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Proteasome subunit beta (EC 3.4.25.1) (20S proteasome beta subunit) (Proteasome core protein PrcB)

 PSB_GEOOG               Reviewed;         280 AA.
D2S6E2;
10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
02-MAR-2010, sequence version 1.
12-SEP-2018, entry version 44.
RecName: Full=Proteasome subunit beta {ECO:0000255|HAMAP-Rule:MF_02113};
EC=3.4.25.1 {ECO:0000255|HAMAP-Rule:MF_02113};
AltName: Full=20S proteasome beta subunit {ECO:0000255|HAMAP-Rule:MF_02113};
AltName: Full=Proteasome core protein PrcB {ECO:0000255|HAMAP-Rule:MF_02113};
Flags: Precursor;
Name=prcB {ECO:0000255|HAMAP-Rule:MF_02113};
OrderedLocusNames=Gobs_2682;
Geodermatophilus obscurus (strain ATCC 25078 / DSM 43160 / JCM 3152 /
G-20).
Bacteria; Actinobacteria; Geodermatophilales; Geodermatophilaceae;
Geodermatophilus.
NCBI_TaxID=526225;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 25078 / DSM 43160 / JCM 3152 / G-20;
US DOE Joint Genome Institute (JGI-PGF);
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K.,
Ivanova N., Munk A.C., Brettin T., Detter J.C., Han C., Larimer F.,
Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P.,
Woyke T., Wu D., Jando M., Schneider S., Klenk H.-P., Eisen J.A.;
"The complete genome of Geodermatophilus obscurus DSM 43160.";
Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Component of the proteasome core, a large protease
complex with broad specificity involved in protein degradation.
{ECO:0000255|HAMAP-Rule:MF_02113}.
-!- CATALYTIC ACTIVITY: Cleavage of peptide bonds with very broad
specificity. {ECO:0000255|HAMAP-Rule:MF_02113}.
-!- ACTIVITY REGULATION: The formation of the proteasomal ATPase ARC-
20S proteasome complex, likely via the docking of the C-termini of
ARC into the intersubunit pockets in the alpha-rings, may trigger
opening of the gate for substrate entry. Interconversion between
the open-gate and close-gate conformations leads to a dynamic
regulation of the 20S proteasome proteolysis activity.
{ECO:0000255|HAMAP-Rule:MF_02113}.
-!- PATHWAY: Protein degradation; proteasomal Pup-dependent pathway.
{ECO:0000255|HAMAP-Rule:MF_02113}.
-!- SUBUNIT: The 20S proteasome core is composed of 14 alpha and 14
beta subunits that assemble into four stacked heptameric rings,
resulting in a barrel-shaped structure. The two inner rings, each
composed of seven catalytic beta subunits, are sandwiched by two
outer rings, each composed of seven alpha subunits. The catalytic
chamber with the active sites is on the inside of the barrel. Has
a gated structure, the ends of the cylinder being occluded by the
N-termini of the alpha-subunits. Is capped by the proteasome-
associated ATPase, ARC. {ECO:0000255|HAMAP-Rule:MF_02113}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02113}.
-!- SIMILARITY: Belongs to the peptidase T1B family.
{ECO:0000255|HAMAP-Rule:MF_02113}.
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EMBL; CP001867; ADB75316.1; -; Genomic_DNA.
SMR; D2S6E2; -.
STRING; 526225.Gobs_2682; -.
MEROPS; T01.005; -.
PRIDE; D2S6E2; -.
EnsemblBacteria; ADB75316; ADB75316; Gobs_2682.
KEGG; gob:Gobs_2682; -.
eggNOG; ENOG4105KPK; Bacteria.
eggNOG; COG0638; LUCA.
HOGENOM; HOG000245308; -.
KO; K03433; -.
OMA; TMCAGVT; -.
OrthoDB; POG091H08LD; -.
UniPathway; UPA00997; -.
Proteomes; UP000001382; Chromosome.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005839; C:proteasome core complex; IEA:InterPro.
GO; GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
GO; GO:0010498; P:proteasomal protein catabolic process; IEA:InterPro.
Gene3D; 3.60.20.10; -; 1.
HAMAP; MF_02113_B; Proteasome_B_B; 1.
InterPro; IPR029055; Ntn_hydrolases_N.
InterPro; IPR022483; Pept_T1A_Psome_suB_actinobac.
InterPro; IPR001353; Proteasome_sua/b.
InterPro; IPR023333; Proteasome_suB-type.
Pfam; PF00227; Proteasome; 1.
SUPFAM; SSF56235; SSF56235; 1.
TIGRFAMs; TIGR03690; 20S_bact_beta; 1.
PROSITE; PS51476; PROTEASOME_BETA_2; 1.
3: Inferred from homology;
Autocatalytic cleavage; Complete proteome; Cytoplasm; Hydrolase;
Protease; Proteasome; Reference proteome; Threonine protease; Zymogen.
PROPEP 1 53 Removed in mature form; by autocatalysis.
{ECO:0000255|HAMAP-Rule:MF_02113}.
/FTId=PRO_0000397510.
CHAIN 54 280 Proteasome subunit beta.
/FTId=PRO_0000397511.
ACT_SITE 54 54 Nucleophile. {ECO:0000255|HAMAP-
Rule:MF_02113}.
SEQUENCE 280 AA; 29436 MW; D3F1DEB8112F9BE3 CRC64;
MSEYSAGRSG FSPAYLDRVG SSFTDFLAAA APHLLPGSRP VPQIPVGNVT PHGTTIVSVT
YDGGVLMGGD RRATMGNLIS SREIEKVYPA DAWSVIGIAG AAGIAIEMVR LYQVELEHYE
KIEGLTLSLD GKANRLAQMI RGNLGAALQG LAVVPLFAGF DLDAAPGAAP GRIFSYDVTG
GNYEERGYSA VGSGSLFARN SLKKTWRPNL DGDAATRSLV EALYDAADDD SATGGPDPVR
RLYPIVYRVD AEGAVRVPDD EIAAVATRIT DERSAADGQG


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