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Progonadoliberin IIB [Cleaved into: Gonadoliberin II (Gonadotropin-releasing hormone II) (GnRH II) (Luliberin II) (Luteinizing hormone-releasing hormone II) (LH-RH II); GnRH-associated peptide IIB]

 GON2B_CARAU             Reviewed;          86 AA.
O42471;
15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
01-JAN-1998, sequence version 1.
10-MAY-2017, entry version 59.
RecName: Full=Progonadoliberin IIB;
Contains:
RecName: Full=Gonadoliberin II;
AltName: Full=Gonadotropin-releasing hormone II;
Short=GnRH II;
AltName: Full=Luliberin II;
AltName: Full=Luteinizing hormone-releasing hormone II;
Short=LH-RH II;
Contains:
RecName: Full=GnRH-associated peptide IIB;
Flags: Precursor;
Name=gnrh2b;
Carassius auratus (Goldfish).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Carassius.
NCBI_TaxID=7957;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
STRAIN=Comet, and Common; TISSUE=Liver;
PubMed=9289408; DOI=10.1006/gcen.1997.6920;
Lin X.-W., Peter R.E.;
"Cloning and expression pattern of a second
[His5Trp7Tyr8]gonadotropin-releasing hormone (chicken GnRH-H-II) mRNA
in goldfish: evidence for two distinct genes.";
Gen. Comp. Endocrinol. 107:262-272(1997).
-!- FUNCTION: Stimulates the secretion of gonadotropins.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Olfactory bulbs, hypothalamus and
telencephalon, midbrain and posterior brain areas.
{ECO:0000269|PubMed:9289408}.
-!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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EMBL; U40567; AAB86989.1; -; mRNA.
EMBL; U40665; AAB86990.1; -; Genomic_DNA.
HOVERGEN; HBG014746; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
GO; GO:0007275; P:multicellular organism development; IEA:InterPro.
InterPro; IPR002012; GnRH.
InterPro; IPR019792; Gonadoliberin_I.
PANTHER; PTHR10522; PTHR10522; 1.
Pfam; PF00446; GnRH; 1.
PROSITE; PS00473; GNRH; 1.
2: Evidence at transcript level;
Amidation; Cleavage on pair of basic residues; Hormone;
Pyrrolidone carboxylic acid; Secreted; Signal.
SIGNAL 1 24 {ECO:0000250}.
CHAIN 25 86 Progonadoliberin IIB.
/FTId=PRO_0000012471.
PEPTIDE 25 34 Gonadoliberin II.
/FTId=PRO_0000012472.
PEPTIDE 38 86 GnRH-associated peptide IIB.
/FTId=PRO_0000012473.
MOD_RES 25 25 Pyrrolidone carboxylic acid.
{ECO:0000250}.
MOD_RES 34 34 Glycine amide. {ECO:0000250}.
SEQUENCE 86 AA; 9917 MW; AC1778CE75C1C313 CRC64;
MVHICRLFVV MGMLMFLSVQ FASSQHWSHG WYPGGKREID VYDPSEVSEE IKLCNAGKCS
FLIPQGRNIL KTILLDALTR DFQKRK


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