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Proprotein convertase subtilisin/kexin type 7 (EC 3.4.21.-) (Prohormone convertase 7) (Proprotein convertase 7) (PC7) (rPC7) (Subtilisin/kexin-like protease PC7)

 PCSK7_RAT               Reviewed;         783 AA.
Q62849;
11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
12-SEP-2018, entry version 143.
RecName: Full=Proprotein convertase subtilisin/kexin type 7;
EC=3.4.21.-;
AltName: Full=Prohormone convertase 7;
AltName: Full=Proprotein convertase 7;
Short=PC7;
Short=rPC7;
AltName: Full=Subtilisin/kexin-like protease PC7;
Flags: Precursor;
Name=Pcsk7; Synonyms=Pc7;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, AND TISSUE
SPECIFICITY.
TISSUE=Pheochromocytoma, and Spleen;
PubMed=8622945; DOI=10.1073/pnas.93.8.3388;
Seidah N.G., Hamelin J., Mamarbachi M., Dong W., Tadros H., Mbikay M.,
Chretien M., Day R.;
"cDNA structure, tissue distribution, and chromosomal localization of
rat PC7, a novel mammalian proprotein convertase closest to yeast
kexin-like proteinases.";
Proc. Natl. Acad. Sci. U.S.A. 93:3388-3393(1996).
-!- FUNCTION: Serine endoprotease that processes various proproteins
by cleavage at paired basic amino acids, recognizing the RXXX[KR]R
consensus motif. Likely functions in the constitutive secretory
pathway.
-!- COFACTOR:
Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
-!- ACTIVITY REGULATION: Inhibited by zinc and copper.
-!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network
membrane; Single-pass type I membrane protein. Note=Seems to be
localized intracellularly to the trans Golgi network.
-!- TISSUE SPECIFICITY: Widely expressed. Highly expressed in colon
and spleen. {ECO:0000269|PubMed:8622945}.
-!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000305}.
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EMBL; U36580; AAB39919.1; -; mRNA.
PIR; JC6136; JC6136.
RefSeq; NP_062119.1; NM_019246.1.
UniGene; Rn.10653; -.
ProteinModelPortal; Q62849; -.
SMR; Q62849; -.
DIP; DIP-29905N; -.
IntAct; Q62849; 1.
STRING; 10116.ENSRNOP00000023677; -.
MEROPS; S08.077; -.
iPTMnet; Q62849; -.
PhosphoSitePlus; Q62849; -.
PaxDb; Q62849; -.
PRIDE; Q62849; -.
Ensembl; ENSRNOT00000023677; ENSRNOP00000023677; ENSRNOG00000017478.
GeneID; 29606; -.
KEGG; rno:29606; -.
UCSC; RGD:3275; rat.
CTD; 9159; -.
RGD; 3275; Pcsk7.
eggNOG; KOG3525; Eukaryota.
eggNOG; COG1404; LUCA.
eggNOG; COG4935; LUCA.
GeneTree; ENSGT00750000117358; -.
HOGENOM; HOG000192536; -.
HOVERGEN; HBG008705; -.
InParanoid; Q62849; -.
KO; K08673; -.
OMA; EVLWNVS; -.
OrthoDB; EOG091G01XU; -.
PhylomeDB; Q62849; -.
TreeFam; TF314277; -.
PMAP-CutDB; Q62849; -.
PRO; PR:Q62849; -.
Proteomes; UP000002494; Chromosome 8.
Bgee; ENSRNOG00000017478; Expressed in 10 organ(s), highest expression level in colon.
Genevisible; Q62849; RN.
GO; GO:0030173; C:integral component of Golgi membrane; IEA:Ensembl.
GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO; GO:0016485; P:protein processing; IEA:Ensembl.
CDD; cd04059; Peptidases_S8_Protein_converta; 1.
Gene3D; 2.60.120.260; -; 1.
Gene3D; 3.30.70.850; -; 1.
Gene3D; 3.40.50.200; -; 1.
InterPro; IPR008979; Galactose-bd-like_sf.
InterPro; IPR034182; Kexin/furin.
InterPro; IPR002884; P_dom.
InterPro; IPR000209; Peptidase_S8/S53_dom.
InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
InterPro; IPR022398; Peptidase_S8_His-AS.
InterPro; IPR023828; Peptidase_S8_Ser-AS.
InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
InterPro; IPR032815; S8_pro-domain.
InterPro; IPR038466; S8_pro-domain_sf.
Pfam; PF01483; P_proprotein; 1.
Pfam; PF00082; Peptidase_S8; 1.
Pfam; PF16470; S8_pro-domain; 1.
PRINTS; PR00723; SUBTILISIN.
SUPFAM; SSF49785; SSF49785; 1.
SUPFAM; SSF52743; SSF52743; 1.
PROSITE; PS51829; P_HOMO_B; 1.
PROSITE; PS00137; SUBTILASE_HIS; 1.
PROSITE; PS00138; SUBTILASE_SER; 1.
1: Evidence at protein level;
Cleavage on pair of basic residues; Complete proteome;
Direct protein sequencing; Glycoprotein; Golgi apparatus; Hydrolase;
Membrane; Protease; Reference proteome; Serine protease; Signal;
Transmembrane; Transmembrane helix; Zymogen.
SIGNAL 1 36
PROPEP 37 140
/FTId=PRO_0000027118.
CHAIN 141 783 Proprotein convertase subtilisin/kexin
type 7.
/FTId=PRO_0000027119.
TOPO_DOM 141 666 Extracellular. {ECO:0000255}.
TRANSMEM 667 687 Helical. {ECO:0000255}.
TOPO_DOM 688 783 Cytoplasmic. {ECO:0000255}.
DOMAIN 181 473 Peptidase S8.
DOMAIN 480 617 P/Homo B. {ECO:0000255|PROSITE-
ProRule:PRU01173}.
ACT_SITE 186 186 Charge relay system. {ECO:0000250}.
ACT_SITE 227 227 Charge relay system. {ECO:0000250}.
ACT_SITE 405 405 Charge relay system. {ECO:0000250}.
SITE 140 141 Cleavage; by autolysis.
CARBOHYD 166 166 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 174 174 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 240 240 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 510 510 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 783 AA; 85599 MW; 595E159819F5E653 CRC64;
MPKGRQKVPR LDARLGLPIC LCLELAIFFL VPQVMGLTEA GGLDTLGAGG LSWAVHLDSL
EGERKEESLI QQANAVAQAA GLVNAGRIGE LQGHYLFVQP AGHGQAMEAE AMRQQAEAVL
AKHEAVRWHS EQRLLKRAKR SIHFNDPKYP QQWHLNNRRS PGRDINVTGV WERNVTGRGV
TVVVVDDGVE HTVQDIAPNY SPEGSYDLNS NDPDPMPHPD EENGNHHGTR CAGEIAAVPN
NSFCAVGVAY GSRIAGIRVL DGPLTDSMEA VAFNKHYQIN DIYSCSWGPD DDGKTVDGPH
QLGKAALQHG VMAGRQGFGS IFVVASGNGG QHNDNCNYDG YANSIYTVTI GAVDEEGRMP
FYAEECASML AVTFSGGDKM LRSIVTTDWD LQKGTGCTEG HTGTSAAAPL AAGMIALMLQ
VRPCLTWRDV QHIIVFTATQ YEDHRADWLT NEAGFSHSHQ HGFGLLNAWR LVNAAKIWTS
VPYLASYVSP MLKENKAVPR SPHSLEVLWN VSRTDLEMSG LKTLEHVAVT VSITHPRRGS
LELKLFCPSG MMSLIGAPRS MDSDPNGFND WTFSTVRCWG ERARGVYRLV IRDVGDEPLQ
VGILQQWQLT LYGSTWSPVD IKDRQSLLES AMSGKYLHDD FTLPCPPGLK IPEEDGYSIT
PNTLKTLVLV GCFSVFWTIY YMLEVCLSQR SKASTHGCRR GCCPWPPQSQ NSKEVGTALE
SMPLCSSKDL DGVDSEHGDC TTASSLLAPE LLGEADWSLS QNSKSDLDCP PHQPPDLKDG
QIC


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