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Protein 3a (Accessory protein 3a) (Protein U274) (Protein X1)

 AP3A_CVHSA              Reviewed;         274 AA.
P59632; Q7T6R6; Q7TA10; Q7TA18; Q7TFB0; Q7TLD0; Q80BV5;
23-APR-2003, integrated into UniProtKB/Swiss-Prot.
23-APR-2003, sequence version 1.
25-OCT-2017, entry version 85.
RecName: Full=Protein 3a;
AltName: Full=Accessory protein 3a;
AltName: Full=Protein U274;
AltName: Full=Protein X1;
ORFNames=3a;
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome
coronavirus).
Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage;
Nidovirales; Coronaviridae; Coronavirinae; Betacoronavirus.
NCBI_TaxID=227859;
NCBI_TaxID=9606; Homo sapiens (Human).
NCBI_TaxID=9675; Paguma larvata (Masked palm civet).
[1]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate Urbani;
PubMed=12730500; DOI=10.1126/science.1085952;
Rota P.A., Oberste M.S., Monroe S.S., Nix W.A., Campagnoli R.,
Icenogle J.P., Penaranda S., Bankamp B., Maher K., Chen M.-H.,
Tong S., Tamin A., Lowe L., Frace M., DeRisi J.L., Chen Q., Wang D.,
Erdman D.D., Peret T.C.T., Burns C., Ksiazek T.G., Rollin P.E.,
Sanchez A., Liffick S., Holloway B., Limor J., McCaustland K.,
Olsen-Rasmussen M., Fouchier R., Guenther S., Osterhaus A.D.M.E.,
Drosten C., Pallansch M.A., Anderson L.J., Bellini W.J.;
"Characterization of a novel coronavirus associated with severe acute
respiratory syndrome.";
Science 300:1394-1399(2003).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate Tor2;
PubMed=12730501; DOI=10.1126/science.1085953;
Marra M.A., Jones S.J.M., Astell C.R., Holt R.A., Brooks-Wilson A.,
Butterfield Y.S.N., Khattra J., Asano J.K., Barber S.A., Chan S.Y.,
Cloutier A., Coughlin S.M., Freeman D., Girn N., Griffith O.L.,
Leach S.R., Mayo M., McDonald H., Montgomery S.B., Pandoh P.K.,
Petrescu A.S., Robertson A.G., Schein J.E., Siddiqui A., Smailus D.E.,
Stott J.M., Yang G.S., Plummer F., Andonov A., Artsob H., Bastien N.,
Bernard K., Booth T.F., Bowness D., Czub M., Drebot M., Fernando L.,
Flick R., Garbutt M., Gray M., Grolla A., Jones S., Feldmann H.,
Meyers A., Kabani A., Li Y., Normand S., Stroher U., Tipples G.A.,
Tyler S., Vogrig R., Ward D., Watson B., Brunham R.C., Krajden M.,
Petric M., Skowronski D.M., Upton C., Roper R.L.;
"The genome sequence of the SARS-associated coronavirus.";
Science 300:1399-1404(2003).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate CUHK-Su10, and Isolate CUHK-W1;
PubMed=12853594; DOI=10.1056/NEJM200307103490216;
Tsui S.K.W., Chim S.S.C., Lo Y.M.D.;
"Coronavirus genomic-sequence variations and the epidemiology of the
severe acute respiratory syndrome.";
N. Engl. J. Med. 349:187-188(2003).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate HKU-39849;
PubMed=12876307; DOI=10.1177/15353702-0322807-13;
Zeng F.Y., Chan C.W., Chan M.N., Chen J.D., Chow K.Y.C., Hon C.C.C.,
Hui R.K.H., Li J., Li V.Y.Y., Wang C.Y., Wang P.Y., Guan Y., Zheng B.,
Poon L.L.M., Chan K.H., Yuen K.Y., Peiris J.S.M., Leung F.C.;
"The complete genome sequence of severe acute respiratory syndrome
coronavirus strain HKU-39849 (HK-39).";
Exp. Biol. Med. 228:866-873(2003).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate BJ01, Isolate BJ02, Isolate BJ03, Isolate BJ04, and
Isolate GD01;
Qin E., Zhu Q., Yu M., Fan B., Chang G., Si B., Yang B., Peng W.,
Jiang T., Liu B., Deng Y., Liu H., Zhang Y., Wang C., Li Y., Gan Y.,
Li X., Lu F., Tan G., Yang R., Cao W.S., Wang J., Chen W., Cong L.,
Deng Y., Dong W., Han Y., Hu W., Lei M., Li C., Li G., Li G., Li H.,
Li S., Li S., Li W., Li W., Lin W., Liu J., Liu Z., Lu H., Ni P.,
Qi Q., Sun Y., Tang L., Tong Z., Wang J., Wang X., Wu Q., Xi Y.,
Xu Z., Yang L., Ye C., Ye J., Zhang B., Zhang F., Zhang J., Zhang X.,
Zhou J., Yang H.;
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate TW1;
Yeh S.-H., Kao C.-L., Tsai C.-Y., Liu C.-J., Chen D.-S., Chen P.-J.;
"The complete genome of SARS coronavirus clone TW1.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate FRA;
Eickmann M., Becker S., Klenk H.-D., Doerr H.W., Stadler K.,
Censini S., Guidotti S., Masignani V., Scarselli M., Mora M.,
Donati C., Han J., Song H.C., Abrignani S., Covacci A., Rappuoli R.;
"SARS virus is a close relative of type II coronaviruses.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
[8]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate Frankfurt 1;
Thiel V., Hertzig T., Putics A., Ivanov K.A., Schelle B., Bayer S.,
Scheiner B., Weinand H., Weissbrich B., Ziebuhr J.;
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
[9]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate Taiwan TC1, Isolate Taiwan TC2, and Isolate Taiwan TC3;
Chang J.-G.C., Lin T.-H., Chen C.-M., Lin C.-S., Chan W.-L.,
Shih M.-C.;
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
[10]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate TWH, Isolate TWJ, Isolate TWK, Isolate TWS, and
Isolate TWY;
Shu H.Y., Wu K.M., Tsai S.F.;
"The complete genome of SARS coronavirus TWH.";
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
[11]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate HSR 1;
Canducci F., Clementi M., Poli G., Vicenzi E.;
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
[12]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate AS;
Balotta C., Corvasce S., Violin M., Galli M., Moroni M.,
Vigevani G.M., Ruan Y.J., Salemi M.;
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
[13]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate Shanghai QXC1;
Yuan Z., Zhang X., Hu Y., Lan S., Wang H., Zhou Z., Wen Y.;
"Analysis of SARS coronavirus genome in Shanghai isolates.";
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
[14]
NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1-125.
STRAIN=Isolate Shanghai LY;
Yuan Z., Zhang X., Hu Y., Lan S., Wang H., Zhou Z., Wen Y.;
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
[15]
IDENTIFICATION.
PubMed=15135062; DOI=10.1016/j.febslet.2004.03.086;
Yu C.-J., Chen Y.-C., Hsiao C.-H., Kuo T.-C., Chang S.C., Lu C.-Y.,
Wei W.-C., Lee C.-H., Huang L.-M., Chang M.-F., Ho H.-N., Lee F.-J.S.;
"Identification of a novel protein 3a from severe acute respiratory
syndrome coronavirus.";
FEBS Lett. 565:111-116(2004).
[16]
SUBCELLULAR LOCATION, TOPOLOGY, AND INTERACTION WITH M PROTEIN; E
PROTEIN; SPIKE GLYCOPROTEIN AND ACCESSORY PROTEIN 7A.
PubMed=15194747; DOI=10.1128/JVI.78.13.6723-6734.2004;
Tan Y.-J., Teng E., Shen S., Tan T.H.P., Goh P.-Y., Fielding B.C.,
Ooi E.-E., Tan H.-C., Lim S.G., Hong W.;
"A novel severe acute respiratory syndrome coronavirus protein, U274,
is transported to the cell surface and undergoes endocytosis.";
J. Virol. 78:6723-6734(2004).
[17]
SUBCELLULAR LOCATION, AND INTERACTION WITH M AND E PROTEINS.
PubMed=15763150; DOI=10.1016/j.virusres.2005.01.001;
Yuan X., Li J., Shan Y., Yang Z., Zhao Z., Chen B., Yao Z., Dong B.,
Wang S., Chen J., Cong Y.;
"Subcellular localization and membrane association of SARS-CoV 3a
protein.";
Virus Res. 109:191-202(2005).
[18]
CHARACTERIZATION.
PubMed=15781262; DOI=10.1016/j.bbrc.2005.02.153;
Shen S., Lin P.S., Chao Y.C., Zhang A., Yang X., Lim S.G., Hong W.,
Tan Y.J.;
"The severe acute respiratory syndrome coronavirus 3a is a novel
structural protein.";
Biochem. Biophys. Res. Commun. 330:286-292(2005).
[19]
CHARACTERIZATION, AND SUBCELLULAR LOCATION.
PubMed=15709039; DOI=10.1128/JVI.79.5.3182-3186.2005;
Ito N., Mossel E.C., Narayanan K., Popov V.L., Huang C., Inoue T.,
Peters C.J., Makino S.;
"Severe acute respiratory syndrome coronavirus 3a protein is a viral
structural protein.";
J. Virol. 79:3182-3186(2005).
[20]
FUNCTION.
PubMed=16014971; DOI=10.1128/JVI.79.15.10083-10087.2005;
Tan Y.J., Tham P.Y., Chan D.Z., Chou C.-F., Shen S., Fielding B.C.,
Tan T.H., Lim S.G., Hong W.;
"The severe acute respiratory syndrome coronavirus 3a protein up-
regulates expression of fibrinogen in lung epithelial cells.";
J. Virol. 79:10083-10087(2005).
[21]
FUNCTION.
PubMed=15958670; DOI=10.1099/vir.0.80813-0;
Law P.T., Wong C.H., Au T.C., Chuck C.P., Kong S.K., Chan P.K.,
To K.F., Lo A.W., Chan J.Y., Suen Y.K., Chan H.Y., Fung K.P.,
Waye M.M., Sung J.J., Lo Y.M.D., Tsui S.K.W.;
"The 3a protein of severe acute respiratory syndrome-associated
coronavirus induces apoptosis in Vero E6 cells.";
J. Gen. Virol. 86:1921-1930(2005).
[22]
GLYCOSYLATION, AND MUTAGENESIS OF SER-27; THR-28; THR-32 AND THR-34.
PubMed=16474139; DOI=10.1128/JVI.80.5.2326-2336.2006;
Oostra M., de Haan C.A., de Groot R.J., Rottier P.J.M.;
"Glycosylation of the severe acute respiratory syndrome coronavirus
triple-spanning membrane proteins 3a and M.";
J. Virol. 80:2326-2336(2006).
[23]
SUBCELLULAR LOCATION.
PubMed=16352545; DOI=10.1128/JVI.80.1.210-217.2006;
Huang C., Narayanan K., Ito N., Peters C.J., Makino S.;
"Severe acute respiratory syndrome coronavirus 3a protein is released
in membranous structures from 3a protein-expressing cells and infected
cells.";
J. Virol. 80:210-217(2006).
[24]
FUNCTION, SUBUNIT, AND MUTAGENESIS OF CYS-81; CYS-117; CYS-121;
CYS-127; CYS-130; CYS-133; CYS-148 AND CYS-157.
PubMed=16894145; DOI=10.1073/pnas.0605402103;
Lu W., Zheng B.-J., Xu K., Schwarz W., Du L., Wong C.K.L., Chen J.,
Duan S., Deubel V., Sun B.;
"Severe acute respiratory syndrome-associated coronavirus 3a protein
forms an ion channel and modulates virus release.";
Proc. Natl. Acad. Sci. U.S.A. 103:12540-12545(2006).
[25]
FUNCTION.
PubMed=20020050; DOI=10.1371/journal.pone.0008342;
Minakshi R., Padhan K., Rani M., Khan N., Ahmad F., Jameel S.;
"The SARS Coronavirus 3a protein causes endoplasmic reticulum stress
and induces ligand-independent downregulation of the type 1 interferon
receptor.";
PLoS ONE 4:E8342-E8342(2009).
-!- FUNCTION: Forms homotetrameric potassium sensitive ion channels
(viroporin) and may modulate virus release. Up-regulates
expression of fibrinogen subunits FGA, FGB and FGG in host lung
epithelial cells. Induces apoptosis in cell culture. Downregulates
the type 1 interferon receptor by inducing serine phosphorylation
within the IFN alpha-receptor subunit 1 (IFNAR1) degradation motif
and increasing IFNAR1 ubiquitination.
{ECO:0000269|PubMed:15958670, ECO:0000269|PubMed:16014971,
ECO:0000269|PubMed:16894145, ECO:0000269|PubMed:20020050}.
-!- SUBUNIT: Homotetramer composed of two homodimers linked non
covalently. Interacts with M, S and E proteins. Also interacts
with the accessory protein 7a. {ECO:0000269|PubMed:15194747,
ECO:0000269|PubMed:15763150, ECO:0000269|PubMed:16894145}.
-!- SUBCELLULAR LOCATION: Virion. Host Golgi apparatus membrane;
Multi-pass membrane protein. Host cell membrane; Multi-pass
membrane protein. Secreted. Host cytoplasm. Note=The cell surface
expressed protein can undergo endocytosis. The protein is secreted
in association with membranous structures.
-!- DOMAIN: The second or the third transmembrane region are
responsible for Golgi localization.
-!- PTM: Exists in both O-glycosylated and non-glycosylated forms. The
glycosylated form is associated with the virion.
{ECO:0000269|PubMed:16474139}.
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EMBL; AY278741; AAP13446.1; -; Genomic_RNA.
EMBL; AY274119; AAP41038.1; -; Genomic_RNA.
EMBL; AY282752; -; NOT_ANNOTATED_CDS; Genomic_RNA.
EMBL; AY278554; AAP13568.1; -; Genomic_RNA.
EMBL; AY278491; -; NOT_ANNOTATED_CDS; Genomic_RNA.
EMBL; AY278487; -; NOT_ANNOTATED_CDS; Genomic_RNA.
EMBL; AY278488; AAP30031.1; -; Genomic_RNA.
EMBL; AY278489; AAP51228.1; -; Genomic_RNA.
EMBL; AY278490; -; NOT_ANNOTATED_CDS; Genomic_RNA.
EMBL; AY279354; -; NOT_ANNOTATED_CDS; Genomic_RNA.
EMBL; AY291451; AAP37018.1; -; Genomic_RNA.
EMBL; AY310120; AAP50486.1; -; Genomic_RNA.
EMBL; AY291315; AAP33698.1; -; Genomic_RNA.
EMBL; AY338174; AAQ01598.1; -; Genomic_RNA.
EMBL; AY338175; AAQ01610.1; -; Genomic_RNA.
EMBL; AY348314; AAP97883.1; -; Genomic_RNA.
EMBL; AP006557; BAC81349.1; -; Genomic_RNA.
EMBL; AP006558; BAC81363.1; -; Genomic_RNA.
EMBL; AP006559; BAC81377.1; -; Genomic_RNA.
EMBL; AP006560; BAC81391.1; -; Genomic_RNA.
EMBL; AP006561; BAC81405.1; -; Genomic_RNA.
EMBL; AY323977; AAP72975.1; -; Genomic_RNA.
EMBL; AY427439; AAQ94061.1; -; Genomic_RNA.
EMBL; AY463059; AAP82984.2; -; Genomic_RNA.
EMBL; AY322207; AAP82969.1; -; Genomic_RNA.
SMR; P59632; -.
DIP; DIP-61251N; -.
TCDB; 1.A.57.1.1; the human sars caronavirus viroporin (sars-vp).
iPTMnet; P59632; -.
PRIDE; P59632; -.
OrthoDB; VOG090000JI; -.
Proteomes; UP000000354; Genome.
Proteomes; UP000103670; Genome.
Proteomes; UP000109640; Genome.
Proteomes; UP000116947; Genome.
Proteomes; UP000121636; Genome.
Proteomes; UP000131569; Genome.
Proteomes; UP000131955; Genome.
Proteomes; UP000137377; Genome.
Proteomes; UP000138690; Genome.
Proteomes; UP000143093; Genome.
Proteomes; UP000145651; Genome.
Proteomes; UP000146108; Genome.
Proteomes; UP000146181; Genome.
Proteomes; UP000146296; Genome.
Proteomes; UP000148194; Genome.
Proteomes; UP000153467; Genome.
Proteomes; UP000160648; Genome.
Proteomes; UP000164441; Genome.
Proteomes; UP000172416; Genome.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0044385; C:integral to membrane of host cell; IEA:UniProtKB-KW.
GO; GO:0019012; C:virion; IEA:UniProtKB-SubCell.
GO; GO:0005216; F:ion channel activity; IEA:UniProtKB-KW.
GO; GO:0039707; P:pore formation by virus in membrane of host cell; IEA:UniProtKB-KW.
GO; GO:0051259; P:protein oligomerization; IEA:UniProtKB-KW.
GO; GO:0039511; P:suppression by virus of host interferon receptor activity; IEA:UniProtKB-KW.
GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW.
InterPro; IPR024407; SARS_coronavirus_Orf3/3a.
Pfam; PF11289; APA3_viroporin; 1.
ProDom; PD719245; PD719245; 1.
1: Evidence at protein level;
Apoptosis; Complete proteome; Glycoprotein; Host cell membrane;
Host cytoplasm; Host Golgi apparatus; Host membrane;
Host-virus interaction;
Inhibition of host innate immune response by virus;
Inhibition of host interferon receptors by virus;
Inhibition of host interferon signaling pathway by virus; Ion channel;
Ion transport; Membrane; Reference proteome; Secreted; Transmembrane;
Transmembrane helix; Transport; Viral immunoevasion;
Viral ion channel; Virion.
CHAIN 1 274 Protein 3a.
/FTId=PRO_0000106131.
TOPO_DOM 1 34 Extracellular.
{ECO:0000305|PubMed:15194747}.
TRANSMEM 35 55 Helical. {ECO:0000255}.
TOPO_DOM 56 78 Cytoplasmic. {ECO:0000255}.
TRANSMEM 79 99 Helical. {ECO:0000255}.
TOPO_DOM 100 104 Extracellular. {ECO:0000255}.
TRANSMEM 105 125 Helical. {ECO:0000255}.
TOPO_DOM 126 274 Cytoplasmic.
{ECO:0000305|PubMed:15194747}.
COMPBIAS 83 86 Poly-Leu.
COMPBIAS 267 270 Poly-Thr.
SITE 133 133 Involved in polymerization.
CARBOHYD 27 27 O-linked (GalNAc...) serine; by host.
{ECO:0000255}.
CARBOHYD 28 28 O-linked (GalNAc...) threonine; by host.
{ECO:0000305|PubMed:16474139}.
CARBOHYD 32 32 O-linked (GalNAc...) threonine; by host.
{ECO:0000305|PubMed:16474139}.
CARBOHYD 34 34 O-linked (GalNAc...) threonine; by host.
{ECO:0000255}.
VARIANT 11 11 G -> R (in strain: Isolate Tor2, Isolate
BJ02 and Isolate BJ03).
VARIANT 20 20 I -> T (in strain: Isolate Shanghai LY).
VARIANT 29 29 V -> A (in strain: Isolate Shanghai
QXC1).
VARIANT 101 101 M -> K (in strain: Isolate HKU-39849).
VARIANT 129 129 L -> F (in strain: Isolate TWK).
VARIANT 136 136 K -> Q (in strain: Isolate BJ01).
VARIANT 171 171 E -> A (in strain: Isolate GD01).
VARIANT 193 193 R -> W (in strain: Isolate GD01).
VARIANT 222 222 D -> N (in strain: Isolate Shanghai
QXC1).
MUTAGEN 27 27 S->G: Complete loss of O-glycosylation;
when associated with A-28; A-32 and A-34.
{ECO:0000269|PubMed:16474139}.
MUTAGEN 28 28 T->A: Complete loss of O-glycosylation;
when associated with A-27; A-32 and A-34.
{ECO:0000269|PubMed:16474139}.
MUTAGEN 32 32 T->A: Complete loss of O-glycosylation;
when associated with A-27; A-28 and A-34.
{ECO:0000269|PubMed:16474139}.
MUTAGEN 34 34 T->A: Complete loss of O-glycosylation;
when associated with A-27; A-28 and A-32.
{ECO:0000269|PubMed:16474139}.
MUTAGEN 81 81 C->A: No effect on polymerization.
{ECO:0000269|PubMed:16894145}.
MUTAGEN 117 117 C->A: No effect on polymerization.
{ECO:0000269|PubMed:16894145}.
MUTAGEN 121 121 C->A: No effect on polymerization.
{ECO:0000269|PubMed:16894145}.
MUTAGEN 127 127 C->A: No effect on polymerization.
{ECO:0000269|PubMed:16894145}.
MUTAGEN 130 130 C->A: No effect on polymerization.
{ECO:0000269|PubMed:16894145}.
MUTAGEN 133 133 C->A: Almost complete loss of
polimerization ability.
{ECO:0000269|PubMed:16894145}.
MUTAGEN 148 148 C->A: No effect on polymerization.
{ECO:0000269|PubMed:16894145}.
MUTAGEN 157 157 C->A: No effect on polymerization.
{ECO:0000269|PubMed:16894145}.
SEQUENCE 274 AA; 30903 MW; E48C7D44A4DE34FE CRC64;
MDLFMRFFTL GSITAQPVKI DNASPASTVH ATATIPLQAS LPFGWLVIGV AFLAVFQSAT
KIIALNKRWQ LALYKGFQFI CNLLLLFVTI YSHLLLVAAG MEAQFLYLYA LIYFLQCINA
CRIIMRCWLC WKCKSKNPLL YDANYFVCWH THNYDYCIPY NSVTDTIVVT EGDGISTPKL
KEDYQIGGYS EDRHSGVKDY VVVHGYFTEV YYQLESTQIT TDTGIENATF FIFNKLVKDP
PNVQIHTIDG SSGVANPAMD PIYDEPTTTT SVPL


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E2764Hu Human Interleukin 1 Receptor Accessory Protein Like Protein 2 (IL1RAPL2)ELISA Kit 96T
18-003-42517 ETS domain-containing protein Elk-4 - Serum response factor accessory protein 1; SAP-1 Polyclonal 0.1 mg Protein A
27759 Mouse Interleukin 1 Receptor Accessory Protein Like Protein 2 (IL1RAPL2) ELISA Kit 10ng/ml-0.156ng/ml <0.05ng/ml


 

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