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Protachykinin-1 (PPT) [Cleaved into: Substance P; Neurokinin A (NKA) (Neuromedin L) (Substance K); Neuropeptide K (NPK); Neuropeptide gamma; C-terminal-flanking peptide]

 TKN1_MOUSE              Reviewed;         130 AA.
P41539; Q00073;
01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
01-NOV-1995, sequence version 1.
20-JUN-2018, entry version 145.
RecName: Full=Protachykinin-1;
AltName: Full=PPT;
Contains:
RecName: Full=Substance P;
Contains:
RecName: Full=Neurokinin A;
Short=NKA;
AltName: Full=Neuromedin L;
AltName: Full=Substance K;
Contains:
RecName: Full=Neuropeptide K;
Short=NPK;
Contains:
RecName: Full=Neuropeptide gamma;
Contains:
RecName: Full=C-terminal-flanking peptide;
Flags: Precursor;
Name=Tac1; Synonyms=Nka, Nkna, Tac2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA).
STRAIN=ICR; TISSUE=Brain;
Kako K., Munekata E., Hosaka M., Murakami K., Nakayama K.;
"Cloning and sequence analysis of mouse cDNAs encoding
preprotachykinin A and B.";
Biomed. Res. 14:253-259(1993).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 36-122 (ISOFORMS BETA AND GAMMA).
TISSUE=Brain;
PubMed=1708336; DOI=10.1210/endo-128-5-2441;
Chiwakata C., Brackmann B., Hunt N., Davidoff M., Schulze W.,
Ivell R.;
"Tachykinin (substance-P) gene expression in Leydig cells of the human
and mouse testis.";
Endocrinology 128:2441-2448(1991).
-!- FUNCTION: Tachykinins are active peptides which excite neurons,
evoke behavioral responses, are potent vasodilators and
secretagogues, and contract (directly or indirectly) many smooth
muscles.
-!- SUBCELLULAR LOCATION: Secreted.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=4;
Name=Beta;
IsoId=P41539-1; Sequence=Displayed;
Name=Alpha;
IsoId=P41539-3; Sequence=Not described;
Name=Gamma;
IsoId=P41539-2; Sequence=VSP_006379;
Name=Delta;
IsoId=P41539-4; Sequence=Not described;
-!- PTM: The substance P form is cleaved at Pro-59 by the prolyl
endopeptidase FAP (seprase) activity (in vitro).
{ECO:0000250|UniProtKB:P20366}.
-!- SIMILARITY: Belongs to the tachykinin family. {ECO:0000305}.
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EMBL; D17584; BAA04508.1; -; mRNA.
EMBL; M68908; AAA39969.1; -; mRNA.
EMBL; M68909; AAA39970.1; -; mRNA.
CCDS; CCDS19906.1; -. [P41539-1]
CCDS; CCDS80486.1; -. [P41539-2]
PIR; I52526; I52526.
RefSeq; NP_033337.1; NM_009311.2. [P41539-1]
RefSeq; XP_006505090.1; XM_006505027.1. [P41539-1]
UniGene; Mm.1440; -.
UniGene; Mm.410823; -.
ProteinModelPortal; P41539; -.
SMR; P41539; -.
STRING; 10090.ENSMUSP00000088175; -.
BindingDB; P41539; -.
iPTMnet; P41539; -.
PhosphoSitePlus; P41539; -.
PaxDb; P41539; -.
PRIDE; P41539; -.
Ensembl; ENSMUST00000184986; ENSMUSP00000138818; ENSMUSG00000061762. [P41539-2]
Ensembl; ENSMUST00000185187; ENSMUSP00000139347; ENSMUSG00000061762. [P41539-1]
GeneID; 21333; -.
KEGG; mmu:21333; -.
UCSC; uc009axc.1; mouse. [P41539-1]
CTD; 6863; -.
MGI; MGI:98474; Tac1.
eggNOG; ENOG410IWZZ; Eukaryota.
eggNOG; ENOG4112BW1; LUCA.
GeneTree; ENSGT00390000002457; -.
HOGENOM; HOG000082514; -.
HOVERGEN; HBG000127; -.
InParanoid; P41539; -.
KO; K05239; -.
OMA; QITRKRH; -.
OrthoDB; EOG091G0Y2V; -.
PhylomeDB; P41539; -.
TreeFam; TF333405; -.
Reactome; R-MMU-380095; Tachykinin receptors bind tachykinins.
Reactome; R-MMU-416476; G alpha (q) signalling events.
PRO; PR:P41539; -.
Proteomes; UP000000589; Chromosome 6.
Bgee; ENSMUSG00000061762; -.
CleanEx; MM_TAC1; -.
CleanEx; MM_TAC2; -.
ExpressionAtlas; P41539; baseline and differential.
Genevisible; P41539; MM.
GO; GO:0030424; C:axon; IDA:MGI.
GO; GO:0005576; C:extracellular region; IDA:MGI.
GO; GO:0005615; C:extracellular space; ISO:MGI.
GO; GO:0043025; C:neuronal cell body; IDA:MGI.
GO; GO:0005886; C:plasma membrane; ISO:MGI.
GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
GO; GO:0031835; F:substance P receptor binding; ISO:MGI.
GO; GO:0008306; P:associative learning; ISO:MGI.
GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
GO; GO:1990090; P:cellular response to nerve growth factor stimulus; IDA:MGI.
GO; GO:0007268; P:chemical synaptic transmission; IEA:UniProtKB-KW.
GO; GO:0006954; P:inflammatory response; IDA:MGI.
GO; GO:0007616; P:long-term memory; ISO:MGI.
GO; GO:0010459; P:negative regulation of heart rate; ISO:MGI.
GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
GO; GO:0045760; P:positive regulation of action potential; ISO:MGI.
GO; GO:0002675; P:positive regulation of acute inflammatory response; ISO:MGI.
GO; GO:2000854; P:positive regulation of corticosterone secretion; ISO:MGI.
GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISO:MGI.
GO; GO:0010634; P:positive regulation of epithelial cell migration; ISO:MGI.
GO; GO:0050671; P:positive regulation of lymphocyte proliferation; ISO:MGI.
GO; GO:0045778; P:positive regulation of ossification; ISO:MGI.
GO; GO:0035815; P:positive regulation of renal sodium excretion; ISO:MGI.
GO; GO:0046878; P:positive regulation of saliva secretion; ISO:MGI.
GO; GO:0051496; P:positive regulation of stress fiber assembly; ISO:MGI.
GO; GO:0032224; P:positive regulation of synaptic transmission, cholinergic; ISO:MGI.
GO; GO:0032230; P:positive regulation of synaptic transmission, GABAergic; ISO:MGI.
GO; GO:0008217; P:regulation of blood pressure; ISO:MGI.
GO; GO:0009725; P:response to hormone; ISO:MGI.
GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
GO; GO:0043278; P:response to morphine; IEA:Ensembl.
GO; GO:0048265; P:response to pain; IMP:MGI.
GO; GO:0019233; P:sensory perception of pain; IMP:MGI.
GO; GO:0007217; P:tachykinin receptor signaling pathway; IBA:GO_Central.
InterPro; IPR013055; Tachy_Neuro_lke_CS.
InterPro; IPR008215; Tachykinin_dom.
InterPro; IPR008216; Tachykinin_fam.
PANTHER; PTHR11250; PTHR11250; 1.
PRINTS; PR01829; PROTACHYKNIN.
SMART; SM00203; TK; 2.
PROSITE; PS00267; TACHYKININ; 2.
2: Evidence at transcript level;
Alternative splicing; Amidation; Cleavage on pair of basic residues;
Complete proteome; Neuropeptide; Neurotransmitter; Reference proteome;
Secreted; Signal.
SIGNAL 1 19 {ECO:0000255}.
PROPEP 20 56 {ECO:0000255}.
/FTId=PRO_0000033543.
PEPTIDE 58 68 Substance P.
/FTId=PRO_0000033544.
PEPTIDE 72 107 Neuropeptide K.
/FTId=PRO_0000033545.
PEPTIDE 72 73 Neuropeptide gamma, 1st part.
/FTId=PRO_0000033546.
PEPTIDE 89 107 Neuropeptide gamma, 2nd part.
/FTId=PRO_0000033547.
PEPTIDE 98 107 Neurokinin A.
/FTId=PRO_0000033548.
PEPTIDE 111 126 C-terminal-flanking peptide.
{ECO:0000250}.
/FTId=PRO_0000033549.
SITE 59 60 Cleavage; by FAP.
{ECO:0000250|UniProtKB:P20366}.
MOD_RES 68 68 Methionine amide. {ECO:0000250}.
MOD_RES 107 107 Methionine amide. {ECO:0000250}.
VAR_SEQ 74 88 Missing (in isoform Gamma).
{ECO:0000303|PubMed:1708336}.
/FTId=VSP_006379.
SEQUENCE 130 AA; 15045 MW; 7BE8DA15FDE72FF8 CRC64;
MKILVAVAVF FLVSTQLFAE EIDANDDLNY WSDWSDSDQI KEAMPEPFEH LLQRIARRPK
PQQFFGLMGK RDADSSVEKQ VALLKALYGH GQISHKRHKT DSFVGLMGKR ALNSVAYERS
AMQNYERRRK


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