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Prolactin (PRL)

 PRL_SHEEP               Reviewed;         229 AA.
P01240; Q28587;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
01-JUL-1989, sequence version 2.
10-MAY-2017, entry version 104.
RecName: Full=Prolactin;
Short=PRL;
Flags: Precursor;
Name=PRL;
Ovis aries (Sheep).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Ovis.
NCBI_TaxID=9940;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Pituitary;
PubMed=2911473; DOI=10.1093/nar/17.1.440;
Adams T.E., Baker L., Brandon M.R.;
"Cloning and nucleotide sequence of an ovine prolactin cDNA.";
Nucleic Acids Res. 17:440-440(1989).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Pituitary;
PubMed=2666265; DOI=10.1016/0378-1119(89)90083-8;
Varma S., Kwok S., Ebner K.E.;
"Cloning and nucleotide sequence of ovine prolactin cDNA.";
Gene 77:349-359(1989).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=7969789;
le Provost F., Leroux C., Martin P., Gaye P., Djiane J.;
"Prolactin gene expression in ovine and caprine mammary gland.";
Neuroendocrinology 60:305-313(1994).
[4]
PROTEIN SEQUENCE OF 31-229.
PubMed=5497153; DOI=10.1016/0003-9861(70)90191-8;
Li C.H., Dixon J.S., Lo T.-B., Schmidt K.D., Pankov Y.A.;
"Studies on pituitary lactogenic hormone. XXX. The primary structure
of the sheep hormone.";
Arch. Biochem. Biophys. 141:705-737(1970).
[5]
SEQUENCE REVISION.
PubMed=1270193;
Li C.H.;
"Studies on pituitary lactogenic hormone. The primary structure of the
porcine hormone.";
Int. J. Pept. Protein Res. 8:205-224(1976).
-!- FUNCTION: Prolactin acts primarily on the mammary gland by
promoting lactation, mammogenesis, mitogenesis and osmoregulation.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the somatotropin/prolactin family.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAA31578.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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EMBL; X13483; CAA31839.1; -; mRNA.
EMBL; M27057; AAA31578.1; ALT_INIT; mRNA.
EMBL; X76050; CAA53635.1; -; mRNA.
PIR; I83983; LCSH.
RefSeq; NP_001009306.1; NM_001009306.1.
UniGene; Oar.390; -.
ProteinModelPortal; P01240; -.
iPTMnet; P01240; -.
PRIDE; P01240; -.
GeneID; 443317; -.
KEGG; oas:443317; -.
CTD; 5617; -.
HOVERGEN; HBG104895; -.
KO; K05439; -.
Proteomes; UP000002356; Unplaced.
GO; GO:0005615; C:extracellular space; ISS:AgBase.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
GO; GO:0005148; F:prolactin receptor binding; IDA:AgBase.
GO; GO:0009058; P:biosynthetic process; ISS:AgBase.
GO; GO:0001825; P:blastocyst formation; ISS:AgBase.
GO; GO:0007595; P:lactation; IEA:UniProtKB-KW.
GO; GO:0043066; P:negative regulation of apoptotic process; IMP:AgBase.
GO; GO:0033685; P:negative regulation of luteinizing hormone secretion; IMP:AgBase.
GO; GO:0010751; P:negative regulation of nitric oxide mediated signal transduction; ISS:AgBase.
GO; GO:0090278; P:negative regulation of peptide hormone secretion; IDA:AgBase.
GO; GO:0030072; P:peptide hormone secretion; IDA:AgBase.
GO; GO:0045723; P:positive regulation of fatty acid biosynthetic process; IDA:AgBase.
GO; GO:0010628; P:positive regulation of gene expression; IDA:AgBase.
GO; GO:1903489; P:positive regulation of lactation; ISS:AgBase.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR001400; Somatotropin/Prolactin.
InterPro; IPR018116; Somatotropin_CS.
PANTHER; PTHR11417; PTHR11417; 1.
Pfam; PF00103; Hormone_1; 1.
PRINTS; PR00836; SOMATOTROPIN.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00266; SOMATOTROPIN_1; 1.
PROSITE; PS00338; SOMATOTROPIN_2; 1.
1: Evidence at protein level;
Complete proteome; Direct protein sequencing; Disulfide bond;
Glycoprotein; Hormone; Lactation; Phosphoprotein; Reference proteome;
Secreted; Signal.
SIGNAL 1 30 {ECO:0000269|PubMed:5497153}.
CHAIN 31 229 Prolactin.
/FTId=PRO_0000032926.
MOD_RES 56 56 Phosphoserine.
{ECO:0000250|UniProtKB:P01239}.
MOD_RES 64 64 Phosphoserine.
{ECO:0000250|UniProtKB:P01239}.
MOD_RES 120 120 Phosphoserine.
{ECO:0000250|UniProtKB:P01239}.
CARBOHYD 61 61 N-linked (GlcNAc...) asparagine; partial.
DISULFID 34 41 {ECO:0000269|PubMed:1270193}.
DISULFID 88 204 {ECO:0000269|PubMed:1270193}.
DISULFID 221 229 {ECO:0000269|PubMed:1270193}.
CONFLICT 40 40 N -> D (in Ref. 2; AAA31578).
{ECO:0000305}.
SEQUENCE 229 AA; 25778 MW; 97FD8AF2991B9B39 CRC64;
MDSKGSAQKG SRLLLLLVVS NLLLCQGVVS TPVCPNGPGN CQVSLRDLFD RAVMVSHYIH
NLSSEMFNEF DKRYAQGKGF ITMALNSCHT SSLPTPEDKE QAQQTHHEVL MSLILGLLRS
WNDPLYHLVT EVRGMKGVPD AILSRAIEIE EENKRLLEGM EMIFGQVIPG AKETEPYPVW
SGLPSLQTKD EDARHSAFYN LLHCLRRDSS KIDTYLKLLN CRIIYNNNC


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