Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Prostate androgen-regulated mucin-like protein 1 (PARM-1)

 PARM1_HUMAN             Reviewed;         310 AA.
Q6UWI2; B3KMQ9; Q96DV8; Q9Y4S1;
10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 1.
12-SEP-2018, entry version 101.
RecName: Full=Prostate androgen-regulated mucin-like protein 1;
Short=PARM-1;
Flags: Precursor;
Name=PARM1; ORFNames=UNQ1879/PRO4322;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=12975309; DOI=10.1101/gr.1293003;
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale
effort to identify novel human secreted and transmembrane proteins: a
bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-127.
TISSUE=Brain;
PubMed=11230166; DOI=10.1101/gr.GR1547R;
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H.,
Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N.,
Mewes H.-W., Ottenwaelder B., Obermaier B., Tampe J., Heubner D.,
Wambutt R., Korn B., Klein M., Poustka A.;
"Towards a catalog of human genes and proteins: sequencing and
analysis of 500 novel complete protein coding human cDNAs.";
Genome Res. 11:422-435(2001).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Mammary gland;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Muscle;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
PROTEIN SEQUENCE OF 21-35.
PubMed=15340161; DOI=10.1110/ps.04682504;
Zhang Z., Henzel W.J.;
"Signal peptide prediction based on analysis of experimentally
verified cleavage sites.";
Protein Sci. 13:2819-2824(2004).
[6]
SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, AND
GLYCOSYLATION.
PubMed=18027867; DOI=10.1002/ijc.23185;
Fladeby C., Gupta S.N., Barois N., Lorenzo P.I., Simpson J.C.,
Saatcioglu F., Bakke O.;
"Human PARM-1 is a novel mucin-like, androgen-regulated gene
exhibiting proliferative effects in prostate cancer cells.";
Int. J. Cancer 122:1229-1235(2008).
[7]
GLYCOSYLATION AT ASN-80.
PubMed=19139490; DOI=10.1074/mcp.M800504-MCP200;
Jia W., Lu Z., Fu Y., Wang H.P., Wang L.H., Chi H., Yuan Z.F.,
Zheng Z.B., Song L.N., Han H.H., Liang Y.M., Wang J.L., Cai Y.,
Zhang Y.K., Deng Y.L., Ying W.T., He S.M., Qian X.H.;
"A strategy for precise and large scale identification of core
fucosylated glycoproteins.";
Mol. Cell. Proteomics 8:913-923(2009).
-!- FUNCTION: May regulate TLP1 expression and telomerase activity,
thus enabling certain prostatic cells to resist apoptosis.
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18027867};
Single-pass type I membrane protein {ECO:0000269|PubMed:18027867}.
Golgi apparatus membrane {ECO:0000269|PubMed:18027867}; Single-
pass type I membrane protein {ECO:0000269|PubMed:18027867}.
Endosome membrane {ECO:0000269|PubMed:18027867}; Single-pass type
I membrane protein {ECO:0000269|PubMed:18027867}.
-!- TISSUE SPECIFICITY: Widely expressed with highest levels in heart,
kidney and placenta. {ECO:0000269|PubMed:18027867}.
-!- INDUCTION: By androgens. {ECO:0000269|PubMed:18027867}.
-!- PTM: Highly N-glycosylated and O-glycosylated.
{ECO:0000269|PubMed:18027867, ECO:0000269|PubMed:19139490}.
-!- SIMILARITY: Belongs to the PARM family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=CAB45720.1; Type=Frameshift; Positions=239; Evidence={ECO:0000305};
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AY358777; AAQ89137.1; -; mRNA.
EMBL; AL080121; CAB45720.1; ALT_FRAME; mRNA.
EMBL; AK022311; BAG51071.1; -; mRNA.
EMBL; BC013294; AAH13294.1; -; mRNA.
CCDS; CCDS47077.1; -.
PIR; T12458; T12458.
RefSeq; NP_056208.2; NM_015393.3.
UniGene; Hs.105460; -.
UniGene; Hs.623905; -.
ProteinModelPortal; Q6UWI2; -.
IntAct; Q6UWI2; 1.
STRING; 9606.ENSP00000370224; -.
iPTMnet; Q6UWI2; -.
PhosphoSitePlus; Q6UWI2; -.
BioMuta; PARM1; -.
DMDM; 74738099; -.
MaxQB; Q6UWI2; -.
PaxDb; Q6UWI2; -.
PeptideAtlas; Q6UWI2; -.
PRIDE; Q6UWI2; -.
ProteomicsDB; 67482; -.
DNASU; 25849; -.
Ensembl; ENST00000307428; ENSP00000370224; ENSG00000169116.
GeneID; 25849; -.
KEGG; hsa:25849; -.
UCSC; uc003hih.3; human.
CTD; 25849; -.
DisGeNET; 25849; -.
EuPathDB; HostDB:ENSG00000169116.11; -.
GeneCards; PARM1; -.
HGNC; HGNC:24536; PARM1.
HPA; HPA038236; -.
MIM; 617688; gene.
neXtProt; NX_Q6UWI2; -.
OpenTargets; ENSG00000169116; -.
PharmGKB; PA165664393; -.
eggNOG; ENOG410IVTQ; Eukaryota.
eggNOG; ENOG410XTVA; LUCA.
GeneTree; ENSGT00390000014545; -.
HOGENOM; HOG000280689; -.
HOVERGEN; HBG082108; -.
InParanoid; Q6UWI2; -.
OMA; MQEVEHA; -.
OrthoDB; EOG091G0Z5B; -.
PhylomeDB; Q6UWI2; -.
TreeFam; TF335903; -.
ChiTaRS; PARM1; human.
GeneWiki; DKFZP564O0823; -.
GenomeRNAi; 25849; -.
PRO; PR:Q6UWI2; -.
Proteomes; UP000005640; Chromosome 4.
Bgee; ENSG00000169116; Expressed in 211 organ(s), highest expression level in pigmented layer of retina.
ExpressionAtlas; Q6UWI2; baseline and differential.
Genevisible; Q6UWI2; HS.
GO; GO:0005829; C:cytosol; IDA:HPA.
GO; GO:0005769; C:early endosome; IDA:UniProtKB.
GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO; GO:0005770; C:late endosome; IDA:UniProtKB.
GO; GO:0005634; C:nucleus; IDA:HPA.
GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO; GO:0051973; P:positive regulation of telomerase activity; ISS:UniProtKB.
InterPro; IPR031431; PARM1.
PANTHER; PTHR35453; PTHR35453; 1.
Pfam; PF17061; PARM; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Direct protein sequencing; Endosome;
Glycoprotein; Golgi apparatus; Membrane; Phosphoprotein; Polymorphism;
Reference proteome; Signal; Transmembrane; Transmembrane helix.
SIGNAL 1 20 {ECO:0000269|PubMed:15340161}.
CHAIN 21 310 Prostate androgen-regulated mucin-like
protein 1.
/FTId=PRO_0000045498.
TOPO_DOM 21 258 Extracellular. {ECO:0000255}.
TRANSMEM 259 279 Helical. {ECO:0000255}.
TOPO_DOM 280 310 Cytoplasmic. {ECO:0000255}.
MOD_RES 298 298 Phosphoserine.
{ECO:0000250|UniProtKB:Q6P9X9}.
CARBOHYD 58 58 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 62 62 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 80 80 N-linked (GlcNAc...) (complex)
asparagine.
{ECO:0000269|PubMed:19139490}.
CARBOHYD 176 176 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
VARIANT 127 127 S -> L (in dbSNP:rs3822109).
{ECO:0000269|PubMed:11230166}.
/FTId=VAR_062257.
CONFLICT 82 82 S -> P (in Ref. 3; BAG51071).
{ECO:0000305}.
CONFLICT 123 123 E -> K (in Ref. 4; AAH13294).
{ECO:0000305}.
SEQUENCE 310 AA; 32289 MW; 0DFD58B134FAF9BD CRC64;
MVYKTLFALC ILTAGWRVQS LPTSAPLSVS LPTNIVPPTT IWTSSPQNTD ADTASPSNGT
HNNSVLPVTA SAPTSLLPKN ISIESREEEI TSPGSNWEGT NTDPSPSGFS STSGGVHLTT
TLEEHSSGTP EAGVAATLSQ SAAEPPTLIS PQAPASSPSS LSTSPPEVFS ASVTTNHSST
VTSTQPTGAP TAPESPTEES SSDHTPTSHA TAEPVPQEKT PPTTVSGKVM CELIDMETTT
TFPRVIMQEV EHALSSGSIA AITVTVIAVV LLVFGVAAYL KIRHSSYGRL LDDHDYGSWG
NYNNPLYDDS


Related products :

Catalog number Product name Quantity
EIAAB29918 Mouse,Mus musculus,Parm1,PARM-1,Prostate androgen-regulated mucin-like protein 1 homolog
EIAAB29919 Homo sapiens,Human,PARM1,PARM-1,Prostate androgen-regulated mucin-like protein 1,UNQ1879_PRO4322
EIAAB29917 Castration-induced prostatic apoptosis-related protein 1,Cipar1,CIPAR-1,Parm1,PARM-1,Prostate androgen-regulated mucin-like protein 1 homolog,Prostatic androgen-repressed message 1 protein,Rat,Rattus
EH2352 Prostate androgen-regulated mucin-like protein 1 Elisa Kit 96T
EM787 Prostate androgen-regulated mucin-like protein 1 homolog Elisa Kit 96T
PARP1 PARM1 Gene prostate androgen-regulated mucin-like protein 1
E6940r ELISA Kit FOR Prostate androgen-regulated mucin-like protein 1 homolog; organism: Rat; gene name: Parm1 96T
E6940h ELISA Kit FOR Prostate androgen-regulated mucin-like protein 1; organism: Human; gene name: PARM1 96T
E6940m ELISA Kit FOR Prostate androgen-regulated mucin-like protein 1 homolog; organism: Mouse; gene name: Parm1 96T
E6940h Human Prostate Androgen Regulated Mucin Like Prote 96T
25-042 The homeodomain-containing transcription factor NKX3-1 is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. Loss of NKX3-1 protein ex 0.05 mg
PARVB PART1 Gene prostate androgen-regulated transcript 1 (non-protein coding)
EIAAB38853 Mouse,Msg1,Mus musculus,Salivary protein MSG1,Smr1,Smr3a,Submaxillary gland androgen-regulated protein 1,Submaxillary gland androgen-regulated protein 3A
EIAAB30443 Androgen-induced proliferation inhibitor,Androgen-induced prostate proliferative shutoff-associated protein AS3,Aprin,As3,Pds5b,Rat,Rattus norvegicus,Sister chromatid cohesion protein PDS5 homolog B
EIAAB30441 Androgen-induced proliferation inhibitor,Androgen-induced prostate proliferative shutoff-associated protein AS3,Aprin,As3,Kiaa0979,Mouse,Mus musculus,Pds5b,Sister chromatid cohesion protein PDS5 homol
EIAAB30444 Androgen-induced proliferation inhibitor,Androgen-induced prostate proliferative shutoff-associated protein AS3,APRIN,AS3,Homo sapiens,Human,KIAA0979,PDS5B,Sister chromatid cohesion protein PDS5 homol
EIAAB34152 Androgen-regulated short-chain dehydrogenase_reductase 1,Arsdr1,Cell line MC_9.IL4-derived protein 1,M42C60,Mdt1,Mouse,Mus musculus,Prostate short-chain dehydrogenase_reductase 1,Psdr1,RalR1,Rdh11,Ret
EIAAB34151 Androgen-regulated short-chain dehydrogenase_reductase 1,ARSDR1,CGI-82,HCV core-binding protein HCBP12,Homo sapiens,Human,Prostate short-chain dehydrogenase_reductase 1,PSDR1,RalR1,RDH11,Retinal reduc
EIAAB28223 Androgen-regulated protein RP2,D7Rp2e,Mouse,Mus musculus,Nucleoside diphosphate-linked moiety X motif 19, mitochondrial,Nudix motif 19,Nudt19,RP2p,Testosterone-regulated RP2 protein
20-272-191831 Prostate Mucin Antigen_PMA - Mouse monoclonal [BDI183] to Prostate Mucin Antigen_PMA Monoclonal 0.1 mg
20-272-191779 Prostate Mucin Antigen_PMA - Mouse monoclonal [YPMA-1] to Prostate Mucin Antigen_PMA Monoclonal 0.25 mg
20-272-191830 Prostate Mucin Antigen_PMA - Mouse monoclonal [BDI134] to Prostate Mucin Antigen_PMA Monoclonal 0.1 mg
ER702 Kidney androgen-regulated protein Elisa Kit 96T
EM809 Kidney androgen-regulated protein Elisa Kit 96T
EH2468 Kidney androgen-regulated protein Elisa Kit 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur