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Protein ALEX (Alternative gene product encoded by XL-exon)

 ALEX_RAT                Reviewed;         738 AA.
Q9Z213; Q924W1;
17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
01-MAY-1999, sequence version 1.
20-JUN-2018, entry version 65.
RecName: Full=Protein ALEX;
AltName: Full=Alternative gene product encoded by XL-exon;
Name=Gnas {ECO:0000312|RGD:2716};
Synonyms=Gnas1 {ECO:0000312|RGD:2716};
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1] {ECO:0000312|EMBL:AAD03033.1}
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Wistar {ECO:0000312|EMBL:AAD03033.1};
Wang Y.Z., Kehlenbach R.H., Huttner W.B.;
"The XL-domain of rat XLas is encoded by a single exon.";
Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000305, ECO:0000312|EMBL:CAC39212.1}
NUCLEOTIDE SEQUENCE [MRNA] OF 227-738, INTERACTION WITH GNAS XLAS
ISOFORMS, AND SUBCELLULAR LOCATION.
STRAIN=Wistar {ECO:0000312|EMBL:AAD03033.1};
PubMed=11447126; DOI=10.1093/emboj/20.14.3849;
Klemke M., Kehlenbach R.H., Huttner W.B.;
"Two overlapping reading frames in a single exon encode interacting
proteins -- a novel way of gene usage.";
EMBO J. 20:3849-3860(2001).
-!- FUNCTION: May inhibit the adenylyl cyclase-stimulating activity of
guanine nucleotide-binding protein G(s) subunit alpha which is
produced from the same locus in a different open reading frame.
{ECO:0000250|UniProtKB:P84996}.
-!- SUBUNIT: Interacts with the N-terminal region of the XLas isoforms
of guanine nucleotide-binding protein G(s) subunit alpha.
{ECO:0000269|PubMed:11447126}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11447126};
Peripheral membrane protein {ECO:0000269|PubMed:11447126}. Cell
projection, ruffle {ECO:0000269|PubMed:11447126}.
Note=Predominantly associated with cell membrane ruffles.
-!- MISCELLANEOUS: This protein is produced by a bicistronic gene
which also produces the guanine nucleotide-binding protein G(s)
subunit alpha from an overlapping reading frame.
{ECO:0000269|PubMed:11447126}.
-!- SIMILARITY: Belongs to the ALEX family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=CAC39212.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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EMBL; AF093569; AAD03033.1; -; Genomic_DNA.
EMBL; X84047; CAC39212.1; ALT_INIT; mRNA.
UniGene; Rn.127731; -.
UniGene; Rn.31; -.
PRIDE; Q9Z213; -.
RGD; 2716; Gnas.
HOVERGEN; HBG080831; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0005737; C:cytoplasm; IDA:RGD.
GO; GO:0005829; C:cytosol; IDA:RGD.
GO; GO:0005768; C:endosome; IDA:RGD.
GO; GO:0005834; C:heterotrimeric G-protein complex; IDA:RGD.
GO; GO:0016020; C:membrane; IDA:RGD.
GO; GO:0045121; C:membrane raft; IDA:RGD.
GO; GO:0043025; C:neuronal cell body; IDA:RGD.
GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
GO; GO:0005886; C:plasma membrane; IDA:RGD.
GO; GO:0055037; C:recycling endosome; IDA:RGD.
GO; GO:0001726; C:ruffle; IDA:RGD.
GO; GO:0043014; F:alpha-tubulin binding; IDA:RGD.
GO; GO:0031698; F:beta-2 adrenergic receptor binding; IPI:RGD.
GO; GO:0051430; F:corticotropin-releasing hormone receptor 1 binding; IPI:RGD.
GO; GO:0031748; F:D1 dopamine receptor binding; IPI:RGD.
GO; GO:0001965; F:G-protein alpha-subunit binding; IPI:RGD.
GO; GO:0031681; F:G-protein beta-subunit binding; IDA:RGD.
GO; GO:0005525; F:GTP binding; IDA:RGD.
GO; GO:0005159; F:insulin-like growth factor receptor binding; IPI:RGD.
GO; GO:0035255; F:ionotropic glutamate receptor binding; IPI:RGD.
GO; GO:0031852; F:mu-type opioid receptor binding; IDA:RGD.
GO; GO:0019904; F:protein domain specific binding; IPI:RGD.
GO; GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IDA:RGD.
GO; GO:0055074; P:calcium ion homeostasis; IMP:RGD.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IMP:RGD.
GO; GO:0045776; P:negative regulation of blood pressure; IMP:RGD.
GO; GO:0035814; P:negative regulation of renal sodium excretion; IMP:RGD.
GO; GO:0008284; P:positive regulation of cell proliferation; IDA:RGD.
GO; GO:0001934; P:positive regulation of protein phosphorylation; IMP:RGD.
GO; GO:0010765; P:positive regulation of sodium ion transport; IMP:RGD.
GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IMP:RGD.
1: Evidence at protein level;
Cell membrane; Cell projection; Complete proteome; Membrane;
Reference proteome.
CHAIN 1 738 Protein ALEX.
/FTId=PRO_0000253966.
COMPBIAS 397 578 Pro-rich. {ECO:0000255}.
SEQUENCE 738 AA; 80341 MW; 51EA2B3A7D9D018A CRC64;
MSPSPTRLTV RSVDPLKTPN LTSRAPVRPS RKSKWAETTA HLQRKPCHSR SNSPAWEISG
PPWSSLDHLD PIRHQSLQPS DFGARTPTGA HPGLGAYSPP PEEAMPFEFN EPAQEDRCQP
PLQVPDLAPG GPEAWVSRAL PAEPGNLGFE NTGFREDYSP PPEESVPFQL DGEEFGGDSP
PPDSASHATN RHWRFEFPTV AVPSTLCLRP ARTRLPSGSR APLADHARLS DLLTSHTTFP
QWRSPDPCLR LAEPPLGSTT TPLSIWTAPQ SQVMARPSKS REPQLRASTQ RDPHLSDKQP
RQETALSAAP LQRRQKSPPS SEEKDPPPNL KQCISSQLLL RSPERTLPKP IRTQLHTQFF
RSVLRKSEES QPCPPIFRLL LKMRAQMSGQ NQTEGQPQPP LPSPKTTENQ PPPPPPSQPP
SQPLSQPPSQ PPSQPPSQLP RQSLTPKPSL PPGQSPTPKR SPQPRQPLPR RRSLPPGQPP
SPLRSPLPGL SLLPEPIQPP GLSLEPQRCQ PLLGQPPLEQ PMQVLWSGEP GHSRLLQPLG
HPSLPAQQLP PEQPLLPAQS LPAGQPLPPQ AGPILDPPAR RSRLLTRLLR GLLRGRVPGL
TNTNVAEAAA GMRLRPASAR SSPPAMSRKK GPLAASSGFC GETAALASPG ATQSGATRSA
TSSPEPSEAA SVYLSVPDHD PSAPGRPRIL WKRGANRCAK KPWRCESRSA QIRNAASSST
SNWRRRRWTT CVHTACCF


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