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Proteasome subunit pbs-5 (EC 3.4.25.1)

 PBS5_CAEEL              Reviewed;         284 AA.
Q9XUV0;
22-NOV-2017, integrated into UniProtKB/Swiss-Prot.
01-NOV-1999, sequence version 1.
07-NOV-2018, entry version 149.
RecName: Full=Proteasome subunit pbs-5 {ECO:0000312|WormBase:K05C4.1};
EC=3.4.25.1 {ECO:0000250|UniProtKB:P28074};
Flags: Precursor;
Name=pbs-5 {ECO:0000312|WormBase:K05C4.1};
ORFNames=K05C4.1 {ECO:0000312|WormBase:K05C4.1};
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
Caenorhabditis.
NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
[1] {ECO:0000312|Proteomes:UP000001940}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
[2] {ECO:0000305}
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=27528192; DOI=10.7554/eLife.17721;
Lehrbach N.J., Ruvkun G.;
"Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the
aspartic protease DDI-1.";
Elife 5:0-0(2016).
-!- FUNCTION: Component of the 20S core proteasome complex involved in
the proteolytic degradation of most intracellular proteins
(PubMed:27528192). This complex plays numerous essential roles
within the cell by associating with different regulatory particles
(By similarity). Associated with two 19S regulatory particles,
forms the 26S proteasome and thus participates in the ATP-
dependent degradation of ubiquitinated proteins (By similarity).
The 26S proteasome plays a key role in the maintenance of protein
homeostasis by removing misfolded or damaged proteins that could
impair cellular functions, and by removing proteins whose
functions are no longer required (By similarity).
{ECO:0000250|UniProtKB:P28074, ECO:0000269|PubMed:27528192}.
-!- CATALYTIC ACTIVITY: Cleavage of peptide bonds with very broad
specificity. {ECO:0000250|UniProtKB:P28074}.
-!- SUBUNIT: The 26S proteasome consists of a 20S proteasome core and
two 19S regulatory subunits. The 20S proteasome core is composed
of 28 subunits that are arranged in four stacked rings, resulting
in a barrel-shaped structure. The two end rings are each formed by
seven alpha subunits, and the two central rings are each formed by
seven beta subunits. The catalytic chamber with the active sites
is on the inside of the barrel. {ECO:0000250|UniProtKB:P28074}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|PROSITE-
ProRule:PRU00809}. Nucleus {ECO:0000250|UniProtKB:P28074}.
-!- DISRUPTION PHENOTYPE: No visible phenotype. Constitutive skn-1-
dependent expression of the proteasomal subunit rpt-3. Double
knockout with ddi-1, sel-1, sel-9, png-1 or skn-1a results in
failed expression of the proteasomal subunit rpt-3.
{ECO:0000269|PubMed:27528192}.
-!- SIMILARITY: Belongs to the peptidase T1B family.
{ECO:0000255|PROSITE-ProRule:PRU00809}.
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EMBL; BX284601; CAB04567.1; -; Genomic_DNA.
PIR; T23336; T23336.
RefSeq; NP_493558.1; NM_061157.4.
UniGene; Cel.4934; -.
ProteinModelPortal; Q9XUV0; -.
SMR; Q9XUV0; -.
DIP; DIP-25961N; -.
IntAct; Q9XUV0; 4.
STRING; 6239.K05C4.1.2; -.
MEROPS; T01.A09; -.
EPD; Q9XUV0; -.
PaxDb; Q9XUV0; -.
PeptideAtlas; Q9XUV0; -.
EnsemblMetazoa; K05C4.1; K05C4.1; WBGene00003951.
GeneID; 173334; -.
KEGG; cel:CELE_K05C4.1; -.
UCSC; K05C4.1.1; c. elegans.
CTD; 173334; -.
WormBase; K05C4.1; CE19969; WBGene00003951; pbs-5.
eggNOG; KOG0175; Eukaryota.
eggNOG; ENOG410XQRP; LUCA.
GeneTree; ENSGT00510000046395; -.
HOGENOM; HOG000091082; -.
InParanoid; Q9XUV0; -.
KO; K02737; -.
OMA; NLGMAMQ; -.
OrthoDB; EOG091G0BPS; -.
PhylomeDB; Q9XUV0; -.
Reactome; R-CEL-1234176; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
Reactome; R-CEL-1236978; Cross-presentation of soluble exogenous antigens (endosomes).
Reactome; R-CEL-174113; SCF-beta-TrCP mediated degradation of Emi1.
Reactome; R-CEL-195253; Degradation of beta-catenin by the destruction complex.
Reactome; R-CEL-382556; ABC-family proteins mediated transport.
Reactome; R-CEL-4608870; Asymmetric localization of PCP proteins.
Reactome; R-CEL-4641258; Degradation of DVL.
Reactome; R-CEL-5632684; Hedgehog 'on' state.
Reactome; R-CEL-5689603; UCH proteinases.
Reactome; R-CEL-5689880; Ub-specific processing proteases.
Reactome; R-CEL-68949; Orc1 removal from chromatin.
Reactome; R-CEL-69601; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
Reactome; R-CEL-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
Reactome; R-CEL-8948751; Regulation of PTEN stability and activity.
Reactome; R-CEL-983168; Antigen processing: Ubiquitination & Proteasome degradation.
PRO; PR:Q9XUV0; -.
Proteomes; UP000001940; Chromosome I.
Bgee; WBGene00003951; Expressed in 5 organ(s), highest expression level in multi-cellular organism.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0005839; C:proteasome core complex; IBA:GO_Central.
GO; GO:0004175; F:endopeptidase activity; IBA:GO_Central.
GO; GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
GO; GO:0010498; P:proteasomal protein catabolic process; IBA:GO_Central.
GO; GO:0010499; P:proteasomal ubiquitin-independent protein catabolic process; IBA:GO_Central.
GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
Gene3D; 3.60.20.10; -; 1.
InterPro; IPR029055; Ntn_hydrolases_N.
InterPro; IPR000243; Pept_T1A_subB.
InterPro; IPR001353; Proteasome_sua/b.
InterPro; IPR023333; Proteasome_suB-type.
Pfam; PF00227; Proteasome; 1.
PRINTS; PR00141; PROTEASOME.
SUPFAM; SSF56235; SSF56235; 1.
PROSITE; PS51476; PROTEASOME_BETA_2; 1.
3: Inferred from homology;
Complete proteome; Cytoplasm; Hydrolase; Nucleus; Protease;
Proteasome; Reference proteome; Threonine protease; Zymogen.
CHAIN 1 284 Proteasome subunit pbs-5. {ECO:0000305}.
/FTId=PRO_0000442337.
PROPEP 1 64 Removed in mature form.
{ECO:0000250|UniProtKB:P28074}.
/FTId=PRO_0000442336.
ACT_SITE 65 65 Nucleophile.
{ECO:0000250|UniProtKB:P28074}.
SEQUENCE 284 AA; 31230 MW; A382E295F2C50604 CRC64;
MWGETFDDFE NDEGEMAMAK QNLIAEPARA DFTFAKLPLG IQPVDFMKTH FAETAGKSMQ
FRKGTTTLAF VYEPATPADK GGIIVAVDSR ASSGEYISSK SVMKILDIGD RMVATMAGGA
ADCQFWTRIV AKYCTLYELR EKTSITVSAA SKYFANTLYG YRGQGLSVGS MVAGYDKKGP
QIFKVDSEGD RCQLKVCSVG SGSLNAYGIL DNHYKPKMTD DEARKLGLRA IMHATYRDSG
SGGVCNLCHI TPTEKIRLPP MDVSKLWYEF ADELGRDITY NPVE


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