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Protein 3 (Accessory protein 3)

 AP3A_BCRP3              Reviewed;         274 AA.
Q3I5J4;
22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
08-NOV-2005, sequence version 1.
23-MAY-2018, entry version 64.
RecName: Full=Protein 3;
AltName: Full=Accessory protein 3;
ORFNames=3;
Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3).
Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage;
Nidovirales; Coronaviridae; Coronavirinae; Betacoronavirus.
NCBI_TaxID=349344;
NCBI_TaxID=59479; Rhinolophus ferrumequinum (Greater horseshoe bat).
NCBI_TaxID=196889; Rhinolophus macrotis (Big-eared horseshoe bat).
NCBI_TaxID=188571; Rhinolophus pearsonii.
NCBI_TaxID=89399; Rhinolophus sinicus (Chinese rufous horseshoe bat).
[1]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
PubMed=16195424; DOI=10.1126/science.1118391;
Li W., Shi Z., Yu M., Ren W., Smith C., Epstein J.H., Wang H.,
Crameri G., Hu Z., Zhang H., Zhang J., McEachern J., Field H.,
Daszak P., Eaton B.T., Zhang S., Wang L.F.;
"Bats are natural reservoirs of SARS-like coronaviruses.";
Science 310:676-679(2005).
-!- FUNCTION: Forms homotetrameric potassium sensitive ion channels
(viroporin) and may modulate virus release. Up-regulates
expression of fibrinogen subunits FGA, FGB and FGG in host lung
epithelial cells. Induces apoptosis in cell culture. Downregulates
the type 1 interferon receptor by inducing serine phosphorylation
within the IFN alpha-receptor subunit 1 (IFNAR1) degradation motif
and increasing IFNAR1 ubiquitination (By similarity).
{ECO:0000250}.
-!- SUBUNIT: Homotetramer composed of two homodimers linked non
covalently. Interacts with M, S and E proteins. Also interacts
with the accessory protein 7a (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Host Golgi apparatus
membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Host cell membrane {ECO:0000250}; Multi-pass membrane protein
{ECO:0000250}. Secreted {ECO:0000250}. Host cytoplasm
{ECO:0000250}. Note=The cell surface expressed protein can undergo
endocytosis. The protein is secreted in association with
membranous structures (By similarity). {ECO:0000250}.
-!- DOMAIN: The second or the third transmembrane region are
responsible for Golgi localization. {ECO:0000250}.
-!- PTM: Exists in both O-glycosylated and non-glycosylated forms. The
glycosylated form is associated with the virion (By similarity).
{ECO:0000250}.
-!- MISCELLANEOUS: Bat coronavirus rp3 is highly similar to SARS-CoV
(SARS-like).
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EMBL; DQ071615; AAZ67053.1; -; Genomic_RNA.
OrthoDB; VOG090000JI; -.
Proteomes; UP000006570; Genome.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0044385; C:integral to membrane of host cell; IEA:UniProtKB-KW.
GO; GO:0019012; C:virion; IEA:UniProtKB-SubCell.
GO; GO:0005216; F:ion channel activity; IEA:UniProtKB-KW.
GO; GO:0039707; P:pore formation by virus in membrane of host cell; IEA:UniProtKB-KW.
GO; GO:0051259; P:protein complex oligomerization; IEA:UniProtKB-KW.
InterPro; IPR024407; SARS_coronavirus_Orf3/3a.
Pfam; PF11289; APA3_viroporin; 1.
ProDom; PD719245; PD719245; 1.
3: Inferred from homology;
Apoptosis; Complete proteome; Glycoprotein; Host cell membrane;
Host cytoplasm; Host Golgi apparatus; Host membrane; Ion channel;
Ion transport; Membrane; Secreted; Transmembrane; Transmembrane helix;
Transport; Viral ion channel; Virion.
CHAIN 1 274 Protein 3.
/FTId=PRO_0000106130.
TOPO_DOM 1 34 Extracellular. {ECO:0000250}.
TRANSMEM 35 55 Helical. {ECO:0000255}.
TOPO_DOM 56 78 Cytoplasmic. {ECO:0000255}.
TRANSMEM 79 99 Helical. {ECO:0000255}.
TOPO_DOM 100 104 Extracellular. {ECO:0000255}.
TRANSMEM 105 125 Helical. {ECO:0000255}.
TOPO_DOM 126 274 Cytoplasmic. {ECO:0000250}.
COMPBIAS 83 86 Poly-Leu.
COMPBIAS 94 97 Poly-Leu.
COMPBIAS 267 270 Poly-Thr.
SITE 133 133 Involved in polymerization.
{ECO:0000250}.
CARBOHYD 27 27 O-linked (GalNAc...) serine; by host.
{ECO:0000255}.
CARBOHYD 28 28 O-linked (GalNAc...) threonine; by host.
{ECO:0000250}.
CARBOHYD 32 32 O-linked (GalNAc...) threonine; by host.
{ECO:0000250}.
CARBOHYD 34 34 O-linked (GalNAc...) threonine; by host.
{ECO:0000255}.
SEQUENCE 274 AA; 30794 MW; AE17D810FD454594 CRC64;
MDLFMSIFTL GAITRQPAKI ENASPASTVH ATATIPLQAS LPFGWLVVGV ALLAVFQSAS
KVIALHKRWQ LALHKGIQLV CNLLLLFVTI YSHLLLLAAG MEAQFLYIYA LIYILQIVSF
CRFIMRCWLC WKCRSKNPLL YDANYFVCWH TNCFDYCIPY NSITDTIVLT SGDGTTQPKL
KEDYQIGGYS EDWHSGVKDY VVIHGYFTEV YYQLESTQLS TDTGAENATF FIYSKLVKDV
DHVQIHTIDG SSGVVNPAMD PIYDEPTTTT SVPL


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