_0000306337.
PEPTIDE 211 227 Dynorphin A(1-17).
/FTId=PRO_0000008165.
PEPTIDE 211 223 Dynorphin A(1-13). {ECO:0000250}.
/FTId=PRO_0000306338.
PEPTIDE 211 218 Dynorphin A(1-8). {ECO:0000250}.
/FTId=PRO_0000306339.
PEPTIDE 211 215 Leu-enkephalin. {ECO:0000250}.
/FTId=PRO_0000306340.
PEPTIDE 230 258 Leumorphin. {ECO:0000250}.
/FTId=PRO_0000008166.
PEPTIDE 230 242 Rimorphin. {ECO:0000250}.
/FTId=PRO_0000008167.
PEPTIDE 230 234 Leu-enkephalin.
/FTId=PRO_0000008168.
SEQUENCE 258 AA; 28790 MW; AA51C34022F18046 CRC64;
MVWQGLVLAA CLLALPSVTA DCLAQCSLCA VKTQDGPQPI NPLVCSLECQ AALQPAQEWE
RCQGLLSFLT PFTVGLNGKE DLKSKTVLEE SSSEPAKHIR PYLKELEKNR FLLSTPAEKN
ALSSSLVEKL RGLSGRLGED AESELMGDAQ LNDGALEAEA RDSNEEEPKE QVKRYGGFLR
KYPKRSSEVT GKEAGEGEGG EVGHEDLYKR YGGFLRRIRP KLKWDNQKRY GGFLRRQFKV
VTRSQEDPSA YYEELFDV


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