Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Prosaposin receptor GPR37 (G-protein coupled receptor 37)

 GPR37_MOUSE             Reviewed;         600 AA.
Q9QY42; Q8BKF8; Q8BXP9; Q8C022; Q9Z0G3;
11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
05-DEC-2018, entry version 130.
RecName: Full=Prosaposin receptor GPR37;
AltName: Full=G-protein coupled receptor 37;
Flags: Precursor;
Name=Gpr37;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
STRAIN=BALB/cJ; TISSUE=Brain, and Liver;
PubMed=9799598; DOI=10.1006/geno.1998.5433;
Marazziti D., Gallo A., Golini E., Matteoni R.,
Tocchini-Valentini G.P.;
"Molecular cloning and chromosomal localization of the mouse Gpr37
gene encoding an orphan G-protein-coupled peptide receptor expressed
in brain and testis.";
Genomics 53:315-324(1998).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Platzer M., Zhao W., Herman G.E., Rosenthal A.;
"Genomic structure of the murine G protein-coupled receptor 37 on
chromosome 6.";
Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
STRAIN=C57BL/6J; TISSUE=Eye, Olfactory bulb, and Retina;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Eye;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Receptor for the neuroprotective and glioprotective
factor prosaposin. Ligand binding induces endocytosis, followed by
an ERK phosphorylation cascade (By similarity). {ECO:0000250}.
-!- SUBUNIT: Forms a complex with PRKN, STUB1 and HSP70. The amount of
STUB1 in the complex increases during ER stress. STUB1 promotes
the dissociation of HSP70 from PRKN, thus facilitating PRKN-
mediated GPR37 ubiquitination. Interacts with PACRG (By
similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass
membrane protein {ECO:0000250}. Endoplasmic reticulum membrane
{ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=1;
IsoId=Q9QY42-1; Sequence=Displayed;
Name=2;
IsoId=Q9QY42-2; Sequence=VSP_011762;
Name=3;
IsoId=Q9QY42-3; Sequence=VSP_011763, VSP_011764;
-!- PTM: Ubiquitinated by PRKN in the presence of ubiquitin-
conjugating enzymes in the endoplasmic reticulum. {ECO:0000250}.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AJ223305; CAA11247.1; -; mRNA.
EMBL; AJ223834; CAA11579.1; -; Genomic_DNA.
EMBL; AJ223835; CAA11579.1; JOINED; Genomic_DNA.
EMBL; AF132039; AAF22144.1; -; Genomic_DNA.
EMBL; AK032525; BAC27911.1; -; mRNA.
EMBL; AK044508; BAC31956.1; -; mRNA.
EMBL; AK053287; BAC35333.1; -; mRNA.
EMBL; BC031918; AAH31918.1; -; mRNA.
CCDS; CCDS19949.1; -. [Q9QY42-1]
RefSeq; NP_034468.2; NM_010338.2. [Q9QY42-1]
UniGene; Mm.409670; -.
ProteinModelPortal; Q9QY42; -.
STRING; 10090.ENSMUSP00000052185; -.
iPTMnet; Q9QY42; -.
PhosphoSitePlus; Q9QY42; -.
SwissPalm; Q9QY42; -.
PaxDb; Q9QY42; -.
PeptideAtlas; Q9QY42; -.
PRIDE; Q9QY42; -.
Ensembl; ENSMUST00000054867; ENSMUSP00000052185; ENSMUSG00000039904. [Q9QY42-1]
Ensembl; ENSMUST00000200812; ENSMUSP00000144683; ENSMUSG00000039904. [Q9QY42-3]
GeneID; 14763; -.
KEGG; mmu:14763; -.
UCSC; uc009bcd.2; mouse. [Q9QY42-1]
CTD; 2861; -.
MGI; MGI:1313297; Gpr37.
eggNOG; KOG3656; Eukaryota.
eggNOG; ENOG410XRW9; LUCA.
GeneTree; ENSGT00940000153565; -.
HOGENOM; HOG000252922; -.
HOVERGEN; HBG051808; -.
InParanoid; Q9QY42; -.
KO; K04243; -.
OMA; SDLYYWP; -.
OrthoDB; EOG091G04SU; -.
PhylomeDB; Q9QY42; -.
TreeFam; TF331292; -.
Reactome; R-MMU-375276; Peptide ligand-binding receptors.
Reactome; R-MMU-418594; G alpha (i) signalling events.
PRO; PR:Q9QY42; -.
Proteomes; UP000000589; Chromosome 6.
Bgee; ENSMUSG00000039904; Expressed in 175 organ(s), highest expression level in utricle of membranous labyrinth.
CleanEx; MM_GPR37; -.
Genevisible; Q9QY42; MM.
GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; ISO:MGI.
GO; GO:0043235; C:receptor complex; ISO:MGI.
GO; GO:0000151; C:ubiquitin ligase complex; ISO:MGI.
GO; GO:0008528; F:G protein-coupled peptide receptor activity; ISO:MGI.
GO; GO:0031072; F:heat shock protein binding; ISO:MGI.
GO; GO:0030544; F:Hsp70 protein binding; ISO:MGI.
GO; GO:0042277; F:peptide binding; ISO:MGI.
GO; GO:0036505; F:prosaposin receptor activity; ISO:MGI.
GO; GO:0031625; F:ubiquitin protein ligase binding; ISO:MGI.
GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; ISO:MGI.
GO; GO:0042416; P:dopamine biosynthetic process; IMP:MGI.
GO; GO:0031987; P:locomotion involved in locomotory behavior; IMP:MGI.
GO; GO:1903206; P:negative regulation of hydrogen peroxide-induced cell death; IMP:ParkinsonsUK-UCL.
GO; GO:0045964; P:positive regulation of dopamine metabolic process; IMP:MGI.
GO; GO:0043410; P:positive regulation of MAPK cascade; IMP:ParkinsonsUK-UCL.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR003909; GPR37_orph.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR01421; GPR37ORPHANR.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
2: Evidence at transcript level;
Alternative splicing; Cell membrane; Complete proteome;
Disulfide bond; Endoplasmic reticulum; G-protein coupled receptor;
Glycoprotein; Membrane; Receptor; Reference proteome; Signal;
Transducer; Transmembrane; Transmembrane helix; Ubl conjugation.
SIGNAL 1 26 {ECO:0000255}.
CHAIN 27 600 Prosaposin receptor GPR37.
/FTId=PRO_0000012800.
TOPO_DOM 27 252 Extracellular. {ECO:0000255}.
TRANSMEM 253 273 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 274 286 Cytoplasmic. {ECO:0000255}.
TRANSMEM 287 307 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 308 322 Extracellular. {ECO:0000255}.
TRANSMEM 323 343 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 344 366 Cytoplasmic. {ECO:0000255}.
TRANSMEM 367 387 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 388 430 Extracellular. {ECO:0000255}.
TRANSMEM 431 451 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 452 480 Cytoplasmic. {ECO:0000255}.
TRANSMEM 481 501 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 502 518 Extracellular. {ECO:0000255}.
TRANSMEM 519 539 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 540 600 Cytoplasmic. {ECO:0000255}.
COMPBIAS 538 558 Cys-rich.
COMPBIAS 550 555 Poly-Cys.
CARBOHYD 36 36 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 210 210 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 227 227 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 321 406 {ECO:0000255|PROSITE-ProRule:PRU00521}.
VAR_SEQ 1 251 Missing (in isoform 2).
{ECO:0000303|PubMed:16141072}.
/FTId=VSP_011762.
VAR_SEQ 418 440 IYVLALTYDGARLWWYFGCYFCL -> VQVERDCFIKIRTR
NHWIRLSHL (in isoform 3).
{ECO:0000303|PubMed:16141072}.
/FTId=VSP_011763.
VAR_SEQ 441 600 Missing (in isoform 3).
{ECO:0000303|PubMed:16141072}.
/FTId=VSP_011764.
CONFLICT 205 205 R -> M (in Ref. 3; BAC27911).
{ECO:0000305}.
CONFLICT 224 224 R -> P (in Ref. 1; CAA11247/CAA11579).
{ECO:0000305}.
CONFLICT 228 228 T -> P (in Ref. 1; CAA11247/CAA11579).
{ECO:0000305}.
CONFLICT 326 326 Y -> N (in Ref. 3; BAC27911).
{ECO:0000305}.
CONFLICT 399 399 G -> V (in Ref. 3; BAC31956).
{ECO:0000305}.
CONFLICT 551 551 C -> Y (in Ref. 3; BAC27911).
{ECO:0000305}.
CONFLICT 598 598 T -> N (in Ref. 3; BAC27911).
{ECO:0000305}.
SEQUENCE 600 AA; 66775 MW; 5F92E65984746B30 CRC64;
MPARGAPLSR TSRLLLLLLF KVSVSAALSF VPEPRNGTCL GESCSPLIQR RSRDARGPGN
SAKDALRVHV PREKLEAEVR GATSWDLPPP RGGDTGVIEE AAAAGPLGPP TKPPSAWRWK
SAQGKEPSGH LRRRDPTDPQ LFFPTSEGGE MSSKRDGIPQ SRQEHSVKTE PRDLFYWPRR
TGQLQDSQHR PSAVHEGRTL APPGRALPQN GSADDWVPDQ GGPRRGNTTR RVRLKNPFYP
LTQESYGAYA VMCLSVVIFG TGIIGNLAVM CIVCHNYYMR SISNSLLANL AFWDFLIIFF
CLPLVIFHEL TKKWLLEDFS CKIVPYIEVA SLGVTTFTLC ALCIDRFRAA TNVQMYYEMI
ENCSSTTAKL AVIWVGALLL ALPEVVLRQL SKEDLGFSGQ APAERCVIKI SPDLPDTIYV
LALTYDGARL WWYFGCYFCL PTLFTITCSL VTARKIRKAE KASTRGNKRQ IHLESQMNCT
VVALTILYGF CIIPENICNI VTAYMATGVS QQTMDLLNII SQFLLFFKSC VTPVLLFCLC
RPFSRAFMEC CCCCCEECIQ KSSTVTSDDN DNEYTTELEL SPFSTIRREM STFASVGTHC


Related products :

Catalog number Product name Quantity
DL-GPR37-Hu Human G Protein Coupled Receptor 37 (GPR37) ELISA Kit 96T
201-20-2364 GPR37{G protein-coupled receptor 37 (endothelin receptor type B-like)}rabbit.pAb 0.2ml
GPR39 GPR37 Gene G protein-coupled receptor 37 (endothelin receptor type B-like)
EIAAB28476 GPR120,GPR129,G-protein coupled receptor 120,G-protein coupled receptor 129,G-protein coupled receptor GT01,G-protein coupled receptor PGR4,Homo sapiens,Human,O3FAR1,Omega-3 fatty acid receptor 1,PGR4
EIAAB29406 5-oxo-ETE G-protein coupled receptor,GPR170,G-protein coupled receptor 170,G-protein coupled receptor R527,G-protein coupled receptor TG1019,Homo sapiens,Human,OXER1,Oxoeicosanoid receptor 1,TG1019
18-461-10342 Leucine-rich repeat-containing G-protein coupled receptor 5 - Orphan G-protein coupled receptor HG38; G-protein coupled receptor 49; G-protein coupled receptor 67 Polyclonal 0.05 ml
18-461-10341 Leucine-rich repeat-containing G-protein coupled receptor 5 - Orphan G-protein coupled receptor HG38; G-protein coupled receptor 49; G-protein coupled receptor 67 Polyclonal 0.05 ml
CSB-EL009810RA Rat G protein-coupled receptor 37 (endothelin receptor type B-like) (GPR37) ELISA kit, Species Rat, Sample Type serum, plasma 96T
GPR37 GPR35 Gene G protein-coupled receptor 35
E96720Hu ELISA Kit for G Protein Coupled Receptor 37 (GPR37) 96T/Kit
EIAAB36674 AGR16,Edg5,Endothelial differentiation G-protein coupled receptor 5,G-protein coupled receptor H218,Rat,Rattus norvegicus,S1P receptor 2,S1P receptor Edg-5,S1P2,S1pr2,Sphingosine 1-phosphate receptor
201-12-2706 Human G Protein Coupled Receptor 37 (GPR37)ELISA Kit 96T
E2705Hu Human G Protein Coupled Receptor 37 (GPR37)ELISA Kit 48T
201-12-2706 Human G Protein Coupled Receptor 37(GPR37)ELISA Kit 96T
E-EL-MK0912 Monkey GPR37 (G Protein Coupled Receptor 37) ELISA Kit 96T
YHB1274Hu Human G Protein Coupled Receptor 37 (GPR37)ELISA Kit 96T
QY-E04892 Human G Protein Coupled Receptor 37(GPR37)ELISA Kit 96T
E-EL-P0387 Porcine GPR37 (G Protein Coupled Receptor 37) ELISA Kit 96T
201-12-2706 Human G Protein Coupled Receptor 37 (GPR37)ELISA Kit 48T
E96720Hu ELISA Kit for Human G Protein Coupled Receptor 37(GPR37) 96T
YHB1274Hu Human G Protein Coupled Receptor 37 (GPR37)ELISA Kit 48T
UB-E04892 Human G Protein Coupled Receptor 37(GPR37)ELISA Kit 96T
CSB-EL009810RA Rat Probable G-protein coupled receptor 37(GPR37) ELISA kit 96T
G1200 Probable G-protein coupled receptor 37 (GPR37), Rat, ELISA Kit 96T
UT-E04892 Human G Protein Coupled Receptor 37 (GPR37) ELISA Kit 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur