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Progonadoliberin-3 (Progonadoliberin III) (Salmon-type gonadotropin-releasing hormone) (sGnRH) [Cleaved into: Gonadoliberin-3 (Gonadoliberin III) (Gonadotropin-releasing hormone III) (GnRH III) (Luliberin III) (Luteinizing hormone-releasing hormone III) (LH-RH III); GnRH-associated peptide 3 (GnRH-associated peptide III)]

 GON3_ORYLA              Reviewed;          90 AA.
Q9DD49; Q8JIQ3;
15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
01-MAR-2001, sequence version 1.
11-MAY-2016, entry version 66.
RecName: Full=Progonadoliberin-3;
AltName: Full=Progonadoliberin III;
AltName: Full=Salmon-type gonadotropin-releasing hormone;
Short=sGnRH;
Contains:
RecName: Full=Gonadoliberin-3;
AltName: Full=Gonadoliberin III;
AltName: Full=Gonadotropin-releasing hormone III;
Short=GnRH III;
AltName: Full=Luliberin III;
AltName: Full=Luteinizing hormone-releasing hormone III;
Short=LH-RH III;
Contains:
RecName: Full=GnRH-associated peptide 3;
AltName: Full=GnRH-associated peptide III;
Flags: Precursor;
Name=gnrh3;
Oryzias latipes (Japanese rice fish) (Japanese killifish).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae;
Oryziinae; Oryzias.
NCBI_TaxID=8090 {ECO:0000312|EMBL:BAB16302.1};
[1] {ECO:0000305}
NUCLEOTIDE SEQUENCE, AND TISSUE SPECIFICITY.
TISSUE=Brain {ECO:0000312|EMBL:BAB16301.1};
PubMed=11006121; DOI=10.1006/bbrc.2000.3476;
Okubo K., Amano M., Yoshiura Y., Suetake H., Aida K.;
"A novel form of gonadotropin-releasing hormone in the medaka, Oryzias
latipes.";
Biochem. Biophys. Res. Commun. 276:298-303(2000).
[2] {ECO:0000312|EMBL:BAC06425.1}
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Himedaka {ECO:0000269|PubMed:12137956}, and
HNI {ECO:0000312|EMBL:BAC06425.1};
PubMed=12137956; DOI=10.1016/S0378-1119(02)00724-2;
Okubo K., Mitani H., Naruse K., Kondo M., Shima A., Tanaka M.,
Asakawa S., Shimizu N., Yoshiura Y., Aida K.;
"Structural characterization of GnRH loci in the medaka genome.";
Gene 293:181-189(2002).
-!- FUNCTION: Stimulates the secretion of gonadotropins.
{ECO:0000250|UniProtKB:P45653, ECO:0000255|RuleBase:RU000635}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P45653}.
-!- TISSUE SPECIFICITY: Expressed in neuron cell bodies of the nucleus
olfactoretinalis. {ECO:0000269|PubMed:11006121}.
-!- MISCELLANEOUS: Teleost species possess three paralogous GnRHs:
mdGnRH and cGnRH-II have been identified in tetrapods; sGnRH has
no tetrapod ortholog and is thought to be a duplication of cGnRH-
II. {ECO:0000303|PubMed:12137956}.
-!- SIMILARITY: Belongs to the GnRH family.
{ECO:0000255|RuleBase:RU000635, ECO:0000305}.
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EMBL; AB041331; BAB16301.1; -; mRNA.
EMBL; AB041332; BAB16302.1; -; mRNA.
EMBL; AB041335; BAC06418.1; -; Genomic_DNA.
EMBL; AB074501; BAC06425.1; -; Genomic_DNA.
PIR; JC7395; JC7395.
RefSeq; NP_001098142.1; NM_001104672.1.
UniGene; Ola.148; -.
STRING; 8090.ENSORLP00000007327; -.
GeneID; 100049220; -.
KEGG; ola:100049220; -.
CTD; 360141; -.
eggNOG; ENOG410KFT9; Eukaryota.
eggNOG; ENOG4110T0V; LUCA.
HOGENOM; HOG000132479; -.
HOVERGEN; HBG081562; -.
InParanoid; Q9DD49; -.
KO; K05252; -.
Proteomes; UP000001038; Unplaced.
GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
GO; GO:0005183; F:gonadotropin hormone-releasing hormone activity; ISS:UniProtKB.
GO; GO:0007275; P:multicellular organism development; ISS:UniProtKB.
InterPro; IPR002012; GnRH.
InterPro; IPR019792; Gonadoliberin_I.
PANTHER; PTHR10522; PTHR10522; 1.
Pfam; PF00446; GnRH; 1.
PROSITE; PS00473; GNRH; 1.
2: Evidence at transcript level;
Amidation; Cleavage on pair of basic residues; Complete proteome;
Hormone; Pyrrolidone carboxylic acid; Reference proteome; Secreted;
Signal.
SIGNAL 1 23 {ECO:0000250}.
CHAIN 24 90 Progonadoliberin-3.
/FTId=PRO_0000012520.
PEPTIDE 24 33 Gonadoliberin-3.
/FTId=PRO_0000012521.
PEPTIDE 37 90 GnRH-associated peptide 3.
/FTId=PRO_0000012522.
MOD_RES 24 24 Pyrrolidone carboxylic acid.
{ECO:0000250}.
MOD_RES 33 33 Glycine amide. {ECO:0000250}.
CONFLICT 17 17 V -> M (in Ref. 2; BAC06425).
{ECO:0000305}.
SEQUENCE 90 AA; 10176 MW; AE0B3DC9047475B9 CRC64;
MDVSSKVVVQ VLLLALVVQV TLCQHWSYGW LPGGKRSVGE LEATIRMMGT GRVVSLPEDA
SAQTQERLRQ YNLINDGSTY FDRKKRFMSQ


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