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Prolactin receptor (PRL-R)

 PRLR_MOUSE              Reviewed;         608 AA.
Q08501; P15212; P15213; Q62099;
01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
01-FEB-1995, sequence version 1.
20-JUN-2018, entry version 163.
RecName: Full=Prolactin receptor;
Short=PRL-R;
Flags: Precursor;
Name=Prlr;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PRL-R3).
STRAIN=C3H/HeJ; TISSUE=Mammary gland;
PubMed=8262385; DOI=10.1016/0378-1119(93)90104-B;
Moore R.C., Oka T.;
"Cloning and sequencing of the cDNA encoding the murine mammary gland
long-form prolactin receptor.";
Gene 134:263-265(1993).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PRL-R3).
STRAIN=Swiss Webster; TISSUE=Liver;
PubMed=8319571; DOI=10.1210/endo.133.1.8319571;
Clarke D.L., Linzer D.I.H.;
"Changes in prolactin receptor expression during pregnancy in the
mouse ovary.";
Endocrinology 133:224-232(1993).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PRL-R3).
Sasaki M.;
Submitted (JUL-1992) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PRL-R3).
STRAIN=BALB/cJ; TISSUE=Mammary gland;
Edery M., Pezet A., Nandi S., Kelly P.A.;
Submitted (JUN-1993) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PRL-R2 AND PRL-R1).
STRAIN=Swiss Webster; TISSUE=Liver;
PubMed=2725531; DOI=10.1210/mend-3-4-674;
Davis J.A., Linzer D.I.H.;
"Expression of multiple forms of the prolactin receptor in mouse
liver.";
Mol. Endocrinol. 3:674-680(1989).
-!- FUNCTION: This is a receptor for the anterior pituitary hormone
prolactin.
-!- SUBUNIT: Interacts with SMARCA1. Interacts with NEK3 and VAV2 and
this interaction is prolactin-dependent. {ECO:0000250}.
-!- INTERACTION:
Q99490-2:AGAP2 (xeno); NbExp=2; IntAct=EBI-7737664, EBI-7737644;
-!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
protein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=PRL-R3;
IsoId=Q08501-1; Sequence=Displayed;
Name=PRL-R1;
IsoId=Q08501-2; Sequence=VSP_001723, VSP_001724;
Name=PRL-R2;
IsoId=Q08501-3; Sequence=VSP_001721, VSP_001722;
-!- DOMAIN: The WSXWS motif appears to be necessary for proper protein
folding and thereby efficient intracellular transport and cell-
surface receptor binding.
-!- DOMAIN: The box 1 motif is required for JAK interaction and/or
activation.
-!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 1
subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; L13593; AAC37641.1; -; mRNA.
EMBL; L14811; AAA02686.1; -; mRNA.
EMBL; D10214; BAA01066.1; -; mRNA.
EMBL; X73372; CAA51789.1; -; mRNA.
EMBL; M22959; AAA39977.1; -; mRNA.
EMBL; M22958; AAA39976.1; -; mRNA.
CCDS; CCDS27377.1; -. [Q08501-1]
CCDS; CCDS56975.1; -. [Q08501-2]
PIR; I53269; I53269.
PIR; I77524; I77524.
PIR; I77525; I77525.
RefSeq; NP_001240711.1; NM_001253782.2. [Q08501-2]
RefSeq; NP_035299.4; NM_011169.5. [Q08501-1]
RefSeq; XP_006520097.1; XM_006520034.3. [Q08501-1]
RefSeq; XP_006520098.1; XM_006520035.1. [Q08501-1]
RefSeq; XP_006520099.1; XM_006520036.1. [Q08501-1]
RefSeq; XP_006520100.1; XM_006520037.2. [Q08501-1]
RefSeq; XP_006520101.1; XM_006520038.1. [Q08501-2]
UniGene; Mm.10516; -.
UniGene; Mm.442446; -.
ProteinModelPortal; Q08501; -.
BioGrid; 202385; 4.
IntAct; Q08501; 3.
MINT; Q08501; -.
STRING; 10090.ENSMUSP00000122219; -.
GuidetoPHARMACOLOGY; 1721; -.
iPTMnet; Q08501; -.
PhosphoSitePlus; Q08501; -.
MaxQB; Q08501; -.
PaxDb; Q08501; -.
PRIDE; Q08501; -.
Ensembl; ENSMUST00000124470; ENSMUSP00000122219; ENSMUSG00000005268. [Q08501-1]
Ensembl; ENSMUST00000128450; ENSMUSP00000122209; ENSMUSG00000005268. [Q08501-3]
Ensembl; ENSMUST00000137867; ENSMUSP00000121935; ENSMUSG00000005268. [Q08501-3]
Ensembl; ENSMUST00000148257; ENSMUSP00000118355; ENSMUSG00000005268. [Q08501-2]
GeneID; 19116; -.
KEGG; mmu:19116; -.
UCSC; uc007vfw.2; mouse. [Q08501-3]
UCSC; uc007vfy.2; mouse. [Q08501-1]
UCSC; uc029snt.1; mouse. [Q08501-2]
CTD; 5618; -.
MGI; MGI:97763; Prlr.
eggNOG; ENOG410IUSW; Eukaryota.
eggNOG; ENOG410XRJS; LUCA.
GeneTree; ENSGT00530000063112; -.
HOGENOM; HOG000059569; -.
HOVERGEN; HBG007314; -.
InParanoid; Q08501; -.
KO; K05081; -.
OMA; EDQQLMP; -.
OrthoDB; EOG091G07CK; -.
PhylomeDB; Q08501; -.
TreeFam; TF330851; -.
Reactome; R-MMU-1170546; Prolactin receptor signaling.
Reactome; R-MMU-982772; Growth hormone receptor signaling.
ChiTaRS; Prlr; mouse.
PRO; PR:Q08501; -.
Proteomes; UP000000589; Chromosome 15.
Bgee; ENSMUSG00000005268; -.
CleanEx; MM_PRLR; -.
ExpressionAtlas; Q08501; baseline and differential.
Genevisible; Q08501; MM.
GO; GO:0009986; C:cell surface; ISO:MGI.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0017046; F:peptide hormone binding; ISO:MGI.
GO; GO:0004925; F:prolactin receptor activity; IDA:MGI.
GO; GO:0019901; F:protein kinase binding; ISO:MGI.
GO; GO:0007171; P:activation of transmembrane receptor protein tyrosine kinase activity; ISO:MGI.
GO; GO:0007259; P:JAK-STAT cascade; IMP:MGI.
GO; GO:0007595; P:lactation; IMP:MGI.
GO; GO:0060749; P:mammary gland alveolus development; IMP:MGI.
GO; GO:0060644; P:mammary gland epithelial cell differentiation; IGI:MGI.
GO; GO:0061180; P:mammary gland epithelium development; IMP:MGI.
GO; GO:0060736; P:prostate gland growth; IMP:MGI.
GO; GO:0030155; P:regulation of cell adhesion; IMP:MGI.
GO; GO:0030856; P:regulation of epithelial cell differentiation; IMP:MGI.
CDD; cd00063; FN3; 1.
Gene3D; 2.60.40.10; -; 2.
InterPro; IPR003961; FN3_dom.
InterPro; IPR036116; FN3_sf.
InterPro; IPR015152; Growth/epo_recpt_lig-bind.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003528; Long_hematopoietin_rcpt_CS.
InterPro; IPR033230; PRLR.
PANTHER; PTHR23036:SF86; PTHR23036:SF86; 1.
Pfam; PF09067; EpoR_lig-bind; 1.
SMART; SM00060; FN3; 2.
SUPFAM; SSF49265; SSF49265; 2.
PROSITE; PS50853; FN3; 2.
PROSITE; PS01352; HEMATOPO_REC_L_F1; 1.
1: Evidence at protein level;
Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein;
Membrane; Metal-binding; Receptor; Reference proteome; Repeat; Signal;
Transmembrane; Transmembrane helix; Zinc.
SIGNAL 1 19 {ECO:0000255}.
CHAIN 20 608 Prolactin receptor.
/FTId=PRO_0000010978.
TOPO_DOM 20 229 Extracellular. {ECO:0000250}.
TRANSMEM 230 253 Helical. {ECO:0000250}.
TOPO_DOM 254 608 Cytoplasmic. {ECO:0000250}.
DOMAIN 22 122 Fibronectin type-III 1.
{ECO:0000255|PROSITE-ProRule:PRU00316}.
DOMAIN 124 224 Fibronectin type-III 2.
{ECO:0000255|PROSITE-ProRule:PRU00316}.
MOTIF 210 214 WSXWS motif.
MOTIF 262 270 Box 1 motif.
METAL 206 206 Zinc. {ECO:0000250}.
METAL 207 207 Zinc. {ECO:0000250}.
CARBOHYD 54 54 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 99 99 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 127 127 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 31 41 {ECO:0000250}.
DISULFID 70 81 {ECO:0000250}.
VAR_SEQ 281 303 KGKSEELLSALGCQDFPPTSDCE -> LWCSILQLTSLVKI
PTTEFLCDL (in isoform PRL-R1).
{ECO:0000303|PubMed:2725531}.
/FTId=VSP_001723.
VAR_SEQ 281 292 KGKSEELLSALG -> VHNKEQLENYVY (in isoform
PRL-R2). {ECO:0000303|PubMed:2725531}.
/FTId=VSP_001721.
VAR_SEQ 293 608 Missing (in isoform PRL-R2).
{ECO:0000303|PubMed:2725531}.
/FTId=VSP_001722.
VAR_SEQ 304 608 Missing (in isoform PRL-R1).
{ECO:0000303|PubMed:2725531}.
/FTId=VSP_001724.
CONFLICT 558 558 L -> F (in Ref. 2; CAA51789).
{ECO:0000305}.
SEQUENCE 608 AA; 68241 MW; B8CE202B2EFC9FC6 CRC64;
MSSALAYMLL VLSISLLNGQ SPPGKPEIHK CRSPDKETFT CWWNPGSDGG LPTNYSLTYS
KEGEKNTYEC PDYKTSGPNS CFFSKQYTSI WKIYIITVNA TNEMGSSTSD PLYVDVTYIV
EPEPPRNLTL EVKQLKDKKT YLWVKWLPPT ITDVKTGWFT MEYEIRLKSE EADEWEIHFT
GHQTQFKVFD LYPGQKYLVQ TRCKPDHGYW SRWGQEKSIE IPNDFTLKDT TVWIIVAVLS
AVICLIMVWA VALKGYSMMT CIFPPVPGPK IKGFDTHLLE KGKSEELLSA LGCQDFPPTS
DCEDLLVEFL EVDDNEDERL MPSHSKEYPG QGVKPTHLDP DSDSGHGSYD SHSLLSEKCE
EPQAYPPAFH IPEITEKPEN PEANIPPTPN PQNNTPNCHT DTSKSTTWPL PPGQHTRRSP
YHSIADVCKL AGSPGDTLDS FLDKAEENVL KLSEDAGEEE VAVQEGAKSF PSDKQNTSWP
PLQEKGPIVY AKPPDYVEIH KVNKDGVLSL LPKQRENHQT ENPGVPETSK EYAKVSGVTD
NNILVLVPDS RAQNTALLEE SAKKVPPSLE QNQSEKDLAS FTATSSNCRL QLGRLDYLDP
TCFMHSFH


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