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Progonadoliberin-1 (Progonadoliberin I) [Cleaved into: Gonadoliberin-1 (Gonadoliberin I) (Gonadotropin-releasing hormone I) (GnRH-I) (Luliberin I) (Luteinizing hormone-releasing hormone I) (LH-RH I); Prolactin release-inhibiting factor 1 (Prolactin release-inhibiting factor I)]

 GON1_RAT                Reviewed;          92 AA.
P07490;
01-APR-1988, integrated into UniProtKB/Swiss-Prot.
01-APR-1988, sequence version 1.
23-MAY-2018, entry version 130.
RecName: Full=Progonadoliberin-1;
AltName: Full=Progonadoliberin I;
Contains:
RecName: Full=Gonadoliberin-1;
AltName: Full=Gonadoliberin I;
AltName: Full=Gonadotropin-releasing hormone I;
Short=GnRH-I;
AltName: Full=Luliberin I;
AltName: Full=Luteinizing hormone-releasing hormone I;
Short=LH-RH I;
Contains:
RecName: Full=Prolactin release-inhibiting factor 1;
AltName: Full=Prolactin release-inhibiting factor I;
Flags: Precursor;
Name=Gnrh1; Synonyms=Gnrh;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2867548; DOI=10.1073/pnas.83.1.179;
Adelman J.P., Mason A.J., Hayflick J.S., Seeburg P.H.;
"Isolation of the gene and hypothalamic cDNA for the common precursor
of gonadotropin-releasing hormone and prolactin release-inhibiting
factor in human and rat.";
Proc. Natl. Acad. Sci. U.S.A. 83:179-183(1986).
[2]
NUCLEOTIDE SEQUENCE.
PubMed=2476669; DOI=10.1210/mend-3-8-1257;
Bond C.T., Hayflick J.S., Seeburg P.H., Adelman J.P.;
"The rat gonadotropin-releasing hormone: SH locus: structure and
hypothalamic expression.";
Mol. Endocrinol. 3:1257-1262(1989).
[3]
NUCLEOTIDE SEQUENCE.
TISSUE=Thymus;
PubMed=1468115; DOI=10.1007/BF00711545;
Maier C.C., Marchetti B., Leboeuf R.D., Blalock J.E.;
"Thymocytes express a mRNA that is identical to hypothalamic
luteinizing hormone-releasing hormone mRNA.";
Cell. Mol. Neurobiol. 12:447-454(1992).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-47.
TISSUE=Heart;
PubMed=3547652; DOI=10.1126/science.3547652;
Adelman J.P., Bond C.T., Douglass J., Herbert E.;
"Two mammalian genes transcribed from opposite strands of the same DNA
locus.";
Science 235:1514-1517(1987).
-!- FUNCTION: Stimulates the secretion of gonadotropins; it stimulates
the secretion of both luteinizing and follicle-stimulating
hormones.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Central nervous system.
-!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; S50870; AAB24572.1; -; mRNA.
EMBL; M12579; AAA41263.1; -; mRNA.
EMBL; M31670; AAA41264.1; -; Genomic_DNA.
EMBL; M15527; AAA42141.1; ALT_SEQ; mRNA.
EMBL; M15529; AAA42139.1; -; mRNA.
EMBL; M15528; -; NOT_ANNOTATED_CDS; mRNA.
PIR; A40147; RHRTG.
RefSeq; NP_036899.1; NM_012767.2.
UniGene; Rn.159986; -.
UniGene; Rn.59459; -.
SMR; P07490; -.
STRING; 10116.ENSRNOP00000018006; -.
BindingDB; P07490; -.
PaxDb; P07490; -.
Ensembl; ENSRNOT00000018006; ENSRNOP00000018006; ENSRNOG00000013441.
GeneID; 25194; -.
KEGG; rno:25194; -.
UCSC; RGD:2720; rat.
CTD; 2796; -.
RGD; 2720; Gnrh1.
eggNOG; ENOG410J18B; Eukaryota.
eggNOG; ENOG410ZDKS; LUCA.
GeneTree; ENSGT00390000008225; -.
HOGENOM; HOG000033698; -.
HOVERGEN; HBG014746; -.
InParanoid; P07490; -.
KO; K05252; -.
OMA; EPQRFEC; -.
OrthoDB; EOG091G147V; -.
PhylomeDB; P07490; -.
TreeFam; TF330934; -.
Reactome; R-RNO-375281; Hormone ligand-binding receptors.
Reactome; R-RNO-416476; G alpha (q) signalling events.
PRO; PR:P07490; -.
Proteomes; UP000002494; Chromosome 15.
Bgee; ENSRNOG00000013441; -.
Genevisible; P07490; RN.
GO; GO:0043679; C:axon terminus; IDA:RGD.
GO; GO:0098556; C:cytoplasmic side of rough endoplasmic reticulum membrane; IDA:RGD.
GO; GO:0030425; C:dendrite; IDA:RGD.
GO; GO:0005615; C:extracellular space; IDA:RGD.
GO; GO:0005798; C:Golgi-associated vesicle; IDA:RGD.
GO; GO:0005739; C:mitochondrion; IDA:RGD.
GO; GO:0043005; C:neuron projection; IDA:RGD.
GO; GO:1990008; C:neurosecretory vesicle; IDA:RGD.
GO; GO:0043204; C:perikaryon; IDA:RGD.
GO; GO:0005183; F:gonadotropin hormone-releasing hormone activity; IDA:RGD.
GO; GO:0007568; P:aging; IEP:RGD.
GO; GO:0044849; P:estrous cycle; IEP:RGD.
GO; GO:0007565; P:female pregnancy; IEP:RGD.
GO; GO:0030238; P:male sex determination; IMP:RGD.
GO; GO:0043066; P:negative regulation of apoptotic process; IDA:RGD.
GO; GO:0033087; P:negative regulation of immature T cell proliferation; IMP:RGD.
GO; GO:2001223; P:negative regulation of neuron migration; IEA:Ensembl.
GO; GO:0030728; P:ovulation; TAS:RGD.
GO; GO:0042698; P:ovulation cycle; IEP:RGD.
GO; GO:0010468; P:regulation of gene expression; IEA:Ensembl.
GO; GO:2000354; P:regulation of ovarian follicle development; IEA:Ensembl.
GO; GO:0031960; P:response to corticosteroid; IEP:RGD.
GO; GO:0045471; P:response to ethanol; IEA:Ensembl.
GO; GO:0032496; P:response to lipopolysaccharide; IEP:RGD.
GO; GO:0014070; P:response to organic cyclic compound; IEP:RGD.
GO; GO:0043434; P:response to peptide hormone; IEP:RGD.
GO; GO:0035864; P:response to potassium ion; IEP:RGD.
GO; GO:1990637; P:response to prolactin; IEP:RGD.
GO; GO:0034695; P:response to prostaglandin E; IEP:RGD.
GO; GO:0033574; P:response to testosterone; IEP:RGD.
InterPro; IPR002012; GnRH.
InterPro; IPR019792; Gonadoliberin_I.
InterPro; IPR004079; Gonadoliberin_I_precursor.
PANTHER; PTHR10522; PTHR10522; 1.
PANTHER; PTHR10522:SF0; PTHR10522:SF0; 1.
Pfam; PF00446; GnRH; 1.
PRINTS; PR01541; GONADOLIBRNI.
PROSITE; PS00473; GNRH; 1.
2: Evidence at transcript level;
Amidation; Cleavage on pair of basic residues; Complete proteome;
Hormone; Pyrrolidone carboxylic acid; Reference proteome; Secreted;
Signal.
SIGNAL 1 23
CHAIN 24 92 Progonadoliberin-1.
/FTId=PRO_0000012410.
PEPTIDE 24 33 Gonadoliberin-1.
/FTId=PRO_0000012411.
PEPTIDE 37 92 Prolactin release-inhibiting factor 1.
/FTId=PRO_0000012412.
SITE 26 26 Appears to be essential for biological
activity.
MOD_RES 24 24 Pyrrolidone carboxylic acid.
{ECO:0000250|UniProtKB:P01148}.
MOD_RES 33 33 Glycine amide. {ECO:0000250}.
SEQUENCE 92 AA; 10500 MW; 494B5C64DA8A3EB3 CRC64;
METIPKLMAA VVLLTVCLEG CSSQHWSYGL RPGGKRNTEH LVDSFQEMGK EEDQMAEPQN
FECTVHWPRS PLRDLRGALE RLIEEEAGQK KM


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