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Protein 60A (Protein glass bottom boat)

 60A_DROME               Reviewed;         455 AA.
P27091; Q9W1I4;
01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
01-AUG-1992, sequence version 1.
28-MAR-2018, entry version 154.
RecName: Full=Protein 60A;
AltName: Full=Protein glass bottom boat;
Flags: Precursor;
Name=gbb; Synonyms=60A, gbb-60A, TGFb-60A; ORFNames=CG5562;
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DEVELOPMENTAL STAGE.
PubMed=1924384; DOI=10.1073/pnas.88.20.9214;
Wharton K.A., Thomsen G.H., Gelbart W.M.;
"Drosophila 60A gene, another transforming growth factor beta family
member, is closely related to human bone morphogenetic proteins.";
Proc. Natl. Acad. Sci. U.S.A. 88:9214-9218(1991).
[2]
NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT, SUBCELLULAR LOCATION, TISSUE
SPECIFICITY, AND DEVELOPMENTAL STAGE.
PubMed=1601181; DOI=10.1016/0012-1606(92)90188-M;
Doctor J.S., Jackson P.D., Rashka K.E., Visalli M., Hoffmann F.M.;
"Sequence, biochemical characterization, and developmental expression
of a new member of the TGF-beta superfamily in Drosophila
melanogaster.";
Dev. Biol. 151:491-505(1992).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
PubMed=10731132; DOI=10.1126/science.287.5461.2185;
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[4]
GENOME REANNOTATION.
STRAIN=Berkeley;
PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[5]
FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
PubMed=9636086;
Khalsa O., Yoon J.-W., Torres-Schumann S., Wharton K.A.;
"TGF-beta/BMP superfamily members, Gbb-60A and Dpp, cooperate to
provide pattern information and establish cell identity in the
Drosophila wing.";
Development 125:2723-2734(1998).
-!- FUNCTION: Required for the growth of imaginal tissues and for
patterning of the adult wing. {ECO:0000269|PubMed:9636086}.
-!- SUBUNIT: Homodimer; disulfide-linked.
{ECO:0000269|PubMed:1601181}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1601181}.
-!- TISSUE SPECIFICITY: Expressed in cells of the developing foregut
and hindgut during germ band retraction and later embryonic
stages. Expressed in the wing disk, mainly in the posterior
compartment in the pteropleural and medial regions extending into
the progenitors of the scutellum. High levels are found within the
posterior and anterior compartments of the wing pouch and low
levels in the hinge region. In the eye/antennal disk, expression
is highest anterior to the morphogenetic furrow and in the medial
regions with lower levels of expression posterior to the
morphogenetic furrow. Expressed throughout the posterior
compartment of the leg imaginal disks and within the ventral
anterior compartment. {ECO:0000269|PubMed:1601181,
ECO:0000269|PubMed:9636086}.
-!- DEVELOPMENTAL STAGE: Expressed throughout development with peaks
of transcription during early embryogenesis, in pupae, and in
adult males. {ECO:0000269|PubMed:1601181,
ECO:0000269|PubMed:1924384}.
-!- DISRUPTION PHENOTYPE: Flies exhibit transparent larvae, and a
reduction of the adult wing size. {ECO:0000269|PubMed:9636086}.
-!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; M77012; AAA28306.1; -; Genomic_DNA.
EMBL; M84795; AAA28307.1; -; mRNA.
EMBL; AE013599; AAF47075.1; -; Genomic_DNA.
PIR; A43918; A43918.
RefSeq; NP_001286786.1; NM_001299857.1.
RefSeq; NP_477340.1; NM_057992.3.
UniGene; Dm.4758; -.
ProteinModelPortal; P27091; -.
BioGrid; 63372; 30.
DIP; DIP-19466N; -.
IntAct; P27091; 8.
STRING; 7227.FBpp0072036; -.
PaxDb; P27091; -.
PRIDE; P27091; -.
EnsemblMetazoa; FBtr0072127; FBpp0072036; FBgn0024234.
EnsemblMetazoa; FBtr0343274; FBpp0309939; FBgn0024234.
GeneID; 37778; -.
KEGG; dme:Dmel_CG5562; -.
CTD; 37778; -.
FlyBase; FBgn0024234; gbb.
eggNOG; KOG3900; Eukaryota.
eggNOG; ENOG410XT8Z; LUCA.
GeneTree; ENSGT00760000118883; -.
InParanoid; P27091; -.
KO; K16621; -.
OMA; IYKDCVV; -.
OrthoDB; EOG091G0C2J; -.
PhylomeDB; P27091; -.
SignaLink; P27091; -.
ChiTaRS; Gbeta13F; fly.
GenomeRNAi; 37778; -.
PRO; PR:P27091; -.
Proteomes; UP000000803; Chromosome 2R.
Bgee; FBgn0024234; -.
ExpressionAtlas; P27091; differential.
Genevisible; P27091; DM.
GO; GO:0031045; C:dense core granule; IDA:FlyBase.
GO; GO:0012505; C:endomembrane system; HDA:FlyBase.
GO; GO:0005576; C:extracellular region; IDA:FlyBase.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0097467; C:type III terminal bouton; IDA:FlyBase.
GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0005160; F:transforming growth factor beta receptor binding; ISS:FlyBase.
GO; GO:0030509; P:BMP signaling pathway; IBA:GO_Central.
GO; GO:0007391; P:dorsal closure; TAS:FlyBase.
GO; GO:0036099; P:female germ-line stem cell population maintenance; IMP:FlyBase.
GO; GO:0008586; P:imaginal disc-derived wing vein morphogenesis; IMP:FlyBase.
GO; GO:0007474; P:imaginal disc-derived wing vein specification; IMP:FlyBase.
GO; GO:0007528; P:neuromuscular junction development; IMP:FlyBase.
GO; GO:0007274; P:neuromuscular synaptic transmission; IMP:FlyBase.
GO; GO:0030707; P:ovarian follicle cell development; IMP:FlyBase.
GO; GO:0048636; P:positive regulation of muscle organ development; IGI:FlyBase.
GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IBA:GO_Central.
GO; GO:0045887; P:positive regulation of synaptic growth at neuromuscular junction; IMP:FlyBase.
GO; GO:0042981; P:regulation of apoptotic process; IBA:GO_Central.
GO; GO:0043408; P:regulation of MAPK cascade; IBA:GO_Central.
GO; GO:0046928; P:regulation of neurotransmitter secretion; IDA:FlyBase.
GO; GO:0060395; P:SMAD protein signal transduction; IBA:GO_Central.
GO; GO:0099504; P:synaptic vesicle cycle; IMP:FlyBase.
GO; GO:0007419; P:ventral cord development; HMP:FlyBase.
GO; GO:0035222; P:wing disc pattern formation; IMP:FlyBase.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR001839; TGF-b_C.
InterPro; IPR001111; TGF-b_propeptide.
InterPro; IPR015615; TGF-beta-rel.
InterPro; IPR017948; TGFb_CS.
PANTHER; PTHR11848; PTHR11848; 1.
Pfam; PF00019; TGF_beta; 1.
Pfam; PF00688; TGFb_propeptide; 1.
SMART; SM00204; TGFB; 1.
SUPFAM; SSF57501; SSF57501; 1.
PROSITE; PS00250; TGF_BETA_1; 1.
PROSITE; PS51362; TGF_BETA_2; 1.
1: Evidence at protein level;
Cleavage on pair of basic residues; Complete proteome; Cytokine;
Developmental protein; Disulfide bond; Glycoprotein; Growth factor;
Reference proteome; Secreted; Signal.
SIGNAL 1 36 {ECO:0000255}.
PROPEP 37 335 {ECO:0000255}.
/FTId=PRO_0000033660.
CHAIN 336 455 Protein 60A.
/FTId=PRO_0000033661.
CARBOHYD 238 238 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 250 250 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 396 396 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 354 420 {ECO:0000250}.
DISULFID 383 452 {ECO:0000250}.
DISULFID 387 454 {ECO:0000250}.
DISULFID 419 419 Interchain. {ECO:0000250}.
SEQUENCE 455 AA; 51687 MW; C8FA795556341F94 CRC64;
MSGLRNTSEA VAVLASLGLG MVLLMFVATT PPAVEATQSG IYIDNGKDQT IMHRVLSEDD
KLDVSYEILE FLGIAERPTH LSSHQLSLRK SAPKFLLDVY HRITAEEGLS DQDEDDDYER
GHRSRRSADL EEDEGEQQKN FITDLDKRAI DESDIIMTFL NKRHHNVDEL RHEHGRRLWF
DVSNVPNDNY LVMAELRIYQ NANEGKWLTA NREFTITVYA IGTGTLGQHT MEPLSSVNTT
GDYVGWLELN VTEGLHEWLV KSKDNHGIYI GAHAVNRPDR EVKLDDIGLI HRKVDDEFQP
FMIGFFRGPE LIKATAHSSH HRSKRSASHP RKRKKSVSPN NVPLLEPMES TRSCQMQTLY
IDFKDLGWHD WIIAPEGYGA FYCSGECNFP LNAHMNATNH AIVQTLVHLL EPKKVPKPCC
APTRLGALPV LYHLNDENVN LKKYRNMIVK SCGCH


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