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Prolactin-releasing peptide (PrRP) (Prolactin-releasing hormone) [Cleaved into: Prolactin-releasing peptide PrRP31; Prolactin-releasing peptide PrRP20]

 PRRP_HUMAN              Reviewed;          87 AA.
P81277;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-JUN-1998, sequence version 1.
12-SEP-2018, entry version 120.
RecName: Full=Prolactin-releasing peptide;
Short=PrRP;
AltName: Full=Prolactin-releasing hormone;
Contains:
RecName: Full=Prolactin-releasing peptide PrRP31;
Contains:
RecName: Full=Prolactin-releasing peptide PrRP20;
Flags: Precursor;
Name=PRLH; Synonyms=PRH;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
PubMed=9607765; DOI=10.1038/30515;
Hinuma S., Habata Y., Fujii R., Kawamata Y., Hosoya M., Fukusumi S.,
Kitada C., Masuo Y., Asano T., Matsumoto H., Sekiguchi M.,
Kurokawa T., Nishimura O., Onda H., Fujino M.;
"A prolactin-releasing peptide in the brain.";
Nature 393:272-276(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
TISSUE SPECIFICITY.
PubMed=10498338; DOI=10.1016/S0167-0115(99)00028-2;
Fujii R., Fukusumi S., Hosoya M., Kawamata Y., Habata Y., Hinuma S.,
Sekiguchi M., Kitada C., Kurokawa T., Nishimura O., Onda H.,
Sumino Y., Fujino M.;
"Tissue distribution of prolactin-releasing peptide (PrRP) and its
receptor.";
Regul. Pept. 83:1-10(1999).
-!- FUNCTION: Stimulates prolactin (PRL) release and regulates the
expression of prolactin through its receptor GPR10. May stimulate
lactotrophs directly to secrete PRL.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Medulla oblongata and hypothalamus.
{ECO:0000269|PubMed:10498338}.
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EMBL; AB015419; BAA29027.1; -; mRNA.
EMBL; BC069081; AAH69081.1; -; mRNA.
EMBL; BC069284; AAH69284.1; -; mRNA.
CCDS; CCDS2519.1; -.
RefSeq; NP_056977.1; NM_015893.1.
UniGene; Hs.247710; -.
ProteinModelPortal; P81277; -.
STRING; 9606.ENSP00000165524; -.
iPTMnet; P81277; -.
PhosphoSitePlus; P81277; -.
BioMuta; PRLH; -.
DMDM; 8134649; -.
PaxDb; P81277; -.
PRIDE; P81277; -.
ProteomicsDB; 57694; -.
Ensembl; ENST00000165524; ENSP00000165524; ENSG00000071677.
GeneID; 51052; -.
KEGG; hsa:51052; -.
CTD; 51052; -.
DisGeNET; 51052; -.
EuPathDB; HostDB:ENSG00000071677.1; -.
GeneCards; PRLH; -.
HGNC; HGNC:17945; PRLH.
HPA; HPA014976; -.
MIM; 602663; gene.
neXtProt; NX_P81277; -.
OpenTargets; ENSG00000071677; -.
PharmGKB; PA134927756; -.
eggNOG; ENOG410J49T; Eukaryota.
eggNOG; ENOG4111800; LUCA.
GeneTree; ENSGT00390000005489; -.
HOGENOM; HOG000115720; -.
HOVERGEN; HBG004601; -.
InParanoid; P81277; -.
KO; K05269; -.
OMA; INPAWYA; -.
OrthoDB; EOG091G191K; -.
PhylomeDB; P81277; -.
TreeFam; TF330717; -.
Reactome; R-HSA-375276; Peptide ligand-binding receptors.
GeneWiki; PRLH; -.
GeneWiki; Prolactin-releasing_peptide; -.
GenomeRNAi; 51052; -.
PRO; PR:P81277; -.
Proteomes; UP000005640; Chromosome 2.
Bgee; ENSG00000071677; Expressed in 90 organ(s), highest expression level in C1 segment of cervical spinal cord.
CleanEx; HS_PRLH; -.
ExpressionAtlas; P81277; baseline and differential.
Genevisible; P81277; HS.
GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
GO; GO:0005576; C:extracellular region; TAS:Reactome.
GO; GO:0005179; F:hormone activity; TAS:ProtInc.
GO; GO:0005184; F:neuropeptide hormone activity; IEA:Ensembl.
GO; GO:0031861; F:prolactin-releasing peptide receptor binding; IEA:Ensembl.
GO; GO:0048483; P:autonomic nervous system development; IEA:Ensembl.
GO; GO:0006112; P:energy reserve metabolic process; IEA:Ensembl.
GO; GO:0045444; P:fat cell differentiation; IEA:Ensembl.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IEA:Ensembl.
GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
GO; GO:0002023; P:reduction of food intake in response to dietary excess; IEA:Ensembl.
GO; GO:0040014; P:regulation of multicellular organism growth; IEA:Ensembl.
GO; GO:0009749; P:response to glucose; IEA:Ensembl.
GO; GO:0032868; P:response to insulin; IEA:Ensembl.
GO; GO:0001894; P:tissue homeostasis; IEA:Ensembl.
InterPro; IPR026194; PrRP.
PANTHER; PTHR17206; PTHR17206; 1.
Pfam; PF15172; Prolactin_RP; 1.
2: Evidence at transcript level;
Amidation; Cleavage on pair of basic residues; Complete proteome;
Hormone; Reference proteome; Secreted; Signal.
SIGNAL 1 22 {ECO:0000250}.
PEPTIDE 23 53 Prolactin-releasing peptide PrRP31.
/FTId=PRO_0000022144.
PEPTIDE 34 53 Prolactin-releasing peptide PrRP20.
/FTId=PRO_0000022145.
PROPEP 58 87
/FTId=PRO_0000022146.
MOD_RES 53 53 Phenylalanine amide. {ECO:0000250}.
SEQUENCE 87 AA; 9639 MW; 229A2F3F50CF981B CRC64;
MKVLRAWLLC LLMLGLALRG AASRTHRHSM EIRTPDINPA WYASRGIRPV GRFGRRRATL
GDVPKPGLRP RLTCFPLEGG AMSSQDG


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